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| 1 | Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors显示文摘The tumor microenvironment(TME)significantly influences cancer evolution and therapeutic efficacy.Targeting biofunctional molecules to the TME has long been appreciated as a means of raising local drug concentrations and reducing systemic toxicities.The booming nanotechnology field has realized the importance of cathepsin B to derive a variety of intelligent enzyme-responsive nanosized drug delivery systems(nanoDDS)to improve treatment responses and clinical outcomes.In this tutorial review,after introducing the molecular structure and physiological/pathological functions of cathepsin B,the outstanding achievements of cathepsin B-responsive nanoplatforms in the precise diagnosis,targeted therapy,and synergistic theranostics of malignant tumors are systematically described.Finally,the challenges of enzyme-substrate incompatibility,low diagnostic sensitivity,mass production and biocompatibility of multifunctional nanoDDS are considered in order to successfully promote them to clinical applications. | Yanan Li Ting Mei Shupeng Han Tao Han Yongbing Sun Hui Zhang Feifei An | 2020 | Chinese Chemical Letters2020，31，12： | 5 |
| 2 | XCO_2 satellite retrieval experiments in short-wave infrared spectrum and ground-based validation显示文摘Based on the optimal estimation method, a satellite XCO2 retrieval algorithm was constructed by combining LBLRTM with VLIDORT. One-year GOSAT/TANSO observations over four TCCON stations were tested by our algorithm, and retrieval results were compared with GOSAT L2 B products and ground-based FTS measurements. Meanwhile, the influence of CO2 line mixing effect on retrieval was estimated, and the research showed that neglecting CO2 line mixing effect could result in approximately 0.25% XCO2 underestimation. The accuracy of XCO2 retrievals was similar to GOSAT L2 B products at cloud-free footprints with aerosol optical depth less than 0.3, and 1% accuracy of XCO2 retrievals can be reached based on the validation result with TCCON measurements. | ZHOU MinQiang ZHANG XingYing WANG PuCai WANG ShuPeng GUO LiLi HU LieQun | 2015 | Science China Earth Sciences2015，58，7： | 4 |
| 3 | An artificial neural network approach to estimate evapotranspiration from remote sensing and AmeriFlux data显示文摘估计土壤水分蒸发蒸腾损失总量(et ) 的一个简单、精确的方法为在大规模的地球系统的动态监视是必要的。在这份报纸,我们开发了遥感和 AmeriFlux 数据强迫估计 et 第一的一个人工的神经网络( ANN )模型, ANN 被训练, et 大小在 13 个 AmeriFlux 地点做了,陆地表面产品遥远地源于卫星察觉到的数据(规范的差别植被索引,陆地表面温度和表面网络放射)为时期 2002-2006 。与 ANN 估计的 et 然后被在一样的时期期间在五个 AmeriFlux 地点观察的 et 验证。确认地点盖住五种不同植被类型并且不涉及训练的 ANN。决心的系数(R ^ 啜 2 ^) 为在估计并且测量的 et 之间的比较的价值是 0.77, root-mean-square 错误是 0.62 mm/d,并且吝啬的剩余是 0.28。简单模型在捕获的这份报纸发展了季节并且总体上的 et 的 interannual 变化特征。然而,估计的 et 的精确性取决于植被类型,估计的 et 与另外的四种植被类型相比为脱落阔叶烟草森林在之中显示出最好的结果[出版摘要] | Zhuoqi CHEN Runhe SHI Shupeng Zhang | 2013 | Frontiers of Earth Science2013，7，1： | 4 |
| 4 | High-Sensitivity Gas Detection with Air-Lasing-Assisted Coherent Raman Spectroscopy显示文摘Remote or standoff detection of greenhouse gases,air pollutants,and biological agents with innovative ultrafast laser technology attracts growing interests in recent years.Hybrid femtosecond/picosecond coherent Raman spectroscopy is considered as one of the most versatile techniques due to its great advantages in terms of detection sensitivity and chemical specificity.However,the simultaneous requirement for the femtosecond pump and the picosecond probe increases the complexity of optical system.Herein,we demonstrate that air lasing naturally created inside a filament can serve as an ideal light source to probe Raman coherence excited by the femtosecond pump,producing coherent Raman signal with molecular vibrational signatures.The combination of pulse self-compression effect and air lasing action during filamentation improves Raman excitation efficiency and greatly simplifies the experimental setup.The air-lasing-assisted Raman spectroscopy was applied to quantitatively detect greenhouse gases mixed in air,and it was found that the minimum detectable concentrations of CO_(2) and SF_(6) can reach 0.1%and 0.03%,respectively.The ingenious designs,especially the optimization of pump-seed delay and the choice of perpendicular polarization,ensure a high detection sensitivity and signal stability.Moreover,it is demonstrated that this method can be used for simultaneously measuring CO_(2) and SF_(6) gases and distinguishing ^(12)CO_(2) and ^(13)CO_(2).The developed scheme provides a new route for high-sensitivity standoff detection and combustion diagnosis. | Zhihao Zhang Fangbo Zhang Bo Xu Hongqiang Xie Botao Fu Xu Lu Ning Zhang Shupeng Yu Jinping Yao Ya Cheng Zhizhan Xu | 2022 | Ultrafast Science2022，，2： | 4 |
| 5 | Mapping Near-surface Air Temperature, Pressure, Relative Humidity and Wind Speed over China's Mainland with High Spatiotemporal Resolution显示文摘As part of a joint effort to construct an atmospheric forcing dataset for China's Mainland with high spatiotemporal resolution, a new approach is proposed to construct gridded near-surface temperature, relative humidity, wind speed and surface pressure with a resolution of 1 km×1 km. The approach comprises two steps:(1) fit a partial thin-plate smoothing spline with orography and reanalysis data as explanatory variables to ground-based observations for estimating a trend surface;(2)apply a simple kriging procedure to the residual for trend surface correction.The proposed approach is applied to observations collected at approximately 700 stations over China's Mainland. The generated forcing fields are compared with the corresponding components of the National Centers for Environmental Prediction(NCEP) Climate Forecast System Reanalysis dataset and the Princeton meteorological forcing dataset. The comparison shows that, both within the station network and within the resolutions of the two gridded datasets, the interpolation errors of the proposed approach are markedly smaller than the two gridded datasets. | LI Tao ZHENG Xiaogu DAI Yongjiu YANG Chi CHEN Zhuoqi ZHANG Shupeng WU Guocan WANG Zhonglei HUANG Chengcheng SHEN Yan LIAO Rongwei | 2014 | Advances in Atmospheric Sciences2014，31，5： | 3 |
| 6 | Assessment of global meteorological,hydrological and agricultural drought under future warming based on CMIP6显示文摘在全球变暖背景下,分析和预测干旱的变化趋势和传播规律对于区域生态环境安全和灾害管理具有重要意义.本文基于第六次国际耦合模式比较计划(CMIP6),分析了SSP2-4.5和SSP5-8.5两种变暖情景下的气象(标准化降水指数SPI和标准化降水蒸发指数SPEI),水文(标准化径流指数SRI)和农业(标准化土壤水分指数SSI)干旱情况.从1901年到2100年,全球范围内不同类型的干旱事件普遍都表现出空间范围,持续时间和严重程度上的增长,其中SPEI干旱的增长最为显著.干旱加剧的地区主要包括美国西南部,亚马逊地区,地中海地区,非洲南部,亚洲南部和澳大利亚.尽管结果显示SRI和SSI干旱程度强于SPI干旱,但不同模式对SPI干旱的预测具有更高的一致性.此外,研究发现气象干旱与水文干旱的相关性高于气象干旱与农业干旱的相关性,在温暖湿润地区尤为明显,同时水文干旱与短时间尺度的气象干旱具有更好的相关性.本文的研究结果将有助于气候变化下的干旱监测和水资源管理. | Jianxin Zeng Jiaxian Li Xingjie Lu Zhongwang Wei Wei Shangguan Shupeng Zhang Yongjiu Dai Shulei Zhang | 2022 | Atmospheric and Oceanic Science Letters2022，15，1： | 2 |
| 7 | Expression of Intercellular Adhesion Molecule 1 by Hepatocellular Carcinoma Stem Cells and Circulating Tumor Cells显示文摘 | Shupeng Liu Nan Li Xiya Yu Xiao Xiao Kai Cheng Jingjing Hu Jiaqi Wang Dandan Zhang Shuqun Cheng Shanrong Liu | 2013 | Gastroenterology2013，，5： | 2 |
| 8 | Experimental study on enhancement of the metastatic potential of portal vein tumor thrombus-originated hepatocellular carcinoma cells using portal vein serum显示文摘Objective: Portal vein metastasis of hepatocellular carcinoma(HCC) results in a poor prognosis and seriously affects the survival rate of patients. The mechanism underlying the formation of portal vein tumor thrombus(PVTT) is complex and is not yet fully understood. This study was conducted to investigate the impact of portal vein blood on the proliferation, metastasis, invasion and apoptosis of PVTT cells and to explore its possible mechanisms, which was expected to lay a foundation for ascertaining the mechanism underlying the portal vein metastasis of HCC.Methods: Peripheral blood and portal vein blood were collected from patients with HCC, and the sera from these two sources were used to culture the PVTT-originated HCC cell line CSQT-2. The cells were collected after 24 h, and flow cytometry was performed to detect cell proliferation, cell cycle stages and apoptosis. Transwell migration and invasion assays were applied to detect the metastasis and invasion of the cells in each group. The changes in the expression of MMP-2 and MMP-9 in cells were detected via Western blotting. The contents of IL-12, IFN-γ, IL-1β, IL-2 and TNF-α in the two groups of sera were quantified using corresponding kits. Results: Compared with the group of cells cultured with peripheral serum, the cells cultured with portal vein serum showed significantly lower apoptosis(P<0.01), significantly enhanced cell metastasis and invasion(P<0.01), whereas cell proliferation and the stages of the cell cycle did not differ significantly(P>0.05). A significantly increased expression level of MMP-2 has been observed in tumor cells treated portal vein serum. In addition, compared with peripheral serum, the content of IL-12 was significantly decreased in portal vein serum(P<0.05), while the contents of IFN-γ, IL-1β, IL-2, and TNF-α did not differ significantly(P>0.05). Conclusions: Portal vein serum from HCC patients could inhibit the apoptosis of PVTT-originated HCC cells and promote cell metastasis and invasion. This effect may be related to the lower level of IL-12 in portal vein serum. | Yufu Tang Hongming Yu Long Zhang Kang Wang Weixing Guo Jie Shi Shupeng Liu Mengchao Wu Hongyang Wang Shuqun Cheng | 2014 | Chinese Journal of Cancer Research2014，26，5： | 2 |
| 9 | Control Strategy and Simulation of Hybrid electric Vehicle 显示文摘 | Zhao shupeng Zhang shifang Xu pengyun | 2007 | The Eighth hltemationa! Conference on Electronic Measurement and Instruments2007，，7： | 1 |
| 10 | Maximum likelihood estimation of inflation factors on error covariance matrices for ensemble Kalman filter as-similation 显示文摘 | Liang Xiao Zheng Xiaogu Zhang Shupeng | 2012 | Quarterly Journal of the Royal Meteoro- logical Society2012，138，662： | 1 |
| 11 | Learning to recognize misaligned hyperfine orbital angular momentum modes显示文摘Orbital angular momentum(OAM)-carrying beams have received extensive attention due to their high-dimensional characteristics in the context of free-space optical communication.However,accurate OAM mode recognition still suffers from reference misalignment of lateral displacement,beam waist size,and initial phase.Here we propose a deep-learning method to exquisitely recognize OAM modes under misalignment by using an alignment-free fractal multipoint interferometer.Our experiments achieve 98.35% recognizing accuracy when strong misalignment is added to hyperfine OAM modes whose Bures distance is 0.01.The maximum lateral displacement we added with respect to the perfectly on-axis beam is about±0.5 beam waist size.This work offers a superstable proposal for OAM mode recognition in the application of free-space optical communication and allows an increase of the communication capacity. | Xiao Wang Yufeng Qian JingJing Zhang Guangdong Ma Shupeng Zhao RuiFeng Liu Hongrong Li Pei Zhang Hong Gao Feng Huang Fuli Li | 2021 | Photonics Research2021，9，4： | 1 |
| 12 | Nonlinear dynamic characteristics of journal bearing-rotor system considering the pitching and roll-ing motion for marine turbo machinery显示文摘 | ZHANG Guanghui LIU Shupeng MA Ruixian | 2015 | Journal of Engineering for the Maritime Environment2015，229，1： | 1 |
| 13 | Optimizing photosynthetic and respiratory parameters based on the seasonal variation pattern in regional net ecosystem productivity obtained from atmospheric inversion显示文摘In this study, we explore the feasibility of optimizing ecosystem photosynthetic and respiratory parameters from the seasonal variation of the net carbon flux. An optimization scheme is proposed to estimate two key parameters(Vmax25and Q10) by exploiting the seasonal variation in the net ecosystem carbon flux retrieved by an atmospheric inversion system. This scheme is implemented to estimate Vmax25 and Q10of the boreal ecosystem productivity simulator(BEPS) to improve its NEP simulation in the boreal North American region. Then, in situ NEE observations at six eddy covariance sites are used to evaluate the NEE simulations from BEPS with initial and optimized parameters. The results show that the performance of the optimized BEPS is superior to that of the BEPS with the default parameter values. These results implicate that it is possible to optimize ecosystem model parameters by different sensitivities of Vmax25 and Q10during growing and non-growing seasons through atmospheric inversion or data assimilation techniques. | Zhuoqi Chen Jing M.Chen Xiaogu Zheng Fei Jiang Jun Qin Shupeng Zhang Wenping Yuan Weiming Ju Gang Mo | 2015 | Science Bulletin2015，60，22： | 1 |
| 14 | Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide显示文摘Approximately 80%of primary tumors in the central nervous system are malignant glioma,and>50%of those are diagnosed as glioblastoma(GBM),the most aggressive glioma.Despite treatment advances,GBM prognosis is unsatisfying,and the median survival time of patients is only 14-17 months. | Bohan Chen Anshun He Jinfang Bi Shupeng Sun Yiping Ma Wenbin Wang Dianhao Guo Jun Chen Yuyang Qian Tengfei Shi Guohui Nie Zhongfang Zhao Jiandang Shi Hongzhen Yang Lei Zhang Wange Lu | 2021 | Journal of Genetics and Genomics2021，48，10： | 1 |
| 15 | Satisfactory surgical outcome of T2 gastric cancer after modified D2 lymphadenectomy显示文摘Objective: Though D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer(GC), the modified D2(D1 + 7, 8a and 9) lymphadenectomy may be more suitable than D2 dissection for T2 stage GC. The purpose of this study is to elucidate whether the surgical outcome of modified D2 lymphadenectomy was comparable to that of standard D2 dissection in T2 stage GC patients.Methods: A retrospective cohort study with 77 cases and 77 controls matched for baseline characteristics was conducted. Patients were categorized into two groups according to the extent of lymphadenectomy: the modified D2 group(m D2) and the standard D2 group(D2). Surgical outcome and recurrence date were compared between the two groups.Results: The 5-year overall survival(OS) rate was 71.4% for patients accepted m D2 lymphadenectomy and70.1% for those accepted standard D2, respectively, and the difference was not statistically significant. Multivariate survival analysis revealed that curability, tumor size, TNM stage and postoperative complications were independently prognostic factors for T2 stage GC patients. Patients in the m D2 group tended to have less intraoperative blood loss(P=0.001) and shorter operation time(P<0.001) than those in the D2 group. While there were no significant differences in recurrence rate and types, especially lymph node recurrence, between the two groups.Conclusions: The surgical outcome of m D2 lymphadenectomy was equal to that of standard D2, and the use of m D2 instead of standard D2 can be a better option for T2 stage GC. | Shupeng Zhang Liangliang WU Xiaona Wang Xuewei Ding Han Liang | 2017 | Chinese Journal of Cancer Research2017，29，2： | 1 |
| 16 | Plant drought tolerance trait is the key parameter in improving the modeling of terrestrial transpiration in arid and semi-arid regions显示文摘陆面过程蒸腾作用的模拟制约着天气,气候降水预测的精确度.近几十年来,为了更好地描述植被蒸腾的水力约束,陆面过程模式发展了基于植物性状的植物水力胁迫方案.然而,我们对于植物性状在蒸腾模拟中的地位仍然缺乏了解,植物性状对蒸腾的重要性仍需进一步量化.本研究利用Morris方法评估植物性状参数在通用陆面模式植物水力胁迫方案(CoLM-P_(50)HS)中的重要性,针对17种植物性状,筛选出最为重要的:耐旱性状(P_(50)),气孔性状,和光合作用性状.在12个FLUXNET站点中,参数的重要性由归一化敏感度来衡量.P_(50)的重要性随着降水的减少而增加,而气孔性状和光合作用性状的重要性则随着降水的减少而减少.在干旱或半干旱地区,P_(50)比气孔性状和光合作用性状更重要,这意味着当植物经常经历干旱时,水力安全策略比植物生长策略更关键.而耐旱性状的巨大变异性进一步暗示了多种植物水力安全策略的共存.忽视P_(50)的变异性可能会对陆面过程模式蒸腾作用的模拟造成严重误差.因此,为了更好地表示植物水力功能的变异性,需要增加对耐旱性状的观测并耦合到陆面模式中. | Xintao Liu Xingjie Lu Shulei Zhang Zhongwang Wei Nan Wei Shupeng Zhang Hua Yuan Wei Shangguan Shaofeng Liu Jianfeng Huang Lu Li Xiulan Ye Jinxuan Zhou Wenke Hu Yongjiu Dai | 2022 | Atmospheric and Oceanic Science Letters2022，15，1： | 1 |
| 17 | Up‐regulated microRNA‐143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression显示文摘 | Xiaoying Zhang Shanrong Liu Tingsong Hu Shupeng Liu Ying He Shuhan Sun | 2009 | Hepatology2009，，2： | 1 |
| 18 | Dual functions of PsmiR172b-PsTOE3 module in dormancy release and flowering in tree peony (Paeonia suffruticosa)显示文摘MicroRNAs(miRNAs)are non-coding RNAs that interact with target genes and are involved in many physiological processes in plants.miR172-AP2 mainly plays a role in the regulation of f lowering time and floral organ differentiation.Bud dormancy release is necessary for forcing culture of tree peony in winter,but the mechanism of dormancy regulation is unclear.In this study,we found that a miR172 family member,PsmiR172b,was downregulated during chilling-induced bud dormancy release in tree peony,exhibiting a trend opposite to that of PsTOE3.RNA ligase-mediated(RLM)5-RACE(rapid amplification of cDNA ends)confirmed that miR172b targeted PsTOE3,and the cleavage site was between bases 12(T)and 13(C)within the complementary site to miR172b.The functions of miR172b and PsTOE3 were detected by virus-induced gene silencing(VIGS)and their overexpression in tree peony buds.PsmiR172b negatively regulated bud dormancy release,but PsTOE3 promoted bud dormancy release,and the genes associated with bud dormancy release,including PsEBB1,PsEBB3,PsCYCD,and PsBG6,were upregulated.Further analysis indicated that PsTOE3 directly regulated PsEBB1 by binding to its promoter,and the specific binding site was a C-repeat(ACCGAC).Ectopic expression in Arabidopsis revealed that the PsmiR172b-PsTOE3 module displayed conservative function in regulating f lowering.In conclusion,our results provided a novel insight into the functions of PsmiR172-PsTOE3 and possible molecular mechanism underlying bud dormancy release in tree peony. | Yuxi Zhang Linqiang Gao Yanyan Wang Demei Niu Yanchao Yuan Chunying Liu Xinmei Zhan Shupeng Gai | 2023 | Horticulture Research2023，10，4： | 0 |
| 19 | E®ect of laser acupuncture combined with electrical stimulation on recovery from exercise fatigue in mice显示文摘In sports events,the rapid recovery after high-intensity training or sport competition performance is very important for athletes'performance and health.The aim of this study is to evaluate the effect of laser acupuncture and electrical stimulation on the recovery from exercise fatigue,using mice with swimming fatigue as experimental model and the electromyography(EMG)and the Raman spectroscopy of blood as evaluation indicators.Root mean square(RMS)and mean power frequency(MPF)of EMG were analyzed after laser acupuncture and electrical stimulation.The amplitude frequency combined analysis(JASA)showed that the proportion of muscles in the fatigue recovery area of the control group,the laser acupuncture group,the multi-channel laser acupuncture group and the laser combined with electrical stimulation group were 34.78%,39.13%,39.13%and 43.48%,respectively.Raman spectroscopy of the mice blood during fatigue recovery showed there is a significant difference between the multi-channel laser acupuncture group and the laser combined with electric stimulation group compared with the recovery period and fatigue period(P<0:05)at the peak of 997 cm^(-1) and the laser combined electrical stimulation group had a statistical difference in the recovery period compared with the fatigue period(P<0.05)at the peak of 1561 cm^(-1).The results showed that laser acupuncture combined with electrical stimulation was beneficial to fatigue recovery in mice,and had the potential value in sports fatigue recovery. | Shupeng Liu Yudan Xia Zehai Hou Haotian Hong Na Chen Taihao Li Chunlei Shan Heng Zhang | 2023 | Journal of Innovative Optical Health Sciences2023，16，4： | 0 |
| 20 | PsRGL1 negatively regulates chilling- and gibberellin-induced dormancy release by PsF-box1-mediated targeting for proteolytic degradation in tree peony显示文摘Tree peony bud endodormancy is a common survival strategy similar to many perennial woody plants in winter,and the activation of the GA signaling pathway is the key to breaking endodormancy.GA signal transduction is involved in many physiological processes.Although the GA-GID1-DELLA regulatory module is conserved in many plants,it has a set of specific components that add complexity to the GA response mechanism.DELLA proteins are key switches in GA signaling.Therefore,there is an urgent need to identify the key DELLA proteins involved in tree peony bud dormancy release.In this study,the prolonged chilling increased the content of endogenously active gibberellins.PsRGL1 among three DELLA proteins was significantly downregulated during chilling-and exogenous GA3-induced bud dormancy release by cell-free degradation assay,and a high level of polyubiquitination was detected.Silencing PsRGL1 accelerated bud dormancy release by increasing the expression of the genes associated with dormancy release,including PsCYCD,PsEBB1,PsEBB3,PsBG6,and PsBG9.Three F-box protein family members responded to chilling and GA3 treatments,resulting in PsF-box1 induction.Yeast two-hybrid and BiFC assays indicated that only PsF-box1 could bind to PsRGL1,and the binding site was in the C-terminal domain.PsF-box1 overexpression promoted dormancy release and upregulated the expression of the dormancy-related genes.In addition,yeast two-hybrid and pull-down assays showed that PsF-box1 also interacted with PsSKP1 to form an E3 ubiquitin ligase.These findings enriched the molecular mechanism of the GA signaling pathway during dormancy release,and enhanced the understanding of tree peony bud endodormancy. | Linqiang Gao Demei Niu Tianyu Chi Yanchao Yuan Chunying Liu Shupeng Gai Yuxi Zhang | 2023 | Horticulture Research2023，10，5： | 0 |
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