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1Map and analysis of microsatellites in the genome of Populus: The first sequenced perennial plant显示文摘Environmental Sciences Division, Oak Ridge National Laboratory, TN, USA We mapped and analyzed the microsatellites throughout 284295605 base pairs of the unambiguously assembled sequence scaffolds along 19 chromosomes of the haploid poplar genome. Totally, we found 150985 SSRs with repeat unit lengths between 2 and 5 bp. The established microsatellite physical map demonstrated tr at SSRs were distributed relatively evenly across the genome of Populus. On average, These SSRs occurred every 1883 bp within the poplar genome and the SSR densities in intergenic regions, introns, exons and UTRs were 85.4%, 10.7%, 2.7% and 1.2%, respectively. We took di-, tri-, tetra-and pentamers as the four classes of repeat units and found that the density of each class of SSRs decreased with the repeat unit lengths except for the tetranucleotide repeats. It was noteworthy that the length diversification of microsatellite sequences was negatively correlated with their repeat unit length and the SSRs with shorter repeat units gained repeats faster than the SSRs with longer repeat units. We also found that the GC content of poplar sequence significantly correlated with densities of SSRs with uneven repeat unit lengths (tri-and penta-), but had no significant correlation with densities of SSRs with even repeat unit lengths (di-and tetra-). In poplar genome, there were evidences that the occurrence of different microsatellites was under selection and the GC content in SSR sequences was found to significantly relate to the functional importance of microsatellites.LI ShuXian & YIN TongMing College of Environment and Forest Resources, Nanjing Forestry University, Nanjing 210037, China Environmental Sciences Division, Oak Ridge National Laboratory, TN, USA 2007Science China(Life Sciences)2007,50,5:25
2Particle size distribution and characteristics of polycyclic aromatic hydrocarbons during a heavy haze episode in Nanjing,China显示文摘A heavy haze episode caused by agricultural burning occurred in Nanjing from November 7 to November8,2009.PM_(10) samples were collected on normal and hazy days from November 1 to November 14,2009 at both city and suburban sites of Nanjing.Sixteen PAHs were measured during the day and at night.The results show that the concentrations of the particles were as high as 579.55 and 573.43 μg/m^3 during the haze episode at the city and suburban sites,respectively,3-4 times higher than those on a normal day.The proportions of fine particles during the haze episode were also higher than those on a normal day.The changes in the concentrations of PAHs were in accordance with the concentrations of the particles.Highmolecular-weight PAHs composed approximately 80% of the total PAHs on normal days and during the haze episode.The concentration of PAHs in fine fractions significantly increased during the haze episode,and this increase was most obvious at night at the city site.The proportion of total carcinogenic PAHs in fine particles was relatively high during the haze episode at both sampling sites,particularly at night at the city site.Qingzi Meng Shuxian Fan Jiabao He Jian Zhang Yu Sun Yue Zhang Fan Zu 2015Particuology2015,13,1:16
3Combined treatment with erythropoietin and granulocyte colony-stimulating factor enhances neovascularization and improves cardiac function after myocardial infarction显示文摘Xue Jingyi Du Guoqing Shi Jing Li Yue Masahiro Yasutake Liu Lei Li Jianqiang Kong Yihui Wang Shuxian Yun Fengxiang Li Weimin 2014Chinese Medical Journal2014,,9:12
4COVID-19 containment: China provides important lessons for global response显示文摘The world must act fast to contain wider international spread of the epidemic of COVID-19 now.The unprecedented public health efforts in China have contained the spread of this new virus.Measures taken in China are currently proven to reduce human-to-human transmission successfully.We summarized the effective intervention and prevention measures in the fields of public health response,clinical management,and research development in China,which may provide vital lessons for the global response.It is really important to take collaborative actions now to save more lives from the pandemic of COVID-19.Shuxian Zhang Zezhou Wang Ruijie Chang Huwen Wang Chen Xu Xiaoyue Yu Lhakpa Tsamlag Yinqiao Dong Hui Wang Yong Cai 2020Frontiers of Medicine2020,14,2:11
5The biological function of type I receptors of bone morphogenetic protein in bone显示文摘Bone morphogenetic proteins(BMPs) have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serine/threonine kinase receptors(BMPRI and BMPRII). In recent decades, genetic studies in humans and mice have demonstrated that perturbations in BMP signaling via BMPRI resulted in various diseases in bone, cartilage, and muscles. In this review, we focus on all three types of BMPRI, which consist of activin-like kinase 2(ALK2, also called type IA activin receptor), activinlike kinase 3(ALK3, also called BMPRIA), and activin-like kinase 6(ALK6, also called BMPRIB). The research areas covered include the current progress regarding the roles of these receptors during myogenesis,chondrogenesis, and osteogenesis. Understanding the physiological and pathological functions of these receptors at the cellular and molecular levels will advance drug development and tissue regeneration for treating musculoskeletal diseases and bone defects in the future.Shuxian Lin Kathy KH Svoboda Jian Q Feng Xinquan Jiang 2016Bone Research2016,4,2:10
6Glycerol aerobic oxidation to glyceric acid over Pt/hydrotalcite catalysts at room temperature显示文摘Glycerol(GLY) aerobic oxidation in an aqueous solution is one of the most prospective pathways in biomass transformation, where the supported catalysts based on noble metals(mainly Au, Pd, Pt) are most commonly employed. Herein, Pt nanoparticles supported on rehydrated MgxAl1-hydrotalcite(denoted as re-MgxAl1-LDH-Pt) were prepared via impregnation-reduction method followed by an in situ rehydration process, which showed high activity and selectivity towards GLY oxidation to produce glyceric acid(GLYA) at room temperature. The metal-support interfacial structure and catalyst basicity were modulated by changing the Mg/Al molar ratio of the hydrotalcite precursor, and the optimal performance was achieved on re-Mg6Al1-LDH-Pt with a GLY conversion of 87.6% and a GLYA yield of 58.6%, which exceeded the traditional activated carbon and oxide supports. A combinative study on structural characterizations(XANES, CO-FTIR spectra, and benzoic acid titration) proves that a higher Mg/Al molar ratio promotes the formation of positively charged Ptd+species at metal-support interface, which accelerates bond cleavage of a-C–H and improves catalytic activity. Moreover, a higher Mg/Al molar ratio provides a stronger basicity of support that contributes to the oxidation of terminal-hydroxyl and thus enhances the selectivity of GLYA. This catalyst with tunable metal-support interaction shows prospective applications toward transformation of biomass-based polyols.Junbo Zhang Xiaolin Li Ming Xu Yusen Yang Yinwen Li Ning Liu Xiaoyu Meng Lifang Chen Shuxian Shi Min Wei 2019Science Bulletin2019,64,23:8
7Estimation of reproduction numbers of COVID-19 in typical countries and epidemic trends under different prevention and control scenarios显示文摘The coronavirus disease 2019(COVID-19)has become a life-threatening pandemic.The epidemic trends in different countries vary considerably due to different policy-making and resources mobilization.We calculated basic reproduction number(R0)and the time-varying estimate of the effective reproductive number(Rt)of COVID-19 by using the maximum likelihood method and the sequential Bayesian method,respectively.European and North American countries possessed higher (R0)and unsteady Rt fluctuations,whereas some heavily affected Asian countries showed relatively low (R0)and declining Rt now.The numbers of patients in Africa and Latin America are still low,but the potential risk of huge outbreaks cannot be ignored.Three scenarios were then simulated,generating distinct outcomes by using SEIR(susceptible,exposed,infectious,and removed)model.First,evidence-based prompt responses yield lower transmission rate followed by decreasing Rt.Second,implementation of effective control policies at a relatively late stage,in spite of huge casualties at early phase,can still achieve containment and mitigation.Third,wisely taking advantage of the time-window for developing countries in Africa and Latin America to adopt adequate measures can save more people’s life.Our mathematical modeling provides evidence for international communities to develop sound design of containment and mitigation policies for COVID-19.Chen Xu Yinqiao Dong Xiaoyue Yu Huwen Wang Lhakpa Tsamlag Shuxian Zhang Ruijie Chang Zezhou Wang Yuelin Yu Rusi Long Ying Wang Gang Xu Tian Shen Suping Wang Xinxin Zhang Hui Wang Yong Cai 2020Frontiers of Medicine2020,14,5:8
8Carcinogenesis of nasopharyngeal carcinoma:an alternate hypothetical mechanism显示文摘Current proposed mechanisms implicate both early and latent Epstein-Barr virus(EBV)infection in the carcinogenic cascade,whereas epidemiological studies have always associated nasopharyngeal carcinoma(NPC)with early childhood EBV infection and with chronic ear,nose,and sinus conditions.Moreover,most patients with NPC present with IgA antibody titers to EBV capsid antigen(VCA-lgA),which can precede actual tumor presentation by several years.If early childhood EBV infection indeed constitutes a key event in NPC carcinogenesis,one would have to explain the inability to detect the virus in normal nasopharyngeal epithelium of patients at a high risk for EBV infection.It is perhaps possible that EBV resides within the salivary glands,instead of the epithelium,during latency.This claim is indirectly supported by observations that the East Asian phenotype shares the characteristics of an increased susceptibility to NPC and immature salivary gland morphogenesis,the latter of which is influenced by the association of salivary gland morphogenesis with an evolutionary variant of the human ectodysplasin receptor gene(EDAR),EDARV370A.Whether the immature salivary gland represents a more favorable nidus for EBV is uncertain,but in patients with infectious mononucleosis,EBV has been isolated in this anatomical organ.The presence of EBV-induced lymphoepitheliomas in the salivary glands and lungs further addresses the possibility of submucosal spread of the virus.Adding to the fact that the fossa of Rosen Muller contains a transformative zone active only in the first decade of life,one might be tempted to speculate the possibility of an alternative carcinogenic cascade for NPC that is perhaps not dissimilar to the model of human papillomavirus and cervical cancer.Sharon Shuxian Poh Melvin Lee Kiang Chua Joseph T.S.Wee 2016Chinese Journal of Cancer2016,35,1:8
9Ground-based observation of aerosol optical properties in Lanzhou, China显示文摘Aerosol optical properties from August 2006 to July 2007 were obtained from ground-based and sky radiance measurements in Semi- Arid Climate and Environment Observatory of Lanzhou University (SACOL), China. High aerosol optical thickness (AOT) associated with low ngstrm exponent (α) was mainly observed in spring, which was consistent with the seasonal dust production from Hexi Corridor. The maximum monthly average value of AOT 0.56 occurred in March of 2007, which was two times larger than the minimum value of 0.28 in October of 2006. Approximately 60% of the AOT ranged between 0.3 and 0.5, and nearly 93% of α value varied from 0.1 to 0.8, which occurred in spring. The significant correlation between aerosol properties and water vapor content was not observed. The aerosol volume size distribution can be characterized by the bimodal logarithm normal structure: fine mode (r < 0.6 μm) and coarse mode (r > 0.6 μm). Aerosols in spring of SACOL were dominated by large particles with the volume concentration ratio of coarse to fine modes being 7.85. The average values of asymmetry factor (g) in the wavelength range 440-1020 nm were found to be 0.71, 0.67, 0.67 and 0.69 in spring, summer, autumn and winter, respectively.YU Xingna ZHU Bin FAN Shuxian YIN Yan BU Xiaoli 2009Journal of Environmental Sciences2009,21,11:7
10Lipopolysaccharide promotes angiogenesis in mice model of HCC by stimulating hepatic stellate cell activation via TLR4 pathway显示文摘Angiogenesis 在 hepatocellular 癌(HCC ) 的前进起一个关键作用。这研究试图调查 lipopolysaccharide (LPS ) 是否能在这个过程支持 HCC angiogenesis 和肝的星形的房间(HSC ) 的角色。在 vivo orthotopic HCC,模型和在 vitro 的 HSC 上的 LPS 的效果被学习。我们的结果在老鼠在 HCC 生长和 angiogenesis 的提升期间表明了那导致 LPS 的 HSC 激活。LPS-TLR4 (像使用费的受体 4 ) 在 HSC 的小径为 HCC angiogenesis 负责。从 HSC 的 pro-angiogenic 因素的导致 LPS 的分泌物能支持 endothelial 房间移植和 tubulogenesis。这研究建议 LPS 在肿瘤基质与 HSC 行动并且支持在 HCC 增加 angiogenesis 的 pro-angiogenic 因素的分泌物(吗?作者 2017。代表生物化学和房间生物学的研究所由牛津大学出版社出版了,为生物科学的上海研究所,中国科学院。版权所有。为权限,请发邮件:journals.permissions@oup.com。)Yi Lu Jianliang Xu Shuxian Chen Zheng Zhou Nan Lin 2017Acta Biochimica et Biophysica Sinica2017,49,11:6
11Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng 2013Cell Research2013,23,7:5
12深基坑周围地下水渗流破坏影响因素的分析显示文摘分析了基底的土层性质、防渗墙的埋入深度以及抽水回灌层位等因素对地下水渗流的影响。根据基坑周围地下水渗流特征,指出了基坑中容易发生渗流破坏的地段,并提出了相应的控制措施。Sun Shuxian (Yantai University, Yantai 130026) 1998长春科技大学学报1998,28,4:5
13Germination inhibitors detected in Sapium sebiferum seeds显示文摘This study identifies endogenous inhibitors of germination associated with seed dormancy in Sapium sebiferum,Chinese tallow.Seed extracts were separated into five distinct fractions(petroleum ether,ether,ethyl acetate,methanol,and aqueous)and tested for their effect on germination of cabbage seeds.There were no significant differences in germination percentages and germination index(GI)between the solvents and the control.The five fractions differentially reduced germination percentage and GI values of cabbage seeds.According to the GI results,the greatest inhibition was with the ether fraction followed by methanol,ethyl acetate,petroleum ether,and aqueous fractions.Gas chromatography–mass spectrometry identified the constituents of the four organic fractions.Compared with the mass spectrum of the National Institute of Standards and Technology library,a compound was confirmed,provided it was more than 85%similar.Analysis of ether extracts identified four compounds:butylated hydroxytoluene(BHT;19.7%),1,2-benzenediol(4.1%),phydroxycinnamic acid,ethyl ester(2.8%),and n-hexadecanoic acid(1.4%).Fourteen,20,and 9 compounds were identified in methanol,ethyl acetate,and petroleum ether extracts,respectively.The IC50 of BHT(the concentration at which BHT inhibits radicle growth by 50%)was 54.8 mg/L,indicating that the presence of BHT might be the primary cause of dormancy in S.sebiferum seeds.Tingting Zhao Cunmeng Qian Yunpeng Gao Li Chen Mingwei Zhu Yueting Pan Shuxian Li 2019Journal of Forestry Research2019,30,6:4
14Efficient Algorithm for Energy-Aware Virtual Network Embedding显示文摘Network virtualization is a promising approach for resource management that allows customized Virtual Networks(VNs) to be multiplexed on a shared physical infrastructure. A key function that network virtualization can provide is Virtual Network Embedding(VNE), which maps virtual networks requested by users to a shared substrate network maintained by an Internet service provider. Existing research has worked on this, but has primarily focused on maximizing the revenue of the Internet service provider. In this paper, we consider energy-aware virtual network embedding, which aims at minimizing the energy consumption for embedding virtual networks in a substrate network. In our optimization model, we consider energy consumption of both links and nodes. We propose an efficient heuristic to assign virtual nodes to appropriate substrate nodes based on priority, where existing activated nodes have higher priority for hosting newly arrived virtual nodes. In addition, our proposed algorithm can take advantage of activated links for embedding virtual links so as to minimize total energy consumption. The simulation results show that, for all the cases considered, our algorithm can improve upon previous work by an average of12.6% on acceptance rate, while the consumed energy can be reduced by 12.34% on average.Shuxian Jia Guiyuan Jiang Peilan He Jigang Wu 2016Tsinghua Science and Technology2016,21,4:4
15Preparation of dye-sensitized solar cells with high photocurrent and photovoltage by using mesoporous titanium dioxide particles as photoanode material显示文摘几 mesoporous TiO 2(MT ) 材料在跟随 poly 使用的一个热水的过程(乙烯乙二醇) 的不同条件下面被综合 -block-poly(propylene-glycol)-block-poly(ethylene-glycol)(P123 ) 作为是的模板和钛 isopropoxide 钛来源。Ti/P123 的臼齿的比率,和在一个压热器的反应解决方案的 pH 值被调查。象 BrunauerEmmettTeller (赌注) 那样的各种各样的技术, X 光检查衍射(XRD ) , X 光检查光电子光谱学(XPS ) ,激光拉曼 spectrometry (LRS ) ,扫描电子显微镜学(SEM ) ,和高分辨率的传播电子显微镜学(HRTEM ) 被用来描绘产品。然后,这些材料被装配进敏化染料的太阳能电池(DSSC ) 。JV 曲线和电气化学的阻抗光谱学(EIS ) 的分析被使用描绘房间。结果显示特定的表面区域和这些材料的水晶的结构为房间提供高光电流的可能性,并且标本的结构的特征导致了,这增加了房间的电子转移抵抗,它为 DSSC 的 photovoltage 的改进是有益的。包含 MT 材料的房间的最高光电的变换效率到达了 8.33% ,与基于 P25 的太阳能电池(5.88%) 的相比,它增加了 41.7% 。Yi Zhang Bao Zhang Xiao Peng Lin Liu Shuo Dong Liping Lin Si Chen Shuxian Meng Yaqing Feng 2015Nano Research2015,8,12:4
16Uniform Compact Attractors for a Nonlinear Non-Autonomous Equation of Viscoelasticity显示文摘QIN Yuming DENG Shuxian SCHULZE Bert Wolfgang 2009Journal of Partial Differential Equations2009,22,2:4
17Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome显示文摘The fungus Trichophyton schoenleinii(T.schoenleinii)is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa.Hu-man innate immune system plays an important role in combating with various pathogens including fungi.The inflammasome is one of the most critical arms of host innate immunity,which is a protein complex controlling maturation of IL-1β.To clarify whether T.schoenleinii is able to activate the infl ammasome,we analyzed human monocytic cell line THP-1 for IL-1βproduction upon infec-tion with T.schoenleinii strain isolated from Tinea favosa patients,and rapid IL-1βsecretion from THP-1 cells was observed.Moreover,applying competitive inhibitors and gene specifi c silencing with shRNA,we found that T.sch-oenleinii induced IL-1βsecretion,ASC pyroptosome for-mation as well as caspase-1 activation were all dependent on NLRP3.Cathepsin B activity,ROS production and K+effl ux were required for the infl ammasome activation by T.schoenleinii.Our data thus reveal that the NLRP3 infl am-masome plays an important role in host defense against T.schoenleinii,and suggest that manipulating NLRP3 signaling can be a novel approach for control of diseases caused by T.schoenleinii infection.Hua Li Shuxian Wu Liming Mao Guowei Lei Liping Zhang Ailing Lu Liguo An Guiwen Yang Paride Abliz Guangxun Meng 2013Protein & Cell2013,4,7:3
18FEATURE EXTRACTION OF BONES AND SKIN BASED ON ULTRASONIC SCANNING显示文摘In the prosthetic socket design, aimed at the high cost and radiation deficiency caused by CT scanning which is a routine technique to obtain the cross-sectional image of the residual limb, a new ultrasonic scanning method is developed to acquire the bones and skin contours of the residual limb. Using a pig fore-leg as the scanning object, an overlapping algorithm is designed to reconstruct the 2D cross-sectional image, the contours of the bone and skin are extracted using edge detection algorithm and the 3D model of the pig fore-leg is reconstructed by using reverse engineering technology. The results of checking the accuracy of the image by scanning a cylinder work pieces show that the extracted contours of the cylinder are quite close to the standard circumference. So it is feasible to get the contours of bones and skin by ultrasonic scanning. The ultrasonic scanning system featuring no radiation and low cost is a kind of new means of cross section scanning for medical images.Zheng Shuxian Zhao Wanhua Lu Bingheng Zhao Zhao 2005Chinese Journal of Mechanical Engineering2005,18,4:3
19Application of pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF) for the prevention of neutropenia in triple negative breast cancer patients older than 65 years during adjuvant chemotherapy显示文摘Objective The aim of this study was to compare the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF)and recombinant human granulocyte colonystimulating factor(rhG-CSF)for the prevention of neutropenia in elderly breast cancer patients during adjuvant chemotherapy.Methods A total of 45 oncology inpatients with breast cancer,who received adjuvant chemotherapy and were older than 65 years from May 2017 to October 2018 in the General Hospital of the Northern Theater of the Chinese people’s Liberation Army,were included.Epirubivin Cyclophoshamide-Docetaxel(EC-T)sequential adjuvant chemotherapy was chosen.Forty-five patients were randomly divided into two groups;25 patients in the treatment group were treated with PEG-rhG-CSF and 20 patients in the control group were not treated with PEG-rhG-CSF,but only rhG-CSF.The experimental group was treated with the PEG-rhG-CSF at the end of chemotherapy for 24–48 h,with a 6 mg subcutaneous injection once per chemotherapy cycle.In the control group,rhG-CSF was administered after 48 h of chemotherapy,with a 100μg subcutaneous injection,1/d,d 1–7.The dosage could be increased step by step with the exacerbation of neutropenia.The primary aims of this study was to discover the incidence of leukopenia,neutropenia,neutrophilic fever,and adverse reactions in the two groups.Results The incidence of neutropenia,neutrophilic fever and adverse reactions decreased in the treatment group compared to the control group,but no significant difference existed between two groups(P>0.05).Patients in treatment group had a lower,but not statistically significant,incidence of adverse reactions(P>0.05).Conclusion Applying PEG-rhG-CSF could be effective in preventing neutropenia in elderly patients with postoperative adjuvant chemotherapy to treat breast cancer.It may effectively control the occurrence of neutropenia after chemotherapy and reduce the chance of infection.The incidence of side effects,such as fever and bone pain,was low.The adverse drug reactions were well tolerated by patients,which could ensure the smooth progress of chemotherapy.Shuxian Qu Jianing Qiu Yidan Zhang Yongming Liu Zhendong Zheng 2019Oncology and Translational Medicine2019,5,5:3
20Multi-interface collaboration of graphene cross-linked NiS-NiS_(2)-Ni_(3)S_(4) polymorph foam towards robust hydrogen evolution in alkaline electrolyte显示文摘Electrocatalytic hydrogen production in alkaline media is extensively adopted in industry. Unfortunately, further performance improvement is severely impeded by the retarded kinetics, which requires the fine regulation of water dissociation, hydrogen recombination, and hydroxyl desorption. Herein, we develop a multi-interface engineering strategy to make an elaborate balance for the alkaline hydrogen evolution reaction (HER) kinetics. The graphene cross-linked three-phase nickel sulfide (NiS-NiS_(2)-Ni_(3)S_(4)) polymorph foam (G-NNNF) was constructed through hydrothermal sulfidation of graphene wrapped nickel foam as a three-dimensional (3D) scaffold template. The G-NNNF exhibits superior catalytic activity toward HER in alkaline electrolyte, which only requires an overpotential of 68 mV to drive 10 mA·cm^(−2) and is better than most of the recently reported metal sulfides catalysts. Density functional theory (DFT) calculations verify the interfaces between nickel sulfides (NiS/NiS_(2)-Ni_(3)S_(4)) and cross-linked graphene can endow the electrocatalyst with preferable hydrogen adsorption as well as metallic nature. In addition, the electron transfer from Ni_(3)S_(4)/NiS_(2) to NiS results in the electron accumulation on NiS and the hole accumulation on Ni_(3)S_(4)/NiS_(2), respectively. The electron accumulation on NiS favors the optimization of the H* adsorption, whereas the hole accumulation on Ni_(3)S_(4) is beneficial for the adsorption of H_(2)O. The work about multi-interface collaboration pushes forward the frontier of excellent polymorph catalysts design.Haiqing Wang Wenjing Zhang Xiaowei Zhang Shuxian Hu Zhicheng Zhang Weijia Zhou Hong Liu 2021Nano Research2021,14,12:3
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