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| 1 | Effects of three needling manipulations of the right-side Zusanli(ST 36) on brain using functional magnetic resonance imaging显示文摘OBJECTIVE: To investigate the effects on the brain using three needling manipulations(twirling, lifting-thrusting, and twirling plus lifting-thrusting)when the right-side Zusanli(ST 36) acupoint was stimulated with needles.METHODS: Seventeen healthy subjects accepted three needling manipulations stimulating the right Zusanli(ST 36) over separate days. Functional magnetic resonance imaging was used to detect changes in the brain during the manipulations, and then the needling sensations were recorded using the MGH acupuncture sensation scale(MASS) after each scan. f MRI data were processed using Statistical Parametric Mapping 8 to analyze the positiveand negative activation in the brain induced by different acupuncture manipulations.RESULTS: The individual needling sensations showed no statistically significant differences among the three manipulations. However, the MASS index showed that lifting-thrusting > twirling plus lifting-thrusting > twirling. Lifting-thrusting activated left premotor cortex, left postcentral,right middle frontal gyrus, left inferior frontal gyrus,right lingual gyrus, left insula, right putamen, bilateral cingulate gyrus and right cerebellum; and deactivated bilateral hippocampus and left caudate.Twirling activated bilateral orbital middle frontal gyrus, left opercular and triangular inferior frontal gyrus, and right middle occipital gyrus; and deactivated bilateral precuneus, right amygdala, left anterior cingulate gyrus, right inferior temporal gyrus,right middle frontal gyrus, right supplementary motor gyrus, and left postcentral. Twirling plus lifting-thrusting activated bilateral postcentral, left inferior occipital gyrus, left insula, left thalamus, left cingulate gyrus, and right putamen; and deactivated right superior frontal gyrus, right superior parietal gyrus, right temporal gyrus, right middle occipital gyrus, right insula, and left lingual gyrus. Pairwise comparisons of the three manipulations showed that signals induced by lifting-thrusting were the strongest, especially in the limbic system,followed by twirling plus lifting-thrusting; twirling alone was the weakest.CONCLUSION: Three methods of needling manipulations similarly activated areas associated with the somatosensory system, vision, cognition, and emotional regulation. This may have significant implications for acupuncture in clinical practice. | Lu Fengyan Gao Junhong Wang Yuanyuan Dai Qiufu Bao Yan Hong Yang Zhang Guolei Xin Juanjuan Zhao Yuxue Wu Shuyang Chen Yuanyuan Li Xiaojiao Fang Jiliang Yu Xiaochun | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 5 |
| 2 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 3 | Expression of chromatin modification genes in organs of cloned cattle that died within hours after birth显示文摘Cloning by somatic nuclear transfer is an inefficient process in which many of the cloned ani- mals died shortly after birth and displayed organ ab- normalities. In an effort to determine the possible genetic causes of neonatal death and organ abnor- malities, we have examined expression patterns of four genes that modified chromatin (DNMT1, PCAF,MeCP2 and EED) in six organs (heart, liver, spleen, lung, kidney and brain) of both neonatal death cloned bovines (n=9) and normal control calves produced by artificial insemination (AI) using real-time quantitative RT-PCR. The effect of the age of the fibroblast donor cell on the gene expression profiles was also investigated. Aberrant expressions of DNMT1 and PCAF were found in some studied tissues, but the expression of MeCP2 and EED had similar levels to those of the normal controls. The expression of DNMT1 showed a higher level in heart, liver and brain of both cloned bovines. A higher ex- pression level of PCAF was seen in heart and liver of both cloned bovines, but a lower level was seen only in spleen of adult fibroblast (AF) cell-derived clones. Our results suggest that aberrant expression in gene that modified chromatins were found in cloned bovine tissues of neonatal death. Because DNMT1 and PCAF play an important role in DNA methylation and histone acetylation on nuclear chromatin respectively, and normal expression of DNMT1 and PCAF is needed for precious reprogramming of donor nuclear, the aberrant transcription patterns of DNMT1 andPCAF in these clones may contribute to the defects of organs reported in neonatal death of clones. | LI Shijie LIAN Zhengxing LI Dongjie YU Shuyang ZHANG Lei DAI Yunping LI Rong FEI Jing LI Ning | 2006 | Chinese Science Bulletin2006，51，2： | 1 |
| 4 | Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice显示文摘Porcine reproductive and respiratory syndrome virus(PRRSV)is a major pathogen that causes reproductive failure and respiratory disease in pigs,resulting in devastating economic losses worldwide[1].Porcine alveolar macrophages(PAMs)are the primary target cells of PRRSV[2],and the putative receptors,including CD163,CD169,and CD151,play key roles during infection[3–6].However,the understanding of PRRSV infection and pathogenesis is | Zhengzhi Cui Shuaishuai Niu Jingjing Liu Lei Xu Yunping Dai Ning Li Youmin Kang Linlin Zhang Lei Zhou Shuyang Yu | 2017 | Science Bulletin2017，62，24： | 1 |
| 5 | Truncated L1 Regularized Linear Regression:Theory and Algorithm显示文摘Truncated L1 regularization proposed by Fan in[5],is an approximation to the L0 regularization in high-dimensional sparse models.In this work,we prove the non-asymptotic error bound for the global optimal solution to the truncated L1 regularized linear regression problem and study the support recovery property.Moreover,a primal dual active set algorithm(PDAS)for variable estimation and selection is proposed.Coupled with continuation by a warm-start strategy leads to a primal dual active set with continuation algorithm(PDASC).Data-driven parameter selection rules such as cross validation,BIC or voting method can be applied to select a proper regularization parameter.The application of the proposed method is demonstrated by applying it to simulation data and a breast cancer gene expression data set(bcTCGA). | Mingwei Dai Shuyang Dai Junjun Huang Lican Kang Xiliang Lu | 2021 | Communications in Computational Physics2021，30，6： | 0 |
| 6 | Hierarchical Absorbing Interface Conditions for Wave Propagation on Non-Uniform Meshes显示文摘In this paper,we propose hierarchical absorbing interface conditions to solve the problem of wave propagation in domains with a non-uniform space discretization or grid size inhomogeneity using Pad´e Via Lanczos(PVL)method.The proposed interface conditions add an auxiliary variable in the wave system to eliminate the spurious reflection at the interface between regions with different mesh sizes.The auxiliary variable with proper boundary condition can suppress the spurious reflection by cancelling the boundary source term produced by the space inhomogeneity in variational perspective.The new hierarchical interface conditions with the help of PVL implementation can effectively reduce the degree of freedom in solving the wave propagation problem. | Shuyang Dai Zhiyuan Sun Fengru Wang Jerry Zhijian Yang Cheng Yuan | 2022 | Numerical Mathematics(Theory,Methods and Applications)2022，15，1： | 0 |
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