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| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway显示文摘Over recent decades, many studies have reported that hypocrellin A(HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticancer effect has not been fully defined. HA-mediated cytotoxicity and apoptosis in human lung adenocarcinoma A549 cells were evaluated after photodynamic therapy(PDT). A temporal quantitative proteomics approach by isobaric tag for relative and absolute quantitation(iTRAQ) 2 D liquid chromatography with tandem mass spectrometric(LC–MS/MS) was introduced to help clarify molecular cytotoxic mechanisms and identify candidate targets of HA-induced apoptotic cell death. Specific caspaseinhibitors were used to further elucidate the molecular pathway underlying apoptosis in PDT-treated A549 cells. Finally, down-stream apoptosis-related protein was evaluated. Apoptosis induced by HA was associated with cell shrinkage, externalization of cell membrane phosphatidylserine, DNA fragmentation,and mitochondrial disruption, which were preceded by increased intracellular reactive oxygen species(ROS) generations. Further studies showed that PDT treatment with 0.08 mmol/L HA resulted in mitochondrial disruption, pronounced release of cytochrome c, and activation of caspase-3,-9, and-7.Together, HA may be a possible therapeutic agent directed toward mitochondria and a promising photodynamic anticancer candidate for further evaluation. | Shanshan Qi Lingyuan Guo Shuzhen Yan Robert J.Lee Shuqin Yu Shuanglin Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 12 |
| 3 | Spatial and temporal variability of heat content above the thermocline in the tropical Pacific Ocean显示文摘Heat content of the upper layer above the 20℃ isotherm in the tropical Pacific Ocean is estimated by using the sea temperature data set with a resolution 2°latitude × 5°longitude (1980~1993) for the water depths (every 10 m) from 0 m to 400 m, and its temporal and spatial variabilities are analyzed. ( 1 ) The temporal variability indicates that the total heat in the upper layer of the equatorial Pacific Ocean is characterized by the interannual variability. The time series of the equatorial heat anomaly 5 months lead that of the El Nino index at the best positive lag correlation between the two, and the former 13 months lag behind the latter at their best negative lag correlation. Therefore the equatorial heat content can be used as a better predictor than the El Nino index for a warm or cold event. In addition, it is also found that less heat anomaly in the equator corresponds to the stronger warm events in the period (1980~1993) and much more heat was accumulated in the 4 years including 1992/1993 ENSO (1989~1993) than the 4 years including 1982/1983 ENSO (1980~1983); (2) The spatial variability indicates that the area with the highest lag correlation among the grids moves in an anti-clockwise circle in the northern tropical Pacific Ocean within 4 years period and in a clockwise circle in the southern tropical Pacific Ocean. This result provides scientific evidence for the quasi - cycle theory of El Nino events. | Pu Shuzhen, Yu Fei, Hu Xiaomin, Chen Xingrong First Institute of Oceanography, State Oceanic Administration, Qingdao 266061,China, | 2003 | Acta Oceanologica Sinica2003，22，2： | 6 |
| 4 | Toxic effects of chlortetracycline on maize growth,reactive oxygen species generation and the antioxidant response显示文摘The toxicity of chlortetracycline (CTC) on maize (Zea mays L.) growth and reactive oxygen species (ROS) generation was studied.The root and shoot lengths and fresh weights of maize seedlings were inhibited by CTC treatment (p < 0.05).Root length was more sensitive than other parameters with the EC 10 value of 0.064 mg/L.The spin trapping technique followed by electron paramagnetic resonance (EPR) analysis was used to quantify the ROS production.The ROS generated in maize roots after exposure to CTC was identified as hydroxyl radical (·OH).The EPR signal intensity correlated positively with the logarithm of CTC concentrations exposed (p < 0.05).The dynamic changes of malondialdehyde (MDA) contents and the antioxidative enzyme activities in maize roots were also determined.As compared to the control group,CTC was found to significantly increase MDA content.Treatment of maize roots with the ·OH scavenger sodium benzoate (SB) reduced the MDA content and enhanced the antioxidative enzyme activities.The results demonstrated the harmfulness of CTC at high dose to maize in the early developmental stage,and clarified that the inducement of ·OH is one of the mechanisms of CTC toxicity. | Bei Wen Yu Liu Peng Wang Tong WU Shuzhen Zhang Xiaoquan Shan Jingfen Lu | 2012 | Journal of Environmental Sciences2012，24，6： | 6 |
| 5 | Features of physical oceanography in the oceans near the Prydz Bay during the 1998/1999 austral summer显示文摘南极的 Thermohaline 特征,空间延期,和深度围绕天极的深水,南极底部水,和上面的间层水接近 Prydz 海湾(包括 Prydz 海湾夏天表水,南极冬季水,并且 Prydz 海湾架流水)被在南部的 Oceannear 获得的完整的深度 CTD 数据的使用分析并且学习 Prydz 海湾在 1998/1999 期间南的夏天。向北方,架水,逆温层的厚度,在垂直温度侧面的最小和温度垂直梯度的扩展被解释。根据重力势地的分析,地转风气流和因地球自转而引起的体积运输被计算在 Prydz 海湾附近在纬向环流决定最强壮的水流的地点并且在 64 °~发现体积运输的空间可变性 66.5 ° S 地区。另外,大陆人水边界(CWB ) 的中央地点,正面的力量,垂直深度和厚度从 CTD 数据被估计在学习区域详细说明 CWB 的空间可变性(64 °~ 66。5 ° S, 70 °~ 75 ° E ) 。 | PU Shuzhen HU Xiaomin DONG Zhaoqian XIANG Baoqiang YU Weidong | 2006 | Acta Oceanologica Sinica2006，25，6： | 5 |
| 6 | Sr-Nd-Pb Isotopic Compositions of the Neogene Eolian Deposits in the Xining Basin and Implications for Their Dust Sources显示文摘The Neogene eolian deposits in the Xining Basin are valuable archive for studying the evolution of the Asian monsoon system and geomorphic processes of Northwest China. The Neogene eolian deposits that paleomagnetically dated at about 14 Ma probably were sourced from the middle and west Qinghai-Tibetan Plateau(QTP) as indicated by elemental compositions and magnetic properties. This study provides the Sr-Nd-Pb isotopic ratios of different sediments(gravels from the river terraces, Neogene eolian deposits and Quaternary loess) in the Xining Basin. The results show that:(1) Sr-Nd isotopic compositions of terrace gravels are different from those of the Neogene and Quaternary eolian deposits, although the Nd isotope ratios of gravel on the 10 th terrace(T10) and eolian deposits are similar.(2) Pb isotopic compositions of river gravels are obviously different from the eolian deposits in the Xining Basin. However, Pb isotopic compositions of eolian deposits in the basin are similar to those of eolian deposits in the central Chinese Loess Plateau.(3) Sr-Nd-Pb isotope results indicate that the Neogene eolian deposits in the Xining Basin were probably sourced from remote areas outside of the basin by long-distance transportation. The Qaidam Basin is probably an important source area for the eolian deposits in the Xining Basin. | Fangming Zeng Meiyan Liang Shuzhen Peng Dongmei Yu Shuyuan Xiang | 2015 | Journal of Earth Science2015，26，5： | 4 |
| 7 | 152 W high-power blue diode laser operated at 447 nm显示文摘We demonstrate a high-power blue diode laser operated at 447 nm combining laser diodes using an optical fiber bundle. As many as 127 diode lasers at 447 nm were coupled into 400 μm/0.22 NA fibers using an aspherical lens group with different focus lengths. The bare fibers were mechanically bundled through high temperature ultraviolet adhesive after the coatings of the 127 fibers were stripped. The diameter of the fiber bundle was 6 mm. The total output power of such a bundle was 152 W with electro-optical conversion efficiency of 27.56%and the RMS power instability was less than ±1% within 3 h. | Peng Wu Ling Zhang Haijuan Yu Xiandan Yuan Zhiyan Zhang Pengfei Zhao Shuzhen Zou Chaojian He Yaoyao Qi Yingying Yang Gang Li Xubao Wang Xuechun Lin | 2017 | Journal of Semiconductors2017，38，7： | 4 |
| 8 | Prognostic significance of combining high mobility group Box-1 and OV-6 expression in hepatocellular carcinoma显示文摘The inflammatory environment and existence of cancer stem cells are critical for progression and intrahepatic recurrence of hepatocellular carcinoma(HCC) after curative resections. Here, we investigated the prognostic significance of combining high mobility group box 1(HMGB1) expression and hepatic progenitor marker OV6 in hepatocellular carcinoma. Expression of HMGB1 and OV6 was evaluated using immunohistochemistry profiling in tissue microarrays containing samples from 208 HCC patients. Invasive clinical or pathological factors were found in patients with high expression of HMGB1 or OV6. Higher HMGB1 was associated with poorer clinical outcomes, and independently related to elevated 5-year recurrence incidence(85.5% vs. 62.4%, P<0.001). We also found that more OV6 positive staining was correlated with poor prognosis of HCC patients(P<0.001). Notably, expression of HMGB1 was positively correlated with OV6 in density(R2=0.032, P<0.001) and reversely related to HCC outcomes. Abnormal expression of HMGB1 in combination with positive staining of OV6 displayed poorer prognostic performance than single biomarker alone(area under curve(AUC) survival=0.696). Therefore, HMGB1 and OV6 positive staining are promising prognostic parameters for HCC, and we propose that HMGB1 and OV6 may cooperate with each other and predict poor prognosis of HCC. | Jihui Zhu Han Yu Shuzhen Chen Pinghua Yang Zihui Dong Yan Ling Hao Tang Shilei Bai Wen Yang Liang Tang Feng Shen Hongyang Wang Wen Wen | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
| 9 | Effects of microtopography on spatial point pattern of forest stands on the semi-arid Loess Plateau,China显示文摘Microtopography may affect the distribution of forests through its effect on rain redistribution and soil water distribution on the semi-arid Loess Plateau,China.In this study,we investigated the characteristics of microtopography on two shady slopes(slope A,5 hm2,uniform slope;slope B,5 hm2,microtopography slope) and surveyed the height,the diameter at breast height and the location(x,y coordinates) of all selected individual trees(Robinia pseudoacacia Linn.,Pyrus betulifolia Bunge,Populus hopeiensis Hu & Chow,Armeniaca sibirica Lam.,Populus simonii Carr.and Ulmus pumila Linn.) on slope A and slope B in the watersheds of Wuqi county,Shaanxi province.Subsequently,the effects of microtopography on the spatial pattern of forest stands were analyzed using Ripley's K(r) function.The results showed that:(1) The maximal aggregation radiuses of the tree species on the uniform slope(slope A) were larger than 40 m,whereas those of the tree species on the microtopography slope(slope B) were smaller than 30 m.(2) On slope B,the spatial association of R.pseudoacacia with P.betulifolia,A.sibirica,P.simonii and U.pumila varied from being strongly negative to positive at microtopography scales.The spatial association of Populus hopeiensis Hu & Chow with U.pumila also varied from being strongly negative to positive at microtopography scales.However,there was no spatial association between P.betulifolia and P.hopeiensis,P.betulifolia and A.sibirica,P.betulifolia and P.simonii,P.betulifolia and U.pumila,P.hopeiensis and A.sibirica,P.hopeiensis and P.simonii,A.sibirica and P.simonii,A.sibirica and U.pumila,and P.simonii and U.pumila.On slope A,the spatial association between tree species were strongly negative.The results suggest that microtopography may shape tree distribution patterns on the semi-arid Loess Plateau. | WeiJun ZHAO Yan ZHANG QingKe ZHU Wei QIN ShuZhen PENG Ping LI YanMin ZHAO Huan MA Yu WANG | 2015 | Journal of Arid Land2015，7，3： | 3 |
| 10 | Computer Simulation of Mechanical Properties of Nano-scale Cu/FeS Composite显示文摘The mechanical properties of nano-scale Cu/FeS composite were simulated by molecular dynamics (MD) simulation in this paper. Through the analysis on the stress-strain curves, the results of MD simulation were in good agreement with mechanisms of macroscopic deformation. When the size of particles was smaller than a certain value, the relationship between yield strength and size, which was different from the large size crystals abided by the contrary Hall-Petch relationship. Based on the discussion of nano-scale Cu/FeS composite, some interesting conclusions were obtained. For example, the 'S' type curves were discovered in stress-strain curves and the anisotropy of FeS was very evident when the exposures of reinforcing phase (FeS) were different and so on. The basic theories and calculations of the composite that contains nano-scale particles were discussed. At the same time, a new modeling building method of composites, which was close to actual experiences, were considered in this paper. | Zhenjun Hong Jingchao Chen Jing Feng Yeping Du Jie Yu Lijuan Zhang Shuzhen Wu Futai Xu | 2010 | Journal of Materials Science & Technology2010，26，4： | 2 |
| 11 | IAP's Solar-Powered Unmanned Surface Vehicle Actively Passes through the Center of typhoon Sinlaku(2020)显示文摘The solar-powered marine unmanned surface vehicle(USV) developed by the USV team of the Institute of Atmospheric Physics is a rugged, long-duration, and autonomous navigation vessel designed for the collection of longrange, continuous, real-time, meteorological and oceanographic measurements, especially under extreme sea conditions(sea state 6–7). These solar-powered USVs completed a long-term continuous navigation observation test over 26 days.During this time, they coordinated double-USV observations and actively navigated into the path of Typhoon Sinlaku(2020) before collecting data very close to its center during the 2020 USV South China Sea Typhoon Observation Experiment. Detailed high temporal resolution(1 min) real-time observations collected by the USV on the typhoon were used for operational typhoon forecasting and warning for the first time. As a mobile meteorological and oceanographic observation station capable of reliable, automated deployment, data collection, and transmission, such solar-powered USVs can replace traditional observation platforms to provide valuable real-time data for research, forecasting, and early warnings for potential marine meteorological disasters. | Hongbin CHEN Jun LI Wenying HE Shuqing MA Yingzhi WEI Jidong PAN Yu ZHAO Xuefen ZHANG Shuzhen HU | 2021 | Advances in Atmospheric Sciences2021，38，4： | 2 |
| 12 | Nd-doped structurally disordered YSr_(3)(PO_(4))_(3) single crystal:Growth and laser performances显示文摘Disordered-structure crystals have drawn increasing attention as promising ultrashort laser material hosts owing to their broad linewidth.Herein,a novel disordered Nd:YSr_(3)(PO_(4))_(3)(Nd:YSP)crystal with good quality was successfully grown via the Czochralski pulling technique.The absorption and fluorescence spectra of the Nd:YSP single crystal were recorded at ambient temperature.The maximum absorption cross section for Nd:YSP single crystal is found to be approximately 3.89×10^(-20) cm^(2).The stimulated emission cross section for Nd:YSP crystal at~1060 nm was determined to be 7.64×10^(20) cm^(2) with the full width half maximum value of 22 nm.The fluorescence lifetime of the Nd3+ions in the Nd:YSP crystal is fitted to be 288μs.Diode-pumped continuous-wave laser operation is firstly realized at approximately 1060 nm.The maximum output power value from the Nd:YSP crystal is 714 mW,corresponding to a slope efficiency of-12.8%.The results indicate that the Nd:YSP crystal with a disordered structure may be a promising disordered laser host. | Guangda Wu Xiaoqin Yin Mengdi Fan Fapeng Yu Shuzhen Fan Zhengping Wang Xian Zhao | 2021 | Journal of Rare Earths2021，39，12： | 2 |
| 13 | A COVID-19 Outbreak Emerging in a Food Processing Company——Harbin City,Heilongjiang Province,China,January-February 2021显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)epidemic in China had been effectively controlled for several months,but as the ambient temperature dropped,large gathering-initiated epidemics occurred in northern China,including Hebei,Liaoning,and Jilin provinces. | Lei Hou Hao Zhou Nanxi Meng Xue Yu Xin Wang Tuo Wang Jianfeng Zhang Yan Wang Shie Li Shuzhen Guo Jianxing Yu Muxin Chen Wenhui Shi Ning Xiao Chao Yang Jianxiang Liu | 2021 | China CDC weekly2021，3，32： | 2 |
| 14 | Multifunctional health-promoting effects of oolong tea and its products显示文摘Oolong tea,partially fermented from Camellia sinensis leaves,exhibits significant antioxidative,anti-inflammatory,and anti-cancer activities as indicated in several in vitro and in vivo studies.However,studies on health promoting effects of oolong tea and its characteristic compounds are limited.The potential efficacy of bioactives derived from oolong tea and their roles as promising anticancer agents,their cardio-protective benefits during hypoxic conditions,effects in treating allergic disorders,potential prebiotic activities,improvement of blood lipid status in human beings,effectivity as oral hypoglycemic agent in the treatment of type 2 diabetes,and their potentials to reduce the risk of obesity have been discussed in this review.These promising studies mainly gained from animal studies might broaden the consumption and usage of the phenolic-enriched oolong tea and its products in food and pharmaceutical industries.However,potential health beneficial effects of oolong tea in humans should be further complemented by large-sized,randomized double-blind and placebo-controlled trials to consolidate potential therapeutic applications. | Shuzhen Wang Ting Zeng Shuang Zhao Yu Zhu Changchun Feng Jianfeng Zhan Shiming Li Chi-Tang Ho Alexander Gosslau | 2022 | Food Science and Human Wellness2022，11，3： | 2 |
| 15 | Arsenic accumulation and speciation in maize as affected by in- oculation with arbuscular mycorrhizal fungus glomus mosseae 显示文摘 | YU Yang ZHANG Shuzhen HUANG Honglin | 2009 | Agric Food Chem2009，57，： | 1 |
| 16 | Synergistic in-situ growth of silver nanoparticles with nanozyme activity for dual-mode biosensing and cancer theranostics显示文摘A multifunctional nanocomposite of AgNPs@GQDs is prepared by synergistic in-situ growth of silver nanoparticles(AgNPs)on the complex of tannic acid(TA)and graphene quantum dots(GQDs)for the construction of dual-mode biosensing platform and cancer theranostics.The nanocomposite exhibits a hydrogen peroxide(H_(2)O_(2))-responsive degradation,in which Ag^(0)is oxidized to Ag^(+)along with the release of oxidized TA and GQDs.The degradation induces the decreased absorbance and enhanced fluorescence(FL)intensity due to the suppression of Forster resonance ene rgy transfer(FRET)in AgNPs@GQDs,which is employed for colorimetric/fluorescence dual-mode sensing of H_(2)O_(2).The intrinsic peroxidase-like activity of GQDs nanozyme can effectively catalyze the oxidation reaction,enhancing the detection sensitivity significantly.Based on the generation of H_(2)O_(2)from the oxidation of glucose with the catalysis of glucose oxidase(GOx),this nanoprobe is versatilely used for the determination of glucose in human serum.Further,through combining the H_(2)O_(2)-responsive degradation of AgNPs@GQDs with high H_(2)O_(2)level in cancer cells,the nanocomposites exhibit good performance in cancer cell recognition and therapy,in which the synergistic anticancer effect of Ag^(+)and oxidized TA contribute to effective cell death,and the liberated GQDs are used to monitor the therapeutic effect by cell imaging. | Xin Hai Yuwei Li Kaixin Yu Shuzhen Yue Yuanfang Li Weiling Song Sai Bi Xueji Zhang | 2021 | Chinese Chemical Letters2021，32，3： | 1 |
| 17 | Effects of neuroglobin over - expression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons显示文摘 | Jianxiang Liu Zhangyang Yu Shuzhen Guo | 2009 | J Neurosci Res2009，87，1： | 1 |
| 18 | Acetylcholinesterase liquid crystal biosensor for identification of AChE inhibitors by a reactivator显示文摘An improved acetylcholinesterase liquid crystal(LC) biosensor has been developed for the identification of organophosphates(OPs) by using a reactivator. When the acetylcholinesterases(AChEs) inhibited by different kinds of OPs are reactived by a reactivator, the catalytic activity of AChEs can be recovered with different activation efficiency because of the different phosphorylation structures formed in the inhibited AChEs. Accordingly, the reactived AChEs can catalyze the hydrolysis of acetylthiocholine to generate thiocholine product in different degrees, which will result in different catalytic growth of AuNPs and further form distinct orientational response of LCs. Based on such a reactivation mechanism, the AChE LC biosensor with a simple, rapid and visual procedure achieves an obvious identification of three OPs pesticides, methamidophos, trichlorfon and paraoxon, by using a pralidoxime reactivator. | DING HuaZhi LIAO ShuZhen XIAO FuBing SHEN GuoLi YU RuQin WU ZhaoYang | 2014 | Science China Chemistry2014，57，11： | 1 |
| 19 | Behavior of mercury in a soil–plant system as affected by inoculation with the arbuscular mycorrhizal fungus Glomus mosseae显示文摘 | Yang Yu Shuzhen Zhang Honglin Huang | 2010 | Mycorrhiza2010，，6： | 1 |
| 20 | Effects of music on anxiety and pain in children with cerebral palsy receiving acupuncture:A randomized controlled tria1显示文摘 | Haibo Yu Yongfeng Liu Shuzhen Li | 2009 | Int J Nurs Stud2009，46，10： | 1 |
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