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| 1 | Prevalence of and risk factors for postprandial hypotension in older Chinese men显示文摘ObjectiveTo 估计流行并且冒险因素因为在旧、很旧的中国 men.MethodsThe 学习之中的饭后的低血压(PPH ) 65 包括了 349 个中国人并且更旧,组织了进二个年龄范畴:组 1 (旧) 65 ~ 80 年包括了 163 个人;组 2 (很旧) 超过 80 年包括了 186 个人。在饭以后的血压变化被估计由监视的回廊血压的每 15 min。在饭摄取以后并且在相对血压变化处于基线条件站起来和变化以后的症状连续地被观察。另外的基线数据包括了身体团索引,病历,和 PPH 的药 use.ResultsThe 流行总的来说是 59.3% 并且比组织 1 在组 2 是显著地更高的(63.4% 对 54.6% , P <0.05 ) 。在组 2,在早餐(33.8%) 和午餐(32.1%) 以后的 PPH 的流行在晚饭(20.9%) 以后比那高, P <0.05。高血压和年龄是为 PPH 的重要风险因素(或 = 2.188, 95% CI:1.134 − 4.223, P = 0.02;或 = 1.86, 95% CI:1.112 − 3.11, P = 0.018,分别地) 。相反, acarbose 使用对 PPH 是保护的(或 = 0.4, 95% CI:0.189 − 0.847, P = 0.017 ) 。在血压的减少在 PPH 期间是 20 − 40 mmHg 和最大值是 90 mmHg。 PPH 通常发生在 30 − ;在饭以后的 60 min 并且持续了 30 − ; 120 min.ConclusionsThese 调查结果证明在超过 80 年的人的 PPH 的流行比在 65~80 年的人的那些显著地高,并且血压衰落为超过 80 年的人也是更高的。另外,高血压和年龄是为在老人的 PPH 的主要风险因素,它建议那阻止并且对待的 PPH 是值得的。 | Xiao ZOU Jian CAO Jian-Hua LI Yi-Xin HU Yu-Song GUO Quan-Jin SI Li FAN | 2015 | Journal of Geriatric Cardiology2015，12，6： | 20 |
| 2 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 3 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 4 | Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication显示文摘AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed eradication.METHODS Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori eradication.RESULTS Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication. | Ya-Wen Zhang Wei-Ling Hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai Jian-Min Si | 2018 | World Journal of Gastroenterology2018，24，40： | 18 |
| 5 | NMR-based damage characterisation of backfill material in host rock under dynamic loading显示文摘It is not uncommon that backfill material used in underground mining being exposed to repetitive dynamic stresses induced by blasting operations or rockburst events. Understanding the strength and fracture evolution of backfilled stopes is critical to maintain the long-term stope stability and ensure safe mining activities. This paper aims to study the damage evolution of the backfill material and its host rock behaviour under three-dimensional(3D) dynamic loading. Using a true-triaxial testing machine, multiple samples of backfill material enclosed by country rock were fabricated and tested under various dynamic loadings with different true-triaxial confining stress conditions. In addition, the nuclear magnetic resonance(NMR) measurement was conducted on the samples before and after exerting static and dynamic loading to obtain their porosity distribution changes. The experiment results suggested that with the increase of the dynamic loading, the porosity of the backfill sample goes through a two-stage process,which shows a slightly linear decrease and then followed by an exponential increase. The research findings can help understand the damage mechanism and fracture development of backfilled stopes and its host rock in deep underground mines, which are constantly subject to the combination of 3D static confining stress and dynamic loading. | Binglei Li Jiquan Lan Guangyao Si Guopeng Lin Liuqing Hu | 2020 | International Journal of Mining Science and Technology2020，30，3： | 16 |
| 6 | Prognosis-related classifi cation and dynamic monitoring of immune status in patients with sepsis:A prospective observational study显示文摘BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to explore its prognostic value.METHODS:A prospective observational study was carried out in Zhongshan Hospital,Fudan University,enrolling septic patients admitted between July 2016 and December 2018.Blood samples were collected at days 1 and 3.Serum cytokine levels(e.g.,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])and CD14+monocyte human leukocyte antigen-D-related(HLA-DR)expression were measured to serve as immune markers.Classifi cation of each immune status,namely systemic inflammatory response syndrome(SIRS),compensatory anti-inflammatory response syndrome(CARS),and mixed antagonistic response syndrome(MARS),was defined based on levels of immune markers.Changes of immune status were classifi ed into four groups which were stabilization(SB),deterioration(DT),remission(RM),and non-remission(NR).RESULTS:A total of 174 septic patients were enrolled including 50 non-survivors.Multivariate analysis discovered that IL-10 and HLA-DR expression levels at day 3 were independent prognostic factors.Patients with MARS had the highest mortality rate.Immune status of 46.1%patients changed from day 1 to day 3.Among four groups of immune status changes,DT had the highest mortality rate,followed by NR,RM,and SB with mortality rates of 64.7%,42.9%,and 11.2%,respectively.CONCLUSIONS:Severe immune disorder defi ned as MARS or deterioration of immune status defi ned as DT lead to the worst outcomes.The preliminary model of the classifi cation and dynamic monitoring of immune status based on immune markers has prognostic values and is worthy of further investigation. | Jun Yin Yao Chen Jun-ling Huang Lei Yan Zhong-shu Kuang Ming-ming Xue Si Sun Hao Xiang Yan-yan Hu Zhi-min Dong Chao-yang Tong Chun-xue Bai Zhen-ju Song | 2021 | World Journal of Emergency Medicine2021，12，3： | 16 |
| 7 | A survey on life prediction of equipment显示文摘Once in the hands of end users, such durable equipment as spacecraft, aircraft, ships,automobiles, computers, etc. are in a state of debugging, working or storage. In either state, availability, reliability and super-efficiency are the ultimate goals, which have been achieved through constant monitoring as well as regular, preventive, routine and corrective maintenance. Although some advanced instruments can visualize certain invisible malfunctioning phenomena into visible ones, deeply hidden troubles cannot be found unless monitoring and testing data are addressed using tools that process the data statistically, analytically and mathematically. Some state-of-theart trouble-shooting and life-predicting techniques and approaches are introduced in this paper. | Hu Changhua Zhou Zhijie Zhang Jianxun Si Xiaosheng | 2015 | Chinese Journal of Aeronautics2015，28，1： | 14 |
| 8 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 9 | Multi-Objective Optimization of Surface-Mounted and Interior Permanent Magnet Synchronous Motor Based on Taguchi Method and Response Surface Method显示文摘The surface-mounted and interior permanent magnet synchronous motor(SIPMSM)has the characteristics of multiple variables,strong coupling and nonlinearity.In order to improve the performance of SIPMSM,this paper presents a multi-objective optimal design process using Taguchi and response surface methodology(RSM).The peak value of cogging torque(PVCT),ratio value of average torque and permanent magnet weight(RTW),torque ripple and back-EMF total harmonics distortion(ETHD)are selected as optimization goals.The experiment matrix is established by Taguchi method,and analyzed the tendency and proportion of the effect of the optimization parameters on SIPMSM performance.The rules of choosing multi-objective optimization parameters are obtained.The least-squares method is used to establish the optimal objective function,and RSM is used to obtain the resolutions of the optimization objective function.Comparing the initial performance with optimized performance verifies the effectiveness of the proposed method. | Jikai Si Suzhen Zhao Haichao Feng Ruiwu Cao Yihua Hu | 2018 | Chinese Journal of Electrical Engineering2018，4，1： | 11 |
| 10 | Recombinant adenovirus vector Ad-hIL-10 protects grafts from cold ischemia-reperfusion injury following orthotopic liver transplantation in rats显示文摘BACKGROUND:Interleukin 10(IL-10),a Th2 type cytokine,modulates inflammatory responses by inhibiting the production of proinflammatory cytokines.This study was designed to investigate the protective effects of adenovirus- mediated human IL-10(Ad-hIL-10)gene transfer on protecting grafts from cold ischemia-reperfusion injury following orthotopic liver transplantation in rats. METHODS:Adenoviruses encoding hIL-10 orβ-galactosidase (Ad-lacZ)were injected via the superior mesenteric vein into prospective donor animals.The donor liver was harvested 48 hours after transduction,and stored for 12 hours at 4℃ in lactated Ringer's solution prior to transplantation.The rats were divided into saline,Ad-lacZ,and Ad-hIL-10 groups.Liver function test,histopathological examination,reverse transcriptase-polymerase chain reaction(RT-PCR),and Western blotting were performed at 24 hours after transplantation in the three groups. RESULTS:Liver function(ALT and AST)was significantly improved,and the Suzuki score was significantly decreased in the Ad-hIL-10 group.The levels of hepatic TNF-α,MIP-2,ICAM-1 mRNA,and NF-κB protein in the Ad-hIL-10 group were significantly decreased.The expression of hIL-10 mRNA was detected by RT-PCR in Ad-hIL-10-treated grafts but not in controls treated with saline or Ad-lacZ. CONCLUSIONS:Donor pretreatment with Ad-hIL-10 down- regulates the expression of proinflammatory cytokines TNF-α,MIP-2,and ICAM-1 mRNA.hIL-10 protects against hepatic cold ischemia-reperfusion injury,at least in part,by suppressing NF-κB activation and subsequent expression of proinflammatory mediators. | Si, Zhong-Zhou Li, Jie-Qun Qi, Hai-Zhi He, Zhi-Jun Hu, Wei Li, Yi-Ning | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，2： | 11 |
| 11 | Identification and Fine Mapping of a Gene Related to Pale Green Leaf Phenotype near the Centromere Region in Rice(Oryza sativa)显示文摘A thermo-insensitive pale green leaf mutant (pgl2) was isolated from T-DNA inserted transgenic lines of rice (Oryza sativa L. subsp. japonica cv. Nipponbare). Genetic analysis indicated that the phenotype was caused by a recessive mutation in a single nuclear-encoded gene. To map the PGL2 gene, an F2 population was constructed by crossing the mutant with Longtefu (Oryza sativa L. subsp. indica). The PGL2 locus was roughly linked to SSR marker RM331 on chromosome 8. To finely map the gene, 14 new InDel markers were developed around the marker, and PGL2 was further mapped to a 2.37 Mb centromeric region. Analysis on chlorophyll contents of leaves showed that there was no obvious difference between the mutant and the wild type in total chlorophyll (Chl) content, while the ratio of Chl a / Chl b in the mutant was only about 1, which was distinctly lower than that in the wild type, suggesting that the PGL2 gene was related to the conversion between Chl a and Chl b. Moreover, the method of primer design around the centromeric region was discussed, which would provide insight into fine mapping of the functional genes in plant centromeres. | ZHU Li LiuWenzhen WU Chao LUAN Wei jiang Fu Ya ping Hu Guo cheng SI Hua min SUN Zong xiu | 2007 | Rice science2007，14，3： | 11 |
| 12 | First observation of tropospheric nitrogen dioxide from the Environmental Trace Gases Monitoring Instrument onboard the GaoFen-5 satellite显示文摘The Environmental Trace Gases Monitoring Instrument(EMI)is the first Chinese satellite-borne UV–Vis spectrometer aiming to measure the distribution of atmospheric trace gases on a global scale.The EMI instrument onboard the GaoFen-5 satellite was launched on 9 May 2018.In this paper,we present the tropospheric nitrogen dioxide(NO2)vertical column density(VCD)retrieval algorithm dedicated to EMI measurement.We report the first successful retrieval of tropospheric NO_(2) VCD from the EMI instrument.Our retrieval improved the original EMI NO_(2) prototype algorithm by modifying the settings of the spectral fit and air mass factor calculations to account for the on-orbit instrumental performance changes.The retrieved EMI NO_(2) VCDs generally show good spatiotemporal agreement with the satellite-borne Ozone Monitoring Instrument and TROPOspheric Monitoring Instrument(correlation coefficient R of ~0.9,bias<50%).A comparison with ground-based MAX-DOAS(Multi-Axis Differential Optical Absorption Spectroscopy)observations also shows good correlation with an R of 0.82.The results indicate that the EMI NO_(2) retrieval algorithm derives reliable and precise results,and this algorithm can feasibly produce stable operational products that can contribute to global air pollution monitoring. | Chengxin Zhang Cheng Liu Ka Lok Chan Qihou Hu Haoran Liu Bo Li Chengzhi Xing Wei Tan Haijin Zhou Fuqi Si Jianguo Liu | 2020 | Light(Science & Applications)2020，9，1： | 11 |
| 13 | Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer显示文摘Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking angiogenesis.This study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast cancer.Methods:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were enrolled.Anlotinib was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity occurred.Simultaneously,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment cycles.The primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and biomarkers.Results:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)years.The median follow-up time was 10.5 months.The ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 months.The changes in the detectable ct DNA variant allele frequency were consistent with the tumor response.The most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast cancer.The dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response. | Nanlin Hu Yiran Si Jian Yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu Peng Yuan | 2021 | Cancer Biology & Medicine2021，18，3： | 11 |
| 14 | The Status and Associated Factors of Successful Aging among Older Adults Residing in Longevity Areas in China显示文摘Objective This study aims to assess the status of successful aging(SA) in longevity areas in China and explore multiple factors associated with SA among the young-old and oldest-old. Methods A total of 2296 elderly people aged 65 and older were interviewed in the longevity areas sub-sample of the Chinese Longitudinal Healthy Longevity Survey(CLHLS) in 2012. Baseline assessments included a researcher-administered questionnaire, physical examination, and laboratory testing. A logistic regression model was used to identify factors associated with SA. Results The prevalence of SA was 38.81% in the CLHLS in 2012. There were significant differences between ages groups, with SA compromising 56.85% among ≥65 years group and 20.31% among ≥100 years group(χtrend2=126.73, P<0.01). The prevalence of SA among females was 33.59%, which was significantly lower than that among males(45.58%)(χ2gender=33.65, P<0.05). In the regression analysis, having anemia(OR=0.744, 95% CI: 0.609-0.910), poor lifestyle(OR=0.697, 95% CI: 0.568-0.854), poor sleep quality(OR=0.558, 95% CI: 0.456-0.682), and central obesity(OR=0.684, 95% CI: 0.556-0.841) were the main factors associated with SA. The promoting SA rate decreased as age increased, and the group of 65-79 years had higher odds than the other age group. Conclusion Preventing central obesity, improving sleep quality and promoting healthy lifestyle may contribute to achieve SA among the elderly. | SHI Wen Hui ZHANG Hong Yan ZHANG Juan LYU Yue Bin Melanie Sereny Brasher YIN Zhao Xue LUO Jie Si HU Dong Sheng FEN Lei SHI Xiao Ming | 2016 | Biomedical and Environmental Sciences2016，29，5： | 10 |
| 15 | Fault-Induced Coal Burst Mechanism under Mining-Induced Static and Dynamic Stresses显示文摘Fault is a common geological structure that has been revealed in the process of underground coal excavation and mining.The nature of its discontinuous structure controls the deformation,damage,and mechanics of the coal or rock mass.The interaction between this discontinuous structure and mining activities is a key factor that dominates fault reactivation and the coal burst it can induce.This paper first summarizes investigations into the relationships between coal mining layouts and fault occurrences,along with relevant conceptual models for fault reactivation.Subsequently,it proposes mechanisms of fault reactivation and its induced coal burst based on the superposition of static and dynamic stresses,which include two kinds of fault reactivations from:mining-induced quasi-static stress(FRMSS)-dominated and seismic-based dynamic stress(FRSDS)-dominated.These two kinds of fault reactivations are then validated by the results of experimental investigations,numerical modeling,and in situ microseismic monitoring.On this basis,monitoring methods and prevention strategies for fault-induced coal burst are discussed and recommended.The results show that fault-induced coal burst is triggered by the superposition of high static stress in the fault pillar and dynamic stress from fault reactivation.High static stress comes from the interaction of the fault and the roof structure,and dynamic stress can be ascribed to FRMSS and FRSDS.The results in this paper could be of great significance in guiding the monitoring and prevention of fault-induced coal bursts. | Wu Cai Linming Dou Guangyao Si Yawei Hu | 2021 | Engineering2021，7，5： | 8 |
| 16 | Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation显示文摘The clinical application of doxorubicin(DOX) in cancer chemotherapy is limited by its lifethreatening cardiotoxic effects. Chrysophanol(CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role in a variety of biological processes.However, the effects of CHR’s cardioprotection in DOX-induced cardiomyopathy is poorly understood. In this study, we found that the cardiac apoptosis, mitochondrial injury and cellular PARylation levels were significantly increased in H9 C2 cells treated by Dox, while these effects were suppressed by CHR. Similar results were observed when PARP1 activity was suppressed by its inhibitors 3-aminobenzamide(3 AB)and ABT888. Ectopic expression of PARP1 effectively blocked this CHR’s cardioprotection against DOX-induced cardiomyocyte injury in H9 C2 cells. Furthermore, pre-administration with both CHR and 3 AB relieved DOX-induced cardiac apoptosis, mitochondrial impairment and heart dysfunction in Sprague–Dawley rat model. These results revealed that CHR protects against DOX-induced cardiotoxicity by suppressing cellular PARylation and provided critical evidence that PARylation may be a novel target for DOX-induced cardiomyopathy. | Jing Lu Jingyan Li Yuehuai Hu Zhen Guo Duanping Sun Panxia Wang Kaiteng Guo Dayue Darrel Duan Si Gao Jianmin Jiang Junjian Wang Peiqing Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 17 | Genetic susceptibility to ulcerative colitis in the Chinese Han ethnic population:association with TNF polymorphisms显示文摘背景肿瘤坏死因素α(TNF α) 是在煽动性的肠疾病(IBD ) 的致病被含有的重要 proinflammatorycytokine。Recentstudies 在 IBD 评估了 TNF 倡导者多型性的角色,而数据是不一致的。在不同却同质的人口可以帮助澄清这些协会的人种上的 Trans 种族的印射。我们在中国汉种族人口调查在 TNF 倡导者多型性和危险性之间的协会到 ulcerative 大肠炎(UC ) 。方法我们 studied110 从浙江省的无关的 UC 病人和 292 健康控制,中国。为 6common TNF 倡导者多型性的 Genotyping (TNF -1031T/C,-863C/A,-857C/T,-380G/A,-308G/A,-238G/A) 被聚合酶链反应执行顺序特定的教材(PCR-SSP ) 。结果 TNF-308A 与疾病被联系(等位基因频率病人 14.6% 对控制 8.9% , P=0.02 ) 。TNF -857T 在病人,但是没有统计意义被增加(等位基因频率 17.3% 对 12.2% , P=0.06 ) 。Haplotype 分析揭示了包括二的 6 haplotypes (H5 和 H3 ) ,它包含了 TNF-308A。H5 与疾病被联系(haplotype 频率病人 -12.3% 对控制 7.5% , P=0.03 ) 。笔记,稀罕 haplotype H3 以前没在白种人 populations.Homozygosity 被识别因为在每 TNF promotersingle 核苷酸多型性(SNP ) 包括普通等位基因的 haplotype H4 否定地与疾病被联系(病人对 controls24.5% 对 34.9% , P <
0.05 ) 。我们与 ulcerative 大肠炎在中国病人与 TNF -308A 多型性报导协会的结论。在中国汉种族人口的功能的学习现在被要求。 | CAO Qian ZHU Qin WU Min-liang HU Wei-ling GAO Min SI Jian-min | 2006 | Chinese Medical Journal2006，，14： | 8 |
| 18 | Switchable C02 electroreduction via engineering active phases of Pd nanoparticles显示文摘活跃阶段的工程定期被利用在异构的催化作用调节金属 nanoparticles (NP ) 的选择。然而,在 electrocatalysis 的活跃阶段的理解的缺乏为公司 2 electroreduction 妨碍了有效催化剂的发展。此处,我们报导 Pd NP 的活跃阶段的系统的工程,它被利用为公司 2 electroreduction 选择反应小径。在 situ X光检查吸收光谱学,在稀释的 situ 总计思考红外线的光谱学,并且密度功能的理论计算建议吸附氢的 Pd 的形成出现在混合物上-并且一个钯氢化物核心的阶段(在 0.2 V 上面的+ PdH x @PdH x )(对一个可逆的氢电极)经由 HCOO 便于甲酸盐生产*中间,而阶段 Pd 氢化物核心上的金属性的 Pd 表面的形成( PdH x @主要产品,是甲酸盐或公司,能有选择地与高 Faradaic 效率被生产(>90%) 并且在有可伸缩的申请的 0.05 ~ 0.9 V 的潜在的窗户中的集体活动示范。 | Dunfeng Gao Hu Zhou Fan Cai Dongniu Wang Yongfeng Hu Bei Jiang Wen-Bin Cai Xiaoqi Chen Rui Si Fan Yang Shu Miao Jianguo Wang Guoxiong wang Xinhe Bao | 2017 | Nano Research2017，10，6： | 8 |
| 19 | Characterization and Fine Mapping of a Novel Rice Narrow Leaf Mutant nal9显示文摘A narrow leaf mutant was isolated from transgenic rice(Oryza sativa L.)lines carrying a T-DNA insertion.The mutant is characterized by narrow leaves during its whole growth period,and was named nal9(narrow leaf 9).The mutant also has other phenotypes,such as light green leaves at the seedling stage,reduced plant height,a small panicle and increased tillering.Genetic analysis revealed that the mutation is controlled by a single recessive gene.A hygromycin resistance assay showed that the mutation was not caused by T-DNA insertion,so a map-based cloning strategy was employed to isolate the nal9 gene.The mutant individuals from the F2generations of a cross between the nal9 mutant and Longtepu were used for mapping.With 24 F2mutants,the nal9 gene was preliminarily mapped near the marker RM156 on the chromosome 3.New INDEL markers were then designed based on the sequence differences between japonica and indica at the region near RM156.The nal9 gene was fnally located in a 69.3 kb region between the markers V239B and V239G within BAC OJ1212_C05 by chromosome walking.Sequence and expression analysis showed that an ATP-dependent Clp protease proteolytic subunit gene(ClpP)was most likely to be the nal9 gene.Furthermore,the nal9 mutation was rescued by transformation of the ClpP cDNA driven by the 35S promoter.Accordingly,the ClpP gene was identifed as the NAL9 gene.Our results provide a basis for functional studies of NAL9 in future work. | Wei Li Chao Wu Guocheng Hu Li Xing Wenjing Qian Huamin Si Zongxiu Sun Xingchun Wang Yaping Fu Wenzhen Liu | 2013 | Journal of Integrative Plant Biology2013，55，11： | 8 |
| 20 | A new remaining useful life estimation method for equipment subjected to intervention of imperfect maintenance activities显示文摘As the key part of Prognostics and Health Management(PHM), Remaining Useful Life(RUL) estimation has been extensively investigated in recent years. Current RUL estimation studies considering the intervention of imperfect maintenance activities usually assumed that maintenance activities have a single influence on the degradation level or degradation rate, but not on both.Aimed at this problem, this paper proposes a new degradation modeling and RUL estimation method taking the influence of imperfect maintenance activities on both the degradation level and the degradation rate into account. Toward this end, a stochastic degradation model considering imperfect maintenance activities is firstly constructed based on the diffusion process. Then, the Probability Density Function(PDF) of the RUL is derived by the convolution operator under the concept of First Hitting Time(FHT). To implement the proposed RUL estimation method,the Maximum Likelihood Estimation(MLE) is utilized to estimate the degradation related parameters based on the Condition Monitoring(CM) data, while the Bayesian method is utilized to estimate the maintenance related parameters based on the maintenance data. Finally, a numerical example and a practical case study are provided to demonstrate the superiority of the proposed method. The experimental results show that the proposed method could greatly improve the RUL estimation accuracy for the degrading equipment subjected to imperfect maintenance activities. | Changhua HU Hong PEI Zhaoqiang WANG Xiaosheng SI Zhengxin ZHANG | 2018 | Chinese Journal of Aeronautics2018，31，3： | 8 |
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