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| 1 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 2 | The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγsignaling显示文摘Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells(BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2(Msi2) regulates BMSC lineage commitment. Msi2 is commonly enriched in stem cells and tumor cells. We found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs. Msi2 knockout mice exhibited decreased bone mass with substantial accumulation of marrow adipocytes, similar to aging-induced osteoporosis. Depletion of Msi2 in BMSCs led to increased adipocyte commitment. Transcriptional profiling analysis revealed that Msi2 deficiency led to increased PPARγ signaling.RNA-interacting protein immunoprecipitation assays demonstrated that Msi2 could inhibit the translation of the key adipogenic factor Cebpα, thereby inhibiting PPAR signaling. Furthermore, the expression of Msi2 decreased significantly during the aging process of mice, indicating that decreased Msi2 function during aging contributes to abnormal accumulation of adipocytes in bone marrow and osteoporosis. Thus, our results provide a putative biochemical mechanism for aging-related osteoporosis, suggesting that modulating Msi2 function may benefit the treatment of bone aging. | Jinlong Suo Sihai Zou Jinghui Wang Yujiao Han Lingli Zhang Chenchen Lv Bo Jiang Qian Ren Long Chen Lele Yang Ping Ji Xianyou Zheng Ping Hu Weiguo Zou | 2022 | Bone Research2022，10，3： | 5 |
| 3 | Syntheses, Structures and Magnetic Properties of Mn( Ⅱ ), Co( Ⅱ ) and Ni( Ⅱ ) Metal Organic Frameworks Constructed from 1,3,5-Benzenetricarboxylate and Formate Ligands显示文摘 | FU Ying SU Jie YANG Sihai | 2010 | Inorg Chim Acta2010，363，4： | 1 |
| 4 | Cooperative wireless networks for better green services显示文摘In order to guarantee the overall return on investment (ROI), improve user experience and quality of service (QoS), save energy, reduce electra magnetic interference (EMI) and radiation pollution, and enable the sustainable deployment of new profitable applications and services in heterogeneous wireless networks coexistence reality, this paper proposes a cross-network cooperation mechanism to effectively share network resources and infrastructures, and then adaptively control and match multi-network energy distribution characteristics according to actual user/service requirements in different geographic areas. Some idle or lightly-loaded base stations (BS or BSs) will be temporally turned off for saving energy and reducing EMI. Initial simulation results show that the proposed approach can significantly improve the overall energy efficiency and QoS performance across multiple cooperative wireless networks. | Yang Yang Zhang Wuxiong Hu Honglin Zhang Sihai Wang Xin Zhao Haitao Zhou Wuyang Wei Jibo | 2011 | Engineering Sciences2011，9，1： | 1 |
| 5 | Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits显示文摘 | Qi Yu Yafeng Li Ahmed Bilal Waqar Yanli Wang Bingqiao Huang Yulong Chen Sihai Zhao Peigang Yang Jianglin Fan Enqi Liu George E. Plopper | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 1 |
| 6 | Unique evolutionary pattern of numbers of gramineous NBS–LRR genes显示文摘 | Jing Li Jing Ding Wen Zhang Yuanli Zhang Ping Tang Jian-Qun Chen Dacheng Tian Sihai Yang | 2010 | Molecular Genetics and Genomics2010，，5： | 1 |
| 7 | Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers显示文摘 | Xiaohui Yan Zhongyi Hu Yi Feng Xiaowen Hu Jiao Yuan Sihai D. Zhao Youyou Zhang Lu Yang Weiwei Shan Qun He Lingling Fan Lana E. Kandalaft Janos L. Tanyi Chunsheng Li Chao-Xing Yuan Dongmei Zhang Huiqing Yuan Keqin Hua Yiling Lu Dionyssios Katsaros Qihong H | 2015 | Cancer Cell2015，，4： | 1 |
| 8 | Oleic acid reduces steroidogenesis by changing the lipid type stored in lipid droplets of ovarian granulosa cells显示文摘Background:Oleic acid is an abundant free fatty acid present in livestock that are in a negative energy-balance state,and it may have detrimental effects on female reproduction and fertility.Oleic acid induces lipid accumulation in bovine granulosa cells,which leads to a foam cell-like morphology and reduced steroidogenesis.However,why oleic acid increases lipid accumulation but decreases steroidogenesis remains unclear.This study focused on oleic acid’s effects on lipid type and steroidogenesis.Results:Oleic acid increased the lipid accumulation in a concentration-dependent manner and mainly increased the triglyceride level and decreased the cholesterol ester level.Oleic acid also led to a decline in estradiol and progesterone production in porcine granulosa cells in vitro.In addition,oleic acid up-regulated the expression of CD36 and diacylglycerol acyltransferase 2,but down-regulated the expression of 3-hydroxy-3-methylglutarylcoenzyme A reductase,scavenger receptor class B member 1 and acetyl-Coenzyme A acetyltransferase 2,as well as steroidogenesis-related genes,including cytochrome P450 family 11 subfamily A member 1,cytochrome P450family 19 subfamily A member 1 and 3 as well as steroidogenic acute regulatory protein at the mRNA and protein levels.An oleic acid-rich diet also enhanced the triglyceride levels and reduced the cholesterol levels in ovarian tissues of female mice,which resulted in lower estradiol levels than in control-fed mice.Compared with the control,decreases in estrus days and the numbers of antral follicles and corpora lutea,as well as an increase in the numbers of the atretic follicles,were found in the oleic acid-fed female mice.Conclusions:Oleic acid changed the lipid type stored in lipid droplets of ovarian granulosa cells,and led to a decrease in steroidogenesis.These results improve our understanding of fertility decline in livestock that are in a negative energy-balance state. | Xiaoge Zhou Zhaoyi Mo Yankun Li Liang Huang Sihai Yu Lan Ge Yamei Hu Shengjie Shi Lutong Zhang Liguang Wang Lei Gao Gongshe Yang Guiyan Chu | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 1 |
| 9 | A mesoporous met- al-organic framework constructed from a nanosized C3-sym- metric linker and Cuboctahedra 显示文摘 | Yan Yong Yang Sihai Blake A J | 2011 | ChemComm2011，47，36： | 1 |
| 10 | Erratum to:Borates as a new direction in the design of oxide ion conductors(vol 65,issue 10,page 2737,2022)显示文摘In the version of the article originally published in the volume 62,issue 10,2022 of Sci.china Mater.(page 2737-2745,https://doi.org/10.1007/s40843-022-2044-3).The chemical shift reported in Figure 5f for the^(11)B solid-state NMR spectra is incorrect because no parameter correction was performed during data processing. | Xiaohui Li Li Yang Zhenyu Zhu Xiaoge Wang Bohua Chen Senchuan Huang Xianyi Wei Guohong Cai Pascal Manuel Sihai Yang Jianhua Lin Xiaojun Kuang Junliang Sun | 2022 | Science China Materials2022，65，11： | 0 |
| 11 | Triton X-100辅助合成多级孔道结构ZSM-5沸石催化剂(英文)显示文摘ZSM-5 zeolite with a hexagonal cubic morphology was synthesized by a hydrothermal method using Triton X-100, a nonionic surfactant. The samples prepared with and without the surfactant were characterized by X-ray diffraction(XRD), Fourier transform infrared spectroscopy, N2 adsorption, high resolution transmission electron microscopy(TEM), high resolution scanning electron mi-croscopy, energy dispersive X-ray analysis, and NH3 temperature-programmed desorption. The XRD patterns confirmed the formation of a pure ZSM-5 crystalline phase without secondary phases. TEM images revealed that the hexagonal cubes were made of peanut-shaped nanoparticles with voids.The catalytic activity of the zeolite samples was evaluated using the selective oxidation of benzyl alcohol with tertiary-butyl hydrogen peroxide as the oxidant at 90 °C. The surfactant-assisted prep-aration yielded a zeolite that gave a higher conversion than the one prepared in the absence of the surfactant. The catalyst was retrieved and reused four times without significant loss in activity and selectivity. | S.Narayanan J.Judith Vijaya S.Sivasanker Sihai Yang L.John Kennedy | 2014 | 催化学报2014，35，11： | 0 |
| 12 | Porous framework materials for energy&environment relevant applications:A systematic review显示文摘Carbon peaking and carbon neutralization trigger a technical revolution in energy&environment related fields.Development of new technologies for green energy production and storage,industrial energy saving and efficiency reinforcement,carbon capture,and pollutant gas treatment is in highly imperious demand.The emerging porous framework materials such as metal–organic frameworks(MOFs),covalent organic frameworks(COFs)and hydrogen-bonded organic frameworks(HOFs),owing to the permanent porosity,tremendous specific surface area,designable structure and customizable functionality,have shown great potential in major energy-consuming industrial processes,including sustainable energy gas catalytic conversion,energy-efficient industrial gas separation and storage.Herein,this manuscript presents a systematic review of porous framework materials for global and comprehensive energy&environment related applications,from a macroscopic and application perspective. | Yutao Liu Liyu Chen Lifeng Yang Tianhao Lan Hui Wang Chenghong Hu Xue Han Qixing Liu Jianfa Chen Zeming Feng Xili Cui Qianrong Fang Hailong Wang Libo Li Yingwei Li Huabin Xing Sihai Yang Dan Zhao Jinping Li | 2024 | Green Energy & Environment2024，9，2： | 0 |
| 13 | Manipulation of π-aromatic conjugation in two-dimensional Sn-organic materials for efficient lithium storage显示文摘Sn-based materials are promising candidates for lithium storage but suffer generally from huge volume change during the(de)lithiation processes.Sn-organic materials with monodispersed Sn centers surrounded by lithium active ligands can alleviate the volume change of anode materials based on reversible(de)lithiation processes.However,the structural factors governing the kinetics of lithium storage and utilization efficiency of active sites are not well understood to date.Herein,we report three two-dimensional Sn-organic materials with enhanced lithium storage performance by manipulation ofπ-aromatic conjugation of the ligands.The increasingπ-aromatic conjugation plays a key role in promoting efficient lithium storage,and the volume expansion during the(de)lithiation reaction is suppressed in these Sn-organic materials.This work reveals that theπ-aromatic conjugation of the ligand is crucial for improving the kinetics of lithium storage and the utilization of active sites in metalorganic materials with minimised volume expansion. | Jingwei Liu Jialong Jiang Qingyang Zhou Zhonghang Chen Runhao Zhang Xiufang Xu Xue Han Sihai Yang Zhen Zhou Peng Cheng Wei Shi | 2023 | eScience2023，3，2： | 0 |
| 14 | Development of a colorimetric assay for rapid quantitative measurement of clavulanic acid in microbial samples显示文摘We developed a colorimetric assay to quantify clavulanic acid (CA) in culture broth of Streptomyces clavuligerus, to facilitate screening of a large number of S. clavuligerus mutants. The assay is based on a β-lactamase-catalyzed reaction, in which the yellow substrate nitrocefin (λmax =390 nm) is converted to a red product (λmax =486 nm). Since CA can irreversibly inhibit β-lactamase activity, the level of CA in a sample can be measured as a function of the A 390 /A 486 ratio in the assay mixture. The sensitivity and detection window of the assay were determined to be 50 g L-1 and 50 g L-1 to 10 mg L-1 , respectively. The reliability of the assay was confirmed by comparing assay results with those obtained by HPLC. The assay was used to screen a pool of 65 S. clavuligerus mutants and was reliable for identifying CA over-producing mutants. Therefore, the assay saves time and labor in large-scale mutant screening and evaluation tasks. The detection window and the reliability of this assay are markedly better than those of previously reported CA assays. This assay method is suitable for high throughput screening of microbial samples and allows direct visual observation of CA levels on agar plates. | DAI XiDa XIANG SiHai LI Jia GAO Qiang YANG KeQian | 2012 | Science China(Life Sciences)2012，55，2： | 0 |
| 15 | Dynamic-static coupled sensing of trace biomarkers by molecularly imprinted metal-organic frameworks显示文摘Accommodating target analytes within the pores of metal-organic frameworks(MOFs)to improve the sensing performance is an important but challenging task.Here,we report a novel molecular imprinting strategy to create target recognition sites in a tailored multicomponent MOF with the inter-ligand synergistic antenna effect to lanthanide ions,enabling selective recognition of trace biomarkers,which is critical to the early diagnosis of age-related diseases in blood samples with high sensitivity and ultralow limit of detection(LOD)of 69 nmol L^(-1).Compared with MOF-based sensors without imprinted recognition sites,the significantly enhanced sensing performance(both sensitivity and LOD)was attributed to a dynamic-static coupled sensing mechanism:the dynamic interactions involve concentrating the trace biomarkers at the imprinted recognition sites to enhance the sensing performance at ultralow concentration,and the static interactions are derived from electron/energy exchange between the molecularly imprinted MOF and the biomarker to govern the sensing performance.This work establishes a new molecular imprinting strategy to attain advanced materials for sensing trace bio-analytes. | Hui Min Zongsu Han Tiankai Sun Kunyu Wang Jun Xu Peiyu Yao Sihai Yang Peng Cheng Wei Shi | 2023 | Science China Chemistry2023，66，12： | 0 |
| 16 | A Multicenter Metal–Organic Framework for Quantitative Detection of Multicomponent Organic Mixtures显示文摘Instant recognition and quantification of multicomponent organicmixtures,especially the oneswith similar characteristics,remains a key challenge in the chemical industry.Although luminescence sensing is considered a rapid and facile method for the detection of various chemical substances,the simultaneous and quantitative detection of three or more components has not yet been achieved.Herein,we report a rationally designed white-light-emitting metal–organic framework(MOF)EuTb@NKU-102,and demonstrate its application in the simultaneous discrimination of multicomponent organic mixtures. | Zongsu Han Kunyu Wang Yinlin Chen Jiangnan Li Simon JTeat Sihai Yang Wei Shi Peng Cheng | 2022 | CCS Chemistry2022，4，10： | 0 |
| 17 | Observation of oxygen evolution over a {Ni12}-cluster-based metal-organic framework显示文摘The development of efficient electrocatalysts based on non-noble metals for oxygen evolution reaction(OER) remains an important and challenging task. Multinuclear transition-metal clusters with high structural stability are promising OER catalysts but their catalytic role is poorly understood. Here we report the crystallographic observation of OER activity over robust {Ni12}-clusters immobilised in a porous metal-organic framework, NKU-100, by single-crystal X-ray diffraction as a function of external applied potential. We observed the aggregation of confined oxygen species around the {Ni12}-cluster as a function of applied potential during the electrocatalytic process. The refined occupancy of these oxygen species shows a strong correlation with the variation of current density. This study demonstrates that the enrichment of oxygen species in the secondary coordination sphere of multinuclear transition-metal clusters can promote the OER activity. | Zongsu Han Zheng Yan Kunyu Wang Xinchen Kang Kai Lv Xiaoping Zhang Zhen Zhou Sihai Yang Wei Shi Peng Cheng | 2022 | Science China Chemistry2022，65，6： | 0 |
| 18 | Cascade adsorptive separation of light hydrocarbons by commercial zeolites显示文摘Adsorptive separation of light hydrocarbons by porous solids provides an energy-efficient alternative to state-of-the-art cryogenic distillation.However,an optimal balance between the cost,performance and stability of the sorbent material is yet to be achieved for industrial applications.Here,we report the efficient separation of C2 and C3 hydrocarbons by a faujasite zeolite(Na-X,Si/Al=1.23).A tandem configuration of two fixed-beds packed with Na-X affords complete dynamic separation of the ternary mixture of C_(2)H_(2)/C_(2)H_(4)/C_(2)H_(6)(1/49.5/49.5;v/v/v)under ambient conditions.Pressure-swing desorption on the latter fixed-bed gives ethylene(>99.50%,1.80 mmol g^(-1))and ethane(>99.99%,1.41 mmol g^(-1)).In situ synchrotron X-ray powder diffraction revealed the binding sites for C_(2)H_(2)and C_(2)H_(4)in Na-X.This study highlights the potential application of commercial zeolites for challenging industrial separations. | Shanshan Liu Yinlin Chen Bin Yue Yuanxin Nie Yuchao Chai Guangjun Wu Jiangnan Li Xue Han Sarah JDay Stephen PThompson Naijia Guan Sihai Yang Landong Li | 2022 | Journal of Energy Chemistry2022，31，9： | 0 |
| 19 | STUDY ON THE DECOLORIZATION OF D-RIBOSE ZYMOTIC FLUID BY RESIN ADSORPTION显示文摘In this paper, effects on of six type of resins the decolorization of D-ribosezymotic fluid have been studied for the fist time. The results show that resinNKA-II has the best effect. the decolorization rate of D-ribose zymotic fluid is91% at velocity of 1.0BV/hr and 25℃, the adsorption capacity can reach up to5.7BV. The effects of adsorption conditions as well as conditions of resinregeneration on the resin decolorization capability were also studied. | ZHENG Changcheng GUO Xianzhi DENG Guocai YANG Sihai CHEN Rongti(Department of Chemistry,Nankai University,Tianjin 300071) | 1999 | Chinese Journal of Reactive Polymers1999，8，1： | 0 |
| 20 | Tolerance and dependence of edomorphin-1 in rats and possible mechanisms显示文摘Objective: To observe the tolerance and the dependence of endomorphin-1 ( EM-1) in rats and the possible mechanisms.Methods: Sixty Sprague-Dawley rats were randomly allocated into saline, acute EM-1-treated and chronic EM-1-treated groups.The rats were intracerebroventricularly injected with saline, acute EM-1 10 !g/kg 30 min prior to sacrifice, and chronic EM-1 bydaily administration at 8: 00 A.M. and 15: 00 P.M. from 10 !g/kg on the 1st day to 50 !g/kg on the 9th day, respectively. Inchronic EM-1-treated group, the median antinociceptive dose (AD50) and the catatonic median effective dose (ED50) were deter-mined by the improved Dixon's method. Natural withdrawl test was used to assess the dependence of EM-1. Maximal binding ca-pacity(Bmax) and dissociation constant(Kd) of 3H-DAMGO, binding to mu-opioid receptor(MOR) in brain tissue, was mea-sured by Scatchard analysis. Gene expression of MOR was measured by reverse transcription-polymerase chain reaction(RT-PCR).Results: Tolerance of the antinociceptic and catatonic effects on the 3rd day(3.1-fold and 1.9-fold) and the 9th day(28.4-fold and8.5-fold) were observed in chronic EM-1-treated group (P < 0.05). Jumping times and withdrawal scores of rats were significantlyhigher in the chronic EM-1-treated group than those in saline group on the 9th day (P < 0.05). Bmax and mRNA expression ofMOR in cortex, midbrain and striatum were lower in chronic EM-1-treated group on the 9th day than the other two groups(P < 0.05),but Kd had no significant difference (P > 0.05). AD50, ED50, Bmax, Kd and gene expression of MOR were recorded. Conclusion:EM-1 possesses the tolerance and the dependence. After a long-term treatment, EM-1 down regulates the binding capacity andmRNA of MOR, which somewhat accounts for the dependence. | Weiyan Li Sihai Zhu Hongjun Liu Jianjun Yang Jianguo Xu | 2007 | Journal of Nanjing Medical University2007，21，4： | 0 |
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