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| 1 | A scientometric review of biochar research in the past 20 years(1998-2018)显示文摘Biochar is the carbon-rich product obtained from the thermochemical conversion of biomass under oxygen-limited conditions.Biochar has attained extensive attention due to its agronomical and environmental benefits in agro-ecosystems.This work adopts the scientometric analysis method to assess the development trends of biochar research based on the literature data retrieved from the Web of Science over the period of 1998-2018.By analysing the basic characteristics of 6934 publications,we found that the number of publications grew rapidly since 2010.Based on a keyword analysis,it is concluded that scholars have had a fundamental recognition of biochar and preliminarily found that biochar application had agronomic and environmental benefits during the period of 1998-2010.The clustering results of keywords in documents published during 2011-2015 showed that the main research hotspots were“biochar production”,“biochar and global climate change”,“soil quality and plant growth”,“organic pollutants removal”,and“heavy metals immobilization”.While in 2016-2018,beside these five main research hotspots,“biochar and composting”topic had also received greater attention,indicating that biochar utilization in organic solid waste composting is the current research hotspot.Moreover,updated reactors(e.g.,microwave reactor,fixed-bed reactor,screw-feeding reactor,bubbling fluidized bed reactor,etc.)or technologies(e.g.,solar pyrolysis,Thermo-Catalytic Reforming process,liquefaction technology,etc.)applied for efficient energy production and modified biochar for environmental remediation have been extensively studied recently.The findings may help the new researchers to seize the research frontier in the biochar field. | Ping Wu Syed Tahir Ata-Ul-Karim Bhupinder Pal Singh Hailong Wang Tongliang Wu Cun Liu Guodong Fang Dongmei Zhou Yujun Wang Wenfu Chen | 2019 | Biochar2019，1，1： | 36 |
| 2 | Response of microbial communities to biochar-amended soils:a critical review显示文摘Application of biochar to soils changes soil physicochemical properties and stimulates the activities of soil microorganisms that influence soil quality and plant performance.Studying the response of soil microbial communities to biochar amendments is important for better understanding interactions of biochar with soil,as well as plants.However,the effect of biochar on soil microorganisms has received less attention than its influences on soil physicochemical properties.In this review,the following key questions are discussed:(i)how does biochar affect soil microbial activities,in particular soil carbon(C)mineralization,nutrient cycling,and enzyme activities?(ii)how do microorganisms respond to biochar amendment in contaminated soils?and(iii)what is the role of biochar as a growth promoter for soil microorganisms?Many studies have demonstrated that biochar-soil application enhances the soil microbial biomass with substantial changes in microbial community composition.Biochar amendment changes microbial habitats,directly or indirectly affects microbial metabolic activities,and modifies the soil microbial community in terms of their diversity and abundance.However,chemical properties of biochar,(especially pH and nutrient content),and physical properties such as pore size,pore volume,and specific surface area play significant roles in determining the efficacy of biochar on microbial performance as biochar provides suitable habitats for microorgan-isms.The mode of action of biochar leading to stimulation of microbial activities is complex and is influenced by the nature of biochar as well as soil conditions. | Kumuduni Niroshika Palansooriya James Tsz Fung Wong Yohey Hashimoto Longbin Huang Jörg Rinklebe Scott X.Chang Nanthi Bolan Hailong Wang Yong Sik Ok | 2019 | Biochar2019，1，1： | 34 |
| 3 | Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China显示文摘 | Cao Hailong Qu Rui Zhang Zhihua Kong Xinyue Wang Shan Jiang Kui Wang Bangmao | 2014 | Chinese Medical Journal2014，，7： | 29 |
| 4 | High-entropy ceramics:Present status,challenges,and a look forward显示文摘High-entropy ceramics (HECs) are solid solutions of inorganic compounds with one or more Wyckoff sites shared by equal or near-equal atomic ratios of multi-principal elements.Although in the infant stage,the emerging of this new family of materials has brought new opportunities for material design and property tailoring.Distinct from metals,the diversity in crystal structure and electronic structure of ceramics provides huge space for properties tuning through band structure engineering and phonon engineering.Aside from strengthening,hardening,and low thermal conductivity that have already been found in high-entropy alloys,new properties like colossal dielectric constant,super ionic conductivity,severe anisotropic thermal expansion coefficient,strong electromagnetic wave absorption,etc.,have been discovered in HECs.As a response to the rapid development in this nascent field,this article gives a comprehensive review on the structure features,theoretical methods for stability and property prediction,processing routes,novel properties,and prospective applications of HECs.The challenges on processing,characterization,and property predictions are also emphasized.Finally,future directions for new material exploration,novel processing,fundamental understanding,in-depth characterization,and database assessments are given. | Huimin XIANG Yan XING Fu-zhi DAI Hongjie WANG Lei SU Lei MIAO Guojun ZHANG Yiguang WANG Xiwei QI Lei YAO Hailong WANG Biao ZHAO Jianqiang LI Yanchun ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 28 |
| 5 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 6 | The Yanshan orogeny and late Mesozoic multi-plate convergence in East Asia—Commemorating 90th years of the “Yanshan Orogeny”显示文摘The Yanshan movement/orogeny has been proposed for 90 years, which is of special significance in the history of geological research in China. This study conducted a review by synthesizing major achievements regarding episodic deformation features, sedimentary and magmatic records of the Yanshan orogeny in China, and clarified the episodic tectono-magmatism and its geodynamic origins. The tectonic implications of the Yanshan orogeny are discussed in the context of global plate tectonics and supercontinent reconstruction. Lines of evidence from structural, sedimentary and magmatic data suggest that the Yanshan orogeny represents a regional-scale tectonic event that affected the entire China continent in late Mesozoic period. Numerous age and structural constraints consistently indicate that the Yanshan orogeny was initiated in the Jurassic(at ~170±5 Ma). and was characterized by alternating stages of crustal shortening at ~170–136 Ma, crustal extension at ~135–90 Ma, and weak shortening at ~80 Ma. The 170–136 Ma crustal shortening was reflected in the generation of two regional stratigraphic unconformities(the Tiaojishan and Zhangjiakou unconformities), which were initially named the A and B episodes of 'the Yanshan Orogeny' by Mr.Wong Wenhao in 1928. Geodynamically, the Yanshan orogeny in East Asia was associated with nearly coeval oceanic subduction and continental convergence in the Paleo-Pacific, Neo-Tethys, and Mongol-Okhotsk tectonic domains. As a consequence, three giant accretionary-collisional tectonic systems were formed along the continental margins of East Asia, i.e., the Mongol-Okhotsk, Bangonghu-Nujiang, and SE China subduction-and collision-related accretionary systems. The Yanshan orogeny induced widespread crustal-scale folding and thrusting, tectonic reactivation of long-lived zones of crustal weakness,and extensive magmatism and mineralization in intraplate regions. Based on the time principle of supercontinent assembly and break-up, we propose that the mid-Late Jurassic multi-plate convergence in East Asia might represent the initiation of the assembly of the Amasia supercontinent, and the Yanshan orogeny might be the first 'stirrings' that is a prerequisite for the birth of the Amasia supercontinent. | Shuwen DONG Yueqiao ZHANG Hailong LI Wei SHI Huaimin XUE Jianhua LI Shiqi HUANG Yongchao WANG | 2018 | Science China Earth Sciences2018，61，12： | 21 |
| 7 | Light-absorbing Particles in Snow and Ice: Measurement and Modeling of Climatic and Hydrological impact显示文摘Light absorbing particles(LAP, e.g., black carbon, brown carbon, and dust) influence water and energy budgets of the atmosphere and snowpack in multiple ways. In addition to their effects associated with atmospheric heating by absorption of solar radiation and interactions with clouds, LAP in snow on land and ice can reduce the surface reflectance(a.k.a., surface darkening), which is likely to accelerate the snow aging process and further reduces snow albedo and increases the speed of snowpack melt. LAP in snow and ice(LAPSI) has been identified as one of major forcings affecting climate change, e.g.in the fourth and fifth assessment reports of IPCC. However, the uncertainty level in quantifying this effect remains very high. In this review paper, we document various technical methods of measuring LAPSI and review the progress made in measuring the LAPSI in Arctic, Tibetan Plateau and other mid-latitude regions. We also report the progress in modeling the mass concentrations, albedo reduction, radiative forcing, and climatic and hydrological impact of LAPSI at global and regional scales. Finally we identify some research needs for reducing the uncertainties in the impact of LAPSI on global and regional climate and the hydrological cycle. | Yun QIAN Teppei J.YASUNARI Sarah J.DOHERTY Mark G.FLANNER William K.M.LAU MING Jing Hailong WANG Mo WANG Stephen G.WARREN Rudong ZHANG | 2015 | Advances in Atmospheric Sciences2015，32，1： | 16 |
| 8 | Visualizing the emerging trends of biochar research and applications in 2019:a scientometric analysis and review显示文摘Biochar,derived from thermal pyrolysis of biomass,has been regarded as a low-cost,sustainable and beneficial material and widely applied in agriculture,environment and energy during the last two decades.To elucidate the research status timely and future trends in biochar field,CiteSpace is used to systematically analyze the related literature retrieved from the Web of Science core collection in 2019.Based on the keywords clustering analysis,it was found that“biochar production”,“organic pollutants removal”,“heavy metals immobilization”,“bioremediation”were the main hotspots in research covering biochar.“Bioremediation”is an emerging topic and deserves extensive attention due to its highly effective and environmentally friendly treatment of pollutants.Improving the phytoremediation effect,immobilizing functional microorganisms on biochar,and using microorganisms as raw materials to produce biochar were the common methods of biochar-assisted bioremediation.While studies focused on“soil quality and plant growth”and“biochar and global climate change”decreased,investigations concentrated in the toxicity of biochar to soil biota and ruminants are sustainably growing.Research on direct and catalytic thermal pyrolysis of green waste(mainly microalgae)for biofuels(bio-oil,biodiesel,syngas,etc.)and biochar production is increasing.Converting municipal wastes(e.g.,sewage sludge,fallen leaves)into biochar through pyrolysis was a suitable treatment for municipal waste and became a popular topic in recent time.Moreover,the biochar produced from these municipal wastes exhibited excellent performance in the removal of pollutants from wastewater and soil.This review may help to identify future directions in biochar research and applications. | Ping Wu Zeyu Wang Hailong Wang Nanthi S.Bolan Yujun Wang Wenfu Chen | 2020 | Biochar2020，2，2： | 14 |
| 9 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 10 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 11 | Neuroprotective Autophagic Flux Induced by Hyperbaric Oxygen Preconditioning is Mediated by Cystatin C显示文摘We have previously reported that Cystatin C(CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen(HBO) preconditioning; however,the underlying mechanism and how CysC changes after stroke are not clear. In the present study, we demonstrated that CysC expression was elevated as early as 3 h after reperfusion, and this was further enhanced by HBO preconditioning. Concurrently, LC3-II and Beclin-1, two positive-markers for autophagy induction, exhibited increases similar to CysC, while knockdown of CysC blocked these elevations. As a marker of autophagy inhibition, p62 was downregulated by HBO preconditioning and this was blocked by CysC knockdown. Besides, the beneficial effects of preserving lysosomal membrane integrity and enhancing autolysosome formation induced by HBO preconditioning were abolished in CysC-/-rats.Furthermore, we demonstrated that exogenous CysC reduced the neurological deficits and infarct volume after brain ischemic injury, while 3-methyladenine partially reversed this neuroprotection. In the present study, we showed that CysC is biochemically and morphologically essential for promoting autophagic flux, and highlighted the translational potential of HBO preconditioning and CysC for stroke treatment. | Zongping Fang Yun Feng Yuheng Li Jiao Deng Huang Nie Qianzhi Yang Shiquan Wang Hailong Dong Lize Xiong | 2019 | Neuroscience Bulletin2019，35，2： | 14 |
| 12 | CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization显示文摘Despite the diverse etiologies of drug-induced liver injury(DILI),innate immunity activation is a common feature involved in DILI progression.However,the involvement of innate immunity regulation in inflammation resolution and liver regeneration in DILI remains obscure.Herein,we identified the chemokine CCL5 as a central mediator of innate immunity regulation in the pathogenesis of DILI.First,we showed that serum and hepatic CCL5 levels are elevated in both DILI patients and an APAP-induced liver injury(AILI)mouse model.Interestingly,both nonparenchymal cells and stressed hepatocytes are cell sources of CCL5 induction in response to liver injury.Functional experiments showed that CCL5 deficiency has no effect on the early phase of AILI but promotes liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration,which are associated with an increased number of hepatic M2 macrophages.Mechanistically,CCL5 can directly activate M1 polarization and impede M2 polarization through the CCR1-and CCR5-mediated activation of the MAPK and NF-κB pathways.We then showed that CCL5 inhibition mediated by either a CCL5-neutralizing antibody or the antagonist Met-CCL5 can greatly alleviate liver injury and improve survival in an AILI mouse model.Our data demonstrate CCL5 induction during DILI,identify CCL5 as a novel innate immunity regulator in macrophage polarization,and suggest that CCL5 blockage is a promising therapeutic strategy for the treatment of DILI. | Meng Li Xuehua Sun Jie Zhao Lei Xia Jichang Li Min Xu Bingrui Wang Han Guo Chang Yu Yueqiu Gao Hailong Wu Xiaoni Kong Qiang Xia | 2020 | Cellular & Molecular Immunology2020，17，7： | 13 |
| 13 | Baicalin extracted from Huangqin(Radix Scutellariae Baicalensis) induces apoptosis in gastric cancer cells by regulating B cell lymphoma(Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9显示文摘OBJECTIVE:To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.METHODS:Cell proliferation and apoptosis assays were performed to investigate the anti-proliferation effects of baicalin in human gastric cancer BGC-823 and MGC-803 cells.Real time-quantitative polymerase chain reaction and Western blotting analysis were performed to elucidate the molecular mechanisms underlying the anti-tumor properties of baicalin.RESULTS:In BGC-823 and MGC-803 gastric cancer cells treated with 80, 120, and 160 μmol/L baicalin for 48 h, a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay showed that baicalin significantly inhibited cell proliferation in a dose-dependent manner, while flow cytometric analysis demonstrated that baicalin could induce apoptosis, also in a dose-dependent manner.Moreover, baicalin up-regulated the expression of caspase-3, caspase-9, and B cell lymphoma(Bcl-2)-associated X protein and down-regulated the expression of Bcl-2 at both the m RNA and protein level.CONCLUSION:Baicalin has potential as a therapeutic agent for gastric cancer by inducing apoptosis in cancer cells. | Wang Hongwei Li Hailong Chen Fengqin Luo Jun Gu Jing Wang Huping Wu Hongyan Xu Yan | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 13 |
| 14 | Semi-active Sliding Mode Control of Vehicle Suspension with Magneto-rheological Damper显示文摘The vehicle semi-active suspension with magneto-rheological damper(MRD) has been a hot topic since this decade, in which the robust control synthesis considering load variation is a challenging task. In this paper, a new semi-active controller based upon the inverse model and sliding mode control(SMC) strategies is proposed for the quarter-vehicle suspension with the magneto-rheological(MR) damper, wherein an ideal skyhook suspension is employed as the control reference model and the vehicle sprung mass is considered as an uncertain parameter. According to the asymptotical stability of SMC, the dynamic errors between the plant and reference systems are used to derive the control damping force acquired by the MR quarter-vehicle suspension system. The proposed modified Bouc-wen hysteretic force-velocity(F-v) model and its inverse model of MR damper, as well as the proposed continuous modulation(CM) filtering algorithm without phase shift are employed to convert the control damping force into the direct drive current of the MR damper. Moreover, the proposed semi-active sliding mode controller(SSMC)-based MR quarter-vehicle suspension is systematically evaluated through comparing the time and frequency domain responses of the sprung and unsprung mass displacement accelerations, suspension travel and the tire dynamic force with those of the passive quarter-vehicle suspension, under three kinds of varied amplitude harmonic, rounded pulse and real-road measured random excitations. The evaluation results illustrate that the proposed SSMC can greatly suppress the vehicle suspension vibration due to uncertainty of the load, and thus improve the ride comfort and handling safety. The study establishes a solid theoretical foundation as the universal control scheme for the adaptive semi-active control of the MR full-vehicle suspension decoupled into four MR quarter-vehicle sub-suspension systems. | ZHANG Hailong WANG Enrong ZHANG Ning MIN Fuhong SUBASH Rakheja SU Chunyi | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 12 |
| 15 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 16 | Astragalus saponin attenuates the expression of fibrosis-related molecules in irradiated cardiac fibroblasts显示文摘导致放射的心疾病的主要病理学的变化是纤维变性。新兴的证据显示了那 Astragalusmembranaceus 和它的提炼之物,距骨 saponin (著名计算机生产厂商) ,被用于治疗纤维变性疾病。在现在的学习,照耀导致的纤维变性损坏上的著名计算机生产厂商的效果是坚定的。在与 1 被照耀或 2-Gy X 光以后, endoplasmic 蜂窝胃形态学的明显的变化在心脏的成纤维细胞(CF ) 被观察,建议它的 proteinprocessing 功能是 imbalanced,它间接地显示那纤维变性损坏被照耀引起 CF。TGF-1 和骨胶原的 expressionlevels (Col-1 ) 我在 48-h 被增加照耀以后。20 g/ml 著名计算机生产厂商的管理减少了反应的氧 speciesin 的生产照耀的 CF 并且减少 Col-1, TGF-1,和 p-Smad2/3 的表示。聚合酶链反应(PCR ) 数组分析证明有 30 基因,主要被分类进 extracellularmatrix,改变酶,煽动性的 cytokines/chemokines,和 TGF- 总科,在有 1-Gy X 光检查的处理以后是起来调整的,而大多数这些基因是下面调整的什么时候 pretreatedwith 著名计算机生产厂商的 20 g/ml。另外,在有 1-Gy X 光检查的处理以后是下面调整的 TIMP1 和 Smad7 基因是起来调整的什么时候有著名计算机生产厂商的 20 g/ml 的 pretreated。Inconclusion,导致放射的纤维变性损坏在细胞的水平被观察。著名计算机生产厂商稀释了照耀的 CF 和这反纤维变性效果可以是的这纤维变性损坏 effectin 仔细与它的抗氧化剂行动有关。在照耀的 CF 的 fibrosis-relatedmolecules 的参与被一个 PCR 数组系统地第一次表明。著名计算机生产厂商颠倒了基因的多数由照耀改变了的 expressionof,它进一步证实了它的反纤维变性效果。 | Jing Gu Kai Liu Hailong Li Xiaogang Wang Kehu Yang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 11 |
| 17 | Skyhook-based Semi-active Control of Full-vehicle Suspension with Magneto-rheological Dampers显示文摘The control study of vehicle semi-active suspension with magneto-rheological (MR) dampers has been attracted much attention internationally. However, a simple, real time and easy implementing semi-active controller has not been proposed for the MR full-vehicle suspension system, and a systematic analysis method has not been established for evaluating the multi-objective suspension performances of MR full-vehicle vertical, pitch and roll motions. For this purpose, according to the 7-degree of freedom (DOF) fullvehicle dynamic system, a generalized 7-DOF MR and passive full-vehicle dynamic model is set up by employing the modified Boucwen hysteretic force-velocity (F-v) model of the MR damper. A semi-active controller is synthesized to realize independent control of the four MR quarter-vehicle sub-suspension systems in the full-vehicle, which is on the basis of the proposed modified skyhook damping scheme of MR quarter-vehicle sub-suspension system. The proposed controller can greatly simplify the controller design complexity of MR full-vehicle suspension and has merits of easy implementation in real application, wherein only absolute velocities of sprung and unsprung masses with reference to the road surface are required to measure in real time when the vehicle is moving. Furthermore, a systematic analysis method is established for evaluating the vertical, pitch and roll motion properties of both MR and passive full-vehicle suspensions in a more realistic road excitation manner, in which the harmonic, rounded pulse and real road measured random signals with delay time are employed as different road excitations inserted on the front and rear two wheels, by considering the distance between front and rear wheels in full-vehicle. The above excitations with different amplitudes are further employed as the road excitations inserted on left and right two wheels for evaluating the roll motion property. The multi-objective suspension performances of ride comfort and handling safety of the proposed MR full-vehicle suspension are thus thoroughly evaluated by comparing with those of the passive full-vehicle suspension. The results show that the proposed controller can ideally improve multiobjective suspension performances of the ride comfort and handling safety. The proposed harmonic, rounded pulse and real road measured random signals with delay time and asymmetric amplitudes are suitable for accurately analyzing the vertical, pitch and roll motion properties of MR full-vehicle suspension system in a more realistic road excitation manner. This research has important theoretical significance for improving application study on the intelligent MR semi-active suspension. | ZHANG Hailong WANG Enrong MIN Fuhong SUBASH Rakheja SU Chunyi | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 11 |
| 18 | First six months quality assessment of HY-2A SCAT wind products using in situ measurements显示文摘The first Chinese microwave ocean environment satellite HY-2A,carrying a Ku-band scatteromenter(SCAT),was successfully launched in August 2011.The first quality assessment of HY-2A SCAT wind products is presented through the comparison of the first 6 months operationally released SCAT products with in situ data.The in situ winds from the National Data Buoy Center(NDBC)buoys,R/V Polarstern,Aurora Australis,Roger Revelle and PY30-1 oil platform,were converted to the 10 m equivalent neutral winds.The temporal and spatial differences between the HY-2A SCAT and the in situ observations were limited to less than 5min and 12.5 km.For HY-2A SCAT wind speed products,the comparison and analysis using the NDBC buoys yield a bias of–0.49 m/s,a root mean square error(RMSE)of 1.3 m/s and an increase negative bias with increasing wind speed observation above 3 m/s.Although less accurate of HY-2A SCAT wind direction at low winds,the RMSE of 19.19 with a bias of 0.92 is found for wind speeds higher than 3 m/s.These results are found consistent with those from R/Vs and oil platform comparisons.Moreover,the NDBC buoy comparison results also suggest that the accuracy of HY-2A SCAT winds is consistent over the first half year of 2012.The encouraging assessment results over the first 6 months show that wind products from HY-2A SCAT will be useful for scientific community. | WANG He ZHU Jianhua LIN Mingsen HUANG Xiaoqi ZHAO Yili CHEN Chuntao ZHANG Youguang PENG Hailong | 2013 | Acta Oceanologica Sinica2013，32，11： | 10 |
| 19 | Quality assessment of randomized controlled trials reporting on knee osteoarthritis treated with warming needle moxibustion显示文摘OBJECTIVE: To evaluate the quality of randomized controlled trials(RCTs) testing the efficacy of warming needle moxibustion on knee osteoarthritis(KOA).METHODS: Nine databases were searched systematically including: the Cochrane Library(1/1993-10/2012), Pub Med(1/1980-10/2012), EMBASE(1/1990-10/2012), SCI Expanded(1/1986-10/2012), Science Direct(1/1979-10/2012), Chinese Biomedical Literature Database disc(1/1978-10/2012), China National Knowledge Infrastructure Database(1/1979-10/2012), China Science and Technology Journal Database(a full text issue database of China, 1/1989-10/2012), and Wanfang Database(a full text issue database of China, 1/1990-10/2012). Traditional reference retrieval was also conducted. Language was limited to Chinese and English. We identified 37 RCTs that used warming needle moxibustion as an intervention and they were assessed with the Consolidated Standards for Reporting of Trials Statement 2010(CONSORT 2010) and Standards for Reporting Interventions Controlled Trials of Acupuncture 2010(STRICTA 2010).RESULTS: Of the 37 reports, only seventeen(45.95%) mentioned the random allocation of sequence methods, nine used unacceptable methods, and only one(2.70%) gave the description of the mechanism of allocation concealment. One study(2.70%) mentioned blinding, one(2.70%) had a sample size calculation, and twenty-three(62.16%) used reasonable statistical methods. Thirteen(35.14%) described the background and reason for the RCTs, three(8.11%) gave a description of lost or eliminated patients, and two(5.41%) reported accidental situations. Only three(8.11%)gave analysis of the RCT limitations. No report mentioned intentional analysis.CONCLUSION: The quality of the RCTs assessed in this study was from moderate to low. The design of RCTs, the methods of statistical analysis, and the description of reports information needs to be improved. CONSORT 2010 and STRICTA 2010 should be used to standardize the reporting of acupuncture RCTs in the future. | Hailong Yu Yitong Wang Yi Guo Hong Wang Bo Chen Xue Zhao | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 10 |
| 20 | Pyrosequencing Reveals Significant Changes in Microbial Communities Along the Ecological Succession of Biological Soil Crustsin the Tengger Desert of China显示文摘Biological soil crusts(BSCs)have important ecological functions in arid and semiarid lands,but they remain poorly understood in terms of the changes in microbial communities during BSC succession under in situ field conditions.Here,454 pyrosequencing was used to assess the microbial community composition of four BSC types in the Tengger Desert of China:alga,lichen(cyanolichen and green alga-lichen),and moss crusts,representing early,middle,and final successional stages of BSCs,respectively.The results showed the highest diversity of microbial communities inhabiting lichen crusts,whereas the lowest diversity was observed in moss crusts.Five phyla,Proteobacteria,Actinobacteria,Cyanobacteria,Bacteroidetes,and Acidobacteria,accounted for about 72% to 87%of total prokaryotic sequences in different BSCs.The most abundant eukaryotic microorganism was Ascomycota,accounting for 47%to 93%of the total eukaryotic sequences.Along the succession of BSCs,the abundance of photoautotrophic Cyanobacteria,Chlorophyta,and Bacillariophyta declined,and that of heterotrophic microorganisms such as bacteria and fungi increased.Statistical analysis showed clear divergency of microbial taxa at the class level among the different successional stages of BSCs.The clustering results at class level showed that the moss crusts were the farthest from the rest in prokaryotic composition;the alga crusts were the most different in terms of eukaryotic microorganisms and the two kinds of lichen crusts were relatively closer in both compositions.Ordination analysis showed that the main variations of community structure among BSCs could be explained best by the abundance of Cyanobacteria and Ascomycota and by physiochemical properties of BSCs,including mechanical composition,moisture,and electrical conductivity.In conclusion,our results indicate that Cyanobacteria and Ascomycota likely play an important role in the evolution of BSC structure and functions and highlight the importance of environmental factors in shaping microbial community structures of BSCs in the Tengger Desert of China. | ZHANG Qingyi WANG Qiong OUYANG Hailong LAN Shubin HU Chunxiang | 2018 | Pedosphere2018，28，2： | 9 |
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