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| 1 | Cancer incidence in Beijing, 2014显示文摘Objective: To analyze cancer incidence data in Beijing in 2014 and temporal trends for selected common cancers during 2005 and 2014.Methods: A total of 144 secondary and tertiary hospitals reported newly diagnosed cancer cases to Beijing Cancer Registry, which covers 13 million residents in Beijing. The cancer incidence rate was calculated in strata by cancer type, sex, age group and area. The population composition of China in 1982 and Segi's population structure were used to calculate age-standardized rates. Extensive procedures were used to assure the quality of the data.Results: The overall data quality indicators of the percentage of morphology verification(MV)(%), the percentage of death certificate-only(DCO)(%) and the mortality to incidence ratio(M/I) were 72.15%, 0.94% and0.54 respectively. A total of 45,300 new cancer cases were diagnosed in Beijing in 2014. The incidence rate was341.92/100,000(343.50/100,000 in males, 340.33/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 143.48/100,000 and182.99/100,000, respectively. The cumulative incidence rate for cancer before 75 years was 20.61%. Cancers of lung, colorectum, liver, stomach and prostate were the top five common cancer types for males, while cancers of breast, lung, thyroid, colorectum and uterus were the top five common cancer types for females. The different patterns were also observed between rural and urban areas. Regarding temporal trends, the incidence of thyroid cancer has the fastest growth between 2005 and 2014. The incidence of liver cancer decreased, and stomach and esophageal cancer also decreased significantly for males in the last decade. Incidence rate for lung cancer was relatively stable during that period of time.Conclusions: With more than 45,000 new cases in Beijing in 2014, cancer remains an important public health problem. Actions should be taken to diminish total cancer incidence in Beijing. | Shuo Liu Lei Yang Yannan Yuan Huichao Li Jing Tian Sijia Lu Ning Wang Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，1： | 11 |
| 2 | Cyanoethyl cellulose-based eutectogel electrolyte enabling high-voltage-tolerant and ion-conductive solid-state lithium metal batteries显示文摘Solid-state polymer electrolytes are an important factor in the deployment of highsafety and high-energy-density solid-state lithium metal batteries.Nevertheless,use of the traditional polyethylene oxide-based solid-state polymer electrolyte is limited due to its inherently low ionic conductivity and narrow electrochemical stability window.Herein,for the first time,we specifically designed a cyanoethyl cellulosein-deep eutectic solvent composite eutectogel as a promising candidate for hybrid solid-state polymer electrolytes.It is found that the proposed eutectogel electrolyte achieves high ionic conductivity(1.87×10^(−3) S cm^(−1) at 25℃),superior electrochemical stability(up to 4.8 V),and outstanding lithium plating/striping behavior(low overpotential of 0.04 V at 1mAcm^(−2) and 1mAh cm^(−2) over 300 h).With the eutectogel-based solid-state polymer electrolyte,a 4.45 V LiCoO_(2)/Li metal battery delivers prominent long-term lifespan(capacity retention of 85%after 200 cycles)and high average Coulombic efficiency(99.5%)under ambient conditions,significantly outperforming the traditional carbonate-based liquid electrolyte.Our work demonstrates a promising strategy for designing eutectogel-based solid-state polymer electrolytes to realize high-voltage and high-energy lithium metal batteries. | Hao Zhang Lixue Zhou Xiaofan Du Jianjun Zhang Songwei Tian Tingting Liu Jinning Zhang Sijia Hu Weiling Song Xinhong Zhou Guanglei Cui | 2022 | Carbon Energy2022，4，6： | 3 |
| 3 | In-situ observation of electrical tree evolution in epoxy dielectrics with internal cracks显示文摘Gas-filled internal crack might appear in thermoset materials like epoxy resin during the equipment manufacturing,which would become a vulnerable local region to initiate the electrical tree,thus prone to cause insulation failure.The withstand voltage test was carried on epoxy samples with artificial cracks based on a rod-plane electrode arrange-ment.Simultaneously,surface state variation and tree evolution with crack were observed by an optical microscope in conjunction with a charge-coupled device camera.The changes in morphology and chemical status of the crack surface were characterized by scanning electron microscopy,laser Raman spectrometer and energy dispersive spec-trometer,respectively.It was found that the erosion and tree started from the borderline of crack under a relatively low electric field strength;however,the area near the electrode had relatively little damage.The breaking of epoxy molecular chains coarsens the crack surface and further forms deep channels on a micro-level,which is the forerunner of the electrical tree inception.Based on these,the initiation mechanisms of the crack-induced electrical tree and the reasons for the erosion near the borderline have been revealed.This study provides a train thought for the polymer degradation opening up into the initial tree channel during tree evolution processes. | Zehua Wu Huidong Tian Sijia Zhu He Li Qingyu Wang Zongliang Xie Peng Liu Zongren Peng | 2021 | High Voltage2021，6，2： | 3 |
| 4 | Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy显示文摘Tumor nanovaccines have potential applications in the prevention and treatment of malignant tumors.However,it remains a longstanding challenge in exploiting efficient nanocarriers for inducing potent specifically cellular immune responses.Toward this objective,we herein explore an intensive tumor immunotherapeutic strategy by combining mannosylated nanovaccines and gene regulated PD-L1 blockade for immune stimulation and killing activity.Here,we fabricate a mannose modified PLL-RT(Man-PLL-RT)mediated nanovaccines with dendritic cells(DCs)targeting capacity.Man-PLL-RT is capable of co-encapsulating with antigen(ovalbumin,OVA)and adjuvant(unmethylated cytosine-phosphate-guanine,CpG)by electrostatic interaction.This positively charged Man-PLL-RT/OVA/CpG nanovaccines can facilitate the endocytosis,maturation and cross presentation in DCs.However,the nanovaccines arouse limited inhibition of tumor growth,which is mainly due to the immunosuppressed microenvironment of tumors.Combining tumor nanovaccines with gene regulated PD-L1 blockade leads to an obvious tumor remission in B16F10 melanoma bearing mice.The collaborative strategy provides essential insights to boost the benefits of tumor vaccines by regulating the checkpoint blockade with gene therapy. | Jie Chen Huapan Fang Yingying Hu Jiayan Wu Sijia Zhang Yuanji Feng Lin Lin Huayu Tian Xuesi Chen | 2022 | Bioactive Materials2022，7，1： | 2 |
| 5 | Cardiopulmonary resuscitation and termination of resuscitation on out-of-hospital cardiac arrest in China显示文摘To the Editor: Out-of-hospital cardiac arrest (OHCA) is a major public health challenge. Early initiation, good quality cardiopulmonary resuscitation (CPR), and the use of an automated external defibrillator (AED) have been reported to significantly improve the survival and long-term outcomes in survivors of OHCA. | Xiaojun He Yang Liu Sijia Tian Jun Liang Shengmei Niu Jinjun Zhang | 2022 | Chinese Medical Journal2022，，9： | 2 |
| 6 | Application of Fe^Ⅲ-TAML/H2O_(2) system for treatment of fluoroquinolone antibiotics显示文摘Over the recent past,fluoroquinolone antibiotics(FQs)have raised extensive attention due to their potential to induce the formation of resistance genes and'superbugs',thus various advanced oxidation techniques have been developed to eliminate their release into the environment.In the present study,the prototype tetraamido macrocyclic ligand(Fe^Ⅲ-TAML)/hydrogen peroxide(H2O_(2))system is employed to degrade FQs(i.e.,norfloxacin and ciprofloxacin)over a wide p H range(i.e.,p H 6-10),and the reaction rate increases with the increase in p H level.The effect of dosage of Fe^Ⅲ-TAML and H2O_(2) on the degradation of FQs is evaluated,and the reaction rate is linearly correlated with the added amount of chemicals.Moreover,the impact of natural organic matters(NOM)on the removal of FQs is investigated,and the degradation kinetics show that both NOM type and experimental concentration exhibit negligible influence on the oxidative degradation of selected antibiotics.Based on the results of liquid chromatography-high resolution mass spectrometry and theoretical calculations,the reaction sites and pathways of FQs by Fe^Ⅲ-TAML/H2O_(2) system are further predicted and elucidated. | Zeyu Xian Sijia Liang Xin Jin Haoting Tian Jingyi Ling Chao Wang | 2021 | Journal of Environmental Sciences2021，33，1： | 1 |
| 7 | Freeze-drying and hot-pressing strategy to embed two-dimensional Ti_(0.87)O_(2) monolayers in commercial polypropylene films with enhanced dielectric properties显示文摘The dielectric capacitor has been widely used in advanced electronic and electrical power systems due to its capability of ultrafast charging–discharging and ultrahigh power density.Nevertheless,its energy density is still limited by the low dielectric constant(≈2.2)of the commercial dielectric polypropylene(PP).The conventional enhancement strategy by embedding inorganic fillers in PP matrix is still difficult and challenging due to that PP hardly dissolves in any inorganic/organic solvent.In this work,we develop a new strategy including freeze-drying,surface functionalization,and hot-pressing to incorporate Ti_(0.87)O_(2) monolayers in PP film.A series of uniform composited Ti_(0.87)O_(2)@PP film has been successfully fabricated with Ti0.87O2 content range of 0–15 wt%.The maximum dielectric constant of the as-prepared Ti_(0.87)O_(2)@PP film is 3.27 when the Ti_(0.87)O_(2) content is 9 wt%,which is about 1.5 times higher than that of pure PP.Our study provides a feasible strategy to embed two-dimensional material into commercial PP thin-film with superior dielectric performance for practical application. | Wenchao Tian Fei Yan Cailing Cai Zeyi Wu Chenchen Zhang Ting Yin Sijia Lao Linfeng Hu | 2021 | Journal of Advanced Ceramics2021，10，2： | 1 |
| 8 | Association between duration of return of spontaneous circulation and outcomes after out-of-hospital cardiac arrest显示文摘Background:Return of spontaneous circulation(ROSC)is a core outcome element of cardiopulmonary resuscitation(CPR);however,the definition or criterion of ROSC is disputed and varies in resuscitation for out-of-hospital cardiac arrest(OHCA).Methods:This was a retrospective study of 126 patients with OHCA who achieved ROSC between January and December 2020.The probability of survival after OHCA related to CPR and ROSC duration was analyzed using the probability density function and empirical cumulative density functions.Results:There were no significant differences between ROSC sustained until emergency department arrival and that sustained for at least 20 minutes in terms of the 24-hour survival rate(31.3%[31/99]vs.35.7%[10/30];P=0.84),30-day survival rate(23.2%[23/99]vs.25.0%[7/30];P=0.99),or survival at 30 days with cerebral performance category(CPC)1 and 2(18.2%[18/99]vs.10.7%[3/30];P=0.44).The Kolmogorov-Smirnov test values from the empirical cumulative density functions with ROSC sustained until hospital arrival and that sustained for at least 20 minutes were 0.44,0.20,and 0.24 for CPC 1 or 2,CPC 3 or 4,and CPC 5,respectively.Conclusion:Return of spontaneous circulation is a core outcome element of CPR.It should be defined as sustained for at least 20 minutes or until arrival at the emergency department and as a basic standard for evaluating resuscitation success after OHCA. | Huixin Lian Andong Xia Xinyan Qin Sijia Tian Xuqin Kang Luxi Zhang Shengmei Niu Fei Qin Jinjun Zhang | 2022 | Emergency and Critical Care Medicine2022，2，4： | 1 |
| 9 | Effects of a closed-loop system against SARS-CoV-2 at the Beijing 2022 Olympic Winter Games:a descriptive and modeling study显示文摘BACKGROUND:To assess the efficacy of the epidemic prevention measures of the“closed-loop”system adopted by the Beijing 2022 Olympic Winter Games(BOWG).METHODS:We retrospectively collected and analyzed information,including age,sex,nationality,vaccination status,date of diagnosis,and date of entry,from 280 SARS-CoV-2-positive individuals identified during the BOWG.A susceptibility-exposed-infectious-remove model was employed to evaluate the effectiveness of epidemic prevention strategies on controlling the spread of SARS-CoV-2 under different scenarios during the BOWG.RESULTS:Regarding SARS-CoV-2-positive cases,97.9%were imported,and 96.4%were asymptomatic.The median age was 37 years(range:29–47 years),and 73.9%were male,with the majority of cases being broadcasters and European attendees.Regarding vaccination status,93.5%were fully vaccinated,and six cases were considered to have been infected in the closed-loop system during the BOWG.Assuming that the BOWG adopted a semi-closed-loop management system,the cumulative number of confirmed cases would be 1,137 for quick quarantine measures(3 d later)implemented and 5,530 for delayed quarantine measures(9 d later)implemented.This modeling revealed that stringent pandemic prevention measures and closed-loop management effectively controlled the spread of SARS-CoV-2 during the BOWG.CONCLUSION:Imported cases are considered the main risk factor for SARS-CoV-2 transmission during mass gatherings,but a comprehensive closed-loop system could minimize transmission among attendees and general personnel. | Rong Xiong Jieping Zhou Wenning Li Jie Liu Jing Lou Sijia Tian Huixin Lian Shengmei Niu Luxi Zhang Wenhang Li Jinjun Zhang | 2023 | World Journal of Emergency Medicine2023，14，6： | 0 |
| 10 | Skin‑Inspired Ultra‑Tough Supramolecular Multifunctional Hydrogel Electronic Skin for Human–Machine Interaction显示文摘Multifunctional supramolecular ultra-tough bionic e-skin with unique durability for human–machine interaction in complex scenarios still remains challenging.Herein,we develop a skininspired ultra-tough e-skin with tunable mechanical properties by a physical cross-linking salting-freezing-thawing method.The gelling agent(β-Glycerophosphate sodium:Gp)induces the aggregation and binding of PVA molecular chains and thereby toughens them(stress up to 5.79 MPa,toughness up to 13.96 MJ m^(−3)).Notably,due to molecular self-assembly,hydrogels can be fully recycled and reprocessed by direct heating(100°C for a few seconds),and the tensile strength can still be maintained at about 100%after six recoveries.The hydrogel integrates transparency(>60%),super toughness(up to 13.96 MJ m^(−3),bearing 1500 times of its own tensile weight),good antibacterial properties(E.coli and S.aureus),UV protection(Filtration:80%–90%),high electrical conductivity(4.72 S m^(−1)),anti-swelling and recyclability.The hydrogel can not only monitor daily physiological activities,but also be used for complex activities underwater and message encryption/decryption.We also used it to create a complete finger joint rehabilitation system with an interactive interface that dynamically presents the user’s health status.Our multifunctional electronic skin will have a profound impact on the future of new rehabilitation medical,human–machine interaction,VR/AR and the metaverse fields. | Kun Chen Kewei Liang He Liu Ruonan Liu Yiying Liu Sijia Zeng Ye Tian | 2023 | Nano-Micro Letters2023，15，8： | 0 |
| 11 | Organic molecular aggregates:From aggregation structure to emission property显示文摘Organic molecular aggregates have attracted widespread attention over the past decade owing to their unique optoelectronic properties in the aggregate state,which mainly involves the effects of aggregation structure as well as molecular packing mode.Although many examples of H-and J-aggregates defined by molecular exciton model have been found,there are also other types of unconventional aggregates,especially for aggregation-induced emission(AIE)system.In this review,the recent progress of some examples of basic and novel aggregate forms,as well as coassembled forms,presenting distinctive optical features,such as optical waveguide and polarization emission,polymorph-dependent emission and stimuli-responsive luminescence are presented.The systematic insight into the relationship between the aggregation structure and emission property is discussed.Guidelines are therefore anticipated and will direct the future preprogramming molecular design so as to fine-tune the emission feature through a specific aggregation model for developing organic molecular aggregates with desirable optoelectronic properties. | Suqian Ma Sijia Du Guocui Pan Shuting Dai Bin Xu Wenjing Tian | 2021 | Aggregate2021，2，4： | 0 |
| 12 | LncRNA ZFAS1 regulates cardiomyocyte differentiation of human embryonic stem cells显示文摘Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during differentiation.Long non-coding RNAs(lncRNAs)exert critical epigenetic regulatory functions in multiple differentiation processes.However,the involvement of lncRNAs in the differentiation of hESCs into cardiomyocytes has not yet been fully elucidated.Here,we identified the key roles of ZFAS1(lncRNA zinc finger antisense 1)in the differentiation of cardiomyocytes from hESCs.Methods:A model of cardiomyocyte differentiation from stem cells was established using the monolayer differentiation method,and the number of beating hESCs-derived cardiomyocytes was calculated.Gene expression was analyzed by quantitative real-time PCR(qRTPCR).Immunofluorescence assays were performed to assess the expression of cardiac troponin T(cTnT)andα-actinin protein in cardiomyocytes.Results:qRT-PCR showed that ZFAS1 expression in the mesoderm was significantly higher than that in embryonic stem cells,cardiac progenitor cells,and cardiomyocytes.Knockdown of ZFAS1 inhibited cardiomyocyte differentiation from hESCs,which was characterized by reduced expression of the cardiac-specific markers cTnT,α-actinin,myosin heavy chain 6(MYH6),and myosin heavy chain 7(MYH7).In contrast,ZFAS1 overexpression remarkably increased the percentage of spontaneously beating cardiomyocytes.In terms of the mechanism,we found that ZFAS1 is an antisense lncRNA at the 5′end of the protein-coding gene ZNFX1.Knockdown of ZFAS1 could increase the mRNA expression level of ZNFX1.Furthermore,qRT-PCR demonstrated that the silencing of ZNFX1 led to an increase in cardiac-specific markers that predicted the promotion of cardiomyocyte differentiation.Conclusion:Altogether,these data suggest that lncRNA-ZFAS1 is required for cardiac differentiation by functionally inhibiting the expression of ZNFX1,which may provide a reference for the treatment of heart disease to a certain extent. | YANG CAO YINING LIU YANG YU XIAOFEI GUO XIUXIU WANG WENYA MA HANJING LI ZHONGYU REN XINLU GAO SIJIA LI HAOYU JI HONGYANG CHEN HONG YAN YANAN TIAN XIN WANG BENZHI CAI | 2023 | BIOCELL2023，47，6： | 0 |
| 13 | 神经细胞内新型谷氨酸生物合成通路参与日光照射改善学习记忆显示文摘文章简介日光照射可以影响情绪、学习以及认知等神经系统相关行为。然而,其分子和细胞水平的机制仍然不清楚。本研究揭示了适度的紫外线照射可提高血液中的尿刊酸水平,随后尿刊酸会透过血脑屏障进入大脑。接下来,研究人员用自主研发的单细胞质谱技术并与同位素示踪技术相结合. | 朱洪影 王宁 Lei Yao Qi Chen Ran Zhang Junchao Qian Yiwen Hou Weiwei Guo Sijia Fan Siling Liu Qiaoyun Zhao Feng Du Xin Zuo Yujun Guo Yan Xu Jiali Li Tian Xue Kai Zhong Xiaoyuan Song 黄光明 熊伟 | 2019 | 科学新闻2019，0，2： | 0 |
| 14 | A gel polymer electrolyte with IL@UiO-66-NH_(2) as fillers for high-performance all-solid-state lithium metal batteries显示文摘All solid-state electrolytes have the advantages of good mechanical and thermal properties for safer energy storage,but their energy density has been limited by low ionic conductivity and large interfacial resistance caused by the poor Li~+transport kinetics due to the solid-solid contacts between the electrodes and the solid-state electrolytes.Herein,a novel gel polymer electrolyte(UPP-5)composed of ionic liquid incorporated metal-organic frameworks nanoparticles(IL@MOFs)is designed,it exhibits satisfying electrochemical performances,consisting of an excellent electrochemical stability window(5.5 V)and an improved Li^(+)transference number of 0.52.Moreover,the Li/UPP-5/LiFePO_(4) full cells present an ultra-stable cycling performance at 0.2C for over 100 cycles almost without any decay in capacities.This study might provide new insight to create an effective Li^(+)conductive network for the development of all-solid-state lithium-ion batteries. | Tao Wei Qi Zhang Sijia Wang Mengting Wang Ye Liu Cheng Sun Yanyan Zhou Qing Huang Xiangyun Qiu Fang Tian | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，10： | 0 |
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