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| 1 | Effects of Carboxymethyl-Chitosan on Wound Healing in vivo and in vitro显示文摘Effects of carboxymethyl-chitosan with different molecular weights on wound healing were investigated in vivo and in vitro.A second degree burn model was performed in rats and the accelerative effects of carboxymethyl-chitosan on wound repair were observed.Contents of transforming growth factor(TGF)-β1,interleukin(IL)-6 and matrix metalloproteinase(MMP)-1 in wounds were determined by enzyme-linked immunosorbent assay(ELISA).In vitro study evaluated the influence of carboxy-methyl-chitosan on cytokines secretion of fibroblasts and macrophages.In vivo results showed that carboxymethyl-chitosan effec-tively accelerated the wound healing process in burned rats(P<0.05).Levels of TGF-β1,IL-6 and MMP-1 in carboxymethyl-chitosan groups were significantly elevated,compared with control group(P<0.05).In vitro results indicated that carboxymethyl-chitosan significantly promoted the proliferation of fibroblasts and stimulated its IL-8 and IL-10 secretion at different incubation time,but it did not affect collagen secretion of fibroblasts.Carboxymethyl-chitosan enhanced phagocytosis ability of macrophages,and in-creased its tumor necrosis factor(TNF)-α secretion.In conclusion,carboxymethyl-chitosan promoted wound healing by activating macrophages,accelerating fibroblasts growth and exerting considerable effects on the secretion of a series of cytokines. | PENG Sikai LIU Wanshun HAN Baoqin CHANG Jing LI Minyu ZHI Xuan | 2011 | Journal of Ocean University of China2011，10，4： | 7 |
| 2 | Flexible high energy density zinc-ion batteries enabled by binder-free MnO_(2)/reduced graphene oxide electrode显示文摘We demonstrate a rechargeable zinc-ion battery with high energy density and cyclability using MnO_(2)and reduced graphene oxide(MnO_(2)/rGO)electrode.The flexible and binder free electrode,with high MnO_(2)mass ratio(80 wt%of MnO_(2)),is fabricated using vacuum filtration without any additional additives other than rGO.Compared to batteries with conventional MnO_(2)electrodes,the Zn-MnO_(2)/rGO battery shows a significant enhanced capacity(332.2 mAh g^(-1)at 0.3 A g^(-1)),improved rate capability(172.3 mAh g^(-1)at 6 A g^(-1))and cyclability.The capacity retention remains 96%after 500 charge/discharge cycles at 6 A g^(-1).The high MnO_(2)mass ratio makes MnO_(2)/rGO electrode advantageous when the capacity is normalized to the whole electrode,particularly at high rates.The calculated gravimetric energy density of Zn-MnO_(2)/rGO battery is 33.17Wh kg^(-1),which is comparable to the existing commercial lead-acid batteries(30-40Wh kg^(-1)).Furthermore,the discharge profile and capacity of our Zn-MnO_(2)/rGO battery shows no deterioration during bending test,indicating good flexibility.As a result,zinc-ion battery is believed to be a promising technology for powering next generation flexible electronics. | Yuan Huang Jiuwei Liu Qiyao Huang Zijian Zheng Pritesh Hiralal Fulin Zheng Dilek Ozgit Sikai Su Shuming Chen Ping-Heng Tan Shengdong Zhang Hang Zhou | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 3 | A novel compression framework using energy-sensitive QRS complex detection method for a mobile ECG显示文摘Dear editor,Novel wearable applications provide improved data compression for reduced power consumption [1, 2];however, real-time monitoring of a single source electrocardiogram (ECG) signal leads to extended data usage of 2.77 GB per day. The Q wave, R wave. | Sikai WANG Bo PANG Ming LIU Xu ZHANG Fang YUAN Wentao SHEN Hongda CHEN | 2019 | Science China(Information Sciences)2019，62，6： | 3 |
| 4 | Estimating the macrobenthic species richness with an optimized sampling design in the intertidal zone of Changjiang Estuary显示文摘It is a challenge in the field sampling to face conflict between the statistical requirements and the logistical constraints when explicitly estimating the macrobenthos species richness in the heterogeneous intertidal wetlands. To solve this problem, this study tried to design an optimal, efficient and practical sampling strategy by comprehensively focusing on the three main parts of the entire process(to optimize the sampling method, to determine the minimum sampling effort and to explore the proper sampling interval) in a typical intertidal wetland of the Changjiang(Yangtze) Estuary, China. Transect sampling was selected and optimized by stratification based on pronounced habitat types(tidal flat, tidal creek, salt marsh vegetation). This type of sampling is also termed within-transect stratification sampling. The optimal sampling intervals and the minimum sample effort were determined by two beneficial numerical methods: Monte Carlo simulations and accumulative species curves. The results show that the within-transect stratification sampling with typical habitat types was effective for encompassing 81% of the species, suggesting that this type of sampling design can largely reduce the sampling effort and labor. The optimal sampling intervals and minimum sampling efforts for three habitats were determined: sampling effort must exceed 1.8 m^2 by 10 m intervals in the salt marsh vegetation, 2 m^2 by 10 m intervals in the tidal flat, and 3 m^2 by 1 m intervals in the tidal creek habitat. It was suggested that the differences were influenced by the mobility range of the dominant species and the habitats' physical differences(e.g., tidal water, substrate, vegetation cover). The optimized sampling strategy could provide good precision in the richness estimation of macrobenthos and balance the sampling effort. Moreover, the conclusions presented here provide a reference for recommendations to consider before macrobenthic surveys take place in estuarine wetlands. The sampling strategy, focusing on the three key parts of the sampling design, had a good operational effect and could be used as a guide for field sampling for habitat management or ecosystem assessment. | Tingting Zhang Feng Zhao Sikai Wang Tao Zhang Jianyi Liu Yu Gao Ping Zhuang | 2019 | Acta Oceanologica Sinica2019，38，2： | 3 |
| 5 | Parametric Gait Online Generation of a Lower-limb Exoskeleton for Individuals with Paraplegia显示文摘 | Tianjiao Zheng Yanhe Zhu ZongweiZhang Sikai Zhao Jie Chen Jie Zhao | 2018 | Journal of Bionic Engineering2018，15，6： | 3 |
| 6 | Curing Kinetics of DGEBA Epoxy Resin Modified by Poly (phthalazinone ether ketone) (PPEK)显示文摘 | Yajuan Xu Sikai Zhou Gongxiong Liao Xigao Jian | 2012 | Polymer-Plastics Technology and Engineering2012，，2： | 1 |
| 7 | Investigation of the skin repair and healing mechanism of N ‐carboxymethyl chitosan in second‐degree burn wounds显示文摘 | Jing Chang Wanshun Liu Baoqin Han Sikai Peng Bin He Zhongwei Gu | 2012 | Wound Repair Regen2012，，1： | 1 |
| 8 | Mps1 dimerization and multisite interactions with Ndc80 complex enable responsive spindle assembly checkpoint signaling显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules,which is monitored by the spindle assembly checkpoint(SAC)signaling.As an upstream factor of SAC,the precise and dynamic kinetochore localization of Mps1 kinase is critical for initiating and silencing SAC signaling.However,the underlying molecular mechanism remains elusive.Here,we demonstrated that the multisite interactions between Mps1 and Ndc80 complex(Ndc80C)govern Mps1 kinetochore targeting.Importantly,we identified direct interaction between Mps1 tetratricopeptide repeat domain and Ndc80C.We further identified that Mps1 C-terminal fragment,which contains the protein kinase domain and C-tail,enhances Mps1 kinetochore localization.Mechanistically,Mps1 C-terminal fragment mediates its dimerization.Perturbation of C-tail attenuates the kinetochore targeting and activity of Mps1,leading to aberrant mitosis due to compromised SAC function.Taken together,our study highlights the importance of Mps1 dimerization and multisite interactions with Ndc80C in enabling responsive SAC signaling. | Ping Gui Divine M.Sedzro Xiao Yuan Sikai Liu Mohan Hei Wei Tian Najdat Zohbi Fangwei Wang Yihan Yao Felix O.Aikhionbare Xinjiao Gao Dongmei Wang Xuebiao Yao Zhen Dou | 2020 | Journal of Molecular Cell Biology2020，12，7： | 1 |
| 9 | Investigation of the skin repair and healing mechanism of N ‐carboxymethyl chitosan in second‐degree burn wounds显示文摘 | Jing Chang Wanshun Liu Baoqin Han Sikai Peng Bin He Zhongwei Gu | 2012 | Wound Repair Regen2012，，1： | 1 |
| 10 | Identifying Key Descriptors for the Single-Atom Catalyzed CO Oxidation显示文摘Fundamental knowledge of structure-activity correlations for heterogeneous single-atom catalysts(SACs)is essential in guiding catalytic design.While linear scaling relations are powerful for predicting the performance of traditionalmetal catalysts,they appear to fail with the involvement of SACs.Comparing the catalytic CO oxidation activity of different atomically dispersed metals(3d,4d,and 5d)in conjunction with computational modeling enabled us to establish multiple scaling relations between the activity and simply calculated descriptors. | Max J.Hülsey Sambath Baskaran Shipeng Ding Sikai Wang Hiroyuki Asakura Shinya Furukawa Shibo Xi Qi Yu Cong-Qiao Xu Jun Li Ning Yan | 2022 | CCS Chemistry2022，4，10： | 1 |
| 11 | Novel polyhydroxy cationic collector N-(2,3-propanediol)-Ndodecylamine: Synthesis and flotation performance to hematite and quartz显示文摘To enhance the performance of traditional cationic collector,a novel polyhydroxy amine collector N-(2,3-Propanediol)-N-dodecylamine(PDDA)was designed by introducing one propylene glycol group into dodecylamine(DDA).It was prepared by a nucleophilic substitution reaction,which showed better solubility and hydrophobicity than DDA and was firstly employed as the collector for the separation of hematite and quartz.Flotation tests showed that PDDA had an excellent flotation performance and significantly better selectivity than DDA.In addition,the flotation performance and adsorption mechanism of PDDA on hematite and quartz surfaces were studied using Fourier transform infrared spectroscopy(FTIR),zeta potential and X-ray photoelectron spectroscopy(XPS)tests.These results demonstrated that the interaction between PDDA and the minerals’surfaces was mainly electrostatic adsorption and hydrogen bond,while PDDA tended to adsorb on the surfaces of quartz more than that of hematite.Performance optimization of amine collectors by introducing hydroxyl was also verified,which was of great meaning to the design,development,and application of the polyhydroxy cationic collector.In conclusion,PDDA could be used as a potential collector in the flotation separation of quartz and hematite. | Wenbao Liu Xiangyu Peng Wengang Liu Kelin Tong Yanbai Shen Qiang Zhao Sikai Zhao Wenhan Sun | 2023 | International Journal of Mining Science and Technology2023，33，1： | 1 |
| 12 | Evolution of Artificial Base Pairs with Hydrogen Bond Complementarity显示文摘Artificial base pairs,from the perspective of synthetic biology,are designed to contain the features of modularity,orthogonality,and manipulability.And the development of artificial base pairs has beat endowed with responsibility to understand the biological process,improve the recognition capacity and stability of aptamers,and develop the nucleoside drugs,diagnosis,and drag delivery.In this review,we first gave a concise introduction of artificial base pairs based on their interaction modes including alternative hydrogen bonding,hydrophobic interaction,and metal coordination.Then we displayed the detailed information of artificial base pairs with hydrogen bonding interaction,and analyzed how the changes of their structures affect their functions.Subsequently,we highlighted the applications of functional artificial base pairs in aptamer discovery,diagnosis,and drug delivery.Finally,an insight into the remaining challenges and future perspective of the artificial bases was provided. | TIAN Jimniao CHEN Sikai WANG Xiang LI Juan | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 13 | Changes of China’s Status in the Global System and Its Influencing Factors:A Multiple Contact Networks Perspective显示文摘Clarifying China’s position in the global system is an important logical basis for developing national diplomacy.Although much research has been done on China’s development status,most studies have been based on country comparisons or institutional en-vironment.In today’s networked era in which the global economy,trade,personnel,and information are closely connected,studies on China’s global position and its status changes and influencing factors in multiple contact networks are still insufficient.In this study,from the perspective of diverse global contact networks,we constructed economic,cultural,and political influence indices to explore the changes and influencing factors on China’s status in the global system from 2005 to 2018.The results show that during the study period,China’s global influence in the fields of economic ties,cultural exchanges,and political contacts increased significantly,but its influ-ence in the fields of cultural exchanges and political contacts lagged far economic ties.The pattern of China’s economic influence on various economies around the world has shown a transformation from an‘upright pyramid’to an‘inverted pyramid’structure.The proportion of these economies in low-influence zones has decreased from more than 60%in 2005 to less than 20%in 2018.China’s cultural and political influence on various economies around the world has increased significantly;however,for the former,the percentage of high-influence areas is still less than 20%,whereas for the latter the percentage of these economies in medium-and high-influence areas is still less than 50%.Analyses such as a scatter plot matrix show that geographical proximity,economic globalization,close cooperation with developing countries,and a proactive and peaceful foreign policy are important factors in improving China’s status in the diverse global network system. | LIU Jian LIU Jibin YANG Qingshan CAI Sikai LIU Jie | 2024 | Chinese Geographical Science2024，34，2： | 0 |
| 14 | The study of endometriosis and adenomyosis related microbiota in female lower genital tract in Northern Chinese population显示文摘Background:Endometriosis is a chronic disease that affects women in reproductive age,and adenomyosis was known as“endometriosis in the uterus”.Endometriosis is an immune-dysfunction-related disease,contributing to the diversity of microbiota in the lower genital tract.Endometriosis is also an infection-related disease,the number of bacteria may contribute to some unknown mechanisms.Presently,the feature of microbiota between endometriosis patients and normal people is not fully understood.Methods:To identify the microbiota differences and features of endometriosis patients,298 samples from the cervical canal,posterior fornix of the vagina and uterine cavity were analyzed by 16s-rRNA sequencing.Raw data were filtered,analyzed,and visualized.We conducted diversity analysis,statistical data of microbiota abundance,biomarker identification,random forest,and environmental factors analysis.Results:Alpha diversity was not distinctive in endometriosis and adenomyosis patients.Posterior fornix near cervix was a better sampling location to analyze the dysmenorrhea-related microbiota feature;few dysmenorrhea-related bacteria were identified.Endometrial bacteria is controversial,and the result of 16s-rRNA sequencing was not good enough to conduct further analysis.Anaerococcus was a possible biomarker of adenomyosis-endometriosis patients.The identified bacteria were representative only in specific periods during the menstrual cycle.GnRH-a treatment impacted microbiota feature the most compared with other environmental factors.Conclusion:This study provided us with a new concept of endometriosis and bacteria;different microbiota features may relate to endometriosis.The bacterial involvement should be considered in the future study of endometriosis.New non-invasive diagnosis and therapeutic methods through bacterial medication are prospective. | Sikai Chen Zhiyue Gu Wen Zhang Shuangzheng Jia Ping Zheng Yi Dai Jinhua Leng | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，3： | 0 |
| 15 | Development and testing of an image transformer for explainable autonomous driving systems显示文摘Purpose–Perception has been identified as the main cause underlying most autonomous vehicle related accidents.As the key technology in perception,deep learning(DL)based computer vision models are generally considered to be black boxes due to poor interpretability.These have exacerbated user distrust and further forestalled their widespread deployment in practical usage.This paper aims to develop explainable DL models for autonomous driving by jointly predicting potential driving actions with corresponding explanations.The explainable DL models can not only boost user trust in autonomy but also serve as a diagnostic approach to identify any model deficiencies or limitations during the system development phase.Design/methodology/approach–This paper proposes an explainable end-to-end autonomous driving system based on“Transformer,”a state-ofthe-art self-attention(SA)based model.The model maps visual features from images collected by onboard cameras to guide potential driving actions with corresponding explanations,and aims to achieve soft attention over the image’s global features.Findings–The results demonstrate the efficacy of the proposed model as it exhibits superior performance(in terms of correct prediction of actions and explanations)compared to the benchmark model by a significant margin with much lower computational cost on a public data set(BDD-OIA).From the ablation studies,the proposed SA module also outperforms other attention mechanisms in feature fusion and can generate meaningful representations for downstream prediction.Originality/value–In the contexts of situational awareness and driver assistance,the proposed model can perform as a driving alarm system for both human-driven vehicles and autonomous vehicles because it is capable of quickly understanding/characterizing the environment and identifying any infeasible driving actions.In addition,the extra explanation head of the proposed model provides an extra channel for sanity checks to guarantee that the model learns the ideal causal relationships.This provision is critical in the development of autonomous systems. | Jiqian Dong Sikai Chen Mohammad Miralinaghi Tiantian Chen Samuel Labi | 2022 | Journal of Intelligent and Connected Vehicles2022，5，3： | 0 |
| 16 | Enhanced detection of ppb-level NO_(2)by uniform Pt-doped ZnSnO_(3)nanocubes显示文摘ZnSnO_(3) nanocubes(ZSNCs)with various Pt concentrations(i.e.,1 at%,2 at%,and 5 at%)were synthesized by a simple one-pot hydrothermal method.The microstructures of pure and Pt-doped ZSNCs were characterized by X-ray diffractometry,scanning electron microscopy,transmission electron microscopy,energy-dispersive X-ray spectroscopy,and X-ray photoelectron spectroscopy.Results showed that the pure ZSNCs have a perovskite structure with a side length of approximately 600 nm;this length was reduced to 400 nm after Pt doping.Following doping,PtO_(x)(PtO and PtO_(2)) nanoparticles with a diameter of approximately 5 nm were uniformly coated on the surface of the ZSNCs.Systematic investigation of the gas-sensing abilities of the nanocubes showed that the Pt-doped ZSNCs have excellent sensing properties toward nitrogen dioxide(NO_(2)) gas in the operating temperature range of 75-175℃.Among the sensors prepared,that based on 1 at%Pt-doped ZSNCs exhibited the best response of 16.0 toward 500 ppb NO_(2) at 125℃;this response is over 11 times higher compared with that of pure ZSNCs.The enhanced NO_(2) sensing mechanism of the Pt-doped ZSNCs may be attributed to the synergistic effects of catalytic activity and chemical sensitization by Pt doping. | Yaoyu Yin Yanbai Shen Sikai Zhao Ang Li Rui Lu Cong Han Baoyu Cui Dezhou Wei | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，6： | 0 |
| 17 | Visualization Investigation on Temperature Oscillation and Two-Phase Behaviors of A Flat Loop Heat Pipe显示文摘To better analyzing the temperature oscillation and the two-phase behavior inside a flat loop heat pipe,visual studies were conducted.Under the 20℃ water cooling and horizontal orientation,the effects of the filling ratio and heat loads on the temperature oscillation were analyzed.Based on the experimental data,the results indicate that owing to the increased system pressure,the temperature oscillation decays as the filling ratio increases from 34%to 58%.Meanwhile,during the startup process,temperature oscillation tends to occur during the boiling and steady stages due to the more violent two-phase behavior,while the temperature curves are smooth during the slow evaporation stage.Moreover,as the heat load increases,the evaporation becomes more intense at the active zone of evaporator,leading to a faster startup process and a higher oscillation frequency.Besides,owing to the synergistic effect of two-phase flow in the compensation chamber caused by heat leak and subcooled liquid backflowing,a“breathing”oscillation behavior of the vapor-liquid interface is observed at the compensation chamber,which further leads to the unstable operation behavior of the loop heat pipe system. | DU Sheng ZHANG Quan LING Li ZOU Sikai LIU Lijun MENG Fanxi | 2023 | Journal of Thermal Science2023，32，4： | 0 |
| 18 | Legume-specific SnRK1 promotes malate supply to bacteroids for symbiotic nitrogen fixation显示文摘Nodulation is an energy-expensive behavior driven by legumes by providing carbon sources to bacteroids and obtaining nitrogen sources in return.The energy sensor sucrose nonfermenting 1-related protein kinase 1(SnRK1)is the hub of energy regulation in eukaryotes.However,the molecular mechanism by which SnRK1 coordinates the allocation of energy and substances during symbiotic nitrogen fixation(SNF)remains unknown.In this study,we identified the novel legume-specific SnRK1α4,a member of the SnRK1 family that positively regulates SNF.Phenotypic analysis showed that nodule size and nitrogenase activity increased in SnRK1α4-overexpressing plants and decreased significantly in snrk1α4 mutants.We demonstrated that a key upstream kinase involved in nodulation,Does Not Make Infection 2(DMI2),can phosphorylate SnRK1α4 at Thr175 to cause its activation.Further evidence clarified that SnRK1α4 phosphorylates the malate dehydrogenases MDH1/2 to promote malate production in the cytoplasm,supplying carbon sources to bacteroids.Therefore,our findings reveal an essential role of the DMI2–SnRK1α4–MDH pathway in supplying carbon sources to bacteroids for SNF and provide a new module for constructing cereal crops with SNF. | Da Guo Peng Liu Qianwen Liu Lihua Zheng Sikai Liu Chen Shen Li Liu Shasha Fan Nan Li Jiangli Dong Tao Wang | 2023 | Molecular Plant2023，16，9： | 0 |
| 19 | The influence of H_(2)O and O_(2) on the optoelectronic properties of inverted quantum-dot light-emitting diodes显示文摘The influence of H_(2)O and O_(2) on the performances of Mg-doped zinc oxide (ZnMgO) and ZnMgO-based inverted quantum-dot light-emitting diodes (QLEDs) are studied. With the involvement of H_(2)O from ambience, ZnMgO exhibits a high conductivity, whereas the resultant QLEDs show a low efficiency. The efficiency of QLEDs can be enhanced by annealing ZnMgO in H_(2)O-free glovebox;however, the uniformity and the current of the devices are degraded due to the presence of O_(2), which adsorbs on the surface of ZnMgO and captures the free electrons of ZnMgO. By exposing the devices with ultraviolet (UV) irradiation, the adsorbed O_(2) can be released, consequently leading to the increase of driving current. Our work discloses the influence of the annealing ambience on the conductivity of ZnMgO, and reveals the interaction of H_(2)O/O_(2) and UV with the ZnMgO and its effect on the performance of the resultant inverted QLEDs, which could help the community to better understand the mechanisms of ZnMgO-based QLEDs. | Zinan Chen Zhiyuan Qin Sikai Su Shuming Chen | 2021 | Nano Research2021，14，11： | 0 |
| 20 | De novo transcriptome assembly and metabolomic analysis of three tissue types in Cinnamomum cassia显示文摘Objective:The barks,leaves,and branches of Cinnamomum cassia have been historically used as a traditional Chinese medicine,spice,and food preservative,in which phenylpropanoids are responsible compounds.However phenylpropanoid biosynthesis pathways are not clear in C.cassia.We elucidated the pathways by descriptive analyses of differentially expressed genes related to phenylpropanoid biosynthesis as well as to identify various phenylpropanoid metabolites.Methods:Chemical analysis,metabolome sequencing,and transcriptome sequencing were performed to investigate the molecular mechanisms underlying the difference of active components content in the barks,branches and leaves of C.cassia.Results:Metabolomic analysis revealed that small amounts of flavonoids,coumarine,and cinnamaldehyde accumulated in both leaves and branches.Transcriptome analysis showed that genes associated with phenylpropanoid and flavonoid biosynthesis were downregulated in the leaves and branches relative to the barks.The observed differences in essential oil content among the three tissues may be attributable to the differential expression of genes involved in the phenylpropanoid and flavonoid metabolic pathways.Conclusion:This study identified the key genes in the phenylpropanoid pathway controling the flavonoid,coumarine,and cinnamaldehyde contents in the barks,branches and leaves by comparing the transcriptome and metabolome.These findings may be valuable in assessing phenylpropanoid and flavonoid metabolites and identifying specific candidate genes that are related to the synthesis of phenylpropanoids and flavonoids in C.cassia. | Hongyang Gao Huiju Zhang Yuqing Hu Danyun Xu Sikai Zheng Shuting Su Quan Yang | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
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