|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | A Brief Overview of ChatGPT:The History,Status Quo and Potential Future Development显示文摘ChatG PT,an artificial intelligence generated content (AIGC) model developed by OpenAI,has attracted worldwide attention for its capability of dealing with challenging language understanding and generation tasks in the form of conversations.This paper briefly provides an overview on the history,status quo and potential future development of ChatGPT,helping to provide an entry point to think about ChatGPT.Specifically,from the limited open-accessed resources,we conclude the core techniques of ChatGPT,mainly including large-scale language models,in-context learning,reinforcement learning from human feedback and the key technical steps for developing ChatGPT.We further analyze the pros and cons of ChatGPT and we rethink the duality of ChatGPT in various fields.Although it has been widely acknowledged that ChatGPT brings plenty of opportunities for various fields,mankind should still treat and use ChatG PT properly to avoid the potential threat,e.g.,academic integrity and safety challenge.Finally,we discuss several open problems as the potential development of ChatGPT. | Tianyu Wu Shizhu He Jingping Liu Siqi Sun Kang Liu Qing-Long Han Yang Tang | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，5： | 18 |
| 3 | MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 在最好攻击的恶意之中并且在中国有高发生。MicroRNAs (miRNAs ) 是调整多重 tumorigenic 过程的小内长的 RNA,包括增长,侵略,转移和预后。用 miRNA 表示 proling 分析,我们发现 miR-630 在配对的正常食道的纸巾与那相比在三件 ESCC 织物样品是显著地下面调整的。微分 miR-630 表示随后用量的即时 PCR 被证实。决定 miR-630 下面规定是否能被看作诊断指示物和不利预示的因素,我们与 ESCC 在病人调查了在 miR-630 和 clinicopathological 特征之间的协会。减少的 miR-630 表示总的来说与穷人被联系,这被发现在这些病人的幸存。另外,我们也由指向蛞蝓探索了 miR-630 的生物功能并且调查了在 miR-630 表示和上皮间充质的转变(EMT ) 之间的关联在 vivo 并且在 vitro 的前进。,宫外的 miR-630 表示能禁止增长,侵略和转移 miR-630 击倒的导致的增长,侵略,转移和 EMT 特点。总的来说,我们的学习在 ESCC 作为一个批评新奇调节的人为 miR-630 支持一个角色。 | Li Jin Jun Yi Yanping Gao Siqi Han Zhenyue He Longbang Chen Haizhu Song | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 11 |
| 4 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 5 | Four new observational H(z) data from luminous red galaxies in the Sloan Digital Sky Survey data release seven显示文摘By adopting the differential age method,we select 17 832 luminous red galaxies from the Sloan Digital Sky Survey Data Release Seven covering redshift0 < z < 0.4 to measure the Hubble parameter.Using the full spectrum fitting package UlySS,these spectra are reduced with single stellar population models and optimal age information from our selected sample is derived.With the decreasing age-redshift relation,four new observational H{z) data(OHD) points are obtained,which are H{z) = 69.0± 19.6km s^(-1) Mpc^(-1) at z = 0.07,H(z) = 68.6 ±26.2 km s^(-1) Mpc^(-1)at z = 0.12,H(z)=72.9 ± 29.6 km s^(-1) Mpc^(-1) at z = 0.2 and H{z)=88.8 ± 36.6 km s^(-1) Mpc^(-1) at z = 0.28,respectively.Combined with 21 other available OHD data points,the performance of the constraint on both flat and non-flat ACDM models is presented. | Cong Zhang Han Zhang Shuo Yuan Siqi Liu Tong-Jie Zhang Yan-Chun Sun | 2014 | Research in Astronomy and Astrophysics2014，14，10： | 6 |
| 6 | Upwelling of Mantle-derived Material in Southeast China:Evidence from Noble Gas Isotopes显示文摘Shallow groundwater collected in Chaozhou,Huizhou,and Guangzhou allowed testing of concentrations and the isotope ratios of noble gases.Based on the calculated noble gas temperature(NGT)and the ratio of noble gas isotopes,the recharge temperature,recharge source,and residence time of groundwater can be calculated.In addition,the contribution of noble gas components from different sources to the sample components can be assessed.In the Huizhou area,according to the 1/Xe vs.Ne/Xe and NGT data,the shallow sandstone-confined water samples in the Shiba area and the unconfined water samples of the Huangshadong are in different temperature ranges,indicating that they have different recharge sources,both in time or space.The He components in the samples are calculated to obtain the content of radiogenic ^(4)He in the crust and to simulate the groundwater ages.The noble gas isotope ratios show the addition of mantle components into the basalt aquifers and sandstone aquifers in Chaozhou and Huizhou.Except for atmospheric and crustal sources,there is a certain proportion of mantle-derived components in the shallow underground cold water in Huizhou and Chaozhou.The noble gases in the Chaozhou groundwater have an obvious mantle signature,allowing speculation that there is a deep fluid carrying mantle characteristics.This upwelling of mantle-derived material might be caused by the India-Eurasia collision or that between the Philippine Sea Plate and the Eurasian Plate. | WANG Shuai KUANG Jian HUANG Xuelian ZHANG Hongyan ZHANG Min QI Shihua HAN Yongjie XIAO Zhicai WANG Siqi TANG Ling | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 2 |
| 7 | Electrostatic self-assembly of CdS nanowires-nitrogen doped graphene nanocomposites for enhanced visible light photocatalysis显示文摘CdS nanowires-nitrogen doped graphene(CdS NWs-NGR) nanocomposites have been fabricated by an electrostatic self-assembly strategy followed by a hydrothermal reduction. The CdS NWs-NGR exhibits higher photoactivity for selective reduction of aromatic nitro organics in water under visible light irradiation than blank CdS nanowires(CdS NWs) and CdS nanowires-reduced graphene oxide(CdS NWs-RGO)nanocomposites. The enhanced photoactivity of CdS NWs-NGR can be attributed to the improved electronic conductivity due to the introduction of nitrogen atoms, which thus enhances the separation and transfer of charge carriers photogenerated from CdS NWs.Our work could provide a facile method to synthesize NGR based one-dimensional(1D) semiconductor composites for selective organic transformations, and broaden the potential applications for NGR as a cocatalyst. | Bin Han Siqi Liu Zi-Rong Tang Yi-Jun Xu | 2015 | Journal of Energy Chemistry2015，24，2： | 1 |
| 8 | Research on the impact of high-temperature aging on the thermal safety of lithium-ion batteries显示文摘Understanding the thermal safety evolution of lithium-ion batteries during high-temperature usage conditions bears significant implications for enhancing the safety management of aging batteries.This work investigates the thermal safety evolution mechanism of lithium-ion batteries during high-temperature aging.Similarities arise in the thermal safety evolution and degradation mechanisms for lithium-ion batteries undergoing cyclic aging and calendar aging.Employing multi-angle characterization analysis,the intricate mechanism governing the thermal safety evolution of lithium-ion batteries during high-temperature aging is clarified.Specifically,lithium plating serves as the pivotal factor contributing to the reduction in the self-heating initial temperature.Additionally,the crystal structure of the cathode induced by the dissolution of transition metals and the reductive gas generated during aging attacking the crystal structure of the cathode lead to a decrease in thermal runaway triggering temperature.Furthermore,the loss of active materials and active lithium during aging contributes to a decline in both the maximum temperature and the maximum temperature rise rate,ultimately indicating a decrease in the thermal hazards of aging batteries. | Guangxu Zhang Xuezhe Wei Siqi Chen Gang Wei Jiangong Zhu Xueyuan Wang Guangshuai Han Haifeng Dai | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 9 | Ferroelectricity in hBN intercalated double-layer graphene显示文摘Van der Waals(vdW)assembly of two-dimensional materials has long been recognized as a powerful tool for creating unique systems with properties that cannot be found in natural compounds[Nature 499,419(2013)].However,among the variety of vdW heterostructures and their various properties,only a few have revealed metallic and ferroelectric behaviour signatures[Sci.Adv.5,eaax5080(2019);Nature 560,336(2018)].Here we show ferroelectric semimetal made of double-gated double-layer graphene separated by an atomically thin crystal of hexagonal boron nitride.The structure demonstrates high room temperature mobility of the order of 10 m2·V^(−1)·s^(−1) and exhibits ambipolar switching in response to the external electric field.The observed hysteresis is reversible and persists above room temperature.Our fabrication method expands the family of ferroelectric vdW compounds and offers a promising route for developing novel phase-changing devices.A possible microscopic model of ferroelectricity is discussed. | Yibo Wang Siqi Jiang Jingkuan Xiao Xiaofan Cai Di Zhang Ping Wang Guodong Ma Yaqing Han Jiabei Huang Kenji Watanabe Takashi Taniguchi Yanfeng Guo Lei Wang Alexander S.Mayorov Geliang Yu | 2022 | Frontiers of physics2022，17，4： | 0 |
| 10 | One-step calcination synthesis of interface-coherent crystallized and surface-passivated LiNi_(0.5)Mn_(1.5)O_(4) for high-voltage lithium-ion battery显示文摘LiNi_(0.5)Mn1.5O_(4)(LNMO)with a spinel crystal structure presents a compelling avenue towards the development of economic cobalt-free and high voltage(~5 V)lithium-ion batteries.Nevertheless,the elevated operational voltage of LNMO gives rise to pronounced interfacial interactions between the distorted surface lattices characterized by Jahn-Teller(J-T)distortions and the electrolyte constituents.Herein,a localized crystallized coherent LaNiO_(3) and surface passivated Li_(3)PO_(4) layer is deposited on LNMO via a one-step calcination process.As evidenced by transmission electron microscopy(TEM),time-of-flight secondary ion mass spectrometry(ToF-SIMS)and density functional theory(DFT)calculation,the epitaxial growth of LaNiO_(3) along the LNMO lattice can effectively stabilize the structure and inhibit irreversible phase transitions,and the Li_(3)PO_(4) surface coating can prevent the chemical reaction between HF and transition metals without sacrificing the electrochemical activity.In addition,the ionic conductive Li_(3)PO_(4) and atomic wetting inter-layer enables fast charge transfer transport property.Consequently,the LNMO material enabled by the lattice bonding and surface passivating features,demonstrates high performance at high current densities and good capacity retention during long-term test.The rational design of interface coherent engineering and surface coating layers of the LNMO cathode material offers a new perspective for the practical application of high-voltage lithium-ion batteries. | Min Xu Bifu Sheng Yong Cheng Junjie Lu Minfeng Chen Peng Wang Bo Liu Jizhang Chen Xiang Han Ming-Sheng Wang Siqi Shi | 2024 | Nano Research2024，17，5： | 0 |
| 11 | Nano-engineered Strong,Durable and Multifunctional/Smart Concretes显示文摘Micro/meso scale modification can bring big changes in macroscale property.The addition of nanofillers makes materials strong,durable and multifunctional/smart.This paper aims at studying mechanical property,durability,electrical property,electromagnetic property and piezoresistivity of concrete with nano silica(NS),carbon nanotube(CNT),botryoid hybrid carbon material(BHCBM),nano graphite | Siqi Ding Liqing Zhang Shengwei Sun Jian Ouyang Baoguo Han | 2016 | 功能材料信息2016，13，2： | 0 |
| 12 | Construction of Platform-based Business Ecosystem显示文摘As the core and foundation of the business ecosystem,the platform determines its structure and operation mode.The research on platform strategy and business ecosystem is receiving more and more attention from all walks of life.This paper first provided the concept of a platform-based business ecosystem.Then,on the basis of the platform's'control mode'and'position on the industry chain,it designed four types of construction modes of business ecosystem:open participation,open technology,close symbiosis and channel control.In addition,combined with typical cases,it discussed the structure and operating characteristics of each type of business ecosystem.Finally,it analyzed weak points of this study and made some prospects for future study. | Guanghe HAN Siqi LI Jiayu ZHOU | 2020 | Asian Agricultural Research2020，12，6： | 0 |
| 13 | Multiresponsive Luminescent Behaviors of Assembled Spirocyclic Nonanuclear Silver(I)Clusters显示文摘Supramolecular assembly is regarded as an effective strategy to endow metal clusters with rich and unique photophysical properties.However,the detailed mechanisms and influential factors for intercluster assemblies and their effects on luminescent properties remain unclear to date.In this work,we constructed a series of spirocyclic nonanuclear silver cluster compounds with varying alkyl chain lengths,which demonstrated distinct supramolecular assembly behaviors depending on temperature,concentration,and solvent polarity. | Han Wu Siqi Zhang Liang Zhao | 2022 | CCS Chemistry2022，4，10： | 0 |
| 14 | Coherent and semicoherent α/β interfaces in titanium: structure, thermodynamics, migration显示文摘Theα/βinterface is central to the microstructure and mechanical properties of titanium alloys.We investigate the structure,thermodynamics and migration of the coherent and semicoherent Tiα/βinterfaces as a function of temperature and misfit strain via molecular dynamics(MD)simulations,thermodynamic integration and an accurate,DFT-trained Deep Potential.The structure of an equilibrium semicoherent interface consists of an array of steps,an array of misfit dislocations,and coherent terraces.Analysis determines the dislocation and step(disconnection)array structure and habit plane.The MD simulations show the detailed interface morphology dictated by intersecting disconnection arrays.The steps are shown to facilitateα/βinterface migration,while the misfit dislocations lead to interface drag;the drag mechanism is different depending on the direction of interface migration.These results are used to predict the nature ofαphase nucleation on cooling through theα-βphase transition. | Siqi Wang Tongqi Wen Jian Han David J.Srolovitz | 2023 | npj Computational Materials2023，，1： | 0 |
| 15 | Plasmonic evolution of atomically size-selected Au clusters by electron energy loss spectrum显示文摘The plasmonic response of gold clusters with atom number(N)=100–70000 was investigated using scanning transmission electron microscopy-electron energy loss spectroscopy.For decreasing N,the bulk plasmon remains unchanged above N=887 but then disappears,while the surface plasmon firstly redshifts from 2.4 to 2.3 e V above N=887 before blueshifting towards 2.6 e V down to N=300,and finally splitting into three fine features.The surface plasmon’s excitation ratio is found to follow N^(0.669),which is essentially R^(2).An atomically precise evolution picture of plasmon physics is thus demonstrated according to three regimes:classical plasmon(N=887–70000),quantum confinement corrected plasmon(N=300–887)and molecule related plasmon(N<300). | Siqi Lu Lin Xie Kang Lai Runkun Chen Lu Cao Kuojuei Hu Xuefeng Wang Jinsen Han Xiangang Wan Jianguo Wan Qing Dai Fengqi Song Jiaqing He Jiayu Dai Jianing Chen Zhenlin Wang Guanghou Wang | 2021 | National Science Review2021，8，12： | 0 |
| 16 | G×E Analysis of Growth Traits of Betula platyphylla Clones at Three Separated Sites in Northeastern China显示文摘To select elite materials,the growth traits of 32 Betula platyphylla clones at three separated northern sites in Northeast China were investigated and analyzed.The results showed that there were significant differences among all variation sources in the different investigated traits(P<0.01).Except for the carbon contents,all the coeffi-cients of phenotypic variation of the other investigated traits were higher than 10%.The repeatability of different traits ranged from 0.760 to 0.998.Correlation analysis showed that tree height were significantly correlated with diameter at breast height,but neither was significantly correlated with leaf traits nor element contents.Additive main effects and multiplicative interaction analysis showed that genotype,environment and genotype×environment interactions were significantly different in diameter at breast height,which indicated that environment had a significant effect on genotype.Comprehensive assessment results showed that three clones with high and stable diameters at breast height were selected,and the genetic gains of diameter at breast height on sites Maoershan,Qingan,and Yongji were 21.24%,20.58%,and 38.65%,respectively.The results could provide a theoretical basis for elite clone selection in B.platyphylla and other broad leaved species. | Yuxi Li Xinxin Zhang Qinhui Zhang Luping Jiang Rui Han Siqi Sun Xiaoqing Hu Xiaona Pei Chunli Zhao Xiyang Zhao | 2022 | Phyton-International Journal of Experimental Botany2022，91，9： | 0 |
| 17 | Interfacial nitrogen engineering of robust silicon/MXene anode toward high energy solid-state lithium-ion batteries显示文摘Replacing the conventional carbonate electrolyte by solid-state electrolyte (SSE) will offer improved safety for lithium-ion batteries.To further improve the energy density,Silicon (Si) is attractive for next generation solid-state battery (SSB) because of its high specific capacity and low cost.High energy density and safe Si-based SSB,however,is plagued by large volume change that leads to poor mechanical stability and slow lithium ions transportation at the multiple interfaces between Si and SSE.Herein,we designed a self-integrated and monolithic Si/two dimensional layered T_(3)C_(2)T_(x)(MXene,T_(x) stands for terminal functional groups) electrode architecture with interfacial nitrogen engineering.During a heat treatment process,the polyacrylonitrile not only converts into amorphous carbon (a-C) that shells Si but also forms robust interfacial nitrogen chemical bonds that anchors Si and MXene.During repeated lithiation and delithiation processes,the robust interfacial engineered Si/MXene configuration enhances the mechanical adhesion between Si and MXene that improves the structure stability but also contributes to form stable solid-electrolyte interphase (SEI).In addition,the N-MXene provides fast lithium ions transportation pathways.Consequently,the Si/MXene with interfacial nitrogen engineering (denoted as Si-N-MXene) deliveres high-rate performance with a specific capacity of 1498 m Ah g^(-1) at a high current of 6.4 A g^(-1).A Si-N-MXene/NMC full cell exhibited a capacity retention of 80.5%after 200 cycles.The Si-N-MXene electrode is also applied to SSB and shows a relative stable cycling over 100 cycles,demonstrating the versatility of this concept. | Xiang Han Weijun Zhou Minfeng Chen Jizhang Chen Guanwen Wang Bo Liu Linshan Luo Songyan Chen Qiaobao Zhang Siqi Shi Ching-Ping Wong | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
| 18 | Metformin ameliorates HMGB1-mediated oxidative stress through mTOR pathway in experimental periodontitis显示文摘Periodontitis is an oral chronic inflammatory disease.Inhibiting tissue destruction and promoting tissue regeneration are important means for the treatment of periodontitis.Metformin not only has hypoglycemic effect but also has anti-inflammatory effect.Metformin has been shown to inhibit oxidative stress and activate autophagy through AMPK/mTOR pathway.High mobility group box 1(HMGB1)has been implicated in the pathogenesis of many inflammatory diseases including periodontitis,it can participate in the induction of oxidative stress.HMGB1 is an autophagy regulator under oxidative stress,which can activate mTOR pathway.However,it is not clear whether metformin is related to HMGB1 and its mechanism in the process of periodontitis.Cell viability and expression of inflammatory cytokines were clarified by Cell Counting Kit-8,real-time PCR and enzyme-linked immunosorbent assay.Western blot and immunofluorescence were conducted to determine HMGB1 intracellular localization and expression of autophagy-associated proteins in vitro.Experimental periodontitis mice model was induced by administering a ligature.Immunohistochemistry was performed to detect the expression and localization of HMGB1 in vivo.The results of CCK-8,real-time PCR,enzyme-linked immunosorbent assay,Western blot and immunofluorescence showed lipopolysaccharide(LPS)treatment inhibited cell viability,and increased HMGB1 expression at a dose-independent manner.Metformin can reduce the effect of LPS.It also improves autophagy pathway inhibited by LPS and down-regulates mTOR expression.In addition,metformin attenuated alveolar bone resorption induced by ligation.This study provides new evidence for that metformin is a potential drug for the treatment of periodontitis and HMGB1 may be a potential target for periodontal intervention. | Boyang Sun Siqi Ying Qian Ma Han Li Jie Li Jinlin Song | 2023 | Genes & Diseases2023，10，2： | 0 |
| 19 | Color myth:anthocyanins reactions and enological approaches achieving their stabilization in the aging process of red wine显示文摘Color is a crucial sensory indicator of wine quality.However,changes in anthocyanin concentration and profile occur during wine aging,resulting in noticeable reductions in chroma and shifts in hue from purple to brick red.This is because monomeric anthocyanins degrade and derivative anthocyanins form.The rate of color changes can vary depending on complex factors,such as the anthocyanin content of the must,oenological technology,and environmental conditions,which makes the management of red wine color evolution challenging.To address this issue,appropriate winemaking techniques are required to achieve an elegant wine color.This review summarizes the mechanisms related to anthocyanin stability,including glycosylation,acetylation,and derivatization.The review also discusses factors influencing red wine color fading for specific grape varieties and wine appellations,offering time-and cost-efficient techniques to accelerate anthocyanin derivatization and color stabilization. | Siqi Cheng Tianyang Wu Jie Gao Xiaoyu Han Weidong Huang Yilin You Jicheng Zhan | 2023 | Food Innovation and Advances2023，2，4： | 0 |
| 20 | A Modeling Method for Predicting the Strength of Cemented Paste Backfill Based on a Combination of Aggregate Gradation Optimization and LSTM显示文摘Cemented paste backill(CPB)is a susta inable mining technology that is widely used in mines and helps to improve the mine environment.To investigate the relationship between aggregate grading and different affecting factors and the uniaxial compressive strength(UCS)of the cemented paste backill(CPB),Talbol gradation theory and neural networks is used to evaluate aggregate gradation to determine the optimum aggregate ratio.The mixed aggregate ratio with the least amount of cement(waste stone content river sand content=7:3)is obtained by using Talbol grading theory and pile compactness function and combined with experiments.In addition,the response surface method is used to design strength speaific ratio experiments.The UCS prediction model which ues the ISTM and considers the aggregates gradation have high accuracy.The root mean square error(RMSE)of the prediction results is 0.0914,the coefficient of determination(R^(2))is 0.9973 and the variance account for(VAF)is 99.73.Compared with back propagation neural network(BP-ANN),extreme lea ming machine(ELM)and madal basis function neural network(RBF ANN),LSTM can efectively characterize the nonlinear relationship between UCS and individual affecting factors and predict UCS with high accuracy.The sensitivity analysis of different affecting factors on UCS shows that all 4 factors have significant effect on UCS and sensitivity is in the following ranking:cement content(0.9264)>slurry concentration(0.9179)>aggregate gradation(waste rodk content)(0.9031)>curing time(09031). | Bo Zhang Keqing Li Siqi Zhang Yafei Hu Bin Han | 2022 | Journal of Renewable Materials2022，10，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员