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| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | Molecular Characterization of the Calvin Cycle Enzyme Phosphoribulokinase in the Stramenopile Alga Vaucheria litorea and the Plastid Hosting Mollusc Elysia chlorotica显示文摘Phosphoribulokinase (PRK ) ,一个原子编码对光合的碳减小(加尔文) 唯一的质体局部性的酶周期,从 stramenopile 水藻 Vaucheria litorea 被克隆并且描绘。这水藻是为软体动物(海蛞蝓) 的质体的来源使动物能完全由 photoautotrophic CO2 幸存月的 Elysia chlorotica 固定。1633-bp V。litorea prk 基因被克隆并且编码区域,发现被四 introns 打断,编码 405-amino 酸蛋白质。这蛋白质包含被指导到建筑群的原子编码蛋白质期望的典型由两部组成的目标顺序(即四膜界限) 海藻的质体。PRK 和酶活动的 De novo 合成在 E 被检测。尽管有 V 被饿了的 chlorotica。为几个月的 litorea。不同于海藻的酶,在海蛞蝓的 PRK 没展出氧化还原作用规定。部分编码 PRK 基因的二个拷贝用 PCR 从两海蛞蝓和 aposymbiotic 海蛞蝓鸡蛋 DNA 被孤立。每个拷贝包含跨越 exon 的核苷酸区域 1 并且 exon 的部分 2 V。litorea prk,包括由两部组成的指向肽。然而,更大的 prk 碎片也包括 intron 1。在 E 的 prk 的 exon 和 intron 序列。chlorotica 和 V。litorea 是将近相同的。这些数据建议 PRK 是在 V 调整的差别。litorea 和 E。chlorotica 和 V 的至少部分。litorea 原子 PRK 基因在被饿几个月了的海蛞蝓是在场的。 | Mary E. Rumpho Sirisha Pochareddy Jared M. Worful Elizabeth J. Summer Debashish Bhattacharya Karen N. Pelletreau Mary S. Tyler Jungho Lee James R. Manhart Kara M. Soule | 2009 | Molecular Plant2009，2，6： | 3 |
| 3 | Temperature based generalized wavelet-neural network models to estimate evapotranspiration in India显示文摘In this paper,generalized wavelet-neural network(WNN)based models were developed for estimating reference evapotranspiration(ETo)corresponding to Hargreaves(HG)method for different agro-ecological regions(AERs):semi-arid,arid,sub-humid,and humid in India.The input and target to the WNN models are climate data(minimum and maximum air temperature)and ETo(estimated from FAO-56 Penman Monteith method),respectively.The developed WNN models were compared with the various generalized conventional models such as artificial neural networks(ANN),linear regression(LR),wavelet regression(WR),and HG method to test the best performed model.The performance indices used for the comparison include root mean squared error(RMSE),Nash-Sutcliffe efficiency(NSE),the ratio of average output to the average target ETo values(Rratio),and relative percentage(RP).The WNN and ANN models were performed better as compared to LR,WR and HG methods.Further,the best performed WNN and ANN models were tested on locations,which were not included in training to test their generalizing capability.It is concluded that the WNN and ANN models were shown good generalizing capability for the tested locations as compared to HG method. | Sirisha Adamala | 2018 | Information Processing in Agriculture2018，5，1： | 2 |
| 4 | Isolation of cinnamoyl CoA reductase and cinnamyl alcohol dehydrogenase gene promoters from Leucaena leucocephala , a leguminous tree species, and characterization of tissue-specific activity in transgenic tobacco显示文摘 | S. Prashant M. Sri Lakshmi Sunita V. L. Sirisha V. Vijaya Bhaskar A. Maruthi Rao M. Lakshmi Narasu P. B. Kavi Kishor | 2012 | Plant Cell Tissue and Organ Culture (PCTOC)2012，，3： | 1 |
| 5 | Targeted therapy of cancer using diphtheria toxin-derived immunotoxins显示文摘 | Sirisha P Sanjeeb KS Rama SV | 2008 | Drug Disc T2008，13，1718： | 1 |
| 6 | Androgen receptor CAG repeat polymorphism and epigenetic influence among the south Indianwomen with polycystic ovary syndrome显示文摘 | Dasgupta S Sirisha PV Neelaveni K | 2010 | PLoS One2010，5，12： | 1 |
| 7 | Androgen re- ceptor CAG repeat polymorphism and epigenetic influence among the south Indian women with Polycystic Ovary Syn- drome显示文摘 | Dasgupta S Sirisha PV Neelaveni K | 2010 | Plos One2010，5，12： | 1 |
| 8 | Relationship between Severity of Visual Field Loss at Presentation and Rate of Visual Field Progression in Glaucoma显示文摘 | Harsha L. Rao Addepalli U. Kumar Jonnadula G. Babu Sirisha Senthil Chandra S. Garudadri | 2011 | Ophthalmology2011，，2： | 1 |
| 9 | Heterogeneity and Collective Management: Evidence from Common Forests in Himachal Pradesh, India显示文摘 | Sirisha C. Naidu | 2008 | World Development2008，，3： | 1 |
| 10 | Role of luteinizing hormone β- subunit gene variants among South Indian women with polycystic ovary syndrome显示文摘 | Dasgupta S Sirisha PV Neelaveni K | 2012 | Gene2012，1，1： | 1 |
| 11 | All in the family:TGFβ family action in the testis development显示文摘 | Itman C Sirisha M Barakat B | 2006 | Reproduction2006，132，2： | 1 |
| 12 | Association of CAPN10 SNPs and haplotypes with polycystic ovary syndrome among South Indian Women显示文摘 | Dasgupta S Sirisha PV Neelaveni K | 2012 | PLoS One2012，7，32： | 1 |
| 13 | Association of CAPN10 SNPs and haplotypes with polycystie ovary syndrome among South Indian Women 显示文摘 | Dasgupta S Sirisha PV Neelaveni K | 2012 | PLoS One2012，7，32： | 1 |
| 14 | Polymorphisms in the IRS- 1 and PPAR-/ genes and their association with polycystic ovary syndrome among South Indian women 显示文摘 | Dasgupta S Sirisha P Neelaveni K | 2012 | Gene2012，503，1： | 1 |
| 15 | IYrmeability characterization of polymer matrix eompsites by RTM/VARTM 显示文摘 | NAIK N K SIRISHA M INANI A | 2014 | Progress in Aerospace Sciences2014，65，2： | 1 |
| 16 | Using a Software-Defined Air Interface Algorithm to Improve Service Quality显示文摘In the digital era,the Narrowband Internet of Things(Nb-IoT)influ-ences the massive Machine-Type-Communication(mMTC)features to establish secure routing among the 5G/6G mobile networks.It supports global coverage to the low-cost IoT devices distributed in terrestrial networks.Its key traffic char-acteristics include robust uplink,moderate data rate/device,extremely high energy efficiency,prolonging device lifetime,and Quality of Service(QoS).This paper proposes a Deep Reinforcement Learning(DRL)combined software-defined air interface algorithm applied on the switching system,satisfying the user require-ment and enabling them with the network resources to extend quality of service by choosing the most appropriate quality of service metric.In this framework,Non-Orthogonal Multiple Accesses(NOMA)and Rate-Splitting Multiple Access(RSMA)are combined to accommodate massive(Nb-IoT)devices that can be uti-lized the entire resource(frequency band)for tackling the unknown dynamics pro-hibitive.The proposed algorithm instantly assigns the network resources per user requirements and enhances selecting the best quality of service metric optimiza-tion.Therefore,it has potential benefits of high scalability,low latency,energy efficiency,and spectrum utility. | Madiraju Sirisha P.Abdul Khayum | 2023 | Intelligent Automation & Soft Computing2023，，2： | 1 |
| 17 | Bioslurry Phase Remediation of Chlorpyrilos Contaminated Soil:Process Evaluation and Optimization by Taguchi Design of Experimental(DOE)Methodology显示文摘 | S V Mohan K Sirisha R S Rao | 2007 | Ecotoxicology and Environmental Safety2007，68，： | 1 |
| 18 | Mechanism Linking Cognitive Impairment and Diabetes mellitus 显示文摘 | Vijayakumar TM Sirisha GBN Farzana Beg am MI) | 2012 | European Journal of Applied Sciences2012，4，1： | 1 |
| 19 | Role of 14-bp insertion/deletion polymorphism in HLA-G among Indian women with recurrent spontaneous abortions 显示文摘 | Aruna M Sirisha PV Andal Bhaskar S eta/ | 2011 | Tissue Antigens2011，77，2： | 1 |
| 20 | Androgen receptor CAG repeat polymorphism and epigenetic influence among the south Indian women with polycystic ovary syndrome显示文摘 | Dasgupta S Sirisha PV Neelaveni K | 2010 | PLoS One2010，5，12： | 1 |
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