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| 1 | Exosomes: roles and therapeutic potential in osteoarthritis显示文摘Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis(OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling.This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future. | Zhenhong Ni Siru Zhou Song Li Liang Kuang Hangang Chen Xiaoqing Luo Junjie Ouyang Mei He Xiaolan Du Lin Chen | 2020 | Bone Research2020，8，2： | 10 |
| 2 | 2D nanoplate assembled nitrogen doped hollow carbon sphere decorated with Fe3O4 as an efficient electrocatalyst for oxygen reduction reaction and Zn-air batteries显示文摘Designing a highly efficient non-precious based oxygen reduction reaction(ORR)electrocatalyst is critical for the commercialization of various sustainable energy storage and conversion devices such as metal-air batteries and fuel cells.Herein,we report a convenient strategy to synthesis Fe3O4 embedded in N doped hollow carbon sphere(NHCS)for ORR.What's interesting is that the carbon microsphere is composed of two-dimensional(2D)nanoplate that could provide more exposed active sites.The usage of solid ZnO nanowires as zinc source is crucial to obtain this structure.The Fe3O4@NHCS-2 exhibits better catalytic activity and durability than the commercial PtC catalyst.Moreover,it further displays high-performance of Zn-air batteries as a cathode electrocatalyst with a high-power density of 133 mW·cm^-2 and high specific capacity of 701 mA·h·g^-1.The special hollow structure composed 2D nanoplate,high surface area,as well as synergistic effect between the high active Fe3O4 nanoparticles and N-doped matrix endows this outstanding catalytic activity.The work presented here can be easily extended to prepare metal compounds decorated carbon nanomaterials with special structure for a broad range of energy storage and conversion devices. | Yanqiang Li Huiyong Huang Siru Chen Xin Yu Chao Wang Tingli Ma | 2019 | Nano Research2019，12，11： | 9 |
| 3 | Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice显示文摘The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD. | Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie | 2022 | Bone Research2022，10，1： | 1 |
| 4 | Anchoring polysulfide with artificial solid electrolyte interphase for dendrite-free and low N/P ratio Li-S batteries显示文摘Lithium sulfur batteries are regarded as a promising candidate for high-energy-density energy storage devices.However,the lithium metal anode in lithium-sulfur batteries encounters the problem of lithium dendrites and lithium metal consumption caused by polysulfide corrosion.Herein we design a dualfunction PMMA/PPC/LiNO3composite as an artificial solid electrolyte interphase(PMCN-SEI)to protect Li metal anode.This SEI offers multiple sites of C=O for polysulfide anchoring to constrain corrosion of Li metal anode.The lithiated polymer group and Li3N in PMCN-SEI can homogenize lithium-ion deposition behavior to achieve a dendrite-free anode.As a result,the PMCN-SEI protected Li metal anode enables the Li||Li symmetric batteries to maintain over 300 cycles(1300 h)at a capacity of 5 m Ah cm^(-2),corresponding to a cumulative capacity of 3.25 Ah cm^(-2).Moreover,Li-S batteries assembled with 20μm of Li metal anode(N/P=1.67)still deliver an initial capacity of 1166 m A h g-1at 0.5C.Hence,introducing polycarbonate polymer/inorganic composite SEI on Li provides a new solution for achieving the high energy density of Li-S batteries. | Wei Lu Zhao Wang Guiru Sun Shumin Zhang Lina Cong Lin Lin Siru Chen Jia Liu Haiming Xie Yulong Liu | 2023 | Journal of Energy Chemistry2023，，5： | 1 |
| 5 | Degradation strategies of pesticide residue:From chemicals tosynthetic biology显示文摘The past 50 years have witnessed a massive expansion in the demand and application of pesticides.However,pesticides are difficult to be completely degraded without intervention hence the pesticide residue could pose a persistent threat to non-target organisms in many aspects.To aim at the problem of the abuse of pesticide products and excessive pesticide residues in the environment,chemical and biological degradation methods are widely developed but are scaled and insufficient to solve such a pollution.In recent years,bio-degradative tools instructed by synthetic biological principles have been further studied and have paved a way for pesticide degradation.Combining the customized design strategy and standardized assembly mode,the engineering bacteria for multi-dimensional degradation has become an effective tool for pesticide residue degradation.This review introduces the mechanisms and hazards of different pesticides,summarizes the methods applied in the degradation of pesticide residues,and discusses the advantages,applications,and prospects of synthetic biology in degrading pesticide residues. | Bi Ruomeng Ou Meihao Zhou Siru Geng Shichen Zheng Yixian Chen Junhong Mo Ruijie Li Yuan Xiao Gezhi Chen Xingyu Zhai Shiyi Zhang Aihui Fang Baishan | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 6 | MCU knockdown in hippocampal neurons improves memory performance of an Alzheimer’s disease mouse model显示文摘Alzheimer’s disease(AD)is a progressive and degenerative disorder accompanied by cognitive decline,which could be promoted by mitochondrial dysfunction induced by mitochondrial Ca^(2+)(mCa^(2+))homeostasis Mitochondrial calcium uniporter(MCU),a key channel of mCa^(2+) uptake,may be a target for AD treatment.In the present study,we reveal for the first time that MCU knockdown in hippocampal neurons improves the memory performance of APP/PS1/tau mice through radial arm maze task.Western blot analysis,transmission electron microscopy(TEM),Golgi staining,immunohistochemistry(IHC)and ELISA results demonstrate that MCU knockdown in hippocampal neurons upregulates the levels of postsynaptic density protein 95(PSD95)and synaptophysin(SYP),and increases the numbers of synapses and dendritic spines.Meanwhile,MCU knockdown in hippocampal neurons decreases the neuroinflammatory response induced by astrogliosis and high levels of IL-1βand TNF-α,and improves the PINK1-Parkin mitophagy signaling pathway and increases the level of Beclin-1 but decreases the level of P62.In addition,MCU knockdown in hippocampal neurons recovers the average volume and number of mitochondria.These data confirm that MCU knockdown in hippocampal neurons improves the memory performance of APP/PS1/tau mice through ameliorating the synapse structure and function,relieving the inflammation response and recovering mitophagy,indicating that MCU inhibition has the potential to be developed as a novel therapy for AD. | Hongyan Cai Jing Qiao Siru Chen Junting Yang Christian Hölscher Zhaojun Wang Jinshun Qi Meina Wu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 0 |
| 7 | Interface Engineering and Anion Engineering of Mo-Based Heterogeneous Electrocatalysts for Hydrogen Evolution Reaction显示文摘Development and utilization of hydrogen energy is an effective way to achieve carbon neutrality,only hydrogen production through electrolytic water splitting meets the goal of zero carbon emission.To facilitate the large-scale commercialization of water splitting devices,the development of highly efficient and low-cost catalysts to reduce the energy consumption is essential.MoS_(2)has been regarded as a promising electrocatalyst to replace platinum in hydrogen evolution reaction due to its low price and unique 2D layered structure.However,the poor conductivity and inert basal planes of MoS_(2)limited its wide-spread application.Recently,researches have demonstrated that the conductivity and active sites of MoS_(2)can be improved by heteroatoms doping or constructing of heterogeneous structures.In this review,the recent progress of Mo-based catalysts are summarized centered on MoS_(2)based on interface engineering and anion engineering,including MoS_(2)–MoO_(2),MoS_(2)–Mo_(2)C,MoS_(2)–MoN_(x),MoS_(2)–MoP,and MoS_(2)–MoSe_(2).The preparation method,structure,and performance of the catalysts are introduced and the possible mechanism behind the improved catalytic activity are revealed to give readers an overall comprehension on the progress of the Mo-based electrocatalysts for hydrogen evolution reaction.In addition,an outlook on future opportunities and development directions of Mo-based catalysts are proposed to facilitate the development of Mo-based catalysts for hydrogen production. | Zehao Yin Xuan Liu Siru Chen Tingli Ma Yanqiang Li | 2023 | Energy & Environmental Materials2023，6，1： | 0 |
| 8 | Lattice confined Ru single sites in hollow Co_(9)S_(8)polyhedron triggering Co-S-Ru catalytic centers for rechargeable Zn-air battery显示文摘Single-atom catalysts with precise structure and tunable coordination nature provide opportunities for developing novel catalytic centers and understanding reaction mechanisms.Herein,hollow Co_(9)S_(8)polyhedrons with lattice-confined Ru single atoms(Ru-Co_(9)S_(8))are fabricated.Aberration-corrected scanning transmission electron microscopy and X-ray absorption spectroscopy verify the isolated Ru atoms are confined in Co_(9)S_(8)to form Co-S-Ru catalytic centers.Theoretical calculations indicate that the oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)energy barriers are extensively reduced,the d-band center of Co_(9)S_(8)downshifts from the Fermi level,therefore boosting the desorption of O-containing intermediates.Consequently,the Ru-Co_(9)S_(8)exhibits an ultralow overpotential of 163 mV at 10 mA·cm^(−2)for OER and could catalyze a rechargeable Zn-air battery with a high-power density of 92.0 mW·cm^(−2).This work provides a promising approach for designing novel bifunctional catalytic active centers for energy conversion. | Xuan Liu Siru Chen Huicheng Wang Anmin Liu Shizheng Wen Liwei Mi Yanqiang Li | 2023 | Nano Research2023，16，5： | 0 |
| 9 | 20μm Li metal modified with phosphate rich polymer-inorganic interphase applied in commercial carbonate electrolyte显示文摘Li metal batteries are supposed to reach real application in order to fulfill the high-energy density requirement of energy storage system.Unfortunately,the commonly used carbonate electrolyte react with pristine Li,which result in short lifetime of lithium metal battery.To alleviate the side reactions of Li metal with liquid electrolyte,here we propose a phosphate rich polymer-inorganic layer as an interphase.Due to the inert properties of lithium phosphate derived from LiPO_(2)F_(2)and poly-ether,the side-reaction of carbonate solvent are prevented.As a result,lithium metal anode sustains for 800 cycles in symmetrical cell test under 1 m A cm^(-2).Even under strict condition(20μm Li,capacity ratio N/P=2.3,electrolyte/active material=3μL mg^(-1)),coin cell test still runs stable for 150 cycles with high Coulombic efficiency.Furthermore,both LiFePO_(4)and LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)pouch cell under 5μL m A^(-1)h^(-1)condition also exhibit good stability at 0.5 C and 2 C rate.With this approach,high-energy and high-power Li metal batteries are approaching to real application in the near future. | Lin Lin Wei Lu Feipeng Zhao Siru Chen Jia Liu Haiming Xie Yulong Liu | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
| 10 | Blockchain adoption or contingent sourcing? Advancing food supply chain resilience in the post-pandemic era显示文摘In the post-pandemic era, food supply chains and firms therein are facing unprecedented severe challenges, because once infection is detected, numerous products must be recalled or abandoned, and both suppliers and retailers in the supply chain suffer enormous loss. To survive under the pandemic, retailers have adopted different sourcing strategies, such as contingent sourcing, which, in turn, affect the upstream suppliers and hence the resilience of the whole supply chain. With the rapid development of digital technologies, retailers nowadays can utilize blockchain as a reliable and efficient way to reduce product risk and hence advance the resilience of food supply chains by improving product traceability and inspection accuracy, and making sourcing transparent. In this paper, we develop a game-theoretic model to investigate the interrelation between the retailer’s decisions on blockchain adoption and sourcing strategies. We consider that a retailer originally orders from a risky supplier while conducting an imperfect inspection to detect infected products before selling. The retailer may speculatively keep on ordering from the risky supplier or adopt contingent sourcing by ordering from an alternative safe supplier. The retailer also has an option to implement blockchain to improve the inspection accuracy and product traceability. We derive the optimal retail prices under different sourcing strategies with and without blockchain adoption and then analyze the incentives for sourcing strategy and blockchain adoption. Then, we identify the conditions of an all-win situation for food retailer, supplier, supply chain resilience, and consumers with/without government subsidy. Finally, we extend to consider the situation that some consumers have health-safety concerns and preferences for blockchain adoption. | Xiutian SHI Siru CHEN Xiaofan LAI | 2023 | Frontiers of Engineering Management2023，10，1： | 0 |
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