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| 1 | FGF/FGFR signaling in health and disease显示文摘Growing evidences suggest that the fibroblast growth factor/FGF receptor(FGF/FGFR)signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment,differentiation,proliferation,and apoptosis of various types of cells.In this review,we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development,injury repair,and the pathophysiology of spectrum of diseases,which is a consequence of FGF signaling dysregulation,including cancers and chronic kidney disease(CKD).In this context,the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems. | Yangli Xie Nan Su Jing Yang Qiaoyan Tan Shuo Huang Min Jin Zhenhong Ni Bin Zhang Dali Zhang Fengtao Luo Hangang Chen Xianding Sun Jian Q.Feng Huabing Qi Lin Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | The impact of supply chain risk on supply chain integration and company performance: a global investigation显示文摘 | Li Zhao Baofeng Huo Linyan Sun Xiande Zhao | 2013 | Supply Chain Management: An International Journal2013，，2： | 1 |
| 3 | Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice显示文摘The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD. | Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie | 2022 | Bone Research2022，10，1： | 1 |
| 4 | TTie Intact of Supply Chain Risk m Supply Chain Integratic?i and Company Performance: A Gl<^)al Investigaticm 显示文摘 | Li Zhao Baofeng Huo Linyan Sun Xiande Zhao | 2013 | Supply Chain Managem^it: An International Journal2013，182，： | 1 |
| 5 | Structural Vibration Mode Re-Analysis of Offshore Structures显示文摘-This paper reviews the current methodology for dynamic reanalysis. Rayleigh-Ritz approach and receptance approach are discussed in detail. Based on a general finite element structural analysis program SAPS, an eigenproblem re-analysis prorgram ERP was compiled. With a very small change the program can be implemented readily with any general FEM program. Finally, some numerical examples show that the new algorithm is of high precision and efficiency. In the case of local modification in the offshore platform, the efficiency is raised by 20- 50 times when compared with the re-calculation of the whole model. | Jin Xianding Sun Renzhang Rrofessor, Dept. of Naval Architecture and Ocean Engineering, Shanghai Jiao Tong University, Shanghai 200030 Engineer, Applied Software Development Center of China State Shipbuilding Corp. Shanghai 200032 | 1994 | China Ocean Engineering1994，9，1： | 0 |
| 6 | A New Multigrid 3D-VAR Optimization Method for Bottom Friction Using HF Radar Current Observation显示文摘This paper proposes a new method for data assimilation of the surface radial current observed by High Frequency ground wave radar and optimization of the bottom friction coefficient.In this method,the shallow water wave equation is introduced into the cost function of the multigrid three-dimensional variation data assimilation method as the weak constraint term,the surface current and the bottom friction coefficient are defined as the analytical variables,and the high spatiotemporal resolution surface radial flow observed by the high-frequency ground wave radar is used to optimize the surface current and bottom friction coefficient.This method can effectively consider the spatiotemporal correlation of radar data and extract multiscale information from surface radial flow data from long waves to short waves.Introducing the shallow water wave equation into the cost function as a weak constraint condition can adjust both the momentum and mass fields simultaneously to obtain more reasonable analysis information.The optimized bottom friction coefficient is introduced into the regional ocean numerical model to carry out numerical experiments.The test results show that the bottom friction coefficient obtained by this method can effectively improve the accuracy of the numerical simulation of sea surface height in the offshore area and reduce the simulation error. | ZHANG Xiaoshuang WU Xinrong LI Wei WANG Bin ZHU Xiande LIU Kexiu SHAO Caixia SUN Chunjian CHAO Guofang ZHANG Tiecheng | 2019 | Journal of Ocean University of China2019，18，6： | 0 |
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