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| 1 | Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Cervical Cancer—China,2003–2017显示文摘Introduction:This study reported the trends and analyzed the age-period-cohort effects on the incidence and mortality rates of cervical cancer in China.Methods:The age-standardized incidence rate(ASIR)and mortality rate(ASMR)by Segi’s world standard population were calculated using qualified consecutive data from 22 cancer registries from 2003 to 2017 in China.We performed joinpoint analysis to describe the trends and age-period-cohort analysis to estimate the independent effects of age,period and cohort on trends in incidence and mortality rates of cervical cancer.Results:The ASIR and ASMR for cervical cancer in females over 20 years old increased during 2003−2017.For females<50 years,a decreasing trend in ASIR and a stable trend in ASMR were observed in urban areas after 2009.But the ASIR and ASMR kept increasing in rural areas during the whole period.For females>50 years,the ASIR and ASMR increased both in urban and rural areas.Age-period-cohort analysis showed increasing period effects on cervical cancer incidence and mortality during the whole period.The cohort effects exhibited a downward-upwarddownward pattern for the incidence(1918–1938,1938–1963,1963–1993)and mortality rates(1918–1943,1943–1963,1963–1993)in urban areas,a fluctuating pattern for incidence rate and a continuing downward pattern for mortality rate(1918–1993)in rural areas.Conclusions:The increases in cervical cancer incidence and mortality rates can be mostly explained by period effects.We observed decreases in risk for cervical cancer incidence and mortality in young female generations,which were more obvious in urban areas. | Kexin Sun Rongshou Zheng Lin Lei Siwei Zhang Hongmei Zeng Shaoming Wang Li Li Ru Chen Bingfeng Han Ji Peng Wenqiang Wei Jie He | 2022 | China CDC weekly2022，4，48： | 4 |
| 2 | Effect of grassland degradation on soil quality and soil biotic community in a semi-arid temperate steppe显示文摘Grasslands provide a number of ecosystem services for human society.Degradation of grasslands results in the loss of biodiversity and leads to the deterioration of ecosystem functions.In order to accurately assess the influence of grassland degradation on belowground ecosystems,we conducted experiments on a temperate steppe with different levels of degradation and investigated the influence of degradation on soil quality and soil biotic communities.Our results showed that grassland degradation significantly decreased soil quality,with lower values of soil quality index(SQI)observed in the degraded grassland than the meadow steppe and the grassland from the forest-steppe ecotone.Changes in the SQI along the grassland degradation gradient were positively correlated with soil carbon stock and the aboveground biomass,and negatively correlated with the root shoot ratio.Nematode trophic diversity and the ratio of fungal to bacterial PLFA were lower in the degraded grassland than the grassland from the forest-steppe ecotone.The dissimilarities in soil microbial and nematode community composition increased with the changes in soil quality index.Our results indicate that soil quality index based on the minimum data sets could effectively assess the influence of grassland degradation on soil biodiversity and ecosystem function.In order to effectively restore degraded grasslands,the key contributors to the soil quality,such as soil carbon,should be taken on priority basis for revitalizing the soil biodiversity and ecosystem function. | Xu Han Yuhui Li Xiaofang Du Yingbin Li Zhengwen Wang Siwei Jiang Qi Li | 2020 | Ecological Processes2020，9，1： | 4 |
| 3 | LncRNA LINC00525 suppresses p21 expression viamRNA decay and triplex-mediated changes in chromatin structure in lung adenocarcinoma显示文摘Background:Emerging evidence suggests that long noncoding RNAs(lncRNAs)play crucial roles in various cancers.In the present study,we aim to investigate the function and molecular mechanism of an up-regulated and survivalassociated lncRNA,LINC00525,in lung adenocarcinoma(LUAD).Methods:The expression level of LINC00525 in tissueswas determined by quantitative reverse transcription polymerase chain reaction(RT-qPCR)and in situ hybridization(ISH).The functional role of LINC00525 in LUAD was investigated using gain-and loss-of-function approaches,both in vivo and in vitro.RNA pull-down,RNA immunoprecipitation(RIP),chromatin immunoprecipitation(ChIP),triplex-capture assay,dual-luciferase assay,gene expression microarray,and bioinformatics analysis were used to investigate the potential underlying mechanisms involved.Results:LINC00525 is highly expressed in LUAD cells and tissues.Survival analysis indicated that upregulation of LINC00525 was associated with poor prognosis in patients with LUAD patients.Knockdown of LINC00525 inhibited cell proliferation and cell cycle progression in vitro.In xenograft models,LINC00525 knockdown suppressed tumor growth and tumorigenesis of tumorbearing mice.Mechanistically,LINC00525 epigenetically suppressed p21 transcription by guiding Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit(EZH2)to the p21 promoter through an formation of RNA-DNA triplex with the p21 promoter,leading to increased trimethylation of lysine 27 on histone 3(H3K27me3)of the p21 promoter.In addition,LINC00525 repressed p21 expression post-transcriptionally by enhancing p21mRNA decay.LINC00525 promoted p21mRNAdecay by competitively binding toRNABindingMotif Single Stranded Interacting Protein 2(RBMS2).Conclusion:Our findings demonstrate that LINC00525 promotes the progression of LUAD by reducing the transcription and stability of p21 mRNA in concert with EZH2 and RBMS2,thus suggesting that LINC00525 may be a potential therapeutic target for clinical intervention in LUAD. | Panqi Fang Hao Chen Zhifei Ma Chencheng Han Wenda Yin Siwei Wang Hongyu Zhu Wenjia Xia Jie Wang Lin Xu Tongyan Liu Rong Yin | 2021 | Cancer Communications2021，41，7： | 2 |
| 4 | Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Female Breast Cancer—China,2003-2017显示文摘Introduction:This study reported the trends in female breast cancer incidence and mortality rates in China,and analyzed the corresponding age-periodcohort effects.Methods:Data from 22 population-based cancer registries in China between 2003 and 2017 were analyzed.Age-standardized incidence rates(ASIR)and mortality rates(ASMR)were calculated using Segi’s world standard population.Joinpoint regression was employed to evaluate trends,and age-period-cohort effects were examined using the intrinsic estimator method.Results:The ASIR for female breast cancer exhibited a more rapid increase in rural areas compared to urban areas across all age groups.The most substantial increase was observed in the 20-34 age group in rural areas[annual percent change(APC)=9.0%,95%confidence interval(CI):7.0%-11.0%,P<0.001].The ASMR for females under 50 years old remained stable from 2003 to 2017 in both urban and rural areas.However,the ASMR for females over 50 in rural areas and those over 65 in urban areas demonstrated a significant increase,with the most pronounced increase observed among females over 65 in rural areas(APC=4.9%,95%CI:2.8%-7.0%,P<0.001).Age-period-cohort analysis revealed increasing period effects and decreasing cohort effects for female breast cancer incidence and mortality rates in both urban and rural settings.Notably,the cohort effect for incidence displayed a slight upward trend for females born between 1983 and 1992 in rural areas.Conclusions:Our study revealed a rapid increase in breast cancer incidence among younger generations and an accelerated mortality rate in older populations residing in rural areas.To effectively address the growing burden of female breast cancer in China,it is essential to develop and implement targeted intervention strategies. | Kexin Sun Lin Lei Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming Wang Li Li Ru Chen Bingfeng Han Ji Peng Wenqiang Wei Jie He | 2023 | China CDC weekly2023，5，15： | 1 |
| 5 | Analysis of the current situation and trends of the incidence of prostate cancer in China显示文摘 | Han Sujun Zhang Siwei Han Wanqing | 2013 | J Clin Oncol2013，18，4： | 1 |
| 6 | Hollow FeCo-FeCoP@C nanocubes embedded in nitrogen-doped carbon nanocages for efficient overall water splitting显示文摘Designing readily available and highly active electrocatalysts for water splitting is essential for renewable energy technologies.Here we present the construction of FeCo-FeCoP@C hollow nanocubes encapsulated in nitrogen-doped carbon nanocages(FeCo-FeCoP@C@NCCs) through controlled carbonization and subsequent phosphorization of a Prussian blue analogue.With stronger electronic interaction and hollow structure,the as-obtained FeCo-FeCoP@C@NCCs material requires small overpotentials of 91 mV and280 mV to deliver 10 mA cm^(-2) in 1 M KOH toward hydrogen and oxygen evolution,respectively.More importantly,applying this material for overall water splitting,it only requires 1.64 V to afford10 mA cm^(-2) and exhibits impressively durability over 40 h without obvious performance decay.The present approach inspires potentials for the controllable synthesis of multi-component catalysts for practical applications. | Yuzhi Li Siwei Li Jing Hu Yuanyuan Zhang Yuchen Du Xijiang Han Xi Liu Ping Xu | 2021 | Journal of Energy Chemistry2021，30，2： | 1 |
| 7 | Agrobacterium-mediated insertional mutagenesis (AIM) of the entomopathogenic fungus Beauveria bassiana显示文摘 | Andreas Leclerque Hong Wan Anette Abschütz Siwei Chen Galina V. Mitina Gisbert Zimmermann Hans Ulrich Schairer | 2004 | Current Genetics2004，，2： | 1 |
| 8 | Distribution of antibiotic-resistant bacteria in chicken manure and manure-fertilized vegetables显示文摘 | Qingxiang Yang Siwei Ren Tianqi Niu Yuhui Guo Shiyue Qi Xinkuan Han Dong Liu Feng Pan | 2014 | Environmental Science and Pollution Research2014，，2： | 1 |
| 9 | Agrobacterium-mediated insertional mutagenesis (AIM) of the entomopathogenic fungus Beauveria bassiana显示文摘 | Andreas Leclerque Hong Wan Anette Abschütz Siwei Chen Galina V. Mitina Gisbert Zimmermann Hans Ulrich Schairer | 2004 | Current Genetics2004，，2： | 1 |
| 10 | Bright,photostable and long-circulating NIR-II nanoparticles for whole-process monitoring and evaluation of renal transplantation显示文摘Kidney transplantation is the gold standard for the treatment of end-stage renal diseases(ESRDs).However,the scarcity of donor kidneys has caused more and more ESRD patients to be stuck on the waiting list for transplant surgery.Improving the survival rate for renal grafts is an alternative solution to the shortage of donor kidneys.Therefore,real-time monitoring of the surgical process is crucial to the success of kidney transplantation,but efficient methods and techniques are lacking.Herein,a fluorescence technology based on bright,photostable and long-circulating aggregation-induced emission(AIE)active NIR-II nano-contrast agent DIPT-ICF nanoparticles for the whole-process monitoring and evaluation of renal transplantation has been reported.In the aggregated state,DIPT-ICF exhibits superior photophysical properties compared with the commercial dyes IR-26 and IR-1061.Besides,the long-circulating characteristic of the AIE nano-contrast agent helps to achieve renal angiography in kidney retrieval surgery,donor kidney quality evaluation,diagnosing vascular and ureteral complications,and assessment of renal graft reperfusion beyond renovascular reconstruction,which considerably outperforms the clinically approved indocyanine green(ICG). | Rongyuan Zhang Ping Shen Yu Xiong Tianjing Wu Gang Wang Yucheng Wang Liping Zhang Han Yang Wei He Jian Du Xuedong Wei Siwei Zhang Zijie Qiu Weijie Zhang Zheng Zhao Ben Zhong Tang | 2024 | National Science Review2024，11，2： | 0 |
| 11 | Simulation Study of the Control Strategy of a DC Inverter Heat Pump Using a DC Distribution Network显示文摘Photovoltaics,energy storage,direct current and flexibility(PEDF)are important pillars of achievement on the path to manufacturing nearly zero energy buildings(NZEBs).HVAC systems,which are an important part of public buildings,play a key role in adapting to PDEF systems.This research studied the basic principles and operational control strategies of a DC inverter heat pump using a DC distribution network with the aim of contributing to the development and application of small DC distribution systems.Along with the characteristics of a DC distribution network and different operating conditions,a DC inverter heat pump has the ability to adapt to changes in the DC bus voltage and adds flexibility to the system.Theoretical models of the DC inverter heat pump integrated with an ice storage unit were developed.The control strategies of the DC inverter heat pump system considered the influence of both room temperature and varied bus voltage.A simulation study was conducted using MATLAB&Simulink software with simulation results validated by experimental data.The results showed that:(1)The bus fluctuation under the rated working voltage had little effect on the operation of the unit;(2)When the bus voltage was fluctuating from 80%-90%or 105%-107%,the heat pump could still operate normally by reducing the frequency;(3)When the bus voltage was less than 80%or more than 107%,the unit needed to be shut down for the sake of equipment safety,so that the energy storage device could adjust to the sharp decrease or rise of voltage. | Siwei Han Xianglong Li Wei Zhao Linyu Wang Anqi Liang Shuang Zeng | 2023 | Energy Engineering2023，120，6： | 0 |
| 12 | Electrospun Cu-doped In_(2)O_(3) hollow nanofibers with enhanced H2S gas sensing performance显示文摘One-dimensional nanofibers can be transformed into hollow structures with larger specific surface area, which contributes to the enhancement of gas adsorption. We firstly fabricated Cu-doped In_(2)O_(3) (Cu-In_(2)O_(3)) hollow nanofibers by electrospinning and calcination for detecting H2S. The experimental results show that the Cu doping concentration besides the operating temperature, gas concentration, and relative humidity can greatly affect the H2S sensing performance of the In_(2)O_(3)-based sensors. In particular, the responses of 6%Cu-In_(2)O_(3) hollow nanofibers are 350.7 and 4201.5 to 50 and 100 ppm H2S at 250 ℃, which are over 20 and 140 times higher than those of pristine In_(2)O_(3) hollow nanofibers, respectively. Moreover, the corresponding sensor exhibits excellent selectivity and good reproducibility towards H2S, and the response of 6%Cu-In_(2)O_(3) is still 1.5 to 1 ppm H2S. Finally, the gas sensing mechanism of Cu-In_(2)O_(3) hollow nanofibers is thoroughly discussed, along with the assistance of first-principles calculations. Both the formation of hollow structure and Cu doping contribute to provide more active sites, and meanwhile a little CuO can form p–n heterojunctions with In_(2)O_(3) and react with H2S, resulting in significant improvement of gas sensing performance. The Cu-In_(2)O_(3) hollow nanofibers can be tailored for practical application to selectively detect H2S at lower concentrations. | Yu ZHANG Shuai HAN Mingyuan WANG Siwei LIU Guiwu LIU Xianfeng MENG Ziwei XU Mingsong WANG Guanjun QIAO | 2022 | Journal of Advanced Ceramics2022，11，3： | 0 |
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