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| 1 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 2 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 3 | Ultrasensitive terahertz metamaterial sensor based on vertical split ring resonators显示文摘An ultrasensitive metamaterial sensor based on double-slot vertical split ring resonators(DVSRRs) is designed and numerically calculated in the terahertz frequency. This DVSRR design produces a fundament LC resonance with a quality factor of about 20 when the incidence magnetic field component normal to the DVSRR array. The resonant characteristics and sensing performance of the DVSRR array design are systematically analyzed employing a contrast method among three similar vertical split ring resonator(SRRs) structures. The research results show that the elimination of bianisotropy, induced by the structural symmetry of the DVSRR design, helps to achieve LC resonance of a high quality factor. Lifting the SRRs up from the substrate sharply reduces the dielectric loss introduced by the substrate. All these factors jointly result in superior sensitivity of the DVSRR to the attributes of analytes. The maximum refractive index sensitivity is 788 GHz/RIU or 1.04 × 10~5 nm∕RIU.Also, the DVSRR sensor maintains its superior sensing performance for fabrication tolerance ranging from -4% to 4% and wide range incidence angles up to 50° under both TE and TM illuminations. | WEI WANG FENGPING YAN SIYU TAN HONG ZHOU YAFEI HOU | 2017 | Photonics Research2017，5，6： | 9 |
| 4 | Dual-comb spectroscopy resolved three-degreeof-freedom sensing显示文摘Precise and fast determination of position and orientation, which is normally achieved by distance and angle measurements, has broad applications in academia and industry. We propose a dynamic three-degree-of-freedom measurement technique based on dual-comb interferometry and a self-designed grating-corner-cube(GCC) combined sensor. Benefiting from its unique combination of diffraction and reflection characteristics, the absolute distance, pitch, and yaw of the GCC sensor can be determined simultaneously by resolving the phase spectra of the corresponding diffracted beams. We experimentally demonstrate that the method exhibits a ranging precision(Allan deviation) of 13.7 nm and an angular precision of 0.088 arcsec, alongside a 1 ms reaction time. The proposed technique is capable of precise and fast measurement of distances and two-dimensional angles over long stand-off distances. A system with such an overall performance may be potentially applied to space missions,including in tight formation-flying satellites, for spacecraft rendezvous and docking, and for antenna measurement as well as the precise manufacture of components including lithography machines and aircraftmanufacturing devices. | SIYU ZHOU VUNAM LE SHILIN XIONG YUETANG YANG KAI NI QIAN ZHOU GUANHAO WU | 2021 | Photonics Research2021，9，2： | 8 |
| 5 | Analysis of the Oldest Carbonate Gas Reservoir in China——New Geological Significance of the Dengying Gas Reservoir in the Weiyuan Structure, Sichuan Basin显示文摘The Weiyuan Structure is the largest surface structure in the Sichuan Basin. However, the abundance of the Dengying Formation gas reservoir in the Weiyuan Structure is low. The height of the gas column is 244 m, but the integrated abundance is only 26.4%. After nearly 40 years of exploration, the Gaoshi1 Well and Moxi8 Well yielded gas flows that marked an important exploration success after the discovery of the Sinian Dengying Formation gas reservoir in the Weiyuan Structure, Sichuan Basin, Lower-Paleozoic in 1964. Combined with research examples of oil and gas migration and gas chimneys around the world, the authors used comprehensive geological-geophysical-geochemical research methods to provide a reasonable explanation of the low abundance of the gas reservoir in the Weiyuan Structure based on the surface and subsurface data. The latest research results show that(1) currently, the Weiyuan Structure is the apex of the Dengying Formation in the Mid-Sichuan Basin. The Guang'an, Longnüsi, Gaoshiti-Moxi, and Weiyuan structures are a series of traps in the Dengying Formation with gradual uplifting spill and closure points during the regional uplift of the Himalayan period. The natural gas of the Dengying Formation accumulated in different ways over a wide range and long distance in the Sichuan Basin.(2) At approximately 40 Ma, the Weiyuan area started to uplift and form the present structure, and it is the only outcropped area with the Triassic Jialingjiang Formation and Leikoupo Formation in the surface of the Sichuan Basin(except the steep structural belt in East Sichuan). Caused by the uplift and denudation, the core of the Weiyuan Structure has formed an escaping 'skylight' for natural gas. The evidence of a gas chimney includes(1) the component percentage of non-hydrocarbon gas, which decreased from the bottom to the top,(2) the pressure coefficient is normal because the gas reservoir from the Upper Sinian to the Lower Permian commonly have a normal pressure coefficient(an average of 1.0), and(3) the isotope geochemistry of the argon mostly represents abiogenic characteristics of a deep source, and the 40 Ar/36 Ar ratio is as high as 2 855–5 222 in the Upper Permian. All of these characteristics provide sufficient evidence for a gas chimney effect. The characteristics of low abundance in the Weiyuan Structure can be a reference example for studying the late reconstruction of deep oil and gas reservoirs in the superimposed basins of western China. | Xiao Liang Shugen Liu Shubei Wang Bin Deng Siyu Zhou Wenxin Ma | 2019 | Journal of Earth Science2019，30，2： | 7 |
| 6 | Modeling and Calculation of Impact Friction Caused by Corner Contact in Gear Transmission显示文摘Corner contact in gear pair causes vibration and noise,which has attracted many attentions.However,teeth errors and deformation make it difficulty to determine the point situated at corner contact and study the mechanism of teeth impact friction in the current researches.Based on the mechanism of corner contact,the process of corner contact is divided into two stages of impact and scratch,and the calculation model including gear equivalent error-combined deformation is established along the line of action.According to the distributive law,gear equivalent error is synthesized by base pitch error,normal backlash and tooth profile modification on the line of action.The combined tooth compliance of the first point lying in corner contact before the normal path is inversed along the line of action,on basis of the theory of engagement and the curve of tooth synthetic compliance&load-history.Combined secondarily the equivalent error with the combined deflection,the position standard of the point situated at corner contact is probed.Then the impact positions and forces,from the beginning to the end during corner contact before the normal path,are calculated accurately.Due to the above results,the lash model during corner contact is founded,and the impact force and frictional coefficient are quantified.A numerical example is performed and the averaged impact friction coefficient based on the presented calculation method is validated.This research obtains the results which could be referenced to understand the complex mechanism of teeth impact friction and quantitative calculation of the friction force and coefficient,and to gear exact design for tribology. | ZHOU Changjiang CHEN Siyu | 2014 | Chinese Journal of Mechanical Engineering2014，27，5： | 6 |
| 7 | Modeling and analysis of oil shale refinery process with the indirectly heated moving bed显示文摘China is rich of oil shale as one of alternative fossil energy resources.The exploitation and utilization of oil shale are strategically important in alleviating the shortage of oil and gas resources in China.However,low utilization rate of raw material,low oil yield,and high content of heavy components in the oil are the main problems in current Fushun type oil shale refinery technology.An indirectly heated moving bed is developed to de-bottleneck Fushun type technology.The oil shale refinery process with the indirectly heated moving bed is modeled and simulated in this work.Based on the simulation,a techno-economic analysis is performed and compared with the conventional Fushun oil shale refinery process.Results show that:for a shale refinery of 3.0 Mt/y scale,375 t/h oil shale retorting requires 149.6 MW of heat,in which 60%of the heat is produced by combustion of the oil shale pyrolysis gas,while remaining 40%from the coal gasified gas.In consideration of investment and operation,the cost of product shale oil of the new process is 2636 CNY/t,which is 12%lower than that of the conventional Fushun refinery process.This benefit comes from higher utilization of raw material and oil yield of the new process.The competitive crude oil price of the indirectly heated moving bed refinery process is about 51$/bbl,while that of the Fushun refinery process is 58$/bbl.During 2017 year,the crude oil price fluctuates at around 50$/bbl,thus the new indirectly heated moving bed refinery process shows better economic competitiveness. | Huairong Zhou Shuai Zeng Siyu Yang Guangwen Xu Yu Qian | 2018 | Carbon Resources Conversion2018，1，3： | 5 |
| 8 | Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs显示文摘The limited knowledge of genomic noncoding and regulatory regions has restricted our ability to decipher the genetic mechanisms underlying complex traits in pigs. In this study, we characterized the spatiotemporal landscape of putative enhancers and promoters and their target genes by combining H3K27ac-targeted Ch IP-Seq and RNA-Seq in fetal(prenatal days 74–75) and adult(postnatal days 132–150) tissues(brain, liver, heart, muscle and small intestine) sampled from Asian aboriginal Bama Xiang and European highly selected Large White pigs of both sexes. We identified 101,290 H3K27ac peaks, marking 18,521promoters and 82,769 enhancers, including peaks that were active across all tissues and developmental stages(which could indicate safe harbor locus for exogenous gene insertion) and tissue-and developmental stage-specific peaks(which regulate gene pathways matching tissue-and developmental stage-specific physiological functions). We found that H3K27ac and DNA methylation in the promoter region of the XIST gene may be involved in X chromosome inactivation and demonstrated the utility of the present resource for revealing the regulatory patterns of known causal genes and prioritizing candidate causal variants for complex traits in pigs. In addition, we identified an average of 1,124 super-enhancers per sample and found that they were more likely to show tissue-specific activity than ordinary peaks. We have developed a web browser to improve the accessibility of the results(http://segtp.jxau.edu.cn/pencode/?genome=sus Scr11). | Yaling Zhu Zhimin Zhou Tao Huang Zhen Zhang Wanbo Li Ziqi Ling Tao Jiang Jiawen Yang Siyu Yang Yanyuan Xiao Carole Charlier Michel Georges Bin Yang Lusheng Huang | 2022 | Science China(Life Sciences)2022，65，8： | 5 |
| 9 | Toll-Like Receptor 4 Deficiency Causes Reduced Exploratory Behavior in Mice Under Approach-Avoidance Conflict显示文摘Abnormal approach-avoidance behavior has been linked to deficits in the mesolimbic dopamine(DA)system of the brain. Recently, increasing evidence has indicated that toll-like receptor 4(TLR4), an important pattern-recognition receptor in the innate immune system,can be directly activated by substances of abuse, resulting in an increase of the extracellular DA level in the nucleus accumbens. We thus hypothesized that TLR4-dependent signaling might regulate approach-avoidance behavior. To test this hypothesis, we compared the novelty-seeking and social interaction behaviors of TLR4-deficient(TLR4^(-/-))and wild-type(WT) mice in an approach-avoidance conflict situation in which the positive motivation to explore a novel object or interact with an unfamiliar mouse was counteracted by the negative motivation to hide in exposed,large spaces. We found that TLR4^(-/-)mice exhibitedreduced novelty-seeking and social interaction in the large open spaces. In less stressful test apparatuses similar in size to the mouse cage, however, TLR4^(-/-)mice performed normally in both novelty-seeking and social interaction tests. The reduced exploratory behaviors under approachavoidance conflict were not due to a high anxiety level or an enhanced fear response in the TLR4^(-/-)mice, as these mice showed normal anxiety and fear responses in the open field and passive avoidance tests, respectively. Importantly,the novelty-seeking behavior in the large open field induced a higher level of c-Fos activation in the nucleus accumbens shell(NAc Sh) in TLR4^(-/-)mice than in WT mice. Partially inactivating the NAc Sh via infusion of GABA receptor agonists restored the novelty-seeking behavior of TLR4^(-/-)mice. These data suggested that TLR4 is crucial for positive motivational behavior under approach-avoidance conflict. TLR4-dependent activation of neurons in the NAc Sh may contribute to this phenomenon. | Chunlu Li Yixiu Yan Jingjing Cheng Gang Xiao Jueqing Gu Luqi Zhang Siyu Yuan Junlu Wang Yi Shen Yu-Dong Zhou | 2016 | Neuroscience Bulletin2016，32，2： | 5 |
| 10 | Effect of PdOx structure properties on catalytic performance of Pd/Ce0.67Zr0.33O2 catalyst for CO,HC and NOx elimination显示文摘Pd/Ce0.67Zr0.33O2 catalyst was pretreated in different atmosphere respectively, and characterized by CO chemical adsorption, XPS, HR-TEM, H2-TPR, Raman, OSC and in situ DRIFTS to investigate the effect of the structure properties of PdOx species on the catalytic performance for CO, HC and NOx elimination. The results show that Pd/CZ catalyst pretreated in air atmosphere has higher oxidation activity of HC due to having high Pd dispersion and strong interaction between PdOx and CZ support. Pd/CZ-H catalyst pretreated in reducing atmosphere exhibits better catalytic performance of NOx elimination because of having relatively big Pd particle size, more Pd species in metallic state and higher concentration of oxygen vacancies. While for the Pd/CZ-RG catalyst pretreated in reactant atmosphere, strong adsorption of HC species on the surface of catalysts would lead to a part of active sites being covered, which inhibits HC and NO conversions. | Ting Wang Xiaolin Guo Siyu Lin Renxian Zhou | 2019 | Journal of Rare Earths2019，37，7： | 4 |
| 11 | Thermochemical properties and thermokinetic behavior of energetic triazole ionic salts显示文摘The properties of dissolution in different solvents,the specific heat capacity and thermal decomposition process under the non-isothermal conditions for energetic triazole ionic salts 1,2,4-triazolium nitrate(1a),1,2,3-triazolium nitrate(1b),3,4,5triamino-1,2,4-triazolium nitrate(2a),3,4,5-triamino-1,2,4-triazolium dinitramide(2b)were precisely measured using a Calvet Microcalorimeter.The thermochemical equation,differential enthalpies of dissolution(△difH m ),standard molar enthalpies of dissolution(△difH m ),apparent activation energy(E),pre-exponential constant(A),kinetic equation,linear relationship of specific heat capacity with temperature over the temperature range from 283 to 353 K,standard molar heat capacity(C p,m)and enthalpy,entropy and Gibbs free energy at 283–353 K,taking 298.15 K as the benchmark for 1a,1b,2a and 2b were obtained with treating experimental data and theoretical calculation method.The kinetic and thermodynamic parameters of thermal decomposition reaction,critical temperature of thermal explosion(Tb),self-accelerating decomposition temperature(TSADT)and adiabatic time-to-explosion(t)of 1a,1b,2a and 2b were calculated.Their heat-resistance abilities were evaluated.Information was obtained on the relation between molecular structures and properties of 1a,1b,2a and 2b. | ZHAO FengQi XUE Liang XING XiaoLing HU RongZu ZHOU ZhiMing GAO HongXu YI JianHua XU SiYu PEI Qing | 2011 | Science China Chemistry2011，54，3： | 4 |
| 12 | An artificial chromosome for data storage显示文摘DNA digital storage provides an alternative for information storage with high density and long-term stability.Here,we report the de novo design and synthesis of an artificial chromosome that encodes two pictures and a video clip.The encoding paradigm utilizing the superposition of sparsified error correction codewords and pseudo-random sequences tolerates base insertions/deletions and is well suited to error-prone nanopore sequencing for data retrieval.The entire 254 kb sequence was 95.27%occupied by encoded data.The Transformation-Associated Recombination method was used in the construction of this chromosome from DNA fragments and necessary autonomous replication sequences.The stability was demonstrated by transmitting the data-carrying chromosome to the 100 th generation.This study demonstrates a data storage method using encoded artificial chromosomes via in vivo assembly for write-once and stable replication for multiple retrievals,similar to a compact disc,with potential in economically massive data distribution. | Weigang Chen Mingzhe Han Jianting Zhou Qi Ge Panpan Wang Xinchen Zhang Siyu Zhu Lifu Song Yingjin Yuan | 2021 | National Science Review2021，8，5： | 3 |
| 13 | Enhancing sensing capacity of terahertz metamaterial absorbers with a surface-relief design显示文摘Metamaterial absorbers(MAs)serve as important electromagnetic wave-absorbing devices that have captured the attention of researchers for a long term.Functioning as sensitive detectors to determine perturbations in an ambient environment is another significant subsidiary function.Here,we theoretically propose an optimized fabrication method to implement terahertz MAs with fewer steps and also evaluate both absorption and sensing performances of such MAs realized by the new method.Simulation findings demonstrate that such MAs can basically maintain the original absorption features perfectly,including near-complete absorption at resonance as well as strong robustness to wide incident angles.Specifically,the full width at half-maximum and quality factor of the absorption resonances attenuate less than 26%and 8%with this new method,remaining in the ranges of^0.03–0.04 THz and^20–27 for two selected example MAs.More significantly,sensing capacities of this type of MA,in terms of maximum detection range(enhancing at least 9%),observable spectral modulation(increasing at least 6.3%),and refractive index sensitivity,are improved to a large extent because of more intense coupling between resonant field and matter in the case of surface-relief MAs.This stronger coupling results from exposing more spots of the resonantly high field to direct contact with an approaching analyte,which is illustrated by field profiles of the MAs at resonance in this work.Additionally,other desirable absorber features are also explored with such MAs,like functioning as building blocks to configure multiband MAs and strong robustness against fabrication errors.Such new-style terahertz MAs shown in the paper,acting as good examples,not only prove that terahertz MAs can be fabricated by the proposed time-and cost-saving route in contrast to the traditional MA fabrication process,but also can serve as novel platforms to explore other intriguing terahertz photonic effects,such as the field enhancement effect. | WEI WANG FENGPING YAN SIYU TAN HAISU LI XUEMEI DU LUNA ZHANG ZHUOYA BAI DAN CHENG HONG ZHOU YAFEI HOU | 2020 | Photonics Research2020，8，4： | 3 |
| 14 | Regulating closed pore structure enables significantly improved sodium storage for hard carbon pyrolyzing at relatively low temperature显示文摘The closed pore has been considered as the key structure for Na ion storage in hard carbon.However,the traditional view is that closed pores can only be formed by the curling of graphite-like crystallites in the case of high temperature carbonization.Ingenious designing of closed pore structures at lower temperature is still blank.Herein,for the first time,engineering the wall thickness and number of closed pores in waste rosewood-derived hard carbon was successfully achieved at a low temperature of 1100℃ by removing the lignin and hemicellulose components in wood precursor.When applied as an anode material,the optimum sample exhibits a high capacity of 326 mAh/g at 20 mA/g and a remarkable rate capability of 230mAh/g at 5000 mA/g,significantly higher than those of the untreated sample(only 33 mAh/g at 5000 mA/g).The significantly improved Na storage performance should be attributed to abundant closed pores that provide sufficient spaces forNa storage and thin porewall structure that is beneficial to the diffusion of Na^(+)in the bulk phase.This work provides a new idea for the future application of biomass-based hard carbon for advanced Na ion batteries. | Siyu Zhou Zheng Tang Zhiyi Pan Yuancheng Huang Le Zhao Xi Zhang Dan Sun Yougen Tang Abdelghaffar S.Dhmees Haiyan Wang | 2022 | SusMat2022，2，3： | 2 |
| 15 | A near-infrared multifunctional fluorescent probe for hypoxia monitoring and tumor-targeted therapy显示文摘Hypoxia is one of the key characteristics of solid tumors. The over-expression of azoreductase resulting from hypoxia can be used as a target to visualize hypoxic levels and a trigger of the drug release system in tumor treatment. In this work, we developed a near-infrared fluorescent probe YLOD, composed of a near-infrared fluorophore, an azo bond, and an analogue of the anti-tumor drug melphalan. In the presence of azoreductase, YLOD displayed a red emission at 620 nm and released the anti-tumor drug concomitantly, thus achieving the integrated effects of hypoxic imaging and tumor treatment. Furthermore, YLOD successfully inhibited the growth of solid tumors during the tumor suppression experiments in nude mice. Considering all the results, YLOD emerges as a new fluorescence tool that can quickly determine the location and the edges of a tumor, showing concrete potential in clinical cancer treatment. | Yuxun Lu Jiajia Xu Zongyun Jia Siyu Kong Yimu Qiao Lin Li Qiong Wu Ying Zhou | 2022 | Chinese Chemical Letters2022，33，3： | 2 |
| 16 | Selected-Mapping Peak-to-Average Power Reduction Method with Orthogonal Pilot Sequences in Underwater Acoustic OFDM System Without Side Information显示文摘A novel Selected-mapping(SLM) Peak-to-average power ratio(PAPR) reduction scheme requires no Side information(SI) in Underwater acoustic(UWA)OFDM system is proposed. In the proposed scheme,every distinct phase sequence is represented by a unique Orthogonal comb pilot sequence(OPS), and the orthogonal properties of the OPSs are used to distinguish the index of phase sequences at the receiver. Therefore, the proposed scheme does not need to reserve bits for transmitting SI,so that the data rate can be raised. Simulation results show that the PAPR reduction performance has almost 0.5 d B gains comparing to the Conventional SLM(C-SLM)scheme and the Bit error ratio(BER) performance is approximately the same as the SLM scheme with perfect SI. Field experimental results also demonstrate that the proposed scheme can differentiate phase sequences,therefore significantly enhance the quality of the UWA OFDM communication system. | QIAO Gang XING Siyu and ZHOU Feng | 2021 | Chinese Journal of Electronics2021，30，1： | 2 |
| 17 | Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis显示文摘Dear Editor,Plants utilize K^+ions to maintain hydrostatic pressure,drive irreversible cell expansion for growth,and facilitate reversible changes in guard cell volume that cause stomatal opening or closing.KAT1 is a voltage-dependent potassium channel from Arabidopsis thaliana that is mainly expressed in guard cells.KAT1 allows the influx of K+,leading to the swelling and opening of the stoma,and therefore plays a key role in regulating the aperture of stomatal pores on the surface of plant leaves. | Siyu Li Fan Yang Demeng Sun Yong Zhang Mengge Zhang Sanling Liu Peng Zhou Chaowei Shi Longhua Zhang Changlin Tian | 2020 | Cell Research2020，30，11： | 2 |
| 18 | Towards carbon neutrality:A study on China's long-term low-carbon transition pathways and strategies显示文摘As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 years.This study fully considered the carbon-neutrality goal and the temperature rise constraints required by the Paris Agreement,by developing six long-term development scenarios,and conducting a quantitative evaluation on the carbon emissions pathways,energy transformation,technology,policy and investment demand for each scenario.This study combined both bottom-up and top-down methodologies,including simulations and analyses of energy consumption of end-use and power sectors(bottom-up),as well as scenario analysis,investment demand and technology evaluation at the macro level(top-down).This study demonstrates that achieving carbon neutrality before 2060 translates to significant efforts and overwhelming challenges for China.To comply with the target,a high rate of an average annual reduction of CO_(2) emissions by 9.3%from 2030 to 2050 is a necessity,which requires a huge investment demand.For example,in the 1.5℃ scenario,an investment in energy infrastructure alone equivalent to 2.6%of that year's GDP will be necessary.The technological pathway towards carbon neutrality will rely highly on both conventional emission reduction technologies and breakthrough technologies.China needs to balance a long-term development strategy of lower greenhouse gas emissions that meets both the Paris Agreement and the long-term goals for domestic economic and social development,with a phased implementation for both its five-year and long-term plans. | Jiankun He Zheng Li Xiliang Zhang Hailin Wang Wenjuan Dong Ershun Du Shiyan Chang Xunmin Ou Siyue Guo Zhiyu Tian Alun Gu Fei Teng Bin Hu Xiu Yang Siyuan Chen Mingtao Yao Zhiyi Yuan Li Zhou Xiaofan Zhao Ying Li Danwei Zhang | 2022 | Environmental Science and Ecotechnology2022，，1： | 2 |
| 19 | Improving the Initial Coulombic Efficiency of Carbonaceous Materials for Li/Na‑Ion Batteries:Origins,Solutions,and Perspectives显示文摘Carbonaceous materials for lithium(Li)/sodium(Na)-ion batteries have attracted significant attention because of their widespread availability,renewable nature,and low cost.During the past decades,although great efforts have been devoted to developing high-performance carbonaceous materials with high capacity,long life span,and excellent rate capability,the low initial Coulombic efficiency(ICE)of high-capacity carbonaceous materials seriously limits their practical applications.Various methods have been successfully exploited,and a revolutionary impact has been achieved through the utilization of different techniques.Different carbonaceous materials possess different ion storage mechanisms,which means that the initial capacity loss may vary.However,there has rarely been a special review about the origins of and progress in the ICE for carbonaceous materials from the angle of the crystal structure.Hence,in this review,the structural differences between and ion storage mechanisms of various carbonaceous materials are first introduced.Then,we deduce the correlative factors of low ICE and thereafter summarize the proposed strategies to address these issues.Finally,some challenges,perspectives,and future directions on the ICE of carbonaceous materials are given.This review will provide deep insights into the challenges of improving the ICE of carbonaceous anodes for high-energy Li/Na-ion batteries,which will greatly contribute to their commercialization process. | Zheng Tang Siyu Zhou Yuancheng Huang Hong Wang Rui Zhang Qi Wang Dan Sun Yougen Tang Haiyan Wang | 2023 | Electrochemical Energy Reviews2023，6，1： | 1 |
| 20 | Spatial multi-scaled chimera states of cerebral cortex network and its inherent structure-dynamics relationship in human brain显示文摘Human cerebral cortex displays various dynamics patterns under different states,however the mechanism how such diverse patterns can be supported by the underlying brain network is still not well understood.Human brain has a unique network structure with different regions of interesting to perform cognitive tasks.Using coupled neural mass oscillators on human cortical network and paying attention to both global and local regions,we observe a new feature of chimera states with multiple spatial scales and a positive correlation between the synchronization preference of local region and the degree of symmetry of the connectivity of the region in the network.Further,we use the concept of effective symmetry in the network to build structural and dynamical hierarchical trees and find close matching between them.These results help to explain the multiple brain rhythms observed in experiments and suggest a generic principle for complex brain network as a structure substrate to support diverse functional patterns. | Siyu Huo Changhai Tian Muhua Zheng Shuguang Guan Changsong Zhou Zonghua Liu | 2021 | National Science Review2021，8，1： | 1 |
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