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10篇 您的检索式：作者名="Skawran"

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		题名	作者	年代	出处	被引量
	1	hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma显示文摘AIM To screen clinically relevant micro RNAs (mi RNAs) silenced by DNA methylation in human hepatocellular carcinoma(HCC).METHODS Knockdown of DNA methyltransferases (DNMTs) using si RNAs and mi RNA profiling in HCC cell lines were performed to identify DNA hypermethylation-mediated mi RNA downregulation. Confirmation using individual quantitative real-time PCR (qR T-PCR) assays was thenperformed followed by DNA methylation quantification at the promoter of the mi RNA genes. Quantification of DNA methylation and mi RNA expression was then performed in primary HCC tumor samples and related with clinicopathological variables.RESULTS mi RNA profiling after DNMT knockdown in HCC cell lines revealed upregulation of mi R-23, mi R-25 and mi R-183. After q RT-PCR confirmation and Cp G island methylation quantification of these miR NAs in cell lines, further analysis in primary HCC specimens showed that hsa-mi R-183 is hypermethylated in 30% of HCC (n = 40). Expression of mature miR-183 showed an inverse correlation with DNA methylation levels. In HCC cells, DNMT knockdown and 5-aza-2'-deoxycytidine treatment reduced methylation and stimulated expression of mi R-183. In HCC patients, hypermethylation at hsami R-183 promoter significantly correlates with poor survival (log-rank test P = 0.03). DNA methylation analysis in healthy liver, benign liver tumors (hepatocellular adenoma and focal nodular hyperplasia) and their corresponding adjacent tissues showed absence of hypermethylation supporting the notion that aberrant methylation at hsa-miR-183 is specific for the malignant transformation of hepatocytes.CONCLUSION Our data indicate that hypermethylation of hsa-miR-183 is a frequent event in HCC and potentially useful as a novel surrogate diagnostic and prognostic marker.	Sumadi Lukman Anwar Till Krech Britta Hasemeier Elisa Schipper Nora Schweitzer Arndt Vogel Hans Kreipe Reena Buurman Britta Skawran Ulrich Lehmann	2017	World Journal of Gastroenterology2017，23，9：	3
	2	Bilateral endoscopic total extraperitoneal (TEP) inguinal hernia repair does not induce obstructive azoospermia: data of a retrospective and prospective trial显示文摘	Skawran S Weyhe D Schmitz B	2011	World Journal of Surgery2011，35，7：	1
	3	TSPY variants in six loci on the human Y chromosome显示文摘	DECHEND F WILLIAMS G SKAWRAN B	2000	Cytogenet Cell Genet2000，91，14：	1
	4	Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells显示文摘	Reena Buurman Engin Gürlevik Vera Sch?ffer Marlies Eilers Maria Sandbothe Hans Kreipe Ludwig Wilkens Brigitte Schlegelberger Florian Kühnel Britta Skawran	2012	Gastroenterology2012，，3：	1
	5	Characterization of ahuman TSPY promoter显示文摘	Skawran B Schubert S Dechend F	2005	Mol Cell Biochem2005，276，：	1
	6	Generation andcharacterization of a transgenic mouse with a functional human TSPY1 显示文摘	Schubert S Skawran B Dechend F	2003	Biol Reprod2003，69，：	1
	7	Assessment of Differentiation and Progression of Hepatic Tumors Using Array-Based Comparative Genomic Hybridization显示文摘	Doris Steinemann Britta Skawran Thomas Becker Marcel Tauscher Anja Weigmann Luzie Wingen Sarah Tauscher Tanja Hinrichsen Sabine Hertz Peer Flemming Jacobus Flik Birgit Wiese Hans Kreipe Peter Lichter Brigitte Schlegelberger Ludwig Wilkens	2006	Clinical Gastroenterology and Hepatology2006，，10：	1
	8	Bilateral endoscopic total extraperitoneal (TEP) inguinal hernia repair does not induce obstructive azoospermia:data of a retrospective and prospective trial显示文摘	Skawran S Weyhe D Schmitz B	2011	World J Surg2011，35，7：	1
	9	Amelioration of microcir-culatory damage by an endothelin A receptor antagonist in a ratmodel of reversible acute liver failure显示文摘	Palmes D Skawran S Stratmann U	2005	J Hepatol2005，42，3：	1
	10	Bilateral endoscopic total extra- peritoneal (TEP)inguinal hernia repair does not induce obstructive azoospermia:data of a retrospective and prospective trial显示文摘	Skawran S Weyhe D Schmitz B	2011	World J Surg2011，35，7：	1

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