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| 1 | Bevacizumab for the management of diabetic macular edema显示文摘Diabetic retinopathy (DR) is a leading cause of vision loss in the working-age population and is relatedto 1%-5% of cases of blindness worldwide. Diabetic macular edema (DME) is the most frequent cause of DR vision loss and is an important public health problem. Recent studies have implicated vascular endothelial growth factor (VEGF) in DR and DME pathogenesis, as well as provided evidence of the benefits of anti-VEGF agents for the management of such conditions. Despite the benefits of intravitreal ranibizumab injection for the management of DME, the cost-effectiveness of intravitreal bevacizumab therapy has gained increasing interest in the scientific community. This review summarizes the studies examining bevacizumab for the management of DME, focusing on the efficacy and duration of the clinical benefits of decreasing DME and the improvement of best-corrected visual acuity (BCVA). There is strong evidence that intravitreal bevacizumab injection therapy has a good cost-effective profile in the management of DME and may be associated with laser photocoagulation; however, its clinical superiority in terms of the duration of DME regression and the improvement of BCVA compared with intravitreal ranibizumab and other intravitreal anti-VEGF therapies remains unclear and deserves further investigation. | Francisco Rosa Stefanini J Fernando Arevalo Maurício Maia | 2013 | World Journal of Diabetes2013，4，2： | 18 |
| 2 | Singing on the wings! Male wing fanning performances affect female willingness to copulate in the aphid parasitoid Lysiphlebus testaceipes (Hymenoptera: Braconidae: Aphidiinae)显示文摘Lysiphlebus testaceipes (Hymenoptera:Braconidae:Aphidiinae ) 是攻击超过 100 aphid 种类的通晓各方面知识经验丰富的人 endoparasitoid。在 L。testaceipes,翅膀扇是忍受女性的性 pheromone 唤起的主要男求爱显示。然而,没有信息在特征和在这 parasitoid 的在求爱期间的男性扇的行为的角色上是可得到的。这里, L 的野紧张的求爱行为。testaceipes 被确定,扇表演的男翅膀通过高速度的录像记录被分析并且在与交配成功的关系检验了。野 L 的求爱顺序。testaceipes 实质地没不同于那以前为质量在蚜虫上饲养了的另外的人口报导了。我们观察到男求爱持续时间没假装交配成功。然而,录像分析表明生产高周波的扇的信号的男性更高完成了在显示低频率的扇的那些上交配成功。翅膀在成功、失败的求爱前扇向配偶在翅膀运动和排列的振幅不同,断然加亮那正面的求爱影响交配决定的女性。这研究在蚜虫的关键 parasitoid 在性行为上增加知识,强调翅膀在在 L 的性通讯使用的感觉形式的范围之中扇的重要性。testaceipes。从一个实际观点,这个信息在 L 是有用的。基于 testaceipes 的 biocontrol 策略,后来,它能帮助为随着时间的过去的饲养团的黄蜂的优秀检查建立参数。 | Giovanni Benelli Nickolas G. Kavallieratos Elisa Donati Giulia Giunti Cesare Stefanini Angelo Canale | 2016 | Insect Science2016，23，4： | 2 |
| 3 | Is bigger better? Male body size affects wing-borne courtship signals and mating success in the olive fruit fly, Bactrocera oleae (Diptera: Tephritidae)显示文摘在男身体尺寸的变化被知道影响内部 -- 并且在大量动物的 intrasexual 选择结果。在交配包含在交配前的性发信号的系统,身体尺寸经常充当影响信号力量和配偶选择的一个关键因素。我们在求爱显示和橄榄水果苍蝇的交配成功上评估了男尺寸的效果, Bactrocera oleae (双翅目:Tephritidae ) 。大、小的男性在成功、失败的求爱期间执行的翅膀颤动被高速度的录像记录并且通过 frame-by-frame 分析了分析。交配大、小的男性的成功被调查。交配成功上的男性男性的竞争的效果被评估。男身体尺寸影响了两个男求爱信号和交配结果。成功的男性与高频率和短 interpulse 间隔显示出忍受翅膀的信号。成功的大男性在交媾期间显示的翅膀颤动在更小的男性和失败的大男性上尝试有的更高的频率。处于没有比赛条件,大男性更高完成了关于更小的交配成功。允许大、小的男性为女性,竞争大男性超过更小的获得更多的交配成功。由女性的配偶选择可以基于更大的男性,的选择能生产高周波的翅膀颤动。如此的特点可能 “good 基因是指示的, ”它在性选择下面能意味着好社会相互作用的基因,或 conspecifics 的一个好竞争操纵者。 | Giovanni Benelli Elisa Donati Donato Romano Giacomo Ragni Gabriella Bonsignori Cesare Stefanini Angelo Canale | 2016 | Insect Science2016，23，6： | 2 |
| 4 | A systems biology perspective on sVEGFR1 : itsbiological function, function, pathogenic role and therapeutic use 显示文摘 | Wu F T Stefanini M O Mac Gabhann F | 2010 | J Cell Mol2010，14，3： | 1 |
| 5 | Rap1-Rac1 Circuits Potentiate Platelet Activation显示文摘 | Lucia Stefanini Yacine Boulaftali Timothy D. Ouellette Michael Holinstat Laurent Désiré Bertrand Leblond Patrick Andre Pamela B. Conley Wolfgang Bergmeier | 2012 | Arteriosclerosis, Thrombosis, and Vascular Biology2012，，： | 1 |
| 6 | Impact of sex on clinical and angiographic outcomes among patients undergoing revascularization with drug-eluting stents显示文摘 | Stefanini GG Kalesan B Pilgrim T | 2012 | JACC Cardiovasc Interv2012，5，3： | 1 |
| 7 | A systems biology perspec- tive on sVEGFR1 : its biological function, pathogenic role and ther- apeutic use显示文摘 | Wu FT Stefanini MO Mac F | 2010 | Cell Mol Med2010，14，3： | 1 |
| 8 | High resolution multicontrast-weighted MR imaging from human carotid endarterectomy specimens to assess carotid plaque components显示文摘 | Fabiano S Mancino S Stefanini M | 2008 | Eur Radiol2008，18，： | 1 |
| 9 | Activin stimulates sertoli cell proliferation in a difined period of rat testis development 显示文摘 | Boitani C Stefanini M Fragale A | 1995 | Endocrinology1995，136，： | 1 |
| 10 | Three-year clinical follow-up of the unrestricted use of sirolimus-eluting stents as part of the rapamyein-eluting stent evaluated at Rotterdam cardiology hospital(RESEARCH) registry显示文摘 | Daemen J Ong AT Stefanini G | 2006 | Am J Cardiol2006，98，： | 1 |
| 11 | Integrin receptor alpha 6 beta 1 is localized at specific sites of cell-to-cell contact in rat seminiferous epithelium 显示文摘 | Salanova M Stefanini M De Curtis I | 1995 | Biol Reprod1995，52，1： | 1 |
| 12 | Urokinase redistribution from the secreted to the cell-bound fraction in granulose cells of rat preovulatory follicles显示文摘 | Macchione E Epifano O Stefanini M | 2000 | Biol Reprod2000，62，4： | 1 |
| 13 | Thymosin α1 and transcatheter aterial chemombolization in hepatocellular carcinoma patients: a preliminary experience 显示文摘 | Faschi F G Castelli E | 1998 | Hepatogastroenterology1998，45，： | 1 |
| 14 | The security of power system and the role of information & communication technologies:lessons from recent blackonts显示文摘 | STEFANINI A MASERA M | 2008 | International Journal of Critical Infrastructure2008，4，12： | 1 |
| 15 | Distribution of GABA ( B ) receptor mRNAs in the rat brain and peripheral organs显示文摘 | Castelli MP Ingianni A Stefanini E | 1999 | Life Sci1999，64，： | 1 |
| 16 | High-resolution multicontrast-weighted MR imaging from human carotid endarterectomy specimens to assess carotid plaque components显示文摘 | Fabiano S Mancino S Stefanini M | | 0，，12： | 1 |
| 17 | Morphine-sparing effect in orthopedic sumerv 显示文摘 | Peduto VA Ballabio M Stefanini S Efficacy of propacetamol in the treatment of postoperative pain | 1998 | Acta Anaesthesiol Scand1998，42，3： | 1 |
| 18 | Bovine beta-casein antibodies inbreast-and bottle-fed infants: their relevance in type 1 diabetes显示文摘 | Monetini L Cavallo M G Stefanini L | 2001 | Diabetes Metab ResRev2001，17，： | 1 |
| 19 | RAP1-GTPase signaling and plateletfunction显示文摘 | Stefanini L Bergmeier W | 2015 | Journal of Molecular Medicine2015，，： | 1 |
| 20 | Together We Stand-Analyzing Schooling Behavior in Naive Newborn Guppies through Biorobotic Predators显示文摘A major advantage of animal aggregations concerns cooperative antipredator strategies.Schooling behavior emerges earlier in many fish species,especially in those cannibalizing their offspring.Experience is fundamental for developing schooling behavior.However,the cognitive ability of naive newborn fish to aggregate remains unclear.Herein,Poecilia reticulata,was selected as model organism to investigate how combinations of biomimetic robotic agents and adult conspecific olfactory cues affect collective responses in newborns.The role of white and brown backgrounds in evoking aggregations was also assessed.Olfactory cues were sufficient for triggering aggregations in P.reticulata newborns,although robotic agents had a higher influence on the group coalescence.The combination of robotic agents and olfactory cues increased schooling behavior duration.Notably,schooling was longer in the escape compartment when robotic agents were presented,except for the combination of the male-mimicking robotic fish plus adult guppy olfactory cues,with longer schooling behavior in the exploring compartment.Regardless of the tested cues,newborn fish aggregated preferentially on the brown areas of the arena.Overall,this research provides novel insights on the early collective cognitive ability of newborn fish,paving the way to the use of biomimetic robots in behavioral ecology experiments,as substitutes for real predators. | Donato Romano Hadeel Elayan Giovanni Benelli Cesare Stefanini | 2020 | Journal of Bionic Engineering2020，17，1： | 1 |
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