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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 3 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 4 | 室间隔切除术:治疗梗阻性肥厚型心肌病的金标准显示文摘梗阻性肥厚型心肌病(HCM)间隔切除术的治疗方法几乎与HCM文献报道同时出现。现在越来越清楚的表明,间隔切除术是一种缓解流出道梗阻症状最可靠的治疗方法。间隔切除术在HCM治疗中地位的不断提高,主要是因为:(1)对梗阻的患病率及其影响认识更加清楚;(2)通过与酒精消融术的比较,使我们对该术式的认识更加清楚。下面我们介绍一下Mayo医院外科治疗HCM的经验。 | Joseph A Dearani Hartzell V Schaff Steve R Ommen | 2009 | 中华心血管病杂志2009，37，4： | 7 |
| 5 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 6 | Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice显示文摘 | Bego?a Ochoa Wing‐Kin Syn Igotz Delgado Gamze F. Karaca Youngmi Jung Jiangbo Wang Ana M. Zubiaga Olatz Fresnedo Alessia Omenetti Marzena Zdanowicz Steve S. Choi Anna Mae Diehl | 2010 | Hepatology2010，，： | 2 |
| 7 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 8 | Sex-related differences in IBS patients: central processing of visceral stimuli显示文摘 | Bruce D Naliboff Steve Berman Lin Chang Stuart W.G Derbyshire Brandall Suyenobu Brent A Vogt Mark Mandelkern Emeran A Mayer | 2003 | Gastroenterology2003，，7： | 1 |
| 9 | Effects of inbreeding on survival and growth of Pacific white shrimp Penaeus (Litopenaeus) vannamei 显示文摘 | Dustin R Moss Steve M Arce Clete A Otoshi | 2007 | Aquaculture2007，2721，： | 1 |
| 10 | Mapping Paddy Rice Agriculture in South and Southeast Asia Using Multi-temporal MODIS Images 显示文摘 | Xiao X M Stephen B A Steve F A | 2006 | Remote Sensing of Environment2006，1，15： | 1 |
| 11 | Campbell development of automatic, continuous partial discharge monitoring systems to detect motor and generator partial discharges显示文摘 | Greg C Stone Blake A Lloyd Steve R | 1997 | IEEE1997，，2： | 1 |
| 12 | Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice显示文摘 | Ronaldo A Ribeiro Mariana L Vale Sara M Thomazzi Adriana B.P Paschoalato Steve Poole Sergio H Ferreira Fernando Q Cunha | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 13 | Security awareness of computer users:A Phishing Threat Avoidance Perspective显示文摘 | Nain A G Steve R | 2014 | Computers in Human Behavior2014，38，3： | 1 |
| 14 | Optimal sequential inspections of reliability systems subject to parallel-chain precedence constraints显示文摘 | Chiu Steve Y Jr Cox Louis A Sun Xiaorong | 1999 | Discrete Applied Mathematics1999，9697，： | 1 |
| 15 | Fusarium solani fungal infection of the lateral line canal system in captive scalloped hammerhead sharks (Sphyrna lewini) in Hawaii显示文摘 | Gerald L James A Brock Steve Kaiser | 1995 | Journal of wildlife diseases1995，31，4： | 1 |
| 16 | Seabed properties and sediment erodibility along the western Adriatic margin, Italy显示文摘 | Steves A W Wheatcroft R A Wiberg P L | 2007 | Continental Shelf Research2007，27，34： | 1 |
| 17 | Comparison of the prophylactic antiemetic ef-fect of ondansetron and droperidol on patients undergoing gynecologic laparoscopy显示文摘 | Sniadach M Steve A | 1997 | Anesth Analg1997，85，4： | 1 |
| 18 | Parallel tran-sient dynamics simulations:algorithms for contact detection and smoothed particle hydrodynamics显示文摘 | Steve P Steve A Bruce H | 1998 | Journal of Parallel and Distributed Computing1998，50，： | 1 |
| 19 | Exploring laser-induced breakdown spectroscopy for nuclearmaterials analysis and in-situ applications 显示文摘 | Madhavi Z M Steve A Deanne J B | 2012 | Spectrochimica Acta Part B2012，74，12： | 1 |
| 20 | Phase variation in Helicobacter pylori lipopolysaccharide due to change in the lengths of poly(c)tracts inα3-fucosyltransferase genes显示文摘 | Martin Steve L Monteiro Mario A | 1999 | Infect Immun1999，67，10： | 1 |
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