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| 1 | The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting显示文摘Background Vascular smooth muscle cells (VSMCs) can express heme-oxygenase (HO), a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO). VSMC-derived CO can suppress VSMC proliferation and may serve as an antiproliferation factor. The promoter region of HO-1 shows a polymorphism with different (GT)_n repeats that has been reported to differently induce gene expression. The objective of this study was to examine the effect of this variation on the occurrence of restenosis after in-stent treatment in patients with coronary artery disease. Methods Candidates who underwent coronary stent implantation were genotyped for the HO-1 promoter polymorphism using polymerase chain reaction (PCR) and automated DNA capillary sequencer. Serum levels of IL-6 and C-reactive protein (CRP) were obtained at baseline, 24 hours and 48 hours after stenting. The primary end point for the study was angiographic evidence of in-stent restenosis at 6 months. All parameters for evaluation of restenosis were analysed by quantitatve computer-assisted angiographic analysis (QCA). Results One hundred and eighty-seven patients who underwent coronary stent implantation were studied of whom 27.8% showed ≥50% restenosis after 6 months. The distribution of (GT)_n repeats of all patients in the promoter region of HO-1 genotype ranged from 22 to 42, with (GT)_ 25 and (GT)_ 32 being the two most common alleles. The allelic repeats were divided into the short class (S) with 29 (GT)_n, the middle class (M) with 30-37 (GT)_n and the long class (L) with 38 (GT)_n. There was no significant difference in the restenosis between the genotype groups or between post operation levels of inflammation markers, but carriers of the S allele (n=120) had 33.3% lower baseline IL-6 compared with non-S carriers (n=67, P=0.0008). Conclusions Although no association was observed between the HO-1 promoter polymorphism aod coronary in-stent restenosis following the stent procedure, the association with plasma IL-6 levels suggests that HO-1 S allele might protect from the atherosclerotic inflammatory process. | LI Ping Mohamed A. Elrayess Abuzeid H. Gomma Jutta Palmen Emma Hawe Kim M. Fox Steve E. Humphries | 2005 | Chinese Medical Journal2005，，18： | 6 |
| 2 | Breast cancer angiogenesis — new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting显示文摘 | Adrian L. Harris Huatang Zhang Amir Moghaddam Steve Fox Prudence Scott Adam Pattison Kevin Gatter Ian Stratford Roy Bicknell | 1996 | Breast Cancer Research and Treatment1996，，1： | 1 |
| 3 | Evaluating implicit measures to improve web search显示文摘 | Steve Fox Kuldeep Karnawat Mark Mydland Susan Dumais Thomas White | 2005 | ACM Transactions on Information Systems (TOIS)2005，，2： | 1 |
| 4 | Breast cancer angiogenesis — new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting显示文摘 | Adrian L. Harris Huatang Zhang Amir Moghaddam Steve Fox Prudence Scott Adam Pattison Kevin Gatter Ian Stratford Roy Bicknell | 1996 | Breast Cancer Research and Treatment1996，，1： | 1 |
| 5 | The structure of phosphorylated p38Y is monomeric and reveals a conserved activation-loop conformation显示文摘 | Steve Bellon Matthew J Fitzgibbon Ted Fox | 1999 | Research Article1999，7，： | 1 |
| 6 | Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages显示文摘 | Lauren Kent Lucy Smyth Chris Clayton Laurie Scott Ted Cook Richard Stephens Steve Fox Peter Hext Stuart Farrow Dave Singh | 2008 | Cytokine2008，，2： | 1 |
| 7 | The structure of phos- phorylated p38γis monomeric and reveals a conserved activation-loop conformation 显示文摘 | Steve Bellon Matthew J Fitzgibbon Ted Fox | 1999 | Research Article1999，7，： | 1 |
| 8 | Evaluating Implicit Measures to Improve Web Search 显示文摘 | Steve Fox Kuldeep Karnawat Mark Mydland Susan Dumais Thomas White | 2005 | ACM Transactions on Information Systems2005，2，23： | 1 |
| 9 | Windows95话短长显示文摘Windows 95给业界带来了一阵旋风。几年前,业界曾经热烈地讨论过是否应该从DOS操作系统转到Windows 3.0、3.1,当时的中心话题是从字符界面向图形界面的过渡;而我们现在所讨论的是否应该从Windows 3.1、3.2转到Windows 95,其主题则是从16位操作系统转到32位操作系统是否值得?因此用户所关心的问题应该主要集中在32位的Windows 95能够带来什么实际的好处,以及用户是否负担得起其开销这样的问题上。以下辑录的几篇短文区别于大量关于Windows 95的讨论文章,所探讨的都是最为实际的问题。也许其中反面意见居多,但慎重总是正确的。 | Steve Fox 王冬梅 | 1995 | 计算机世界月刊1995，，11： | 0 |
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