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| 1 | Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test显示文摘AIM:To study intestinal permeability(IP) and its relationship to the disease activity in patients with inflammatory bowel diseases(IBD)-Crohn's disease(CD) and ulcerative colitis(UC).METHODS:Fifty-eight patients with active IBD(32 with CD and 26 with UC) and 25 healthy controls consented to participate in the study.The clinical activity of CD was estimated using the Crohn's Disease Activity Index(CDAI),and the endoscopic activity of UC using the Mayo scoring system.IP was assessed by the rise in levels of iohexol,which was administered orally(25 mL,350 mg/mL) 2 h after breakfast.Three and six hours later serum(SIC mg/L) and urine(UIC g/mol) iohexol concentrations were determined by a validated HPLC-UV technique.RESULTS:In the CD group,SIC values at 3 h(2.95 ± 2.11 mg/L) and at 6 h after ingestion(2.63 ± 2.18 mg/L) were significantly higher compared to those of healthy subjects(1.25 ± 1.40 mg/L and 1.11 ± 1.10 mg/L,respectively,P < 0.05).UIC(g/mol) values were also higher in patients,but the differences were significant only for UIC at 6 h.Significant positive correlation(P < 0.05) was found between the CDAI and IP,assessed by SIC at 3 h(r = 0.60) and 6 h(r = 0.74) after the ingestion.In comparison to controls,SIC and UIC of UC patients were higher in the two studied periods,but the differences were significant at 6 h only.Significantly higher values of SIC(P < 0.05) were found in patients with severe endoscopic activity of UC compared to those of patients with mild and moderate activity(3.68 ± 3.18 vs 0.92 ± 0.69 mg/L).CONCLUSION:Serum levels of iohexol at 3 h and 6 h after its ingestion reflect increased IP,which is related to the disease activity in patients with IBD. | Vanya A Gerova Simeon G Stoynov Dimitar S Katsarov Dobrin A Svinarov | 2011 | World Journal of Gastroenterology2011，17，17： | 6 |
| 2 | Synthesis of nanoparticles by borohydride reduction and their applications显示文摘 | Stoynov Z B Klabunde K J | 2001 | Scripta Materials2001，44，： | 1 |
| 3 | Synthesis ofnanoparticles by borohydride reduction and their applications显示文摘 | Dragieva I D Stoynov Z B Klabunde K J | 2001 | Scripta Mater2001，44，： | 1 |
| 4 | Synthesis of nanoparticles by borohydride reduction and their applications显示文摘 | Dragieva I D Stoynov Z B Klabunde K J | 2001 | Scripta Mater2001，44，： | 1 |
| 5 | Identification and quantification of newly synthesized proteins translationally regulated by YB-1 using a novel Click-SILAC approach显示文摘 | Somasekharan S P Stoynov N Rotblat B Leprivier G Galpin J D Ahern C A | 2012 | J Proteomics2012，77，： | 1 |
| 6 | Impedance measurement on Pb/H2SO4batteries显示文摘 | KEDDAM M STOYNOV Z TAKENOUTI H | 1977 | J Appl Electrochem1977，，7： | 1 |
| 7 | Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study显示文摘 | K.R. Herrlinger M. Diculescu K. Fellermann H. Hartmann S. Howaldt R. Nikolov A. Petrov W. Reindl J.M. Otte S. Stoynov U. Strauch A. Sturm R. Voiosu A. Ammendola B. Dietrich B. Hentsch E.F. Stange | 2013 | Journal of Crohn’s and Colitis2013，，8： | 1 |
| 8 | Synthesis of nanoparticles by borohydride reduction and their applications显示文摘 | STOYNOV Z B KLABUNDE K J | 2001 | Scripta Mater2001，44，： | 1 |
| 9 | 对汽车蓄电池穿壁焊阻抗的研究显示文摘引言穿壁焊的质量决定着汽车铅酸蓄电池的寿命和可靠性。劣质焊接经常引起电池早期失效,因此要求在电池生产过程中采用严格的质量控籍程序。这样一来,人们对进一步完善和发展穿壁焊质量分析试验方法逐渐产生了兴趣。 目前通常的做法是利用机械剪切强度测定焊接质量。 | Z. Stoynov 王惠卿 | 1990 | 蓄电池1990，，4： | 0 |
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