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| 1 | Functional dyspepsia:a pragmatic approach显示文摘 | Giurcan R Voiosu TA | 2010 | Rom J Intern Med2010，48，1： | 1 |
| 2 | NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients显示文摘AIM:To investigate the small bowel of seronegative spondyloarthropathy(SpA) patients in order to ascertain the presence of mucosal lesions.METHODS:Between January 2008 and June 2010,54 consecutive patients were enrolled and submitted to avideo capsule endoscopy(VCE) examination.Historyand demographic data were taken,as well as the history of non-steroidal anti-inflammatory drug(NSAID) consumption.After reading each VCE recording,a capsule endoscopy scoring index for small bowel mucosal inflammatory change(Lewis score) was calculated.Statistical analysis of the data was performed.RESULTS:The Lewis score for the whole cohort was 397.73.It was higher in the NSAID consumption subgroup(P = 0.036).The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel,but not for its distal third(P values of 0.036,0.001 and 0.18,respectively).There was no statistical significant difference between the groups with regard to age or sex of the patients.CONCLUSION:The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel,but not for its distal part. | Mihai Rimba■ Mǎdǎlina Marinescu Mihail Radu Voiosu Cristian Rǎsvan Bǎicu■ Simona Caraiola Adriana Nicolau Doina Ni■escu Georgeta Camelia Badea Magda Ileana Parvu | 2011 | World Journal of Gastroenterology2011，17，8： | 1 |
| 3 | Antibiotic Prophylaxis Prior to Elective ERCP Does Not Alter Cholangitis Rates or Shorten Hospital Stay: Results of an Observational Prospective Study of 138 Consecutive ERCPS显示文摘 | Voiosu T A Bengusa A Haidar A | 2014 | Maedica2014，9，4： | 1 |
| 4 | Functional dyspepsia: a pragmatic ap- proach显示文摘 | Giurean R Voiosu TA | 2010 | Rom J Intern Med2010，48，1： | 1 |
| 5 | Functional dyspepsia: a pragmatic ap- proach显示文摘 | Giurcan R Voiosu TA | 2010 | Rom J Intern Med2010，48，1： | 1 |
| 6 | Gastro-intesfial lesions induced by non-steroidal anti-inflammatory drugs显示文摘 | ALBU R DRAGOMIR P VOIOSU R | 1998 | Rom J Intern Med1998，36，34： | 1 |
| 7 | Thl7 and IL-17 immunity in chronic hepatitis C infection 显示文摘 | Balanescu P Ladaru A Voiosu T | 2012 | Rom J Intern Med2012，50，1： | 1 |
| 8 | Functional dys- pepsia today显示文摘 | Voiosu TA Giurcan R Voiosu AM | 2013 | Maedica(Buchar)2013，8，1： | 1 |
| 9 | Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study显示文摘 | K.R. Herrlinger M. Diculescu K. Fellermann H. Hartmann S. Howaldt R. Nikolov A. Petrov W. Reindl J.M. Otte S. Stoynov U. Strauch A. Sturm R. Voiosu A. Ammendola B. Dietrich B. Hentsch E.F. Stange | 2013 | Journal of Crohn’s and Colitis2013，，8： | 1 |
| 10 | Rapid fecal calprotectin testing predicts mncosal healing better than C-reactive protein and serum tumor necrosis factor ct in patients with ulcerative colitis 显示文摘 | Voiosu T Bengus A Baiaescu P | 2015 | Rom J Intern Med2015，，： | 1 |
| 11 | Th17 and IL-17 immunity inchronic hepatitis C infection显示文摘 | B l nescu P L daru A Voiosu T | 2012 | Rom J Intern Med2012，50，1： | 1 |
| 12 | Surrogate markers of mucosal healing in inflammatory bowel disease:A systematic review显示文摘Mucosal healing(MH)has emerged as a key therapeutic target in inflammatory bowel disease(IBD),and achievement of this goal is documented by endoscopy with biopsy.However,colonoscopy is burdensome and invasive,and substitution with an accurate noninvasive biomarker is desirable.AIM To summarize published data regarding the performance of noninvasive biomarkers in assessing MH in IBD patients.METHODS We conducted a systematic review of studies that reported the performance of biomarkers in diagnosing MH in patients with IBD.The main outcome measure was to review the diagnostic accuracy of serum and fecal markers that showed promising utility in assessing MH.RESULTS We screened 1301 articles,retrieved 46 manuscripts and included 23 articles for full-text analysis.The majority of the included manuscripts referred to fecal markers(12/23),followed by circulatory markers(8/23);only 3/23 of the included manuscripts investigated combined markers(serum and/or fecal markers).Fecal calprotectin(FC)was the most investigated fecal marker for assessing MH.In ulcerative colitis,for cutoff levels ranging between 58 mcg/g and 490 mcg/g,the sensitivity was 89.7%-100%and the specificity was 62%-93.3%.For Crohn’s disease,the cutoff levels of FC ranged from 71 mcg/g to 918 mcg/g(sensitivity 50%-95.9%and specificity 52.3%-100%).The best performance for a serum marker was observed for the endoscopic healing index,which showed a comparable accuracy to the measurement of FC and a higher accuracy than the measurement of serum C-reactive protein.CONCLUSION Several promising biomarkers of MH are emerging but cannot yet substitute for endoscopy with biopsy due to issues with reproducibility and standardization assessing MH.In ulcerative colitis,for cutoff levels ranging between 58 mcg/g and 490 mcg/g,the sensitivity was 89.7%-100%and the specificity was 62%-93.3%.For Crohn’s disease,the cutoff levels of FC ranged from 71 mcg/g to 918 mcg/g(sensitivity 50%-95.9%and specificity 52.3%-100%).The best performance for a serum marker was observed for the endoscopic healing index,which showed a comparable accuracy to the measurement of FC and a higher accuracy than the measurement of serum C-reactive protein.CONCLUSION Several promising biomarkers of MH are emerging but cannot yet substitute for endoscopy with biopsy due to issues with reproducibility and standardization. | Monica State Lucian Negreanu Theodor Voiosu Andrei Voiosu Paul Balanescu Radu Bogdan Mateescu | 2021 | World Journal of Gastroenterology2021，27，16： | 0 |
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