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| 1 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 2 | Robot-assisted surgery for gastric cancer显示文摘Minimally invasive surgery for gastric cancer is a rela-tively new research field, with convincing results mostly stemming from Asian countries. The use of the robotic surgery platform, thus far assessed as a safe procedure, which is also easier to learn, sets the background for a wider spread of minimally invasive technique in the treatment of gastric cancer. This review will cover the literature published so far, analyzing the pros and cons of robotic surgery and highlighting the remaining study questions. | livia procopiuc stefan tudor mircea manuc mircea diculescu catalin vasilescu | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 2 |
| 3 | Folic acid and sul?fasalazine for colorectal carcinoma chemoprevention in patients with ul?cerative colitis: the old and new evidence 显示文摘 | Diculescu M Cioetrlan M Cioctrlan M | 2003 | Rom J Gastroenterol2003，12，4： | 1 |
| 4 | Voltammetric Behavior of Antileukemia Drug Glivec 显示文摘 | Diculescu VC Vivan M Oliveira Brett AM | 2006 | Part Ⅱ -Redox Processes of Glivec Electrochemical Metabolite Electroanalysis2006，14，9： | 1 |
| 5 | The importance of histopathological and clinical variables in predicting the evolution of colon cancer显示文摘 | Diculescu M Iacob R Iacob S | 2002 | Rom J Gastroenterol2002，11，3： | 1 |
| 6 | Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study显示文摘 | Herrlinger KR Diculescu M Fellermann K | 2012 | J Crohns Colitis2012，，： | 1 |
| 7 | Shape controlled palladium nanowires and nanoparticles electrodeposited on carbon electrodes显示文摘 | CORDUNEANU O DICULESCU V C CHIORCEA-PAQUIM A M | 2008 | J Electroanal Chem2008，624，12： | 1 |
| 8 | 查看详情显示文摘 | Oliveira-Brett A.M Diculescu V.C | | 0，，： | 1 |
| 9 | Electrochemical behaviour of isatin at a glassy carbon electrode显示文摘 | Diculescu V C Kumbhat S Oliveira-Brett A M | 2006 | Anal Chim Acta2006，575，： | 1 |
| 10 | 查看详情显示文摘 | Shah A Diculescu V.C Qureshi R Oliveira-Brett A.M | | 0，，： | 1 |
| 11 | Electrochemical study of quercetin-DNA interactions part Ⅱ: in situ sensing with DNA biosensors显示文摘 | OLIVEIRA-BRETT A M DICULESCU V C | 2004 | Bioelectrochem2004，64，： | 1 |
| 12 | The importance of histopathological and clinical variables in predicting the evolution of colon cancer显示文摘 | DICULESCU M IACOB R IACOB S | 2002 | Rom J Gastroenterol2002，11，： | 1 |
| 13 | Interaction of Imatinib with Lipesomes:Voltammetric and AFM Characterization显示文摘 | DICULESCU V C CHIORCEA-PAQUIM A M TUGULEA L | 2009 | Bioelectrechemistry2009，74，2： | 1 |
| 14 | Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study显示文摘 | K.R. Herrlinger M. Diculescu K. Fellermann H. Hartmann S. Howaldt R. Nikolov A. Petrov W. Reindl J.M. Otte S. Stoynov U. Strauch A. Sturm R. Voiosu A. Ammendola B. Dietrich B. Hentsch E.F. Stange | 2013 | Journal of Crohn’s and Colitis2013，，8： | 1 |
| 15 | Electro- chemical DNA Sensors for Detection of DNA Damage 显示文摘 | Diculescu V C Chiorcea Paquim A M Oliveira Brett A M | 2005 | Sensors2005，，5： | 1 |
| 16 | Electrochemistry of nanoscale DNA surface films on carbon显示文摘 | Oliveira-Brett M Paquim A M C Diculescu V C | 2006 | Med Eng Phys2006，28，10： | 1 |
| 17 | Adding pegylated interferon to entecavir for hepatitis B e antigen–positive chronic hepatitis B: A multicenter randomized trial (ARES study)显示文摘 | Willem Pieter Brouwer Qing Xie Milan J. Sonneveld Ningping Zhang Qin Zhang Fehmi Tabak Adrian Streinu‐Cercel Ji‐Yao Wang Ramazan Idilman Hendrik W. Reesink Mircea Diculescu Krzysztof Simon Mihai Voiculescu Meral Akdogan Wlodzimierz Mazur Jurrien G.P. Reij | 2015 | Hepatology2015，，： | 1 |
| 18 | Endoscopic knot tying:In vitro assessment in a porcine stomach model显示文摘AIM:To determine if surgical knotting performed via endoscopy is an effective closure method for natural orifice translumenal endoscopic surgery. METHODS:The proposed method was tested on an in vitro pig stomach model using standard endoscopy suite materials. A single use laparoscopy trocar (Versaport Plus manufactured by Tyco Healthcare) was fixed onto a plastic rectangular box in a horizontal position. A fresh pig stomach was tightly attached via its esophageal end to the trocar opening on the inner side of the box. The stomach cavity was closed at the duodenal end with Kocher forceps. A standard upper gastrointestinal endoscope fitted at its tip with a transparent plastic cap was introduced into the stomach through the outer trocar opening, so that the passage of the surgical trocar would mimic the passage of an esophagus. The stomach was subsequently inflated, followed by irrigation and washing. A neutral electrode of an electrocautery unit was placed inside the plastic box, un-derneath the pig stomach. The stomach's outer surface was kept moist using normal saline in order to maintain the natural elasticity and to ensure good contact with the electrode. RESULTS:The submucosal space on the anterior face of the stomach was accessed using the technique of endoscopic submucosal dissection. First, a site on the anterior face of the stomach was chosen, near the angle. Then, saline was injected into the submucosa with a standard endoscopic needle, so as to create a 20 mm diameter elevation. A linear 15 mm vertical incision was created at its center using a Dual Knife (KD650U manu-factured by Olympus). This incision was used to access the submucosal space, and about 10 mm was dissected on both sides of the incision. The endoscope was then pushed through to the outside of the stomach after dilating a small puncture made by the Dual Knife in the muscularis propria , which simulated the peritoneoscopy procedure. Then, a 0.025' guidewire (Jagwire/450 cm manufactured by Boston Scientific) was inserted into the puncture, followed by a dilating balloon (Quantum TT manufactured by Cook Medical) that was used to enlarge the aperture orifice. After withdrawing the scope back into the stomach, the procedure continued with guidewires being passed from the submucosal space into the gastric lumen through small orifices on the left and right sides of the mucosal opening. These orifices were made with the Dual Knife, and the guidewires were inserted via a guiding catheter (HGC-6 man-ufactured by Cook Medical). As the guidewires were pulled outside of the stomach, they were replaced with a single surgical suture that had been initially attached to their tip and was now untied. Finally, one loop of this surgical suture was formed on the exterior. One loop end was fixed while the opposite suture end was pulled by biopsy forceps through the endoscope channel as the scope was inserted into the stomach. The loop was advanced until it approached and fixed the two muco-sal incision margins. Three alternating loops were made in this manner to create a genuine tight surgical knot.CONCLUSION:Endoscopic knotting of the gastric wall is feasible, but an in vitro survival study is necessary to validate clinical significance. | Mihai Ciocirlan Mirela Elena Ionescu Mircea Mihai Diculescu | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，1： | 0 |
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