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您的检索式：作者名="Sun Fenglan"
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| 1 | A Genomic Variation Map Provides Insights into the Genetic Basis of Spring Chinese Cabbage (Brassica rapa ssp.pekinensis)Selection显示文摘Chinese cabbage is the most consumed leafy crop in East Asian countries.However,premature bolting induced by continuous low temperatures severely decreases the yield and quality of the Chinese cabbage, and therefore restricts its planting season and geographic distribution.In the past 40years,spring Chinese cabbage with strong winterness has been selected to meet the market demand.Here,we report a genome variation map of Chinese cabbage generated from the resequencing data of 194 geographically diverse accessions of three ecotypes.In-depth analyses of the selection sweeps and genome-wide patterns revealed that spring Chinese cabbage was selected from a specific population of autumn Chinese cabbage around the area of Shandong peninsula in northern China.We identified 23 genomic loci that underwent intensive selection,and further demonstrated by gene expression and haplotype analyses that the incorporation of elite alleles of VERNALISATION INSENTIVE 3.1(BrVIN3.1)and FLOWER LOCUS C 1(BrFLC1)is a determinant genetic source of variation during selection.Moreover,we showed that the quantitative response of BrVIN3.1 to cold due to the sequence variations in the cis elements of the BrVlN3.1 promoter significantly contributes to bolting-time variation in Chinese cabbage.Collectively, our study provides valuable insights into the genetic basis of spring Chinese cabbage selection and will facilitate the breeding of bolting-resistant Varieties by molecular-marker-assisted selection,transgenic or gene editingapproaches. | Tongbing Su Weihong Wang Peirong Li Bin Zhang Pan Li Xiaoyun Xin Honghe Sun Yangjun Yu Deshuang Zhang Xiuyun Zhao Changlong Wen Gang Zhou Yuntong Wang Hongkun Zheng Shuancang Yu Fenglan Zhang | 2018 | Molecular Plant2018，11，11： | 6 |
| 2 | Mossbauer spectrum of annealing amorphous FeSiB powders 显示文摘 | Zhang Baofeng Sun Fenglan Wang Jingyin | 2001 | Journal of Tianjin University2001，34，3： | 1 |
| 3 | Microfluidics in cardiovascular disease research: state of the art and future outlook显示文摘Due to extremely severe morbidity and mortality worldwide,it is worth achieving a more in-depth and comprehensive understanding of cardiovascular diseases.Tremendous effort has been made to replicate the cardiovascular system and investigate the pathogenesis,diagnosis and treatment of cardiovascular diseases.Microfluidics can be used as a versatile primary strategy to achieve a holistic picture of cardiovascular disease.Here,a brief review of the application of microfluidics in comprehensive cardiovascular disease research is presented,with specific discussions of the characteristics of microfluidics for investigating cardiovascular diseases integrally,including the study of pathogenetic mechanisms,the development of accurate diagnostic methods and the establishment of therapeutic treatments.Investigations of critical pathogenetic mechanisms for typical cardiovascular diseases by microfluidic-based organ-on-a-chip are categorized and reviewed,followed by a detailed summary of microfluidic-based accurate diagnostic methods.Microfluidic-assisted cardiovascular drug evaluation and screening as well as the fabrication of novel delivery vehicles are also reviewed.Finally,the challenges with and outlook on further advancing the use of microfluidics technology in cardiovascular disease research are highlighted and discussed. | Qingming Ma Haixia Ma Fenglan Xu Xinyu Wang Wentao Sun | 2021 | Microsystems & Nanoengineering2021，7，2： | 1 |
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