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| 1 | Are serum leptin levels predicted by lipoproteins, vitamin D and body composition?显示文摘BACKGROUND Both obesity and vitamin D deficiency are important health issues in Pakistan.The connection between body composition, Vitamin D and leptin in young adults is important to be studied as body composition may affect bone health and therefore the possibility of osteoporosis in later life. Few studies have attempted to investigate the effect of body composition and leptin with vitamin D in adolescence.AIM To investigate the association of serum leptin with body composition, lipids and25-hydroxyvitamin D(25 OHD) in adults.METHODS This cross-sectional study was conducted on 167 apparently healthy adults.Demographics were recorded, bioelectrical impedance analysis was performed and clinical history noted. Serum leptin was measured using DIA source kit on ELISA and total 25 OHD was measured on ADVIA-Centaur; Siemens. Total cholesterol and high density lipoprotein cholesterol were quantified using Enzymatic Endpoint Method and Cholesterol Oxidase-Phenol Aminophenazone method respectively. Biochemical analysis was done in the Departments of Pathology and Laboratory Medicine and Biological and Biomedical Sciences, Aga Khan University Hospital Karachi Pakistan.RESULTS Median age of the group(n = 167) was 20 years(IQR 27-20); 55.7% were females.Majority(89.2%, n = 149) of the study group was 25 OHD deficient, 6%(n = 10)had insufficient serum 25 OHD levels and 4.8%(n = 8) had sufficient D levels.Females, had higher median leptin levels [2.71(IQR 4.76-1.66 ng/mL)] compared to their counterparts [1.3(3.60-0.54 ng/mL), P < 0.01]. Multiple regression analysis suggested that basal metabolic rate, muscle mass, body fat percent, bone mass and serum 25 OHD were the most contributing factors to serum leptin levels. Bone mass and serum 25 OHD in fact bore a negative correlation with leptin.CONCLUSION The results indicate that basal metabolic rate, muscle mass, body fat percent, bone mass and serum 25 OHD have an impact on serum leptin. Being a cross sectional study causal relationship between leptin and other variables could not be determined. | Aysha Habib Khan Syeda Sadia Fatima Ahmed Raheem Lena Jafri | 2019 | World Journal of Diabetes2019，10，4： | 4 |
| 2 | Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study显示文摘AIM To assess circulatory levels of interleukin-18(IL-18) and determine whether the presence of IL-18 promoter polymorphism influences metabolic syndrome phenotypes. METHODS This study recruited one hundred and eighty individuals divided into three groups with sixty subjects each as: Normal weight(18.0-22.9 kg/m^2), overweight(23.0-25.9 kg/m^2) and obese(> 26.0 kg/m^2) according to South Asian criteria of BMI. Fasting blood glucose(FBG), Lipid profile, insulin, IL-18 and tumor necrosis factor(TNF)α were measured using ELISA kits, whereas low density lipoprotein(LDL)-cholesterol, insulin resistance(HOMA-IR) and insulin sensitivity(QUICKI) were calculated. The body fat percentage(BF) was measured through bioelectrical impedance analysis; waist and hip circumference were measured. Genotyping of IL-18-607 C/A polymorphism was performed by using tetraprimer amplification refractory mutation system. Student t test, One-way analysis of variance, Hardy-Weinberg equilibrium, Pearson's χ~2 test and Pearson's correlation were used, where a P value < 0.05 was considered significant.RESULTS In an aged matched study, obese subjects showed higher levels of FBG, cholesterol, triglycerides and LDL levels as compared to normal weight(P < 0.001).Highest levels of IL-18 and TNF levels were also seen in obese subjects(IL-18: 58.87 ± 8.59 ng/L)(TNF: 4581.93 ± 2132.05 pg/m L). The percentage of IL-18-607 A/A polymorphism was higher in overweight and obese subjects vs normal weight subjects(P < 0.001). Moreover, subjects with AA genotype had a higher BF, insulin resistance, TNFα and IL-18 levels when compared with subjects with AC(heterozygous) or CC(wild type) genotypes. However, we did not find any difference in the lipid profile between three subgroups. CONCLUSION This preliminary data suggests that IL-18 polymorphism affects IL-18 levels that might cause low grade inflammation, further exacerbated by increased TNFα. All these increase the susceptibility to develop Met S. Further studies are required to validate our findings. | Syeda Sadia Fatima Zehra Jamil Syed Hani Abidi Daniyal Nadeem Zara Bashir Ahmed Ansari | 2017 | World Journal of Diabetes2017，8，6： | 1 |
| 3 | Serum total bilirubin levels and prevalence of diabetic retinopathy in a Chinese population显示文摘 | Syeda Sadia Najam Jichao | 2014 | Journal of diabetes2014，6，3： | 1 |
| 4 | New roles of the multidimensional adipokine: Chemerin显示文摘 | Syeda Sadia Fatima Rehana Rehman Mukhtiar Baig Taseer Ahmed Khan | 2014 | Peptides2014，，： | 1 |
| 5 | Serum total bilirubin levels and prevalence of diabetic retinopathy in a C hinese population (中国人群血清总胆红素水平与糖尿病视网膜病变相关性的研究)显示文摘 | Syeda Sadia Najam Jichao Sun Jie Zhang Min Xu Jieli Lu Kan Sun Mian Li Tiange Wang Yufang Bi Guang Ning | 2014 | Journal of Diabetes2014，，： | 1 |
| 6 | Epidermal growth factor receptor rs17337023 polymorphism in hypertensive gestational diabetic women: A pilot study显示文摘BACKGROUND Women with gestational diabetes mellitus have an increased risk of developing gestational hypertension,which can increase fetal and neonatal morbidity and mortality.In the past decade,single nucleotide polymorphisms in several genes have been identified as risk factors for development of gestational hypertension.The epidermal growth factor receptor activates tyrosine kinase mediated blood vessels contractility;and inflammatory cascades.Abnormalities in these mechanism are known to contribute towards hypertension.It is thus plausible that polymorphisms in the epidermal growth factor receptor gene would be associated with the development of hypertension in women with gestational diabetes.AIM To determine whether the epidermal growth factor receptor rs17337023 SNP is associated with the occurrence of hypertension in gestational diabetic women.METHODS This pilot case-control study was conducted at two tertiary care hospitals in Karachi,from January 2017-August 2018.Two hundred and two women at 28 week of gestation with gestational diabetes were recruited and classified into normotensive(n=80)and hypertensive(n=122)groups.Their blood samples were genotyped for epidermal growth factor receptor polymorphism rs17337023 using tetra-ARMS polymerase chain reaction.Descriptive analysis was applied on baseline data.Polymorphism data was analyzed for genotype and allele frequency determination using chi-squared statistics.In all cases,a P value of<0.05 was considered significant.RESULTS Subjects were age-matched and thus no difference was observed in relation to age of the study subjects(P>0.05).Body fat percentage was significantly higher in hypertensive females as compared to normotensive subjects(35.138±4.29 Case vs 25.01±8.28 Control;P<0.05).Similarly,systolic and diastolic blood pressures among groups were significantly higher in hypertensive group than the normotensive group(P<0.05).Overall epidermal growth factor receptor rs17337023 polymorphism genotype frequency was similar in both groups,with the heterozygous AT genotype(56 in Case vs 48 in Control;P=0.079)showing predominance in both groups.Furthermore,the odds ratio for A allele was 1.282(P=0.219)and for T allele was 0.780(P=0.221)in this study.CONCLUSION This pilot study indicates that polymorphisms in rs17337023 may not be involved in the pathophysiology of gestational hypertension in gestational diabetes via inflammatory cascade mechanism.Further large-scale studies should explore polymorphism in epidermal growth factor receptor and other genes in this regard. | Russell S Martins Taimur Ahmed Sabah Farhat Sana Shahid Syeda Sadia Fatima | 2019 | World Journal of Diabetes2019，10，7： | 1 |
| 7 | Vaccination Approach Toward Monkeypox: An Urgent Call显示文摘1.Introduction Following the global COVID-19 emergency,another public health emergency was declared by the World Health Organization on July 23,2022:“monkeypox.”Monkeypox virus(MPXV)belongs to the Poxviridae family and causes monkeypox,a disease clinically similar to smallpox.[1,2]Monkeypox was discovered in 1958 after two outbreaks of poxlike disease in research colonies of monkeys.The first known human infection was in 1970 in a newborn in the Democratic Republic of Congo.[3]Monkeypox began to reemerge in 2022,and the evolution of the outbreak is worrisome,as it does not seem that the pandemic,which has affected large numbers of people worldwide,is slowing down significantly.Nature reported more than 57,000 cases and approximately 22 deaths on September 13.[4]Animal-to-human and human-to-human transmissions are two possible routes of transmission for MPXV.According to the clinicians,intimate sexual contact was the suspected route of transmission for the MPXV in 95% of cases.Homosexual or bisexual men,as well as other men who have sex with men,have been particularly hard hit by the current outbreak.Compared with smallpox,symptoms are similar but less severe and include pustular skin lesions,fever,headache,myalgia,and lymphadenopathy.The rash usually begins on the lips and spreads to the face and then to the limbs in a circular pattern. | Minahil Binte Saleem Somina Shaikh Sadia Tahir Syeda Lamiya Mir Govinda Khatri | 2023 | Infectious Diseases & Immunity2023，3，1： | 0 |
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