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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Single line or parallel lines: NK cell differentiation driven by T-bet and Eomes显示文摘 | Xiaojun Jiang Yonglin Chen Hui Peng Zhigang Tian | 2012 | Cellular & Molecular Immunology2012，9，3： | 9 |
| 3 | Memory NK cells: why do they reside in the liver?显示文摘有免疫力的记忆是适应免疫的特点。然而,最近的研究给那个生来的杀手(NK ) 看了房间,天生的免疫系统的关键部件,也调停在鼠标和人的存储器回答。惊人地,记忆 NK 房间是在一些模型的肝居民,提出肝是否是为 NK 房间记忆的获得的一个特殊机关的问题。这里,我们由总结最近的进步考察 NK 房间记忆的特征并且讨论肝怎么可以产生开始和记忆的召回阶段。我们建议肝可以为记忆 NK 房间有唯一的先锋,它从房间从骨头髓导出的 NK 是发展地不同的。 | Xiaojun Jiang Yonglin Chen Hui Peng Zhigang Tian | 2013 | Cellular & Molecular Immunology2013，10，3： | 9 |
| 4 | Optimal deadlock avoidance Petri net supervisors for automated manufacturing systems显示文摘僵局回避问题为与灵活路由生产系统自动化被调查。基于系统的 Petri 网络模型,第一次,这篇论文建议完美的最大的资源转变电路和他们的浸透的状态的概念。这个概念便于实时海角描述和死锁回避 Petri 让监督人赚的系统的开发。僵局作为到达他们的浸透的状态的一些完美的 maximalresource 转变电路被描绘。为生产系统,它不包含中心资源的一个大班,最佳的僵局回避 Petri 网监督人被介绍。为一个一般生产系统,一个方法为减少 systemPetri 网络模型被建议以便减少的模型不包含中心资源并且因此,让最佳的死锁回避 Petri 捕捞监督人。控制减少的 Petri 网模型当时能是使用的著名计算机生产厂商他系统的实时海角监督人。 | Keyi XING Feng TIAN Xiaojun YANG | 2007 | 控制理论与应用(英文版)2007，5，2： | 7 |
| 5 | Fabrication of single-walled carbon nanotube-based highly sensitive gas sensors显示文摘A highly sensitive single-walled carbon nanotube(SWCNT)-based ammonia(NH3) gas detector is manufactured by orderly assembling SWCNT using the dielectrophoretical(DEP) technology.Atom force microscopy(AFM) and scanning electron microscopy(SEM) images revealed that SWCNTs were assembled between the microelectrodes.SWCNTs were affected by the electrophoretic force which was carried out by the related theoretical analysis in a nonuniform electric field.The SWCNT field effect transistors geometry was obtained.The electrical performance of NH3 gas sensor with the SWCNT field effect transistors geometry was tested before and after the adoption of NH3 at room temperature.Experimental results indicated that the efficient assembly of SWCNT was obtained by the applied alternating current voltage with frequency of 2 MHz and amplitude of 10 V.The SWCNTs-based gas sensor had high sensitivity to NH3,and the electrical conductance of NH3 gas sensor reduced two times after interaction with NH3.The SWCNTs surface gas molecules were removed by means of ultraviolet ray irradiation for 10 min.Hence,the fabricated NH3 gas sensor could be reversible.There is a clear evidence that the adsorption of NH3 on the SWCNT channel is easy to be realized.Our theoretical results are consistent with recent experiments. | XU Ke TIAN XiaoJun WU ChengDong LIU Jian LI MengXin SUN Ying WEI FaNan | 2013 | Science China(Technological Sciences)2013，56，1： | 4 |
| 6 | Analysis of Ground Motion Attenuation Characterization for Moderate Earthquakes in the Sichuan-Yunnan Region显示文摘The ground motion attenuation models for PGA,PGV and response spectrum at rock sites and soils sites are derived separately from the digital strong motion records of moderate earthquakes in the Sichuan-Yunnan region after 2007. By comparison with Yu Yanxiangs attenuation model for rock sites in western China,reliability of the model is verified for moderate earthquake. According to the distribution of strong motion data against magnitude and epicentral distance,the applicability and reliability of the results in this paper are discussed. | Yu Tian Cui Jianwen Li Xiaojun Yang Liwei | 2015 | Earthquake Research in China2015，29，2： | 3 |
| 7 | Ultra-stable super-resolution fluorescence cryo-microscopy for correlative light and electron cryo-microscopy显示文摘Remarkable progress in correlative light and electron cryo-microscopy(cryo-CLEM) has been made in the past decade. A crucial component for cryo-CLEM is a dedicated cryo-fluorescence microscope(cryo-FM). Here, we describe an ultra-stable superresolution cryo-FM that exhibits excellent thermal and mechanical stability. The temperature fluctuations in 10 h are less than0.06 K, and the mechanical drift over 5 h is less than 200 nm in three dimensions. We have demonstrated the super-resolution imaging capability of this system(average single molecule localization accuracy of ~13.0 nm). The results suggest that our system is particularly suitable for long-term observations, such as single molecule localization microscopy(SMLM) and cryogenic super-resolution correlative light and electron microscopy(csCLEM). | Xiaojun Xu Yanhong Xue Buyun Tian Fengping Feng Lusheng Gu Weixing Li Wei Ji Tao Xu | 2018 | Science China(Life Sciences)2018，61，11： | 3 |
| 8 | Antisense-Induced Blockade of GATA-3 Expression Could Inhibit Th2 Excursion of Tumor Cells in vitro and in vivo显示文摘Previous studies have shown that tumor cells predominantly express Th2 type cytokines and transcription factors.GATA-3, as a Th2-specific transcription factor, plays a central role in positive-regulating Th2 development. So whether the expression of GATA-3 in tumor cells has any effect on tumor development is a question of interest.In the present study, we inhibited the expression of GATA-3 in tumor cells through antisense RNA blockade technique, and observed its effects on tumor in vitro and in vivo. Our results showed that antisense GATA-3treatment could inhibit the expression of TNF-α and Th2 cytokines in tumor cells, and antisense-induced blockade of GATA-3 could also depress tumor growth in tumor-bearing mice. We suggest that the ratio of T-bet/GATA-3 can be evaluated as a more important marker of the status of Th1/Th2 type. And our results might provide some evidence about the molecular regulatory mechanisms in tumor cell development. | Dongzhu Yao~1 Xiaojun Zhang~1 Haiming Wei~1 Zhigang Tian~(1,2) ~1Institute of Immunology,School of Life Sciences,University of Science & Technology of China ~2Corresponding to:Dr.Zhigang Tian,School of Life Sciences,University of Science & Technology of China,No.443,Huangshan Road,Hefei 230027,China. | 2005 | Cellular & Molecular Immunology2005，2，3： | 3 |
| 9 | Study on the large-scale assembly and fabrication method for SWCNTs nano device显示文摘The large-scale assembly and fabrication method for single-walled carbon nanotube(SWCNT) nano devices was implemented.Assembly of SWCNT field effect transistor(FET) was realized by floating potential dielectrophoresis approach.The simulation of floating potential distribution of the chip was performed by comsol multiphysics coupling software.Six hundred devices were assembled on the area of less than one square centimeter.The fabricated devices were characterized by atomic force microscopy and scanning electron microscopy.The experimental results showed that large-scale assembly had been realized,and the success rate of ideal assembly for SWCNT FET had been assessed. | XU Ke TIAN XiaoJun WU ChengDong LIU Jian LI MengXin DONG ZaiLi | 2013 | Science China Chemistry2013，56，3： | 3 |
| 10 | Self-lubricate and anisotropic wear behavior of AZ91D magnesium alloy reinforced with ternary Ti_2AlC MAX phases显示文摘The dry sliding wear behavior of Ti_2AlC reinforced AZ91 magnesium composites was investigated at sliding velocity of 0.5 m/s under loads of 10, 20, 40 and 80 N using pin-on-disk configuration against a Cr15 steel disc. Wear rates and friction coefficients were registered during wear tests. Worn tracks and wear debris were examined by scanning electron microscopy, energy dispersive X-ray spectrometry and transmission electron microscopy in order to obtain the wear mechanisms of the studied materials. The main mechanisms were characterized as the magnesium matrix oxidation and self-lubrication of Ti_2AlC MAX phase. In all conditions, the composites exhibit superior wear resistance and self-lubricated ability than the AZ91 Mg alloy. In addition, the anisotropic mechanisms in tribological properties of textured Ti_2AlC-Mg composites were confirmed and discussed. | Wenbo Yu Deqiang Chen Liang Tian Hongbin Zhao Xiaojun Wang | 2019 | Journal of Materials Science & Technology2019，35，3： | 2 |
| 11 | Cardiopulmonary resuscitation and termination of resuscitation on out-of-hospital cardiac arrest in China显示文摘To the Editor: Out-of-hospital cardiac arrest (OHCA) is a major public health challenge. Early initiation, good quality cardiopulmonary resuscitation (CPR), and the use of an automated external defibrillator (AED) have been reported to significantly improve the survival and long-term outcomes in survivors of OHCA. | Xiaojun He Yang Liu Sijia Tian Jun Liang Shengmei Niu Jinjun Zhang | 2022 | Chinese Medical Journal2022，，9： | 2 |
| 12 | Analysis of common canopy vegetation indices for indicating leaf nitrogen accumulations in wheat and rice显示文摘 | Yan Zhu Xia Yao YongChao Tian XiaoJun Liu WeiXing Cao | 2007 | International Journal of Applied Earth Observations and Geoinformation2007，，1： | 2 |
| 13 | 调强适形放疗在乳腺癌保乳术后应用的系统评价(英文)显示文摘Objective:The aim of this study was to assess the long-term effect of breast conservation with breast intensitymodulated radiotherapy (IMRT) for early-stage breast cancers.Methods:Pub Med,EMBASE,Cochrane Library,Chinese Biomedical Literature Database were searched to identify relevant original published trails,and the references of eligible studies were manually screened.Randomized controlled trails reported in any language,comparing breast IMRT with conventional radiotherapy (RT) in patients with early-stage breast cancer were eligible for inclusion.Two investigators independently assessed the quality of included trials and extracted data.The RevMan 5.0 software was used for statistical analysis.Results:Four trials involving 1440 patients were included.The results showed that in the IMRT group,the occurrence of acute moist dermatitis,the edema of the mammary gland and the occurrence of hyperpigmentation were lower than those of RT group,the pooled risk ratio value and 95% confidence interval were 0.28 (0.17-0.48),0.03 (0.00-0.21) and 0.06 (0.02-0.15) respectively.The use of IMRT did not correlate with pain and quality of life,but the presence of moist desquamation did significantly correlate with pain and reduced quality of life.Conclusion:The currently available evidence showed that IMRT significantly reduces the occurrence of moist acute dermatitis anywhere in the breast and alleviates the suffering of patients and improves the quality of life of patients.Future large-scale,high-quality,double-blind trials are needed. | Xiupeng Ye Ling Su Xiaohu Wang Kehu Yang inhui Tian Qiuning Zhang Qiang Wang Xiaojun Li Yuqing Kang Liyun Guo Ruifeng Liu Shifang Feng | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，12： | 2 |
| 14 | Di-electrophoresis assembly and fabrication of SWCNT field-effect transistor显示文摘In the process of fabricating nano electrical device or system based on single-walled carbon nanotube (SWCNT), the controllable assembly and fabrication of SWCNT field-effect transistor (SWCNT FET) is a key issue. SWCNT FET is the most basic and important component in nano electronics. After microelectrode chip of back-gate FET is designed and fabricated, di-electrophoresis technology is adopted to realize the controllable alignment and assembly of SWCNTs, based on dispersing SWCNT by sodium dodecyl sulphate (SDS) facilitated ultra-sonication technique and removing impurities by centrifugal technique. The experiments of SWCNTs assembly demonstrate that SWCNTs are aligned and assembled uniformly at the microelectrodes gap with the alignment density nearly proportional to di-electrophoresis duration and solution concentration. After the processes of rinsing, drying and improving, metallic SWCNTs among the assembled SWCNTs are burned out and residual SDS is removed, and perfect field-effect performance of SWCNT FET is eventually obtained. | TIAN XiaoJun WANG YueChao YU HaiBo DONG ZaiLi XI Ning TUNG Steve | 2009 | Chinese Science Bulletin2009，54，23： | 2 |
| 15 | Large-scale assembly of Cu/CuO nanowires for nano-electronic device fabrication显示文摘To improve the efficiency of nano-electronic device fabrication,a new method named floating electrical potential assembly is proposed to realize large-scale assembly of Cu/CuO nanowires.The simulation of floating electrical potential distribution on the micro-electrode chip is performed by COMSOL software,and the simulation result shows that the coupled electrical potential on the floating drain electrodes is very close to the original electrical potential applied on the gate electrode,which means that the method can provide di-electrophoresis(DEP)force for all the electrode pairs at one time,thus realizing large-scale assembly at one time.With Cu/CuO nanowires well dispersed and micro-electrode chip fabrication,nanowires assembly experiments are performed and the experimental results show that Cu/CuO nanowires are assembled at hundreds of micro-electrodes pairs at one time,and the success rate of nanowires assembly also reaches 90%. | XU Ke TIAN XiaoJun YU HaiBo YANG Yang ZHOU Lei LIU LianQing | 2014 | Science China(Technological Sciences)2014，57，4： | 2 |
| 16 | Single Cu nanowire assembled by microdroplet dielectrophoresis on ultrahigh tensible microelectrodes显示文摘At present,study on dynamic tensile properties and atomic chain fabrication of single nanowire,for understanding its dynamic tensile properties and unique physical properties of atomic chain to fabricate atom scale devices,is one of frontier research issues in nanoscale science.However,how to assemble single nanowire on a tensible microstructure becomes one of the most difficult problems,which severely restricts the development of this research field.In this paper,after the ultrahigh tensible microelectrode chip is fabricated by MEMS technology,hexamethyldisilazane is utilized to improve hydrophobicity of the chip,and then a microdroplet dielectrophoresis experimental platform and technology is developed to assemble single nanowire on the sensible microelectrode.Experimental results show that accurate and efficient assembly of single Cu nanowire is realized,which contribute greatly to the further research of dynamic tensile properties and atomic chain fabrication.And for guiding the assembly experiments,finite element technology is also utilized to analyze the local microelectro field around the microelectrodes during dieletrophoresis experiments. | Chaolei Huang Hongjiang Zeng Xiaojun Tian Jie Liu Zaili Dong Tie Li Yuelin Wang | 2014 | Chinese Science Bulletin2014，59，5： | 1 |
| 17 | Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4显示文摘Free fatty acids(FFAs)play important roles in cardiovascular disease.Studies have shown that it is an important way for FAs to exert biological effects through their own receptors besides directly participating biochemical reaction in body.Free fatty acid receptor 2(FFA2)can be activated by short-chain FAs and is involved in inflammatory reactions and lipid accumulation.Since the known pathological changes caused by FFA2 are also implicated in cardiac hypertrophy,we hypothesized that FFA2 might be pathogenic in cardiac hypertrophy.This paper showed that FFA2 expression significantly increased in cardiac hypertrophy in vivo and in vitro.FFA2 agonist 4-CMTB or TUG-1375 promoted the expression of the hypertrophy markers ANF and BNP and increased cell surface area in vitro,which was further strengthened by FFA2 overexpression,suggesting that FFA2 might contribute to cardiomyocyte hypertrophy.Furthermore,4-CMTB treatment or FFA2 overexpression combined with 4-CMTB treatment elevated the phosphorylation and transcriptional activity of GATA4 and STAT3,which were inhibited by an ERK1/2 inhibitor,and GATA4 and STAT3 knockdown inhibited the elevation of hypertrophy biomarkers in cardiomyocytes treated with 4-CMTB.Taken together,these data indicate that FFA2 can enhance cardiomyocyte hypertrophy by activating STAT3 and GATA4 via ERK1/2,providing a potential new target for therapy. | Hui Gao Kunming Tian Xiaojun Feng Mengqing Yan Chen Gao Yisheng Jiang Chenhao Zhu Huzhe Zhu Xueping Liu Yingfu Peng | 2022 | Food Science and Human Wellness2022，11，2： | 1 |
| 18 | Anotomic langdmarks during retroperitoneoscopic radical nephrectomy显示文摘 | Lulin M A Huang Y I Tian Xiaojun | 2005 | Chin J Min Inv Surg2005，3，： | 1 |
| 19 | Ultra-low-loss on-chip zero-index materials显示文摘Light travels in a zero-index medium without accumulating a spatial phase,resulting in perfect spatial coherence.Such coherence brings several potential applications,including arbitrarily shaped waveguides,phase-mismatch-free nonlinear propagation,large-area single-mode lasers,and extended superradiance.A promising platform to achieve these applications is an integrated Dirac-cone material that features an impedance-matched zero index.Although an integrated Dirac-cone material eliminates ohmic losses via its purely dielectric structure,it still entails out-of-plane radiation loss,limiting its applications to a small scale.We design an ultra-low-loss integrated Dirac cone material by achieving destructive interference above and below the material.The material consists of a square array of low-aspectratio silicon pillars embedded in silicon dioxide,featuring easy fabrication using a standard planar process.This design paves the way for leveraging the perfect spatial coherence of large-area zero-index materials in linear,nonlinear,and quantum optics. | Tian Dong Jiujiu Liang Sarah Camayd-Munoz Yueyang Liu Haoning Tang Shota Kita Peipei Chen Xiaojun Wu Weiguo Chu Eric Mazur Yang Li | 2021 | Light(Science & Applications)2021，10，1： | 1 |
| 20 | Facile tailoring of titanate nanostructures at low alkaline concentration by a solvothermal route显示文摘 | Shen Xiaojun Zhang Jinlong Tian Baozhu | 2012 | Journal of Materials Science2012，47，8： | 1 |
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