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| 1 | Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury显示文摘瞄准:高血压蛋白原酶血管收缩素系统(地岬) 在血压控制和身体液体和电解质动态平衡起一个关键作用。在过去几年里,血管收缩素(Ang )(1-7 ) 被报导了抵抗 Ang II 的效果并且甚至在地岬被看作一个新 therapeutical 目标。现在的学习试图在本地地岬上在一个糖尿病的动物模型和调整上调查 Ang (1-7 ) 管理的效果。方法:Streptozotocin (STZ ) 导致注射的糖尿病的老鼠在实验被使用。动物被划分成 3 个组:(1 ) 控制;(2 )导致 STZ 的糖尿病;并且(3 ) 有长期的 Ang (1-7 ) 处理的导致 STZ 的糖尿病[D+Ang (1-7 )] 。在 D+Ang (l-7 ) 组, 25 μ g · k g~ 的剂量(Ang (1-7 ) 的 -1) · h^(-1) 被嵌入微型渗透的泵 6 个星期不断地通过颈部的静脉注射。血浆葡萄糖,到体重的肾的比率,和 24 h 尿蛋白质和浆液肌酸酐被常规测量监视。血浆和肾的 Ang II 层次被放射性免疫测定测量。Ang-con-verting 酶(王牌) , ACE2, Ang II 打 1 (AT1 ) 受体, Ang II 打 2 (AT2 ) 受体, Ang (1-7 ) 妈受体,和 TGF-β 1 niRNA 层次被实时 PCR 测量;王牌, ACE2,和 TGF-β 1 蛋白质层次被西方的弄污分析。结果:当时,糖尿病的老鼠的肾的函数显著地被倒退与控制老鼠的相比。在由为 6 个星期的经常的 Ang (1-7 ) 静脉注射的处理以后,肾的功能被发现平比糖尿病的老鼠,和两 TGF-β 1 更坏 mRNA 和蛋白质层次与糖尿病的老鼠相比在 D+Ang (l-7 ) 组被提高。即时 PCR 结果也在 D+Ang (1-7 ) 组在 ACE2 mRNA 水平在王牌 mRNA 表示和减少看了增加是否与糖尿病的老鼠相比。受体在 Ang (1-7 ) 增加了的 ATI 的数字注射了组,当 AT2 和妈受体的数字减少了时。结论:外长的 Ang (1-7 ) 注射没改善导致 STZ 的糖尿病的老鼠肾损伤;相反,它加速了进步糖尿病的 nephropathies。 | Ying SHAO Ming HE Li ZHOU Tai YAO Yu HUANG Li-min LU | 2008 | Acta Pharmacologica Sinica2008，29，7： | 12 |
| 2 | Ultrafine particle emission characteristics of diesel engine by on-board and test bench measurement显示文摘This study investigated the emission characteristics of ultrafine particles based on test bench and on-board measurements. The bench test results showed the ultrafine particle number concentration of the diesel engine to be in the range of (0.56-8.35)×10 8cm-3. The on-board measurement results illustrated that the ultrafine particles were strongly correlated with changes in real-world driving cycles. The particle number concentration was down to 2.0×106cm-3 and 2.7×107cm-3 under decelerating and idling operations and as high as 5.0×108cm-3 under accelerating operation. It was also indicated that the particle number measured by the two methods increased with the growth of engine load at each engine speed in both cases. The particle number presented a 'U' shaped distribution with changing speed at high engine load conditions, which implies that the particle number will reach its lowest level at medium engine speeds. The particle sizes of both measurements showed single mode distributions. The peak of particle size was located at about 50-80nm in the accumulation mode particle range. Nucleation mode particles will significantly increase at low engine load operations like idling and decelerating caused by the high concentration of unburned organic compounds. | Cheng Huang Diming Lou Zhiyuan Hu Piqiang Tai Di Yao Wei Hu Peng Li Jin Ren Changhong Chen | 2012 | Journal of Environmental Sciences2012，24，11： | 8 |
| 3 | All-trans retinoic acid inhibited angiotensin Ⅱ-induced increase in cell growth and collagen secretion of neonatal cardiac fibroblasts显示文摘瞄准:为了决定 all-trans retinoic 酸(atRA ) 是否行动调制血管收缩素, II (Ang II ) 导致了心脏的成纤维细胞房间生长和骨胶原分泌物。方法:有教养的新生的老鼠心脏的成纤维细胞(CF ) 在实验被使用。A 3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyl tetrazolium 溴化物(MTT ) 试金被用来检测 CF 的细胞生长;并且免疫细胞化学并且西方的弄污被用来测量骨胶原的生产和由 CF 转变生长 factor-beta1 (TGF-beta1 ) 的表示。结果:atRA (10 (到 10 的 -7)(-5) mol/L ) 禁止了 Ang CF (P<0.05 ) 的房间生长的导致 II 的增加。Ang II 刺激了骨胶原类型的分泌物我和由 CF 的 III。这效果被堵住由在(1 ) 受体对手 losartan (10 (-6) mol/L ) ,然而并非由 AT2 受体对手 PD123319 (多达 10 (-6) mol/L ) 。到 atRA 的 CF 的暴露((-5) mol/L ) 10 稀释了骨胶原的分泌物的导致 II 的增加打的 Ang 我和 III (P<0.05 ) 。atRA ((-5) mol/L ) 10 也堵住了 Ang TGF-beta1 的表示的导致 II 的增加。结论:atRA 禁止 Ang 细胞生长和新生的老鼠 CF 的骨胶原分泌物的导致 II 的增加。atRA 的效果被降低 TGF-beta1 水平可能调停。这些观察支持 atRA 是心脏的改变的预防和治疗的一个潜在的候选人的观点。 | Yan HE Ying HUANG Li ZHOU Li-min LU Yi-chun ZHU Tai YAO | 2006 | Acta Pharmacologica Sinica2006，27，4： | 8 |
| 4 | Mechanical behaviors of alumina ceramics doped with rare-earth oxides显示文摘The effects of three types of additives Y2O3,La2O3,and Sm2O3 on the sintering and mechanical behaviors of alumina ceramics were investigated.The bending strengths of alumina ceramics with Sm2O3 and Y2O3 additions were 455 and 439 MPa,respectively,higher than that with La2O3 addition.The fracture toughness of the ceramics with Sm2O3 and Y2O3 were also higher than that with La2O3 addition.The fracture mode of rare earth oxides doped alumina ceramics exhibited obvious transgranular fractures as well as intergranular fracture.The results of research show that the improvement of bending strength and fracture toughness of alumina ceramics with rare earth oxides was achieved by refining the grain size and strengthening the grain boundary. | YAO Yijun LI Chuncheng WANG Ling JIANG Xiaolong QIU Tai | 2010 | Rare Metals2010，29，5： | 8 |
| 5 | Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells显示文摘 | Hong XUE Ping YUAN Li ZHOU Tai YAO Yu HUANG Li-min LU | 2009 | Acta Pharmacologica Sinica2009，30，8： | 7 |
| 6 | IMAGE SEGMENTATION BY PIECEWISE CONSTANT MUMFORD-SHAH MODEL WITHOUT ESTIMATING THE CONSTANTS显示文摘在这个工作,我们试着为 Mumford-Shah 分割模型使用所谓的 Piecewise 经常的水平集合方法(PCLSM ) 。为图象分割, Mumford-Shah 模型需要为分割发现这些区域和在内的经常的价值这些区域。以便为这个目的使用 PCLSM,我们需要作为最小化变量用水平集合函数和经常的值解决一个最小化问题。在这个工作,我们在一个模型上测试以便我们仅仅需要关于水平集合功能最小化,即,我们不需要关于经常的价值最小化。坡度降下方法和牛顿方法被用来为最小化问题解决 theEuler-Lagrange 方程。数字实验被给显示出新模型和算法的效率和优点。 | Xue-cheng Tai Chang-hui Yao | 2006 | Journal of Computational Mathematics2006，24，3： | 6 |
| 7 | First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease显示文摘AIM To compare the one-week clinical effects of single doses of dexlansoprazole and esomeprazole on grades A and B erosive esophagitis.METHODS We enrolled 175 adult patients with gastroesophageal reflux disease(GERD). The patients were randomized in a 1:1 ratio into two sequence groups to define the order in which they received single doses of dexlansoprazole(n = 88) and esomeprazole(n = 87) for an intention-to-treat analysis. The primary endpoints were the complete symptom resolution(CSR) rates at days 1, 3, and 7 after drug administration.RESULTS Thirteen patients were lost to follow-up, resulting in 81 patients in each group for the per-protocol analysis. The CSRs for both groups were similar at days 1, 3 and 7. In the subgroup analysis, the female patients achieved higher CSRs in the dexlansoprazole group than in the esomeprazole group at day 3(38.3% vs 18.4%, P = 0.046). An increasing trend toward a higher CSR was observed in the dexlansoprazole group at day 7(55.3% vs 36.8%, P = 0.09). In the esomeprazole group, female sex was a negative predictive factor for CSR on post-administration day 1 [OR =-1.249 ± 0.543; 95%CI: 0.287(0.099-0.832), P = 0.022] and day 3 [OR =-1.254 ± 0.519; 95%CI: 0.285(0.103-0.789), P = 0.016]. Patients with spicy food eating habits achieved lower CSRs on day 1 [37.3% vs 21.4%, OR =-0.969 ± 0.438; 95%CI: 0.380(0.161-0.896), P = 0.027]. CONCLUSION The overall CSR for GERD patients was similar at days 1-7 for both the dexlansoprazole and esomeprazole groups, although a higher incidence of CSR was observed on day 3 in female patients who received a single dose of dexlansoprazole. | Chih-Ming Liang Ming-Te Kuo Pin-I Hsu Chao-Hung Kuo Wei-Chen Tai Shih-Cheng Yang Keng-Liang Wu Hsing-Ming Wang Chih-Chien Yao Cheng-En Tsai Yao-Kuang Wang Jiunn-Wei Wang Chih-Fang Huang Deng-Chyang Wu Seng-Kee Chuah 无 | 2017 | World Journal of Gastroenterology2017，23，47： | 4 |
| 8 | Standards of care for Kasabach-Merritt phenomenon in China显示文摘Kasabach-Merritt phenomenon(KMP)is a rare disease that is characterized by severe thrombocytopenia and consumptive coagulation dysfunction caused by kaposiform hemangioendothelioma or tufted hemangioma.This condition primarily occurs in infants and young children,usually with acute onset and rapid progression.This review article introduced standardized recommendations for the pathogenesis,clinical manifestation,diagnostic methods and treatment process of KMP in China,which can be used as a reference for clinical practice. | Wei Yao Ke-Lei Li Zhong-Ping Qin Kai Li Jia-Wei Zheng Xin-Dong Fan Lin Ma De-Kai Zhou Xue-Jian Liu Li Wei Li Li Mao-Zhong Tai Jin-Hu Wang Yi Ji Lin Zhou Hai-Jin Huang Xiao-Yun Gao Zhi-Jian Huang Song Gu He-Ying Yang | 2021 | World Journal of Pediatrics2021，17，2： | 4 |
| 9 | Greenhouse gas emissions from a constructed wetland for municipal sewage treatment显示文摘The fluxes of greenhouse gases (methane and nitrous oxide) emission from a constructed wetland in the Eastern China as municipal sewage treatment were measured from June 1999 to August 2000 by the closed chamber method. The constructed wetland for municipal sewage treatment is a significant source of methane, up to 976 6×10 6 g CH 4/a, which was emitted from the constructed wetland with the area of 495000 m 2 and wastewater loading rate of 12000 m 3/d. Its daily mean methane flux reached 5 22 g CH 4/(m 2·d), 250 times as much as that in natural wetland in the same latitude region. 227 8 mg CH 4 was produced from the treatment of 1 liter wastewater, up to 700—1000 times as much as that in the secondary treatment. The emission of nitrous oxide from the constructed wetland is not higher than that from secondary treatment of wastewater, only 0 07 mgN 2O/L. | TAI Pei dong 1, LI Pei jun 1 , SUN Tie heng 1, HE Yao wu 1, ZHOU Qi xing 1 GONG Zong qiang 1, Motoyuki Mizuochi 2, Yuhei Inamori 2 (1 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110015, China. 2 National Insti | 2002 | Journal of Environmental Sciences2002，14，1： | 3 |
| 10 | Alteration of oncogenic IGF-II gene methylation status associates with hepatocyte malignant transformation显示文摘Background: Oncogenic insulin-like growth factor-II(IGF-II) is overexpressed in hepatocellular carcinoma(HCC). The present study aimed to analyze the dynamic alteration of IGF-II CpG site methylation status and its molecular mechanism in HCC progression. Methods: IGF-II alterations were observed in rat hepatocarcinogenesis models induced by 2-acetylaminofluorene. Liver IGF-II expression was compared by immunohistochemistry or tissue IGF-II specific concentration(nmol/mg protein). Status of human IGF-II promoter 3(P3) or rat IGF-II P2 CpG site methylation was amplified by methylation-specific polymerase chain reaction(MSP). Serum IGF-II levels were quantitatively detected by an enzyme-linked immunosorbent assay. Results: The levels of hepatic IGF-II expression were significantly elevated in the HCC group( P < 0.001). The unmethylation rate of IGF-II P3 CpG sites was 100% in the HCC-, 52.5% in the paracancerous-, and none(0%) in the distal noncancerous-tissues. Abnormal IGF-II expression was related to differentiation degree, tumor invasion, and positive HBV-DNA(all P < 0.001), with a negative correlation between P3 methylation degree and IGF-II expression. There was a positive correlation between liver IGF-II specific concentration and circulating IGF-II level( r = 0.97, P < 0.001). Significantly negative correlation was found between IGF-II P2 CpG site methylation and circulating IGF-II( r s =-0.89, P < 0.001) or liver IGF-II level( r s =-0.84, P < 0.001). Conclusions: The increase of serum IGF-II and the alteration of oncogenic gene IGF-II methylation may be biomarkers for HCC diagnosis and DNA methylation may be the therapeutic target of HCC. | Bo-Jun Tai Min Yao Wen-Jie Zheng Yu-Cheng Shen Li Wang Jian-Ying Sun Meng-Na Wu Zhi-Zhen Dong Deng-Fu Yao | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 3 |
| 11 | Dynamic expression of rat heat shock protein gp96 and its gene during development of hepatocellular carcinoma显示文摘BACKGROUND: Hepatocellular carcinoma (HCC) is characterized by multicause, obvious multistage and multifocal processes of tumor progression. The development of HCC is related intimately to overexpression and signal transduction of many cellular factors. This study was undertaken to investigate the dynamic expression and alteration of heat shock protein (HSP) gp96 along with its gene during HCC development. METHODS: A rat model of hepatoma induced with 2-fluorenylacetamide (2-FAA, 0.05%) was established in male Sprague-Dawley rats. Total RNA and pathological changes were observed during hepatocarcinogenesis. Total RNAs were transcribed into cDNA by reverse transcription and the gene fragment of gp96 was amplified by nested RT-PCR. The gp96 expression in rat liver tissues was semi-quantitatively analyzed by immunohistochemistry. RESULTS: Histological examination suggested that hepato-cytes in rats fed with 2-FAA showed vacuole-like denaturation at the early stages, then dysplastic nodules appeared at the middle stage, and finally progressed to tubercles of cancerous nests. A tendency of increasing liver gp96 protein level was found from normal liver to precancerous to cancerous tissues during hepatoma development (P<0.01), and was in accordance with the changes in gp96 mRNA (P<0.05).CONCLUSION: HSP gp96 is involved in HCC development and its overexpression may be a useful marker for early diagnosis. | Wu, Xin-Hua Yao, Deng-Fu Su, Xiao-Qin Tai, Bo-Jun Huang, Hua Qiu, Li-Wei Wu, Wei Shao, Yi-Xiang | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，6： | 3 |
| 12 | Development and application of a throughflow method for high-loaded axial flow compressors显示文摘In this paper, a novel engineering platform for throughflow analysis based on streamline curvature approach is developed for the research of a 5-stage compressor. The method includes several types of improved loss and deviation angle models, which are combined with the authors' adjustments for the purpose of reflecting the influences of three-dimensional internal flow in high-loaded multistage compressors with higher accuracy. In order to validate the reliability and robustness of the method, a series of test cases, including a subsonic compressor P&W 3S1, a transonic rotor NASA Rotor 1B and especially an advanced high pressure core compressor GE E^3 HPC, are conducted. Then the computation procedure is applied to the research of a 5-stage compressor which is designed for developing an industrial gas turbine. The overall performance and aerodynamic configuration predicted by the procedure, both at design- and part-speed conditions, are analyzed and compared with experimental results, which show a good agreement. Further discussion regarding the universality of the method compared with CFD is made afterwards. The throughflow method is verified as a reliable and convenient tool for aerodynamic design and performance prediction of modern high-loaded compressors. This method is also qualified for use in the further optimization of the 5-stage compressor. | LI Bo GU Chun Wei LI Xiao Tang LIU Tai Qiu XIAO Yao Bing | 2016 | Science China(Technological Sciences)2016，59，1： | 3 |
| 13 | 小鼠鼻咽部组织相对特异基因调控区的克隆与分析显示文摘通过RT -PCR证实PLUNC基因在小鼠鼻咽部具有相对特异性表达。进一步用染色体步移的方法克隆该基因 5′端旁侧序列 847bp ,网上分析结果提示此序列具有调控活性 ,体外报道基因的研究亦证实这一结果。进一步的研究表明 ,其核心调控区位于转录起始位点上游 2 0 0bp之内。这一工作将为构建鼻咽癌转基因动物提供良好的前提。 | 张玲 李虹 谢鹭 蓝轲 韩为农 冯湘玲 何志巍 姚开泰 He Zhi YAO Kaitai | 2001 | 遗传2001，23，3： | 2 |
| 14 | Eighty years of Chinese Association for Physiological Sciences in retrospect显示文摘2006年11月,中国生理学会在北京举行了“第22次全国会员代表大会暨庆祝中国生理学会成立80周年学术大会”。在这次大会上,学会特地邀请了美国、英国、加拿大和澳大利亚四个国家生理学会的代表出席,并作学术讲座。他们讲座的题目和内容都很有新意。《生理学报》编辑部约请他们把讲座的内容整理成综述,在我刊发表,本期发表3篇,其它文章在后期陆续发表。并以此同时纪念《生理学报》创刊80周年。此外,我们还请中国生理学会上届理事长、《生理学报》主编姚泰教授将他在庆祝大会上做的关于“中国生理学会八十周年回顾”的讲话用英文撰写,在本期发表,希望国际学术同行对中国生理学会、《生理学报》和中国生理学工作者的情况能增加一些了解。 | YAO Tai Former President of Chinese Association for Physiological Sciences, Editor-in-Chief of Acta Physiologica Sinica | 2007 | 生理学报2007，59，2： | 2 |
| 15 | Aqueous gelcasting of silica ceramics using DMAA显示文摘 | Wei Wan Jian Yang Jinzhen Zeng Lichun Yao Tai Qiu | 2013 | Ceramics International2013，，： | 2 |
| 16 | Adenosine 5'-triphosphate stimulates the increase of TGF-β1 in rat mesangial cells under high-glucose conditions via reactive oxygen species and ERK1/2显示文摘 | Lin-ping QU Hong XUE Ping YUAN Li ZHOU Tai YAO Yu HUANG Li-min LU | 2009 | Acta Pharmacologica Sinica2009，30，12： | 2 |
| 17 | Suppressing the surface passivation of Pt-Mo nanowires via constructing Mo-Se coordination for boosting HER performance显示文摘Modulating the surface coordination environment of Pt based nanocrystals at the atomic level is of great importance to obtain good electrocatalytic performance.Given the fundamental understandings of surface structure degeneration of Pt based nanocrystals,introducing a weak electronegative element to the surface of Pt-based catalysts is beneficial for suppressing surface passivation and improving hydrogen evolution reaction performance of Pt.Density functional theory results reveal that the energy barrier of water dissociation process can be greatly reduced by using Se element as the surface modifier to replace the O.This hypothesis is further validated by experiments that ultralong Pt_(85)Mo_(15)-Se nanowires were fabricated to suppress the excessive passivation behavior of transition metals of Pt based alloy.The Pt_(85)Mo_(15)-Se nanowires exhibit higher activity with 4.98 times the specific activity and 4.87 times the mass activity of commercial Pt/C,as well as a better stability towards alkaline hydrogen evolution reaction.The deep exploration of X-ray photoelectron spectroscopy and theoretical calculations disclose that Se element could maintain the electron-rich state around the electronic orbit of Pt.This study provides a new insight to advance the fundamental understanding on electrocatalytic materials,which exhibits a promising approach to protect the surface chemical environment of Pt based nanocrystals. | Lei Yu Tingting Zhou Shuhua Cao Xishi Tai Lili Liu Yao Wang | 2021 | Nano Research2021，14，8： | 2 |
| 18 | Concentration and chemical composition of PM 2.5 in Shanghai for a 1-year period显示文摘 | Boming Ye Xueli Ji Haizhen Yang Xiaohong Yao Chak K Chan Steven H Cadle Tai Chan Patricia A Mulawa | 2002 | Atmospheric Environment2002，，4： | 2 |
| 19 | Photo-patternable gelatin as protection layers in low-temperature surface micromachinings显示文摘 | Yang Lung-Jieh Lin Wei-zhi Yao Tze-Jung Tai Yu-Chong | 2003 | Sensors and Actuators (A)2003，103，： | 1 |
| 20 | The cytotoxicity of cadmium-based quantum dots显示文摘 | Nan Chen Yao He Yuanyuan Su Xiaoming Li Qing Huang Haifeng Wang Xiangzhi Zhang Renzhong Tai Chunhai Fan | 2011 | Biomaterials2011，，5： | 1 |
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