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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 3 | Mortality of therapeutic fish Garra rufa caused by Aeromonas sobria显示文摘Objective:To investigate a case of mass mortality of Garra rufa(G.rufa)from a fish hatchery farm in Slovakia.Methods:Causative bacterial agent was swabbing out of affected fish skin area and subsequently identified using commercial test system.Antibiotic susceptibility was determined by the disk diffusion method.Results:Infected G.rufa was characterized by abnormal swimming behaviour,bleeding of skin lesions and local haemorrhages.Despite of using recommended aquatic antibiotic treatment no improvement was achieved and Aeromonas sobria{A.sobria)was identified as a causative agent of fish mortality.Due to massive fish mortality,antibiotic susceptibility of pure isolated culture of A.sobria was evaluated employing eight antibiotics against human infections.A.sobria was resistant only against one antibiotic,namely ampicilin.Conclusions:These results indicate that A.sobria can act as a primary pathogen of G.rufa and may be a potential risk factor for immunodeficient or immunoincompetent patients during the ichthyotherapy. | Juraj Majtán Jaroslav erny Alena Ofúkaná Peter Taká Milan Kozánek | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 3 |
| 4 | Higher median levels of free hCG and PAPP-A in a Chinese ethnic group显示文摘 | Tak Y L Kevin S Tse N L | 2006 | Fetal Diagn Ther2006，21，1： | 1 |
| 5 | Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in parkinson's disease显示文摘 | Sohmiya M Tanaka M Wei Tak N | 2004 | Journal of the Neurological Sciences2004，223，2： | 1 |
| 6 | Investigation on turbulent heat transfer to lead-bismuth eutectic flows in circular tubes for nuclear applications显示文摘 | CHENG X TAK N | 2006 | Nucle- ar Engineering and Design2006，236，4： | 1 |
| 7 | Investigation on Turbulent Heat Transfer to Lead-Bismuth Eutectic Flows in Circular Tubes for Nuclear Applications 显示文摘 | Cheng X Tak N | 2006 | Nuclear Engineering and Design2006，236，4： | 1 |
| 8 | Cytokines in Sjogren's syndrome: potential therapeutic targets 显示文摘 | Roescher N Tak PP Illei GG | 2010 | Ann Rheum Dis2010，69，6： | 1 |
| 9 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 10 | Elevated Levels of Anti- Helicobacter pylori Antibodies in Henoch–Sch?nlein Purpura显示文摘 | János Novák Zoltán Szekanecz Judit Sebesi Alajos Takáts Pál Demeter László Bene Sándor Sipka Zoltán Csiki | 2003 | Autoimmunity2003，，5： | 1 |
| 11 | Optimal design of HY-PER target system based on the thermal andstructural analysis of Pb-Bi spallation target andbeam window 显示文摘 | SONG T Y TAK N I | 2003 | Annals of Nuclear Energy2003，30，12： | 1 |
| 12 | A randomized, comparative, multicentre clinical trial to assess the efficacy and safety of zileuton ex- tended-release tablets with montelukast sodium tablets in patients suf- fering from chronic persistent asthma显示文摘 | KUBABAT AH KHIPPAL N TAK S | 2013 | Am J Ther2013，20，2： | 1 |
| 13 | Proximal tubular transport and urinary excretion of sodium after renal denervation in sodium depleted rats显示文摘 | Gábor Szénási Pál Benesáth Lajos Takács Bozena Asztalos Mária Vedres | 1985 | Pflügers Archiv European Journal of Physiology1985，，2： | 1 |
| 14 | Agency and capabilities to achieve a work-life balance:a comparison of Sweden and Hungary显示文摘 | Hobson B Fahlén S Takács J | 2011 | Soc Polit2011，18，2： | 1 |
| 15 | Oral submucous fibrosis: A review article on etiopathogenesis显示文摘 | Tak J Gupta N Bali R | 2014 | Kathmandu Uni versity Medical Journal2014，12，5： | 1 |
| 16 | Investigation on turbulentheat transfer to lead-bismuth eutectic flows incircular tubes for nuclear applications 显示文摘 | CHENG X TAK N | 2006 | NuclEng Des2006，236，4： | 1 |
| 17 | Investigation on turbu- lence heat transfer to lead bismuth eutectic flows in circular tubes for nuclear applications显示文摘 | CHENG X TAK N I | 2006 | Nucl Eng Des2006，236，： | 1 |
| 18 | Pathogenesis of spondyloarthritis: autoimmune or autoinflammatory?显示文摘 | Ambarus C Yeremenko N Tak PP | 2012 | Curr Opin Rheumatol2012，24，4： | 1 |
| 19 | Compu- tational fluid dynamics analysis of spallation target {or experimental accelerator driven trans- mutation system显示文摘 | TAK N I NEITZEL H J CHENG X | 2005 | Nucl Eng Des2005，235，： | 1 |
| 20 | CFD analysis of thermal- hydraulic behavior of liquid metals in sub-chan- nels显示文摘 | CHENG X TAK N I | 2006 | NuclEngDes2006，236，： | 1 |
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