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| 1 | Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?显示文摘BACKGROUND: Excretion of gadolinium-ethoxybenzyl-diethyl- enetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients. METHODS: Forty patients [group 1: normal liver and Child Pugh class A in 20 patients, group 2: Child-Pugh class B in 18 patients and Child-Pugh C in 2] were evaluated. All patients underwent MR imaging of the liver using a 1.5-Tesla system. T1 weighted 3D images were obtained at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA injection. The relation between group 3 (total bilirubin <1.8 mg/dL) and group 4 (total bilirubin ≥1.8 mg/dL) was investigated at 20 minutes. Liver and biliary signals were measured, and compared between groups 1 and 2 or groups 3 and 4. Tumor-to-liver ratio was also evaluated between groups 1 and 2. Scheffé's post-hoc test after two-way repeated measures ANOVA and Pearson's correlation test were used for statistical analysis. RESULTS: Liver enhancement showed significant difference at all time points between groups 1 and 2. Biliary enhancement did not show a significant difference between groups 1 and 2 at 5 minutes, but did at 10, 15 and 20 minutes. At 20 minutes significant differences between groups 3 and 4 were seen for liver and biliary enhancement. At all time points, liver enhancement correlated with biliary enhancement in both groups. At 5 minutes and 20 minutes, statistical differences between groups 1 and 2 were seen for tumor-to-liver ratio.CONCLUSIONS: The degree of biliary enhancement has a close correlation to that of liver enhancement. It is especially important that insufficient liver enhancement causes lower tumor-to-liver contrast in the hepatobiliary phase of Gd-EOB- DTPA. | Masahiro Okada Kazunari Ishii Kazushi Numata Tomoko Hyodo Seishi Kumano Masayuki Kitano Masatoshi Kudo Takamichi Murakami | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 13 |
| 2 | Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma显示文摘BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often challenging.Recently,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ESCC.Although,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ESCC.And,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.This study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for ESCC.AIM To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.METHODS A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively analyzed.FDG uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or not.The invasion depth of ESCC was classified according to the Japan Esophageal Society.Primary endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial ESCC.Secondary endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.RESULTS A total of 82 lesions in 82 patients were included.FDG-PET showed positive uptake in 29(35.4%)lesions.Univariate analysis showed that uptake of FDG-PET had significant correlations with circumferential extension(P=0.014),pathological depth of tumor invasion(P<0.001),infiltrative growth pattern(P<0.001),histological grade(P=0.002),vascular invasion(P=0.001),and lymphatic invasion(P<0.001).On multivariate analysis,only depth of tumor invasion was independently correlated with FDG-PET/computed tomography visibility(P=0.018).The sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of Type B2 in ME-NBI for the invasion depth of T1a muscularis mucosae and T1b upper submucosal layer were 68.4%/79.4%/50.0%/89.3%/76.8%,respectively,and those of Type B3 for the depth of T1b middle and deeper submucosal layers(SM2 and SM3)were 46.7%/100%/100%/89.3%/90.2%,respectively.On the other hand,those of FDGPET for SM2 and SM3 were 93.3%/77.6%/48.2%/98.1%/80.5%,respectively,whereas,if the combination of positive FDG uptake and type B2 and B3 was defined as an indicator for radical esophagectomy or definitive chemoradiotherapy,the sensitivity,specificity,PPV,NPV,and accuracy were 78.3%/91.5%/78.3%/91.5%/87.8%,respectively.CONCLUSION FDG uptake was correlated with the invasion depth of superficial ESCC.Combined use of FDG-PET and ME-NBI,especially with the microvascular findings of Type B2 and B3,is useful to determine whether ER is indicated for the lesion. | Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Yutaka Hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe Yasushi Yatabe Kazuo Hara Keitaro Matsuo Tsuneo Tamaki Yasumasa Niwa | 2019 | World Journal of Gastroenterology2019，25，46： | 7 |
| 3 | Contrast-enhanced harmonic endoscopic ultrasonography for assessment of lymph node metastases in pancreatobiliary carcinoma显示文摘AIM: To assess the usefulness of contrast-enhanced harmonic endoscopic ultrasonography(CH-EUS) for lymph node metastasis in pancreatobiliary carcinoma.METHODS: All patients suspected of pancreatobiliary carcinoma with visible lymph nodes after standard EUS between June, 2009 and January, 2012 were enrolled.In the primary analysis, patients with successful EUSfine needle aspiration(FNA) were included. The lymph nodes were assessed by several standard EUS variables(short and long axis lengths, shape, edge characteristic and echogenicity), color Doppler EUS variable [central intranodal blood vessel(CIV) presence] and CH-EUS variable(heterogeneous/homogeneous enhancement patterns). The diagnostic accuracy relative to EUSFNA was calculated. In the second analysis, N-stage diagnostic accuracy of CH-EUS was compared with EUS-FNA in patients who underwent surgical resection.RESULTS: One hundred and nine patients(143 lymph nodes) fulfilled the criteria. The short axis cutoff ≥ 13 mm predicted malignancy with a sensitivity and specificity of 72% and 85%, respectively. These values were 72% and 63% for the long axis cut-off ≥ 20 mm, 62% and 75% for the round shape variable, 81% and 30% for the sharp edge variable, 66% and 61% for the hypoechogenicity variable, 70% and 72% for the CIV-absent variable, and 83% and 91% for the heterogeneous CH-EUS-enhancement variable, respectively. CH-EUS was more accurate than standard and color Doppler EUS, except the short axis cut-off. Notably, three patients excluded because of EUS-FNA failure were correctly N-staged by CH-EUS.CONCLUSION: CH-EUS complements standard and color Doppler EUS and EUS-FNA for assessment of lymph node metastases. | Takeshi Miyata Masayuki Kitano Shunsuke Omoto Kumpei Kadosaka Ken Kamata Hajime Imai Hiroki Sakamoto Naoshi Nisida Yogesh Harwani Takamichi Murakami Yoshifumi Takeyama Yasutaka Chiba Masatoshi Kudo | 2016 | World Journal of Gastroenterology2016，22，12： | 7 |
| 4 | Removal of phosphate by aluminum oxide hydroxide显示文摘 | Seiki Tanada Mineaki Kabayama Naohito Kawasaki Toru Sakiyama Takeo Nakamura Mamiko Araki Takamichi Tamura | 2003 | Journal of Colloid And Interface Science2003，，1： | 2 |
| 5 | Asian sand dust enhances ovalbumin-induced eosinophil recruitment in the alveoli and airway of mice显示文摘 | Kyoko Hiyoshia Takamichi Ichinoseb Kaori Sadakane | 2005 | Environmental Research2005，99，： | 1 |
| 6 | Small Hypervascular Hepatocellular Carcinoma Revealed by Double Arterial Phase CT Performed with Single Breath-Hold Scanning and Automatic Bolus Tracking显示文摘 | Tonsok K Takamichi M Masatoshi H | 2002 | A JR2002，178，： | 1 |
| 7 | Dynamic characteristics of novel two-DOF resonant actuator by vector Transactions on Magnetics, 2012, control显示文摘 | Takamichi Yoshimoto Yasuyoshi Asai Tomoshiro Ota | 2012 | IEEE2012，48，11： | 1 |
| 8 | Vagus Nerve Stimulation Therapy:Indications,Programing,and Outcomes显示文摘 | Takamichi | 2015 | Neurol Med Chir(Tokyo)2015，55，5： | 1 |
| 9 | Bleaching of alkali-refined vegetable oils with clay minerals显示文摘 | Keito Boki Moriaki Kubo Tetsuyuki Wada Takamichi Tamura | 1992 | Journal of the American Oil Chemists Society1992，，3： | 1 |
| 10 | Effective Transfer Hydrogenation of Unsaturated Compounds by Ruthenium Dihydride Complex in Propan-2-ol显示文摘 | Yamaquchi Motowuo Yamaqishi Takamichi | 1999 | J Mol Catal A:Chemical1999，148，： | 1 |
| 11 | Age estimation of the wild population of Japanese mantis shrimp Oratosquilla oratoria (Crustacea:Stomatopoda) in Tokyo Bay,Japan,using lipofuscin as an age marker显示文摘 | Keita K Takashi Y Takamichi S | 2005 | Fisheries Science2005，71，： | 1 |
| 12 | Controlling a gas/odor plume-tracking robot based on transient responses of gas sensors显示文摘 | ISHIDA Hiroshi NAKAYAMA Gouki NAKAMOTO Takamichi | 2005 | IEEE Sensors Journal2005，5，3： | 1 |
| 13 | Using cluster analysis to uncover L2 learner differences in strategy use, will to learn, and achievement over time显示文摘 | Koyo Yamamori Takamichi Isoda Tomohito Hiromori Rebecca L. Oxford | 2003 | IRAL - International Review of Applied Linguistics in Language Teaching2003，，4： | 1 |
| 14 | Intravenous immunoglobulin therapy for Miller Fisher syndrome显示文摘 | Masahiro Mori Satoshi Kuwabara Toshio Fukutake Takamichi Hattori | 2007 | Neurology2007，，14： | 1 |
| 15 | Hyperplastic polyps and sessile serrated ‘adenomas’ of the colon and rectum display gastric pyloric differentiation显示文摘 | Akiyoshi Mochizuka Takeshi Uehara Takamichi Nakamura Yukihiro Kobayashi Hiroyoshi Ota | 2007 | Histochemistry and Cell Biology2007，，： | 1 |
| 16 | Evaluation of renal arteries in living renal donors: comparison between MDCT angiography and gadolinium-enhanced 3D MR angiography显示文摘 | Tonsok Kim Takamichi Murakami Satoru Takahashi Masatoshi Hori Shirou Takahara Naotsugu Ichimaru Akihiko Okuyama Yoshifumi Narumi Hironobu Nakamura | 2006 | Radiation Medicine2006，，9： | 1 |
| 17 | Urban particulate matter in Beijing, China, enhances allergen-induced murine lung eosinophilia显示文摘 | Miao He Takamichi Ichinose Seiichi Yoshida Masataka Nishikawa Ikuko Mori Rie Yanagisawa Hirohisa Takano Ken-ichiro Inoue Guifan Sun Takayuki Shibamoto | 2010 | Inhalation Toxicology2010，，9： | 1 |
| 18 | Effect of remifentanil infusion rate on stress response in orthopedic surgery using a tourniquet application 显示文摘 | Shinoda T Murakami W Takamichi Y | 2013 | BMC Anesthesiol2013，13，1： | 1 |
| 19 | Differences in airway inflammation development by house dust mite and diesel exhaust inhalation among mouse strains显示文摘 | Takamichi I Hirohisa T Kaori S | 2003 | Toxicol Applied Pharmacol2003，187，1： | 1 |
| 20 | Experimental hepatic dysfunction: Evaluation by MR imaging with Gd-EOB-DTPA显示文摘 | Takamichi Murakami Tonsok Kim Mitsukazu Gotoh Yasunori Hasuike Naoki Kato Tomoaki Miyazawa Morito Monden Hironobu Nakamura | 1998 | Academic Radiology1998，，： | 1 |
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