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4篇 您的检索式：作者名="Takeshi Tabira"

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		题名	作者	年代	出处	被引量
	1	Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice显示文摘The imbalance between β-amyloid(Aβ) generation and clearance plays a fundamental role in the pathogenesis of Alzheimer 's disease(AD). The sporadic form of AD is characterized by an overall impairment in Aβ clearance. Immunotherapy targeting Aβ clearance is believed to be a promising approach and is under active clinical investigation. Autophagy is a conserved pathway for degrading abnormal protein aggregates and is crucial for Aβ clearance. We previously reported that oral vaccination with a recombinant AAV/Aβ vaccine increased the clearance of Aβ from the brain and improved cognitive ability in AD animal models, while the underlying mechanisms were not well understood. In this study, we first demonstrated that oral vaccination with rAAV/Aβ decreased the p62 level and up-regulated the LC3BII/LC3B-I ratio in APP/PS1 mouse brain, suggesting enhanced autophagy. Further, inhibition of the Akt/m TOR pathway may account for autophagy enhancement. We also found increased anti-Aβ antibodies in the sera of APP/PS1 mice with oralvaccination, accompanied by elevation of complement factors C1 q and C3 levels in the brain. Our results indicate that autophagy is closely involved in oral vaccination-induced Aβ clearance, and modulating the autophagy pathway may be an important strategy for AD prevention and intervention.	He-Cheng Wang Tao Zhang Bolati Kuerban Ying-Lan Jin Weidong Le Hideo Hara Dong-Sheng Fan Yan-Jiang Wang Takeshi Tabira De-Hua Chui	2015	Neuroscience Bulletin2015，31，4：	8
	2	Chronic stress differentially regulates glucocorticoid negative feedback response in rats显示文摘	Kazushige Mizoguchi Mitsutoshi Yuzurihara Atsushi Ishige Hiroshi Sasaki De-Hua Chui Takeshi Tabira	2001	Psychoneuroendocrinology2001，，5：	1
	3	Extensive loss of connexins in Baló’s disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte–oligodendrocyte/myelin interaction显示文摘	Katsuhisa Masaki Satoshi Suzuki Takuya Matsushita Tomomi Yonekawa Takeshi Matsuoka Noriko Isobe Kyoko Motomura Xiao-Mu Wu Takeshi Tabira Toru Iwaki Jun-ichi Kira	2012	Acta Neuropathologica2012，，6：	1
	4	Long‐term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in AβPP and AβPP/tau transgenic mice显示文摘	Haruhiko Akiyama Masato Hosokawa Fuyuki Kametani Hiromi Kondo Momoko Chiba Masako Fukushima Takeshi Tabira	2011	Neuropathology2011，，4：	1

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