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| 1 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 2 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 3 | Effect of chain rigidity and effective conjugation length on the structural and photophysical properties of pyridine - based luminescent polymers 显示文摘 | Tammer M Horsburgh L Monkman A P Brown W Burrows H D | 2002 | Advanced Functional materials2002，12，： | 1 |
| 4 | Lipschitz Properties of the Scalarization Function and Applications 显示文摘 | TAMMER C ZALINESCU C | 2010 | Optimization2010，59，2： | 1 |
| 5 | Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies显示文摘 | Michael Selgrad Julia Meile Jan Bornschein Arne Kandulski Cosima Langner Mariya Varbanova Thomas Wex Ina Tammer Dirk Schlüter Peter Malfertheiner | 2013 | European Journal of Gastroenterology & Hepatology2013，，11： | 1 |
| 6 | Perioperative antimicro- bial prophylaxis显示文摘 | Tammer I Geginat G Schliiter D | 2011 | Anasthesiol Intensivmed No(fallmed Schmemther2011，46，10： | 1 |
| 7 | Flexural properties of fiber reinforced root canal posts显示文摘 | Lippo VJ Tammer J Anna-Maria LB | 2004 | Dent Mater2004，20，1： | 1 |
| 8 | On the Internationalization Process of Firms显示文摘 | Cavusgil S Tammer | 1980 | European Research1980，，8： | 1 |
| 9 | Lipschitz properties of the scalar- ization function and applications显示文摘 | Tammer C Zdlinescu C | 2010 | Optimization2010，59，2： | 1 |
| 10 | Intra-and interpatient variability of the hsp65 and 16S-23S intergenic gene region in Mycobacterium abscessus strains from patients with cystic fibrosis显示文摘 | K(o)nig B Tammer I Sollich V | 2005 | J Clin Microbiol2005，43，7： | 1 |
| 11 | Lipschitz properties of the scalarization function and applications 显示文摘 | Tammer C Zlineseu C | 2010 | Optimization2010，59，2： | 1 |
| 12 | Activation of Abl by Helicobacter pylori s a novelkinase for CagA and crucial mediator of host cell scattering显示文摘 | Tammer I Brandt S Hartig | 2007 | Gastroenterology2007，132，4： | 1 |
| 13 | Lipschitz properties of the scalarization function and applications显示文摘 | Tammer C Zalinescu C | 2010 | Optimization2010，59，2： | 1 |
| 14 | Combined effects of mycotoxin mixtures on human T cell function 显示文摘 | Tammer B Lehmann 1 Nieber K | 2007 | Toxicology Letters2007，170，2： | 1 |
| 15 | Lipschitz properties of the scalarization function and applications 显示文摘 | Tammer C Zlinescu C | 2010 | Optimization2010，59，2： | 1 |
| 16 | Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies显示文摘 | Michael Selgrad Julia Meile Jan Bornschein Arne Kandulski Cosima Langner Mariya Varbanova Thomas Wex Ina Tammer Dirk Schlüter Peter Malfertheiner | 2013 | European Journal of Gastroenterology & Hepatology2013，，11： | 1 |
| 17 | A Computer-based Design Reuse System显示文摘 | Tammer M M Sivaloganathan S S | 2005 | Computer-aided Design & Application2005，2，14： | 1 |
| 18 | The influence of quench sensitivity on residual stresses in the aluminium alloys 7010 and 7075显示文摘 | ROBINSON J S TAMMER D A TRUMANB C E | 2012 | Materials Characterization2012，65，3： | 1 |
| 19 | Lipschitz properties of the scalar- ization function and applications 显示文摘 | Tammer C Zcilinescu C | 2010 | Optimization2010，59，2： | 1 |
| 20 | On the vectorial Ekeland variational principle and minimal points in product spaces显示文摘 | Gopfert A Tammer C Zalinescu C | 2000 | Nanlinear Anal2000，39，： | 1 |
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