|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 2 | Bacterial load and degree of gas-tric mucosal inflammation in Helicobacter pylori infection显示文摘 | Varbanova M Malfertheiner P | 2011 | Dig Dis2011，29，6： | 1 |
| 3 | 查看详情显示文摘 | VARBANOVA M YAMAGUCHI S YANG Y | | 0，，： | 1 |
| 4 | Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies显示文摘 | Michael Selgrad Julia Meile Jan Bornschein Arne Kandulski Cosima Langner Mariya Varbanova Thomas Wex Ina Tammer Dirk Schlüter Peter Malfertheiner | 2013 | European Journal of Gastroenterology & Hepatology2013，，11： | 1 |
| 5 | Molecular and biochemical basis for stress-induced accumulation of free and bound p-coumar- aldehyde in cucumber 显示文摘 | Varbanova M Porter K Lu F | 2011 | Plant Physiology2011，157，： | 1 |
| 6 | Molecular and biochemical basis for stress-induced accumulation of free and bound p-coumar- aldehyde in cucumber显示文摘 | VARBANOVA M PORTER K LU F | 2011 | Plant PhysioZogy2011，157，3： | 1 |
| 7 | Chronic gas- tritis -an update 显示文摘 | Varbanova M Frauenschlager K Malfertheiner P | 2014 | Best Pract Res Clin Gastroenterol2014，28，6： | 1 |
| 8 | Comparison between myringotomy and tympanostomy tubes in combination with adenoidectomy in 3-7-year-old children with otitis media with effusion显示文摘 | Popova D Varbanova S Popov TM | 2010 | Int J Pediatr Otorhinolaryngol2010，74，7： | 1 |
| 9 | Bacterial load and degreeof gastric mucosal inflammation in Helicobacter pylori in-fection显示文摘 | Varbanova M Malfertheiner P | 2011 | Dig Dis2011，29，6： | 1 |
| 10 | Chronic gastritis – an update显示文摘 | Mariya Varbanova Katrin Frauenschl?ger Dr.Peter Malfertheiner | 2014 | Best Practice & Research Clinical Gastroenterology2014，，： | 1 |
| 11 | Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies显示文摘 | Michael Selgrad Julia Meile Jan Bornschein Arne Kandulski Cosima Langner Mariya Varbanova Thomas Wex Ina Tammer Dirk Schlüter Peter Malfertheiner | 2013 | European Journal of Gastroenterology & Hepatology2013，，11： | 1 |
| 12 | Comparison between myringotomy and tympanostomy tubes in combination with adenoidectomy in 3-7-year-old children with otitis media with effusion显示文摘 | Popova D Varbanova S Popov TM | 2010 | Int J Pediatr Otorhinolaryngol2010，74，1： | 1 |
| 13 | Reduction of benzenoid synthesis in petunia flowers reveals multiple pathways to benzoic acid and enhancement in auxin transport显示文摘 | Orlova I Marshall-Colón A Schnepp J Wood B Varbanova M Fridman E Blakeslee J J Peer W A Murphy A S Rhodes D | 2006 | The Plant Cell Online2006，18，12： | 1 |
| 14 | Prevalence of IgM-,IgA- and IgG-rheumatoid factors in seronegative polyarthritis disease compared to pauciarticular disease in juvenile chronic arthritis as measured by ELISA显示文摘 | Varbanova BB Baleva M Niolov K | 1999 | Adv Exp Med Biol1999，455，： | 1 |
| 15 | Chronic gastri- tis-an update显示文摘 | Varbanova M Frauenschlager K Malfertheiner P | 2014 | Best Pract Res Clin Gastroenterol2014，28，6： | 1 |
| 16 | Acute abdomen in a patient with ANCA-associated vasculitis显示文摘 | Varbanova M Schatte K Kuester D | 2011 | Dtsch Med Wochenschr2011，136，36： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员