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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Human CD34loCD133lo fetal liver cells support the expansion of human CD34hiCD133hi hematopoietic stem cells显示文摘 | Kylie Su Mei Yong Choong Tat Keng Shu Qi Tan Eva Loh Kenneth TE Chang Thiam Chye Tan Wanjin Hong Qingfeng Chen | 2016 | Cellular & Molecular Immunology2016，13，5： | 5 |
| 3 | Single-frequency Laser at 473 nm by Use of Twisted-mode Technique显示文摘 | HAO Er-juan TAN Hui-ming LI Te | 2007 | Optics communication2007，270，： | 1 |
| 4 | Range of antinuclear an- tibodies in 'healthy' individuals显示文摘 | Tan EM Fehkamp TE Smolen JS | 1997 | Arthritis Rheum1997，40，16： | 1 |
| 5 | Intermittent tepid blood card-ioplegia improves clinical outcome显示文摘 | Tan TE Ahmed S Paterson HS | 2003 | Asian Cardiovasc Thorac Ann2003，11，2： | 1 |
| 6 | Modelling deformation and damage characteristics of woven fabric under small projectile impact显示文摘 | SHIM V P W TAN VBC TAY TE | 1995 | IntJ Impact Engng1995，16，4： | 1 |
| 7 | Range of antinuclear antibodies in 'healthy' individuals 显示文摘 | Tan EM Fehkamp TE Smolen JS | 1997 | Arthritis Rheum1997，40，9： | 1 |
| 8 | EPHX1 polymorphisms do not modify esophageal carcinoma susceptibilityin Dutch Caucasians显示文摘 | Polat Dura Caro Bregitha Rene Te Morsche Hennie Roelofs Jon Kristinsson Theo Wobbes Ben Witteman Adriaan Tan Joost Drenth Wilbert Peters | 2012 | Oncology Reports2012，，6： | 1 |
| 9 | Autologous pericardial pulmonary conduit with single point attached commissures in a sheep modelEur显示文摘 | Goetz WA Tan TE Lim KH | 2008 | J Cardiothorac Surg2008，33，1： | 1 |
| 10 | Truly stentless molded autologous pericardial aortic valve prosthesis with single point attached commissures in a sheep model显示文摘 | Goetz WA Tan TE Lim KH | 2008 | Eur J Cardiothorac Surg2008，33，4： | 1 |
| 11 | Bleeding on probing and pocket probing depth in relation to probing pressure and mucosal health around oral implants显示文摘 | Gerber JA Tan WC Balmer TE | 2009 | Clin Oral Impl2009，20，1： | 1 |
| 12 | Intermittent tepid blood cardioplegia improves clinical outcome显示文摘 | Tan TE | 2003 | Asian Cardiovasc Thorac Ann2003，11，2： | 1 |
| 13 | The preauricular si- nus:a review of its aetiology, clinical presentation and man- agement显示文摘 | Tan T Constantinides H Mitchell TE | 2005 | Int J Pediatr Otorhinolaryngol2005，69，11： | 1 |
| 14 | Comparison of in- flammation in the brain and spinal cord following mechani- cal injury 显示文摘 | Batchelor PE Tan S Wills TE | 2008 | J Neurotrauma2008，25，10： | 1 |
| 15 | Range of antinuclear antibodies in 'healthy' individuals显示文摘 | Tan EM Feltkamp TE Smolen JS | 1997 | Arthritis Rheum1997，40，9： | 1 |
| 16 | Single-frequency laser at 473 nm by use of twisted-mode technique显示文摘 | HAO E TAN H LI Te | 2007 | Optics Communications2007，270，： | 1 |
| 17 | Topoisomerase alpha and Topoismerase beta genes: charecteriztion and mapping to human chromosomes 17 and 3,respectively 显示文摘 | Tan KB Dorman TE Falls KM | 1992 | Cancer Res1992，52，1： | 1 |
| 18 | The preauricular sinus: a review of its aetiology, clinical presentation and management 显示文摘 | Tan T Constantinides H Mitchell TE | 2005 | Int J Pediatr Otorhinolaryngol2005，69，11： | 1 |
| 19 | Bleeding on probing and pocket probing depth in relation to probing pressure and mueosal health around oral implants显示文摘 | Gerber JA Tan WC Balmer TE | 2009 | Clin Oral Impl2009，20，1： | 1 |
| 20 | Single-frequency laser at 473 nm by use of twisted-mode technique 显示文摘 | Erjuan Hao Huiming Tan Te Li | 2007 | Optics Communication2007，，： | 1 |
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