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| 1 | Nitrogen-doped fluorescence carbon dots as multi-mechanism detection for iodide and curcumin in biological and food samples显示文摘Iodine ion is one of the most indispensable anions in living organisms,particularly being an important substance for the synthesis of thyroid hormones.Curcumin is a yellow-orange polyphenol compound derived from the rhizome of Curcuma longa L.,which has been commonly used as a spice and natural coloring agent,food additives,cosmetics as well as Chinese medicine.However,excess curcumin may cause DNA inactivation,lead to a decrease in intracellular ATP levels,and trigger the tissue necrosis.Therefore,quantitative detection of iodine and curcumin is of great significance in the fields of food and life sciences.Herein,we develop nitrogen-doped fluorescent carbon dots(NCDs)as a multi-mechanism detection for iodide and curcumin in actual complex biological and food samples,which was prepared by a one-step solid-phase synthesis using tartaric acid and urea as precursors without adding any other reagents.An assembled NCDs-Hg^(2+) fluorescence-enhanced sensor for the quantitative detection of I^(-) was established based on a fluorescence“turn-off-on”mechanism in a linear range of 0.3-15μM with a detection limit of 69.4 nM and successfully quantified trace amounts of I^(-) in water samples and urine sample.Meanwhile,the as-synthesized NCDs also can be used as a fluorescent quenched sensor for curcumin detection based on the synergistic internal filtration effect(IFE)and static quenching,achieving a good linear range of 0.1-20μM with a satisfactory detection limit of 29.8 nM.These results indicate that carbon dots are potential sensing materials for iodine and curcumin detection for the good of our health. | Xiaodan Tang Hongmei Yu Brian Bui Lingyun Wang Christina Xing Shaoyan Wang Mingli Chen Zhizhi Hu Wei Chen | 2021 | Bioactive Materials2021，6，6： | 11 |
| 2 | Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma显示文摘AIM: To identify the downstream regulated genes of GAEC1 oncogene in esophageal squamous cell carcinoma and their clinicopathological significance. METHODS: The anti-proliferative effect of knocking down the expression of GAEC1 oncogene was stud-ied by using the RNA interference (RNAi) approach through transfecting the GAEC1 -overexpressed esophageal carcinoma cell line KYSE150 with the pSilencer vector cloned with a GAEC1 -targeted sequence, followed by MTS cell proliferation assay and cell cycle analysis using flow cytometry. RNA was then extracted from the parental, pSilencer-GAEC1 -targeted sequence transfected and pSilencer negative control vector transfected KYSE150 cells for further analysis of different patterns in gene expression. Genes differentially expressed with suppressed GAEC1 expression were then determined using Human Genome U133 Plus 2.0 cDNA microarray analysis by comparing with the parental cells and normalized with the pSilencer negative control vector transfected cells. The most prominently regulated genes were then studied by immunohistochemical staining using tissue microarrays to determine their clinicopathological correlations in esophageal squamous cell carcinoma by statistical analyses. RESULTS: The RNAi approach of knocking down gene expression showed the effective suppression of GAEC1 expression in esophageal squamous cell carcinoma cell line KYSE150 that resulted in the inhibition of cell proliferation and increase of apoptotic population. cDNA microarray analysis for identifying differentially expressed genes detected the greatest levels of downregulation of calpain 10 (CAPN10 ) and upregulation of trinucleotide repeat containing 6C (TNRC6C ) transcripts when GAEC1 expression was suppressed. At the tissue level, the high level expression of calpain 10 protein was significantly associated with longer patient survival (month) of esophageal squamous cell carcinoma compared to the patients with low level of calpain 10 expression (37.73 ± 16.33 vs 12.62 ± 12.44, P = 0.032). No significant correction was observed among the TNRC6C protein expression level and the clinocopathologcial features of esophageal squamous cell carcinoma. CONCLUSION: GAEC1 regulates the expression of CAPN10 and TNRC6C downstream. Calpain 10 expression is a potential prognostic marker in patients with esophageal squamous cell carcinoma. | Dessy Chan Miriam Yuen-Tung Tsoi Christina Di Liu SauHing Chan Simon Ying-Kit Law Kwok-Wah Chan Yuen-Piu Chan Vinod Gopalan Alfred King-Yin Lam Johnny Cheuk-On Tang | 2013 | World Journal of Gastroenterology2013，19，18： | 2 |
| 3 | Short - form Tai Chi improves standing balance of people with chronic stroke显示文摘 | Au- Yeung Stephanie SY Hui- Chan Christina WY Tang Jervis CS | 2009 | NeuroFehabilitation and Neural Repair2009，23，5： | 1 |
| 4 | The latent causal chain of industrial water pollution in China显示文摘 | Miao Xin Tang Yanhong Wong Christina W Y | 2015 | Environmental Pollution2015，196，： | 1 |
| 5 | Alginate- polyethylene oxide blend nanofibers and the role of the carrier polymer in electrospinning 显示文摘 | Saquing Carl D Tang Christina Brinda Monian | 2013 | Industrial and Engineering Chemistry Research2013，52，26： | 1 |
| 6 | Forecasting of in situ electron energy loss spectroscopy显示文摘Forecasting models are a central part of many control systems,where high-consequence decisions must be made on long latency control variables.These models are particularly relevant for emerging artificial intelligence(AI)-guided instrumentation,in which prescriptive knowledge is needed to guide autonomous decision-making.Here we describe the implementation of a long short-term memory model(LSTM)for forecasting in situ electron energy loss spectroscopy(EELS)data,one of the richest analytical probes of materials and chemical systems.We describe key considerations for data collection,preprocessing,training,validation,and benchmarking,showing how this approach can yield powerful predictive insight into order-disorder phase transitions.Finally,we comment on how such a model may integrate with emerging AI-guided instrumentation for powerful high-speed experimentation. | Nicholas R.Lewis Yicheng Jin Xiuyu Tang Vidit Shah Christina Doty Bethany E.Matthews Sarah Akers Steven R.Spurgeon | 2022 | npj Computational Materials2022，，1： | 1 |
| 7 | Detection of motor imagery of swallow EEG signals based on the dual-tree complex wavelet transform and adaptive model selection显示文摘 | Huijuan Yang Cuntai Guan Karen Sui Geok Chua See San Chok Chuan Chu Wang Phua Kok Soon Christina Ka Yin Tang Kai Keng Ang | 2014 | Journal of Neural Engineering2014，，3： | 1 |
| 8 | A distinct lineage of influenza A virus from bats 显示文摘 | Suxiang Tong Yah Li Pierre Rivailler Christina Con- rardy Danilo A Alvarez Castillo Li-Mei Chen Sergio Recuenco James A Ellison Charles T Davis Ian A York Amy S Turmelle David Moran Shannon Rog- ers Mang Shi Ying Tao Michael R Weil Kevin Tang Lori A Rowe Scott Sammons Xiyan Xu Mi- chael Frace Kim A Lindblade Nancy J Cox Larry J Anderson Charles E Rupprecht Ruben O Donis | 2012 | PANS U S A2012，109，11： | 1 |
| 9 | Highly N-doped carbon with low graphitic-N content as anode material for enhanced initial Coulombic efficiency of lithium-ion batteries显示文摘N-doped carbons as one of the most prominent anode materials to replace standard graphite exhibit outstanding Li+storage performance.However,N-doped carbon anodes still suffer from low N-doping levels and low initial Coulombic efficiency(ICE).In this study,high N-doped and low graphitic-N carbons(LGNCs)with enhanced ICE were synthesized by taking advantage of a denitrification strategy for graphitic carbon nitride(g-C_(3)N_(4)).In brief,more than 14.5 at%of N from g-C_(3)N_(4)(55.1 at%N)was retained by reacting graphitic-N with lithium,which was subsequently removed.As graphitic-N is largely responsible for the irreversible capacity,the anode's performance was significantly increased.Compared to general N-doped carbons with high graphitic-N proportion(>50%)and low N content(<15 at%),LGNCs delivered a low proportion of 10.8%-17.2% within the high N-doping content of 14.5-42.7 at%,leading to an enhanced specific capacity of 1499.9mAh g^(-1) at an ICE of 93.7% for the optimal sample of LGNC(4:1).This study provides a facile strategy to control the N content and speciation,achieving both high Li+storage capacity and high ICE,and thus promoting research and application of N-doped carbon materials. | Yihua Tang Jingjing Chen Zhiyong Mao Christina Roth Dajian Wang | 2023 | Carbon Energy2023，5，2： | 1 |
| 10 | Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women显示文摘 | Christina A. Gamba Susan M. Swetter Marcia L. Stefanick Jessica Kubo Manisha Desai Katrina M. Spaunhurst Animesh A. Sinha Maryam M. Asgari Susan Sturgeon Jean Y. Tang | 2013 | Cancer2013，，8： | 1 |
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