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| 1 | FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers显示文摘forkhead 盒子抄写因素 A2 (FOXA2 ) 是在动物开发和身体动态平衡的一个重要管理者。然而, FOXA2 是否涉及转变生长因素尾 1 (TGF-尾 1 ) ,调停了 epithelial-to-mesenchymal 转变(EMT ) 和肿瘤转移仍然保持未知。现在的学习证明在人的肺癌症房间线,许多 FOXA2 断然与上皮的显型相关并且否定地与房间的间充质的显型相关,并且 TGF-尾 1 治疗减少了 FOXA2 蛋白质水平。一致地, FOXA2 击倒肺癌症房间的支持的 EMT 和侵略,而 FOXA2 的 overexpression 减少了侵略并且压制了 TGF- ,尾 1 导致了 EMT。另外, FOXA2 击倒禁止的 FOXA2 的导致的蛞蝓表示,和宫外的表示猛击抄写。而且,我们鉴别 FOXA2 能绑通过一个保存有约束力的地点猛击倡导者,并且 FOXA2 的 DNA 有约束力的区域和 transactivation 区域 II 为蛞蝓倡导者的压抑被要求。这些数据证明 FOXA2 由 EMT 的抑制作为肿瘤转移的 suppressor 工作。 | Yunneng Tang Guangwen Shu Xinwang Yuan Naihe Jing Jianguo Song | 2011 | Cell Research2011，21，2： | 27 |
| 2 | A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants显示文摘There are currently approximately 4000 mutations in the SARS-CoV-2 S protein gene and emerging SARS-CoV-2 variants continue to spread rapidly worldwide.Universal vaccines with high efficacy and safety urgently need to be developed to prevent SARS-CoV-2 variants pandemic.Here,we described a novel self-assembling universal mRNA vaccine containing a heterologous receptorbinding domain(HRBD)-based dodecamer(HRBD^(dodecamer))against SARS-CoV-2 variants,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(B.1.1.28.1),Delta(B.1.617.2)and Omicron(B.1.1.529).HRBD containing four heterologous RBD(Delta,Beta,Gamma,and Wild-type)can form a stable dodecameric conformation under T4 trimerization tag(Flodon,FD).The HRBD^(dodecamer)-encoding mRNA was then encapsulated into the newly-constructed LNPs consisting of a novel ionizable lipid(4N4T).The obtained universal mRNA vaccine(4N4T-HRBD^(dodecamer))presented higher efficiency in mRNA transfection and expression than the approved ALC-0315 LNPs,initiating potent immune protection against the immune escape of SARS-CoV-2 caused by evolutionary mutation.These findings demonstrated the first evidence that structure-based antigen design and mRNA delivery carrier optimization may facilitate the development of effective universal mRNA vaccines to tackle SARS-CoV-2 variants pandemic. | Shugang Qin Hai Huang Wen Xiao Kepan Chen Xi He Xiaoshan Tang Zhiying Huang Yupei Zhang Xing Duan Na Fan Qian Zheng Min Wu Guangwen Lu Yuquan Wei Xiawei Wei Xiangrong Song | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 1 |
| 3 | Golden rice is an effective source of vitamin A 显示文摘 | TANG Guangwen QIN Jian DOLNIKOWSKI G | 2009 | Am J Clin Nutr2009，89，6： | 1 |
| 4 | Deuterium enrichment of retinol in humans determined by gas chromatography electron capture negative chemical ionization mass spectrometry显示文摘 | TANG Guangwen QIN Jian DOLNIKOWSKL G | 1998 | J Nutr Biochem1998，9，： | 1 |
| 5 | Green and yellow vegetables can maintain body stores of vitamin A in Chinese children显示文摘 | TANG Guangwen GU Xiufen HU Shanming | 1999 | Am J Clin Nutr1999，70，： | 1 |
| 6 | Vitamin A equivalence of β-carotene in a woman as determined by a stable isotope reference method 显示文摘 | TANG Guangwen QIN Jian GRUSAK M A | 2000 | Eur J Nutr2000，39，： | 1 |
| 7 | β - carotene in Golden Rice is as good as b - car- otene in oil at providing vitamin A to children显示文摘 | Guangwen Tang Yuming Hu Shi - an Yin Yin Wang | 2012 | The American Journal of Clinical Nutrition2012，，96： | 1 |
| 8 | Bioavailability of lutein in humans from intrinsically labeled vegetables determined by LCAPCI-MS显示文摘 | Glaser T Tang Guangwen | 2003 | Journal of Nutritional Biochemistry2003，14，11： | 1 |
| 9 | Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells显示文摘 | Qingning Bian Shasha Gao Jilin Zhou Jian Qin Allen Taylor Elizabeth J. Johnson Guangwen Tang Janet R. Sparrow Dennis Gierhart Fu Shang | 2012 | Free Radical Biology and Medicine2012，，6： | 1 |
| 10 | Golden Rice is an effective source of vitamin A显示文摘 | Guangwen Tang Jian Qin Gregory G Dolnikowski | 2009 | The American Journal of Clinical Nutrition2009，89，： | 1 |
| 11 | β - Carotene in Golden Rice is as good as β- caro- tene in oil at providing vitamin A to children 显示文摘 | Guangwen Tang Yuming Hu Shi - an Yin Yin Wang Gerard E Dallal Michael A Grusak and Robert M Russell | 2012 | Am J Clin Nutr2012，96，： | 1 |
| 12 | Effects of Mobile Phase Ratios on the Separation of Plant Carotenoids by HPLC with a C30 Column显示文摘 | Lei Li Jian Qin Shi-an Yin Guangwen Tang | 2007 | Chromatographia (-)2007，，1： | 1 |
| 13 | Bioavailability of synthetic and biosynthetic deuterated lycopene in humans显示文摘 | TANG Guangwen FERREIRA A L A GRUSAK M A | 2005 | Journal of Nutritional Biochemistry2005，16，： | 1 |
| 14 | Rational design of asymmetric atomic Ni-P1N3 active sites for promoting electrochemical CO_(2)reduction显示文摘The atomic-level interfacial regulation of single metal sites through heteroatom doping can significantly improve the characteristics of the catalyst and obtain surprising activity.Herein,nickel single-site catalysts(SSCs)with dual-coordinated phosphorus and nitrogen atoms were developed and confirmed(denoted as Ni-PxNy,x=1,2 and y=3,2).In CO_(2)reduction reaction(CO_(2)RR),the CO current density on Ni-PxNy was significantly higher than that of Ni-N4 catalyst without phosphorus modification.Besides,Ni-P1N3 performed the highest CO Faradaic efficiency(FECO)of 85.0%–98.0%over a wide potential range of−0.65 to−0.95 V(vs.the reversible hydrogen electrode(RHE)).Experimental and theoretical results revealed that the asymmetric Ni-P1N3 site was beneficial to CO_(2)intermediate adsorption/desorption,thereby accelerating the reaction kinetics and boosting CO_(2)RR activity.This work provides an effective method for preparing well-defined dual-coordinated SSCs to improve catalytic performance,targetting to CO_(2)RR applications. | Ming Qu Zhe Chen Zhiyi Sun Danni Zhou Wenjing Xu Hao Tang Hongfei Gu Tuo Liang Pengfei Hu Guangwen Li Yu Wang Zhuo Chen Tao Wang Binbin Jia | 2023 | Nano Research2023，16，2： | 0 |
| 15 | Electrical Struture of the Crust in Manas Earthquake Area,Xinjiang,China显示文摘Magnetotelluric sounding data obtalned recently in Manas earthquake area were processed. Inthe result, curves of apparent resistivity, impedance Phase, skewness and optimum rotationangle versus period and the real magnetic induction vectors were obtained. Then the data ofall measuring points were interpreted by 2D automatic inversion. The result indicates thatalong the sounding profile the shallow crust can be divided into 5 segments and the deep crustcan be divided into 3 segments, with faults or deep-seated fault zones as the contactboundaries between them. The sedimentary cover along the profile extents down to depthabout 12 km in maximum and a low-resistivity body exists in the crust in southern section ofthe profile. The interpretation results are well consistent with geological and othergeophysical data. The Manas M7. 7 earthquake occurred near a contact zone where theelectrical structure of the crust sharply changes. | Zhao Guoze, Zhan Yan, Tang Ji, Zhao Junmeng, Jin Guangwen, Deng Qianhui, and Wang JijunInstitute of Geology, CSB, Beijing 100029, China | 2000 | Earthquake Research in China2000，14，1： | 0 |
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