|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparison of rescue strategies in lamivudine-resistant patients with chronic hepatitis B显示文摘 | Pan Zhao Chunya Wang LiLi Huang Dongping Xu Tanshi Li | 2012 | Antiviral Research2012，，2： | 2 |
| 2 | Percutaneous injection of hemostatic agents for severe blunt hepatic trauma: an experimental study显示文摘 | Jie Tang Faqin Lv Wenxiu Li Huiqin Zhang Yukun Luo Lichun An Tanshi Li | 2008 | European Radiology2008，，12： | 1 |
| 3 | Emergency contrast-enhanced ultrasonography for pancreatic injuries in blunt abdominal trauma显示文摘 | Faqin Lv Jie Tang Yukun Luo Yongkang Nie Tong Liang Ziyu Jiao Zhihong Zhu Tanshi Li | 2014 | La radiologia medica2014，，： | 1 |
| 4 | VEGF regulates antidepressant effects of lamotrigine显示文摘 | Rongju Sun Nanxin Li Tanshi Li | 2011 | European Neuropsychopharmacology2011，，： | 1 |
| 5 | Discussion on forestry property rights and forestry economic problems显示文摘 | TanShi mlngoTanlin | 1997 | Problems of Forestry Economics1997，，4： | 1 |
| 6 | Effectiveness of contrast-enhanced ultrasound in the classification and emergency management of abdominal trauma显示文摘 | Faqin Lv Yanting Ning Xuan Zhou Yukun Luo Tong Liang Yongkang Nie Tanshi Li Jie Tang | 2014 | European Radiology2014，，： | 1 |
| 7 | Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72显示文摘Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics. | Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 8 | Construction and application of time-effect assessment database for experiments on war-traumatized animals显示文摘Background:High-quality real war trauma data are important,but they are still lacking.Using the database to realize the networked,systematic,standardized,and dynamic management of war injury animal experimental data can provide a real and reliable supplement for the research of war injury treatment.Methods:Through demand analysis,module design,architecture design,compilation and debugging,and other processes,JAVA language development tools were used to develop a time-effect assessment database for experiments on war-traumatized animals,where the browser/server architecture(B/S architecture)is used as the technical architecture and SQL Server as the database management system.Results:A time-effect assessment database for experiments on war-traumatized animals that features reasonable structural design,rich data resources,and convenient use has been established,in which case efficient collection,storage,display,retrieval,and management of animal experimental data have been achieved.At present,the database is running well and has good data quality. | Junkang Wang Jing Wang Hongliang Zhang Chengyu Guo Yanbiao Wang Bing Lu Cong Feng Fei Pan Tanshi Li | 2022 | Emergency and Critical Care Medicine2022，2，4： | 0 |
| 9 | Effi cacy of partial and complete resuscitative endovascular balloon occlusion of the aorta in the hemorrhagic shock model of liver injury显示文摘BACKGROUND:Resuscitative endovascular balloon occlusion of the aorta(REBOA)can temporarily control traumatic bleeding.However,its prolonged use potentially leads to ischemia-reperfusion injury(IRI).Partial REBOA(pREBOA)can alleviate ischemic burden;however,its security and eff ectiveness prior to operative hemorrhage control remains unknown.Hence,we aimed to estimate the effi cacy of pREBOA in a swine model of liver injury using an experimental sliding-chamber ballistic gun.METHODS:Twenty Landrace pigs were randomized into control(no aortic occlusion)(n=5),intervention with complete REBOA(cREBOA)(n=5),continuous pREBOA(C-pREBOA)(n=5),and sequential pREBOA(S-pREBOA)(n=5)groups.In the cREBOA and C-pREBOA groups,the balloon was inflated for 60 min.The hemodynamic and laboratory values were compared at various observation time points.Tissue samples immediately after animal euthanasia from the myocardium,liver,kidneys,and duodenum were collected for histological assessment using hematoxylin and eosin staining.RESULTS:Compared with the control group,the survival rate of the REBOA groups was prominently improved(all P<0.05).The total volume of blood loss was markedly lower in the cREBOA group(493.14±127.31 mL)compared with other groups(P<0.01).The pH was significantly lower at 180 min in the cREBOA and S-pREBOA groups(P<0.05).At 120 min,the S-pREBOA group showed higher alanine aminotransferase(P<0.05)but lower blood urea nitrogen compared with the cREBOA group(P<0.05).CONCLUSION:In this trauma model with liver injury,a 60-minute pREBOA resulted in improved survival rate and was effective in maintaining reliable aortic pressure,despite persistent hemorrhage.Extended tolerance time for aortic occlusion in Zone I for non-compressible torso hemorrhage was feasible with both continuous partial and sequential partial measures,and the significant improvement in the severity of acidosis and distal organ injury was observed in the sequential pREBOA. | Yi Shan Yang Zhao Chengcheng Li Jianxin Gao Guogeng Song Tanshi Li | 2024 | World Journal of Emergency Medicine2024，15，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员