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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 3 | P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte- endothelial adhesion and promotes neurovascular injury during septic encephalopathy显示文摘 | Huan Wang Ling-Juan Hong Ji-Yun Huang Quan Jiang Rong-Rong Tao Chao Tan Nan-Nan Lu Cheng-Kun Wang Muhammad M Ahmed Ying-Mei Lu Zhi-Rong Liu Wei-Xing Shi En-Yin Lai Christopher S Wilcox Feng Han | 2015 | Cell Research2015，25，6： | 16 |
| 4 | Spatial-temporal Pattern and Population Driving Force of Land Use Change in Liupan Mountains Region, Southern Ningxia, China显示文摘The Liupan Mountains is located in the southern Ningxia Hui Autonomous Region of China, which forms an important dividing line between landforms and bio-geographic regions. The populated part of the Liupan Mountains region has suffered tremendous ecological damages over time due to population pressure, excessive demand and inappropriate use of agricultural land resources. In this paper, datasets of land use between 1990 and 2000 were obtained from Landsat TM imagery, and then spatial models were used to characterize landscape conditions. Also, the relationship between the population density and land use/cover change (LUCC) was analyzed. Results indicate that cropland, forestland, and urban areas have increased by 44,186ha, 9001ha and 1550ha, respectively while the grassland area has appreciably decreased by 54,025ha in the study period. The decrease in grassland was most notable. Of the grassland lost, 49.4% was converted into cropland. The largest annual land conversion rate in the study area was less than 2%. These changes are attributed to industrial and agricultural development and population growth. To improve the eco-economic conditions in the study region, population control, urbanization and development of an ecological friendly agriculture were suggested. | QUAN Bin M J M ROMKENS TAO Jianjun LI Bicheng LI Chaokui YU Guanghui CHEN Qichun | 2008 | Chinese Geographical Science2008，18，4： | 15 |
| 5 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 6 | Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: A meta-analysis显示文摘AIM: To undertake a meta-analysis on the value of urinary trypsinogen activation peptide (uTAP) in predicting severity of acute pancreatitis on admission. METHODS: Major databases including Medline, Embase, Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in the Cochrane Library were searched to identify all relevant studies from January 1990 to January 2013. Pooled sensitivity, specificity and the diagnostic odds ratios (DORs) with 95%CI were calculated for each study and were compared to other systems/biomarkers if mentioned within the same study. Summary receiver-operating curves were conducted and the area under the curve (AUC) was evaluated. RESULTS: In total, six studies of uTAP with a cut-off value of 35 nmol/L were included in this meta-analysis. Overall, the pooled sensitivity and specificity of uTAP for predicting severity of acute pancreatitis, at time of admission, was 71% and 75%, respectively (AUC = 0.83, DOR = 8.67, 95%CI: 3.70-20.33). When uTAP was compared with plasma C-reactive protein, the pooled sensitivity, specificity, AUC and DOR were 0.64 vs 0.67, 0.77 vs 0.75, 0.82 vs 0.79 and 6.27 vs 6.32, respectively. Similarly, the pooled sensitivity, specificity, AUC and DOR of uTAPvs Acute Physiology and Chronic Health Evaluation Ⅱ within the first 48 h of admission were found to be 0.64 vs 0.69, 0.77 vs 0.61, 0.82 vs 0.73 and 6.27vs 4.61, respectively. CONCLUSION: uTAP has the potential to act as a stratification marker on admission for differentiating disease severity of acute pancreatitis. | Wei Huang Kiran Altaf Tao Jin Jun-Jie Xiong Li Wen Muhammad A Javed Marianne Johnstone Ping Xue Christopher M Halloran Qing Xia | 2013 | World Journal of Gastroenterology2013，19，28： | 7 |
| 7 | Biological responses of small yellow croaker(Larimichthys polyactis) to multiple stressors: a case study in the Yellow Sea, China显示文摘Temporal changes in biological characteristics of small yellow croaker Larimichthys polyactis in the Yellow Sea were examined for the period of 1960–2008. The body size and age of small yellow croaker decreased substantially, in particular, average length of fish in 2008 was reduced by ~85% than those occurring in 1985, and at that time ~93% of the total catch was dominated by one-year-old individuals. Correspondingly, growth parameters also varied significantly over the years, i.e., k(growth coefficient) and t_0(zero-length age) gradually increased from 0.26 and –0.58 year in 1960 to 0.56 and –0.25 year in 2008, respectively. Although, L∞(body length)sharply decreased from 34.21 cm in 1960 to 24.06 cm in 2008, and t_r(inflexion age) decreased from 3.78 year in1960 to 1.61 year in 2008. There was a great increase both in natural mortality coefficient and fishing mortality coefficient. However, according to the gray correlation analysis, changes in the biological characteristics of small yellow croaker were induced by different stressors ranked as: fishing vessel power>feeding grade>sea surface temperature. This study suggests that the active fishery management measures for biological characters of fish populations should be considered. | SHAN Xiujuan LI Xiansen YANG Tao SHARIFUZZAMAN S M ZHANG Guozheng JIN Xianshi DAI Fangqun | 2017 | Acta Oceanologica Sinica2017，36，10： | 5 |
| 8 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 9 | Discrete large eddy simulation显示文摘Despite the intense effort expended towards obtaining a model for describing the turbulent flows of fluid, there is no model at hand that can do an adequate job. This leads us to look for a non-traditional approach to turbulence modeling. In this work we conjoin the notion of large eddy simulation with those of fuzzy sets and neural networks to describe a class of turbulent flows. In previous works we had discussed several issues concerning large eddy simulation such as filtering and averaging. Here, we discuss the use of fuzzy sets to improve the filtering procedure. | L. TAO, K. R. RAJAGOPAL and G. Q. CHEN(Department of Mechanical Engineering, Texas A&M University, College Station, Texas 77843-3123,USACentre for Environmental Sciences, Peking University, Beijing 100871, China | 2001 | Communications in Nonlinear Science and Numerical Simulation2001，6，1： | 2 |
| 10 | 新型雄激素受体种系错义突变与非裔男性家族性前列腺癌显示文摘种族、家族史和年龄是众所周知的前列腺癌危险因素。雄激素受体依赖性信号传送是前列腺癌变和肿瘤转移的重要基础。非裔男性的前列腺癌发病率、死亡率高于白人,且临床恶性程度高。本实验探究了非裔男性家族性前列腺癌与雄激素受体(AR)基因突变之间的关系。实验中我们对参与路易斯安那州立大学健康科学中心前列腺癌遗传连锁研究的30个高危黑人和白人家庭的60名前列腺癌患者的基因组HDNA序列进行了检测。应用外显子特异性聚合酶链反应,双向自动测序和限制性内切酶基因分型分析AR基因编码区突变,结果在一个有早发前列腺癌家族史黑人家庭的3名成员中发现了种系AR-A1675T(T559S)替换突变,突变位于DNA结合区。本研究首次在患家族性前列腺癌的黑人男性中发现了种系雄激素受体突变,该突变可能会改变受体与DNA结合亲和力和/或对雄激素、非雄性类固醇或雄激素拈抗剂的反应。今后的研究应当探索AR(A1675T)序列对黑人早发和/或家族性前列腺癌的影响和影响频率。 | Si-Yi Hu Tao Liu Zhen-Zhen Liu Elisa Ledet Cruz Velasco-Gonzalez Diptasri M Mandal Shahriar Koochekpour | 2010 | Asian Journal of Andrology2010，12，3： | 2 |
| 11 | Superhydrophobic silica nanocomposite coating by a low-temperature process显示文摘 | DAOUD W A XIN J H TAO X M | 2004 | Journal of American Ceramic Society2004，87，9： | 1 |
| 12 | Superhydrophobie silica nanocom-poaite coating by a low-temperature proeess显示文摘 | DAOUD W A XIN J H TAO X M | 2004 | Journal of the Ameri-Call Ceramic Socienty2004，87，9： | 1 |
| 13 | Use of a photocatalytic membrane reactor for the removal of natural organic matter in water: effect of photoinduced desorption and ferrihydrite adsorption显示文摘 | CHOO K H TAO R KIM M J | 2008 | J Membr Sci2008，322，： | 1 |
| 14 | Remote sensing of crop production in China by production efficiency models: models comparisons estimates and uncertainties显示文摘 | Tao F Yokozawa M Zhang Z | 2005 | Ecological Modelling2005，183，4： | 1 |
| 15 | Sliding mode controller for linear systems with mismatched time-varying uncertainties 显示文摘 | TAO C W LEE T T | 2000 | Journal of Franklin Institute2000，337，： | 1 |
| 16 | Design recommendation for bone of GFRP rebar' s to concrete 显示文摘 | Ehasani M R Saadatmanesh H Tao S | 1996 | Journal of Structural Engineering1996，122，3： | 1 |
| 17 | Surface nanocrystallization of iron induced by ultrasonic shot peening显示文摘 | TAO N R SUI M L LU J | 1999 | Nanostructured Materials1999，11，4： | 1 |
| 18 | Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice显示文摘 | CAVASIN M A TAO Z MENON S | 2004 | Life Sei2004，75，18： | 1 |
| 19 | Design recommendations for bond of GFRP rebars to concrete 显示文摘 | Ehsani M R Saadatmanesh H Tao S | 1996 | Journal of Structural Engineering1996，，3： | 1 |
| 20 | Shear-wave velocity and Q anisotropy in rocks: a laboratory study 显示文摘 | TAO Guo KING M S | 1990 | Rock Mech Min Sci & Geomech Abstr1990，27，5： | 1 |
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