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| 1 | Annexin A1: A new immunohistological marker of cholangiocarcinoma显示文摘AIM: To evaluate a new immunohistological marker, annexin A1 (ANXA1), in cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC). METHODS: Expression of ANXA1 protein was investigated in liver tissues from patients with CCA and HCC by immunohistochemistry. Its expression on differences stages of tumor development was investigated in hamster CCA tissues induced by Opisthorchis viverrini and N -nitrosodimethylamine. Moreover, mRNA expression of ANXA1 was assessed in CCA cell lines by quantitative real-time polymerase chain reaction and silencing of ANXA1 gene expression using small interfering RNA. RESULTS: In human CCA tissue arrays, immunohistochemical analysis revealed that the positive expression of ANXA1 was 94.1% (64/68 cases) consisting of a high expression (66.2%, 45/68 cases) and a low expression (33.8%, 23/68 cases). However, expression of ANXA1 protein was negative in all histologic patterns for HCC (46/46 cases) and healthy individuals (6/6 cases). In hamster with opisthorchiasis-associated CCA, the expression of ANXA1 was observed in the cytoplasm of inflammatory cells, bile duct epithelia and tumor cells. Grading scores of ANXA1 expression were significantly increased with tumor progression. In addition, mRNA expression of ANXA1 significantly increased in all of the various CCA cell lines tested compared to an immortalized human cholangiocyte cell line (MMNK1). Suppressing the ANXA1 gene significantly reduced the matrix metalloproteinase (MMP) 2 and MMP9, and transforming growth factor-β genes, but increased nuclear factor-kB gene expression. CONCLUSION: ANXA1 is highly expressed in CCA, but low in HCC, suggesting it may serve as a new immunohistochemical marker of CCA. ANXA1 may play a role in opisthorchiasis-associated cholangiocarcinogenesis. | Nuttanan Hongsrichan Rucksak Rucksaken Yaovalux Chamgramol Porntip Pinlaor Anchalee Techasen Puangrat Yongvanit Narong Khuntikeo Chawalit Pairojkul Somchai Pinlaorr | 2013 | World Journal of Gastroenterology2013，19，16： | 4 |
| 2 | Tumor necrosis factor-α modulates epithelial mesenchymal transition mediators ZEB2 and S100A4 to promote cholangiocarcinoma progression显示文摘 | Techasen A Namwat N Loilome W | 2014 | Hepatobiliary Pancreat Sci2014，21，9： | 1 |
| 3 | Tumor necrosis factorα (TNF-o) stimulates the epithelial-mesenchymal transition regulator Snail in cholangiocarcinoma显示文摘 | Techasen A Namwat N Loilome W | 2012 | Med Oncol2012，29，5： | 1 |
| 4 | Genetic and environmental determinants of risk for cholangiocarcinoma in Thailand显示文摘Cholangiocarcinoma(CCA) is a difficult cancer to diagnose in the early stage and to treat by curative resec-tion. The incidence of CCA in the northeast of Thailand is the highest in the world. To make progress in detecting a high risk group and in the prevention and detection of CCA, we have been analyzing the risk factors for CCA. Although liver fluke infection is known to be a risk factor, there are patients who are not infected with the liver fluke and not all people infected with the liver fluke will suffer from the disease. Therefore, it is of the utmost importance to analyze the risk factors and the mechanism to prevent the disease and also to detect the disease in its early stage to save patients' lives. Through collaboration among Thai and Japanese researchers, we analyzed the genetic and environmental determinants of risks for CCA. Also, we have been trying to develop methods to detect the disease in a non-invasive way. Without repeating findings reported in various reviews on CCA, we will first discuss the environmental and genetic determinants of the risks for CCA. Second, we will discuss the properties of CCA, including the etiological agents and the mechanism of cholangiocarcinogenesis, and finally, we will discuss future approaches to prevent and cure CCA from the standpoint of evidence-based medicine. We will discuss these points by including the data from our laboratories. We would like to emphasize the importance of the genetic data, especially whole genome approaches, to understand the properties of CCA, to find a high risk population for CCA and to develop effective preventative methods to stop the carcinogenic steps toward CCA in the near future. In addition, it is of the upmost importance to develop a non-invasive, specific and sensitive method to detect CCA in its early stage for the application of modern medical approaches to help patients with CCA. | Masanao Miwa Satoshi Honjo Gyokukou You Masakazu Tanaka Kazuhiko Uchida Petcharin Srivatanakul Thiravud Khuhaprema Watcharin Loilome Anchalee Techasen Chaisiri Wongkham Temduang Limpaiboon Puangrat Yongvanit Sopit Wongkham | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 1 |
| 5 | BMP-7 blocks the effects of TGF-13-induced EMT in cholangiocarci- noma 显示文摘 | Duangkumpha K Techasen A Loilome W | 2014 | Tumour Biol2014，35，： | 1 |
| 6 | Targeting theΔ133p53 isoform can restore chemosensitivity in 5-fluorouracilresistant cholangiocarcinoma cells显示文摘 | Nutthasirikul N Hahnvajanawong C Techasen A | 2015 | Int J Oncol2015，47，6： | 1 |
| 7 | In- creased activation of PI3K/AKT signaling pathway is associ- ated with cholangiocarcinoma metastasis and PI3K/mTOR in- hibition presents a possible therapeutic strategy 显示文摘 | YOTHAISONG S DOKDUANG H TECHASEN A | 2013 | Tumour Biol2013，34，6： | 1 |
| 8 | Upregulation of endothelial nitric oxide synthase(e NOS)and its upstream regulators in Opisthorchis viverrini associated cholangiocarcinoma and its clinical significance显示文摘 | Suksawat M Techasen A Namwat N | 2016 | Parasitol Int2016，30，： | 1 |
| 9 | Loss of E-cadherin promotes migration and invasion of cholangiocarcinoma cells and serves as a potential marker of metastasis显示文摘 | Techasen A Loilome W Namwat N | 2014 | Tumour Biol2014，35，9： | 1 |
| 10 | BMP-7 blocks the effects of TGF-β-induced EMT in cholangiocarcinoma显示文摘 | Kassaporn Duangkumpha Anchalee Techasen Watcharin Loilome Nisana Namwat Raynoo Thanan Narong Khuntikeo Puangrat Yongvanit | 2014 | Tumor Biology2014，，10： | 1 |
| 11 | Loss of E-cadherinpromotes migration and invasion of cholangiocarcinoma cellsand serves as a potential marker of metastasis显示文摘 | Techasen A Loilome W Namwat N | 2014 | Tumor Biol2014，35，9： | 1 |
| 12 | Tumomecrosis factor-or (TNF-α) stimulates the epithelial-mesenchymal transition regulator Snail in cholangiocarciuoma 显示文摘 | Techasen A Namwat N Loilome W | 2012 | Med Oncol2012，29，5： | 1 |
| 13 | Myristoylated alaninerich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase Cdependent pathway显示文摘 | TECHASEN A LOILOME W NAMWAT N | 2010 | Cancer Sci2010，101，3： | 1 |
| 14 | Increased activation of PI3K/Akt signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy显示文摘 | Yothaisong S Dokduang H Techasen A | 2013 | Tumour Biol2013，34，6： | 1 |
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