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| 1 | Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population显示文摘AIM: To investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) among a Mexican population.METHODS: Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 (EBER-1)in situ hybridization was conducted to determine the presence of EBV in neoplastic cells.RESULTS: We studied 330 consecutive, non-selected,primary gastric carcinomas. Among these, there were173 male and 157 female patients (male/female ratio1.1/1). EBER-1 was detected in 24 (7.3%) cases (male/female ratio: 1.2/1). The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years). Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively.CONCLUSION: Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population >50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population. | Roberto Herrera-Goepfert Suminori Akiba Chihaya Koriyama Shan Ding Edgardo Reyes Tetsuhiko Itoh Yoshie Minakami Yoshito Eizuru | 2005 | World Journal of Gastroenterology2005，11，39： | 14 |
| 2 | Risk factors of gastric cancer specific for tumor location and histology in Cali,Colombia显示文摘AIM: To examine histology- and tumor-location specific risk factors of gastric cancer (GC). METHODS: This was a case-control study. The study subjects were 216 GC patients newly diagnosed during the period 2000-2002 and 431 controls selected from non-cancer patients matching in age, gender, and hospital. We obtained information on lifestyles, dietary habits, and others by a questionnaire. RESULTS: The subjects who were not eldest among his/her siblings were at a slightly elevated GC risk (OR 1.3; 95% CI 0.8-2.0). Salting meals before tasting was related to an increased GC risk (OR 3.5; 95% CI 1.6- 7.3). Frequent consumptions of fruits (OR 0.3; 95% CI 0.1-1.0) and vegetables (OR 0.3; 95% CI 0.1-1.0) were related to decreased GC risks. On the other hand, frying foods (OR 1.9; 95% CI 1.0-3.6) and cooking with coal (OR 1.8; 95% CI 1.3-2.6) were related to increased GC risks. Neither Lauren’s histological classification (intestinal and diffuse types) nor tumor location significantly affected those associations except birth order. The subjects who were not eldest among his/her siblings had an increased risk of GCs in the distal and middle thirds, and their ORs were 1.7 (95% CI 1.0-2.8) and 1.9 (95% CI 0.8-4.3), respectively. The corresponding OR in the upper third stomach was 0.3 (95% CI 0.1-0.9). The differences of those three ORs were statistically significant (P = 0.010). CONCLUSION: The present study shows that birth or- der, salt intake, consumption of fruits and vegetables, the type of cooking, and cigarette smoking are related to GC risk. In histology and tumor-location specific analy- ses, non-eldest person among their siblings is related to an increased GC risk in the distal and middle thirds of the stomach, and is related to a decreased GC risk in the cardia. | Francia Campos Gabriel Carrasquilla Chihaya Koriyama Mauricio Serra Edwin Carrascal Tetsuhiko Itoh Mitsuharu Nomoto Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，36： | 11 |
| 3 | Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile显示文摘AIM: To examine the presence of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively. METHODS: We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5+/GP6+ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16INK4A protein immunostaining of all the specimens was conducted. RESULTS: HPV was detected in 21 ESCC specimens (29%). Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases(13%) and in 5 Chilean cases (19%). HPV-18 was detected in 10 cases (21%) in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 (without statistical significance), but a significantly lower prevalence of HPV-18 than in Colombian cases (P = 0.011) even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country. CONCLUSION: HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC. | Andres Castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama Yoshito Eizuru Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，38： | 11 |
| 4 | E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance显示文摘AIM: To examine the role of E-cadherin and beta- catenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas (EBV-GCs). METHODS: We compared the frequency of E-cadherin and beta-catenin expression in 59 EBV-GCs and 120 non-EBV-GCs, and examined the association between patients' prognosis and the expressions of these proteins. RESULTS: Neither the cellular-membranous nor the cytoplasmic E-cadherin expression showed any difference between EBV-GCs and non-EBV-GCs. On the other hand, loss of membranous expression of beta- catenin occurred more frequently in non-EBV-GCs than EBV-GCs [odds ratio = 0.41; 95% confidence interval (CI), 0.19-0.90]. Furthermore, the nuclear and/or cytoplosmic expression of beta-catenin was seen more frequentlyin EBV-GCs than non-EBV-GCs (odds ratio = 2.23; 95% CI, 0.97-5.09), and was observed in a larger proportion of carcinoma cells of EBV-GCs than non-EBV-GCs (P = 0.024). Survival analysis for non-EBV-GC revealed that lymph node metastasis was significantly associated with poor prognosis (P < 0.001). Among EBV- GCs, the depth of invasion (P = 0.005), lymph node metastasis (P = 0.004) and an intestinal type by Lauren classification (hazard ratio = 9.47; 95% CI, 2.67-33.6) were significantly associated with poor prognosis. On the other hand, nuclear and/or cytoplasmic expression of beta-catenin was associated with a better prognosis in patients with EBV-GC (hazard ratio = 0.32; 95% CI, 0.11-0.93). CONCLUSION: We observed more frequent preservation of beta-catenin in cell membrane and accumulation in nuclei and/or cytoplasm in EBV-GCs than in non-EBV- GCs. Factors involved in the prognosis of EBV-GCs and non-EBV-GCs are different in the two conditions. | Chihaya Koriyama Suminori Akiba Tetsuhiko Itoh Kazunobu Sueyoshi Yoshie Minakami Alejandro Corvalan Suguru Yonezawa Yoshito Eizuru | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 5 | Summary of Environmental Impact Assessment for Mining Seafloor Massive Sulfides in Japan显示文摘 | Teruyoshi Narita Junya Oshika Nobuyuki Okamoto Tetsuhiko Toyohara Tetsuya Miwa | 2015 | Journal of Shipping and Ocean Engineering2015，5，3： | 3 |
| 6 | Effects of ultraviolet irradiation and corona discharge on the crystallization from NiO/SiO2 mixed gels 显示文摘 | Tetsuhiko I Satoshi O Mamoru S | 1994 | Journal of Non-Crystalline Solids1994，179，： | 1 |
| 7 | Structural and morphologic evaluation of a novel detergent-enzymatic tissue-engineered tracheal tubular matrix显示文摘 | Jungebluth P Tetsuhiko Go M Asnaghi A | | 0，，： | 1 |
| 8 | Applicability of low-yield-strength steel for ductility improvement of steel bridge piers显示文摘 | K.A.S. Susantha Tetsuhiko Aoki Takushi Kumano Katsuhiro Yamamoto | 2005 | Engineering Structures2005，，7： | 1 |
| 9 | Cloning,sequence analysisand expression in Escherichia coli if the gene encoding a uricasefrom the yeast-like symbionts of brown planthoppers,Nilapa-rvata lugens显示文摘 | Yuichi H Tetsuhiko S Hajime I | 2000 | Insect Biochemistry and Molecular Biology2000，30，： | 1 |
| 10 | Preparation of ultrafine Fe3O4 particles by precipitation in the presence of PVA at high Ph 显示文摘 | Jiwon Lee Tetsuhiko Isobe Mamoru Senna | 1996 | J Colloid Interface Sci1996，177，： | 1 |
| 11 | Nitrogen recycling in the brown planthopper, Nilaparvata lugens : Involvement of yeast-like endosymbionts in uric acid metabolism显示文摘 | Tetsuhiko Sasaki Maki Kawamura Hajime Ishikawa | 1996 | Journal of Insect Physiology1996，，2： | 1 |
| 12 | Low-temperature synthesis of nanosize Zn2SiO4:Mn^2+ phosphor from the precursor sol in supercritical ethanol and its photoluminescent properties 显示文摘 | TAKURO Mild TAKUMI Ogawa TETSUHIKO Isobe | 2004 | J Sol-G3el Sci Technol2004，31，： | 1 |
| 13 | Experimental study of the dynamic behavior of high damping rubber bearing显示文摘 | Yuan Yong Aoki Tetsuhiko Yamamoto Yoshihisa | 2005 | Journal of Structural Engineering2005，51，2： | 1 |
| 14 | Preparation of Ultrafine Fe 3 O 4 Particles by Precipitation in the Presence of PVA at High pH显示文摘 | Jiwon Lee Tetsuhiko Isobe Mamoru Senna | 1996 | Journal of Colloid And Interface Science1996，，2： | 1 |
| 15 | Efficacy of bevacizumab-containing chemotherapy for non-squamous non-small cell lung cancer with bone metastases显示文摘 | Takaaki Tokito Takehito Shukuya Hiroaki Akamatsu Tetsuhiko Taira Akira Ono Hirotsugu Kenmotsu Tateaki Naito Haruyasu Murakami Toshiaki Takahashi Masahiro Endo Nobuyuki Yamamoto | 2013 | Cancer Chemotherapy and Pharmacology2013，，6： | 1 |
| 16 | Structural characterization of CeO2/TiO2 and V2O5/CeO2-TiO2 catalysts by Raman and XPS techniques显示文摘 | REDDY B M KHAN A YAMADA Y TETSUHIKO K LORIDANT S VOLTA J C | 2003 | J Phys Chem B2003，107，22： | 1 |
| 17 | Acrolein formation in the oxidation of ethane over silica catalysts supporting iron and cesium显示文摘 | Kiyoharu Nakagawa Yonghong Teng Zhen Zhao Yusuke Yamada Atsushi Ueda Toshimitsu Suzuki Tetsuhiko Kobayashi | 1999 | Catalysis Letters (-)1999，，1： | 1 |
| 18 | Influence of Overnight Or- thokeratology on Axial Elongation in Childhood Myopia 显示文摘 | Tetsuhiko Kakita Takahiro Hiraoka | 2011 | In- vest Ophthalmol Vis Sci2011，52，5： | 1 |
| 19 | Effects of the homogeneous Bi(3+) doping process on photol properties of YVO(4) :Bi(3+),Eu(3+) nanophosphor显示文摘 | Satoru T Tetsuhiko I Tomohiro S | 2009 | J Lumin2009，129，9： | 1 |
| 20 | Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development显示文摘 | Ryo Aizawa Atsushi Yamada Dai Suzuki Tadahiro Iimura Hidetoshi Kassai Takeshi Harada Masayuki Tsukasaki Gou Yamamoto Tetsuhiko Tachikawa Kazuki Nakao Matsuo Yamamoto Akira Yamaguchi Atsu Aiba Ryutaro Kamijo | 2012 | Mechanisms of Development (-)2012，，1： | 1 |
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