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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Relationship between effective radiation dose and outcome of radioiodine therapy for thyroid cancer显示文摘 | Maxon HR Ⅲ Thomas SR Hertzberg VS | 1983 | N Engl J Med1983，309，： | 2 |
| 3 | Molecules in focus: lndoleamine 2, 3- dioxygenase 显示文摘 | King NJC Thomas SR | 2007 | Int J Bioehem Cell Biol2007，39，12： | 1 |
| 4 | 131I therapy for well-differentiated thyroid cancer-a quantitative radiation dosimetric approach:outcome and validation in 85 patients显示文摘 | Maxon HR 3rd Englaro EE Thomas SR | | 0，，： | 1 |
| 5 | Norgren RB:magnetic resonance imaging of neural transplants in rat brain using a superparamagnetic contrast agent显示文摘 | Norman AB Thomas SR Pratt RG | 1992 | Brain Res1992，594，： | 1 |
| 6 | Magnetic Resonance Imaging of Neural Transplants in Rat Brain Using a Superparamagnetic Contrast Agent显示文摘 | Norman AB Thomas SR Pratt RG | 1992 | Brain Res1992，594，2： | 1 |
| 7 | Radioiodine-131 therapy for well-differentiated thyroid cancer-a quantitative radiation dosimetric approach:outcome and validation in 85 patients显示文摘 | Maxon HR Englaro EE Thomas SR | 1992 | J Nucl Med1992，33，： | 1 |
| 8 | Oxidative stress and endothelial nitric oxide bioactivity显示文摘 | Thomas SR Chen K Keaney JF Jr | 2003 | Antioxid Redox Signal2003，5，2： | 1 |
| 9 | Importance of pathologic staging in the surgical management of adenocarcinoma of the exocine pancreas 显示文摘 | Hermreck AS Thomas CY Friesen SR | 1974 | AMJ Surg1974，127，4： | 1 |
| 10 | Autotransplantation of teeth: is there a role? 显示文摘 | Thomas S Turner SR Sandy JR | 1998 | Br J Orthod1998，25，4： | 1 |
| 11 | Phvsical activity and exercise in asthma:relevance to etiology and treatment显示文摘 | Lucas SR Thomas A Platts-Mills E | 2005 | J A11ergy Clin Immunol2005，115，5： | 1 |
| 12 | Role of the P plasmid in attenuation of Vibrio cholerae O1 显示文摘 | Attridge SR Thomas CJ | 1990 | Infect Immun1990，58，9： | 1 |
| 13 | Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii显示文摘 | Valenzuela JK Thomas L Partridge SR | 2007 | J Clin Microbiol2007，45，2： | 1 |
| 14 | Horizontal genetransfer in a polyclonal outbreak of earbapenem-resistant Acineto-bacter bau- mannii 显示文摘 | Valenzuela JK Thomas L Partridge SR | 2007 | J Clin Microbiol2007，45，2： | 1 |
| 15 | Horizontal gene transfer in a polyclonal outbreak of carbapenem-re- sistant Acinetobacter baumannii显示文摘 | Valenzuela JK Thomas L Partridge SR | 2007 | J Clin Microbiol2007，45，2： | 1 |
| 16 | Artemisinin (qing- haosu): the role of intracellular hemin in its mechanism of antimalarial action显示文摘 | Meshnick SR Thomas A Ranz A | 1991 | Mol Biochem Parasitol1991，49，2： | 1 |
| 17 | The diagnosis and treatment of heel pain:a clinical practice guidelinerevision 2010显示文摘 | Thomas JL Christensen JC Kravitz SR | 2010 | J Foot Ankle Surg2010，49，3： | 1 |
| 18 | Quality and shelf life evaluation of emulsion and restructured buffalomeat nuggets at cold storage (4 ℃ + 1 ℃)显示文摘 | RAJENDRAN THOMAS A SR ANJANEYULU N KONDAIAH | 2006 | Meat Science2006，，72： | 1 |
| 19 | Metabolic syndrome and kidney disease: a systematic review and meta-analysis显示文摘 | Thomas G Sehgal AR Kashyap SR | 2011 | Clin J Am Soc Nephrol2011，6，10： | 1 |
| 20 | Autotransplantation of teeth: is there a role? 显示文摘 | Thomas S Turner SR Sandy JR | 1998 | Br J Orthod1998，25，4： | 1 |
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