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| 1 | Efficacy and safety evaluation of icotinib in patients with advanced non-small cell lung cancer显示文摘Objective: To evaluate the efficacy and safety of icotinib hydrochloride in patients with advanced non-small cell lung cancer (NSCLC). Methods: A total of 89 patients with stage ⅢB or IV NSCLC received icotinib at a dose of 125 mg administered 3 times a day. Icotinib treatment was continued until disease progression or development of unacceptable toxicity. Results: A total of 89 patients were assessable. In patients treated with icotinib, the overall response rate (RR) was 36.0% (32/89), and the disease control rate (DCR) was 69.7% (62/89). RR and DCR were significantly improved in patients with adenocarcinoma versus non-adenocarcinoma (P<0.05). The symptom improvement rate was 57.3% (51/89), and the main symptoms improved were cough, pain, chest distress, dyspnea, and Eastern Cooperative Oncology Group performance status. The main toxic effects were rash [30/89 (33.7%)] and diarrhea [15/89 (16.9%)]. The level of toxicity was typically low. Conclusions: The use of icotinib hydrochloride in the treatment of advanced NSCLC is efficacious and safe, and its toxic effects are tolerable. | Aiqin Gu Chunlei Shi Liwen Xiong Tianqing Chu Jun Pei Baohui Han | 2013 | Chinese Journal of Cancer Research2013，25，1： | 22 |
| 2 | Effective gene targeting in rabbits using RNA-guided Cas9 nucleases显示文摘 | Dongshan Yang Jie Xu Tianqing Zhu Jianglin Fan Liangxue Lai Jifeng Zhang Y. Eugene Chen | 2014 | Journal of Molecular Cell Biology2014，8，1： | 18 |
| 3 | Large-area straight,regular periodic surface structures produced on fused silica by the interference of two femtosecond laser beams through cylindrical lens显示文摘Inhomogeneity and low efficiency are two important factors that limit the application of laser-induced periodic surface structures(LIPSSs),especially on glass surfaces.In this study,two-beam interference(TBI)of femtosecond lasers was used to produce large-area straight LIPSSs on fused silica using cylindrical lenses.Compared with those produced us-ing a single circular or cylindrical lens,the LIPSSs produced by TBI are much straighter and more regular.Depending on the laser fluence and scanning velocity,LIPSSs with grating-like or spaced LIPSSs are produced on the fused silica sur-face.Their structural colors are blue,green,and red,and only green and red,respectively.Grating-like LIPSS patterns oriented in different directions are obtained and exhibit bright and vivid colors,indicating potential applications in surface coloring and anti-counterfeiting logos. | Long Chen Kaiqiang Cao Yanli Li Jukun Liu Shian Zhang Donghai Feng Zhenrong Sun Tianqing Jia | 2021 | Opto-Electronic Advances2021，4，12： | 7 |
| 4 | Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells显示文摘各种各样的干细胞类型在对待光敏电阻器为他们的潜在的申请被测试了退化疾病,例如视网膜炎 pigmentosa (RP ) 和年龄相关的有斑点的退化(AMD ) 。仅仅胚胎的干细胞(转换字符) 到目前为止被显示了产生恢复光敏电阻器缺乏的老鼠的轻反应的功能的光敏电阻器房间,但是仍然有肿瘤形成的一些担心。在这研究,我们有成功地有教养的 Nestin + Sox2 + Pax6 + multipotent 从成年老鼠视网膜的网膜的干细胞(RSC ) ,它能够生产恢复跟随移植的光敏电阻器缺乏的 rd1 异种老鼠的轻反应的功能的光敏电阻器房间。在他们面对 FGF 和 EGF 为超过 35 个段落被扩展了以后,有教养的 RSC 仍然维持稳定的增长和区别潜力。在合适的区别条件下面,他们能区分进在成年视网膜发现的所有主要网膜的房间类型。更重要地,他们能高效地在优化区别条件下面区分进光敏电阻器房间。直到慢慢地堕落的 rd7 异种的 subretinal 空间的后面的移植看,导出 RSC 的光敏电阻器房间与居民一起集成到视网膜,词法上类似于的内长的光敏电阻器和形成的 synapases 网膜的神经原。当移植了进光敏电阻器缺乏的 rd1 异种老鼠的眼睛时,一个 RP 模型,导出 RSC 的光敏电阻器能部分恢复轻反应,显示那些导出 RSC 的光敏电阻器是功能的。最后,为在移植光敏电阻器的眼睛的肿瘤形成没有证据。因此,这研究证明了从成年视网膜孤立的 RSC 有生产能潜在地恢复光敏电阻器房间的损失在 RP 和 AMD 引起的失去的视觉的功能的光敏电阻器房间的潜力。 | Tianqing Li Michelle Lewallen Shuyi Chen Wei Yu Nian Zhang Ting Xie | 2013 | Cell Research2013，23，6： | 7 |
| 5 | Robust Collaborative Optimization Method Based on Dual-response Surface显示文摘A novel method for robust collaborative design of complex products based on dual-response surface (DRS-RCO) is proposed to solve multidisciplinary design optimization (MDO) problems under uncertainty. Collaborative optimization (CO) which decomposes the whole system into a double-level nonlinear optimization problem is widely accepted as an efficient method to solve MDO problems. In order to improve the quality of complex product in design process, robust collaborative optimization (RCO) is developed to solve those problems under uncertain conditions. RCO does optimization on the linear sum of mean and standard deviation of objective function and gets an optimal solution with high robustness. Response surfaces method is an important way to do approximation in robust design. DRS-RCO is an improved RCO method in which dual-response surface replaces system uncertainty analysis module of CO. The dual-response surface is the approximate model of mean and standard deviation of objective function respectively. In DRS-RCO, All the information of subsystems is included in dual-response surfaces. As an additional item, the standard deviation of objective function is added to the subsystem optimization. This item guarantee both the mean and standard deviation of this subsystem is reaching the minima at the same time. Finally, a test problem with two coupled subsystems is conducted to verify the feasibility and effectiveness of DRS-RCO. | WANG Wei FAN Wenhui CHANG Tianqing YUAN Yuming | 2009 | Chinese Journal of Mechanical Engineering2009，22，2： | 5 |
| 6 | Single-shot compressed ultrafast photography: a review显示文摘Compressed ultrafast photography(CUP)is a burgeoning single-shot computational imaging technique that provides an imaging speed as high as 10 trillion frames per second and a sequence depth of up to a few hundred frames.This technique synergizes compressed sensing and the streak camera technique to capture nonrepeatable ultrafast transient events with a single shot.With recent unprecedented technical developments and extensions of this methodology,it has been widely used in ultrafast optical imaging and metrology,ultrafast electron diffraction and microscopy,and information security protection.We review the basic principles of CUP,its recent advances in data acquisition and image reconstruction,its fusions with other modalities,and its unique applications in multiple research fields. | Dalong Qi Shian Zhang Chengshuai Yang Yilin He Fengyan Cao Jiali Yao Pengpeng Ding Liang Gao Tianqing Jia Jinyang Liang Zhenrong Sun Lihong V.Wange | 2020 | Advanced Photonics2020，2，1： | 5 |
| 7 | An analytic formula describing the plasma arc pressure distribution显示文摘 | Li Tianqing Wu Chuansong | 2014 | China Welding2014，23，2： | 5 |
| 8 | Valence state manipulation of Sm3+ ions via a phase-shaped femtosecond laser field显示文摘The ability to manipulate the valence state conversion of rare-earth ions is crucial for their applications in color displays, optoelectronic devices, laser sources, and optical memory. The conventional femtosecond laser pulse has been shown to be a well-established tool for realizing the valence state conversion of rare-earth ions, although the valence state conversion efficiency is relatively low. Here, we first propose a femtosecond laser pulse shaping technique for improving the valence state conversion efficiency of rare-earth ions. Our experimental results demonstrate that the photoreduction efficiency from Sm^(3+) to Sm^(2+) in Sm^(3+)-doped sodium aluminoborate glass using a π phase step modulation can be comparable to that using a transform-limited femtosecond laser field, while the peak laser intensity is decreased by about 63%, which is very beneficial for improving the valence state conversion efficiency under the laser-induced damage threshold of the glass sample. Furthermore, we also theoretically develop a(2 + 1)resonance-mediated three-photon absorption model to explain the modulation of the photoreduction efficiency from Sm^(3+)to Sm^(2+)under the π-shaped femtosecond laser field. | YE ZHENG YUNHUA YAO LIANZHONG DENG WENJING CHENG JIANPING LI TIANQING JIA JIANRONG QIU ZHENRONG SUN SHIAN ZHANG | 2018 | Photonics Research2018，6，2： | 4 |
| 9 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 10 | Extremely regular periodic surface structures in a large area efficiently induced on silicon by temporally shaped femtosecond laser显示文摘Femtosecond laser-induced periodic surface structures(LIPSS) have several applications in surface structuring and functionalization. Three major challenges exist in the fabrication of regular and uniform LIPSS: enhancing the periodic energy deposition, reducing the residual heat, and avoiding the deposited debris. Herein, we fabricate an extremely regular low-spatial-frequency LIPSS(LSFL) on a silicon surface by a temporally shaped femtosecond laser. Based on a 4 f configuration zero-dispersion pulse shaping system, a Fourier transform limit(FTL) pulse is shaped into a pulse train with varying intervals in the range of 0.25–16.2 ps using periodic π-phase step modulation. Under the irradiation of the shaped pulse with an interval of 16.2 ps, extremely regular LSFLs are efficiently fabricated on silicon. The scan velocity for fabricating regular LSFL is 2.3 times faster, while the LSFL depth is 2 times deeper, and the diffraction efficiency is 3 times higher than those of LSFL using the FTL pulse.The formation mechanisms of regular LSFL have been studied experimentally and theoretically. The results show that the temporally shaped pulse enhances the excitation of surface plasmon polaritons and the periodic energy deposition while reducing the residual thermal effects and avoiding the deposition of the ejected debris, eventually resulting in regular and deeper LSFL on the silicon surface. | YUCHAN ZHANG QILIN JIANG KAIQIANG CAO TIANQI CHEN KE CHENG SHIAN ZHANG DONGHAI FENG TIANQING JIA ZHENRONG SUN JIANRONG QIU | 2021 | Photonics Research2021，9，5： | 4 |
| 11 | Femtosecond laser-induced periodic structures:mechanisms, techniques, and applications显示文摘Over the past two decades,femtosecond laser-induced periodic structures(femtosecond-LIPSs)have become ubiquitous in a variety of materials,including metals,semiconductors,dielectrics,and polymers.Femtosecond-LIPSs have become a useful laser processing method,with broad prospects in adjusting material properties such as structural color,data storage,light absorption,and luminescence.This review discusses the formation mechanism of LIPSs,specifically the LIPS formation processes based on the pump-probe imaging method.The pulse shaping of a femtosecond laser in terms of the time/frequency,polarization,and spatial distribution is an efficient method for fabricating high-quality LIPSs.Various LIPS applications are also briefly introduced.The last part of this paper discusses the LIPS formation mechanism,as well as the high-efficiency and high-quality processing of LIPSs using shaped ultrafast lasers and their applications. | Yuchan Zhang Qilin Jiang Mingquan Long Ruozhong Han Kaiqiang Cao Shian Zhang Donghai Feng Tianqing Jia Zhenrong Sun Jianrong Qiu Hongxing Xu | 2022 | Opto-Electronic Science2022，1，6： | 3 |
| 12 | Single-shot spectral-volumetric compressed ultrafast photography显示文摘In ultrafast optical imaging,it is critical to obtain the spatial structure,temporal evolution,and spectral composition of the object with snapshots in order to better observe and understand unrepeatable or irreversible dynamic scenes.However,so far,there are no ultrafast optical imaging techniques that can simultaneously capture the spatial–temporal–spectral five-dimensional(5D)information of dynamic scenes.To break the limitation of the existing techniques in imaging dimensions,we develop a spectral-volumetric compressed ultrafast photography(SV-CUP)technique.In our SV-CUP,the spatial resolutions in the x,y and z directions are,respectively,0.39,0.35,and 3 mm with an 8.8 mm×6.3 mm field of view,the temporal frame interval is 2 ps,and the spectral frame interval is 1.72 nm.To demonstrate the excellent performance of our SV-CUP in spatial–temporal–spectral 5D imaging,we successfully measure the spectrally resolved photoluminescent dynamics of a 3D mannequin coated with CdSe quantum dots.Our SV-CUP brings unprecedented detection capabilities to dynamic scenes,which has important application prospects in fundamental research and applied science. | Pengpeng Ding Yunhua Yao Dalong Qi Chengshuai Yang Fengyan Cao Yilin He Jiali Yao Chengzhi Jin Zhengqi Huang Li Deng Lianzhong Deng Tianqing Jia Jinyang Liang Zhenrong Sun Shian Zhang | 2021 | Advanced Photonics2021，3，4： | 3 |
| 13 | Paving the road for biomedicine: genome editing and stem cells in primates显示文摘Non-human primates(NHPs) are similar with humans in their anatomy, physiology, genetics and neural functions, and in their cognition, emotions and social behavior. The NHP model has played an important role in the biomedical research, development of vaccines and drugs and new therapies for many diseases.Recent advances in genome editing have generated NHP models for human diseases. Genome editing integrated with derivation of NHP pluripotent stem cells now provides an optimal resource to regenerate medicine. | Yuyu Niu Tianqing Li Weizhi Ji | 2017 | National Science Review2017，4，4： | 3 |
| 14 | Battlefield dynamic scanning and staring imaging system based on fast steering mirror显示文摘This paper presents the design of an experimental battlefield dynamic scanning and staring imaging system based on a fast steering mirror(FSM), which is capable of real-time monitoring of hot targets and wide-area reconnaissance of hot regions. First,the working principle and working sequence of the FSM are briefly analyzed. The mathematical model of the FSM system is built by modeling its dynamic and electrical properties, and the rationality of the model is validated by means of model identification. Second,the influence of external sources of disturbance such as the carrier and moment on the control precision of the FSM is effectively suppressed by the jointly controlling of proportional integral(PI)and disturbance observer(DOB), thus realizing a high precision and strong robustness control of the FSM system. Then, this paper designs an experimental prototype and introduces a special optical structure to enable the infrared camera to share the FSM with the visible light camera. Finally, the influence of the velocity difference between the mirror of the FSM and the rotating platform on the imaging quality of the system is experimentally analyzed by using the image sharpness evaluation method based on point sharpness. A good dynamic scanning and staring imaging result is achieved when the velocity of these two components correspond. | CHANG Tianqing WANG Quandong ZHANG Lei HAO Na DAI Wenjun | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 3 |
| 15 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 3 |
| 16 | Existence of multiple periodic orbits of Hamiltonian systems on positive-type hypersurfaces in R2n 显示文摘 | An Tianqing | 2003 | Jour Math Ana Appl2003，278，2： | 2 |
| 17 | High-fidelity image reconstruction for compressed ultrafast photography via an augmented-Lagrangian and deep-learning hybrid algorithm显示文摘Compressed ultrafast photography(CUP) is the fastest single-shot passive ultrafast optical imaging technique,which has shown to be a powerful tool in recording self-luminous or non-repeatable ultrafast phenomena.However, the low fidelity of image reconstruction based on the conventional augmented-Lagrangian(AL)and two-step iterative shrinkage/thresholding(Tw IST) algorithms greatly prevents practical applications of CUP, especially for those ultrafast phenomena that need high spatial resolution. Here, we develop a novel AL and deep-learning(DL) hybrid(i.e., AL+DL) algorithm to realize high-fidelity image reconstruction for CUP. The AL+DL algorithm not only optimizes the sparse domain and relevant iteration parameters via learning the dataset but also simplifies the mathematical architecture, so it greatly improves the image reconstruction accuracy. Our theoretical simulation and experimental results validate the superior performance of the AL+DL algorithm in image fidelity over conventional AL and Tw IST algorithms, where the peak signalto-noise ratio and structural similarity index can be increased at least by 4 d B(9 d B) and 0.1(0.05) for a complex(simple) dynamic scene, respectively. This study can promote the applications of CUP in related fields, and it will also enable a new strategy for recovering high-dimensional signals from low-dimensional detection. | CHENGSHUAI YANG YUNHUA YAO CHENGZHI JIN DALONG QI FENGYAN CAO YILIN HE JIALI YAO PENGPENG DING LIANG GAO TIANQING JIA JINYANG LIANG ZHENRONG SUN SHIAN ZHANG | 2021 | Photonics Research2021，9，2： | 2 |
| 18 | Optimization of technical measures for improving high-temperature performance of asphalt-rubber mixture显示文摘Asphalt-rubber pavements often become damaged in high-temperature regions and appear rutted or wavy,and experience slippage.To improve the high-temperature performance of the asphalt-rubber mixture,technical measurements,such as,the optimal adjustment of gradation,technique of composite modification,and control of compaction were investigated.An optimal adjustment of aggregate gradation based on stone matrix asphalt improves the high-temperature stability of the asphaltrubber mixture significantly.Through composite modification,the effect of asphalt-rubber modification was enhanced,and the dynamic stability and relative deformation indices of the asphalt-rubber mixture were improved significantly.Furthermore,compaction parameters had a significant influence on the high-temperature stability of the asphalt-rubber mixture.The rolling times for compacting the asphalt-rubber mixture should be controlled to within 18-20 round-trips at a molding temperature at 180°C;if the rolling time is a 12 round-trip,the compaction temperature of the asphalt-rubber mixture should be controlled between 180 and 190°C. | Chuan Xiao Tianqing Ling Yanjun Qiu | 2013 | Journal of Modern Transportation2013，21，4： | 2 |
| 19 | A single-task and multi-decision evolutionary game model based on multi-agent reinforcement learning显示文摘In the evolutionary game of the same task for groups,the changes in game rules,personal interests,the crowd size,and external supervision cause uncertain effects on individual decision-making and game results.In the Markov decision framework,a single-task multi-decision evolutionary game model based on multi-agent reinforcement learning is proposed to explore the evolutionary rules in the process of a game.The model can improve the result of a evolutionary game and facilitate the completion of the task.First,based on the multi-agent theory,to solve the existing problems in the original model,a negative feedback tax penalty mechanism is proposed to guide the strategy selection of individuals in the group.In addition,in order to evaluate the evolutionary game results of the group in the model,a calculation method of the group intelligence level is defined.Secondly,the Q-learning algorithm is used to improve the guiding effect of the negative feedback tax penalty mechanism.In the model,the selection strategy of the Q-learning algorithm is improved and a bounded rationality evolutionary game strategy is proposed based on the rule of evolutionary games and the consideration of the bounded rationality of individuals.Finally,simulation results show that the proposed model can effectively guide individuals to choose cooperation strategies which are beneficial to task completion and stability under different negative feedback factor values and different group sizes,so as to improve the group intelligence level. | MA Ye CHANG Tianqing FAN Wenhui | 2021 | Journal of Systems Engineering and Electronics2021，32，3： | 2 |
| 20 | Security and privacy in 6G networks:New areas and new challenges显示文摘With the deployment of more and more 5g networks,the limitations of 5g networks have been found,which undoubtedly promotes the exploratory research of 6G networks as the next generation solutions.These investigations include the fundamental security and privacy problems associated with 6G technologies.Therefore,in order to consolidate and solidify this foundational research as a basis for future investigations,we have prepared a survey on the status quo of 6G security and privacy.The survey begins with a historical review of previous networking technologies and how they have informed the current trends in 6G networking.We then discuss four key aspects of 6G networks–real-time intelligent edge computing,distributed artificial intelligence,intelligent radio,and 3D intercoms–and some promising emerging technologies in each area,along with the relevant security and privacy issues.The survey concludes with a report on the potential use of 6G.Some of the references used in this paper along and further details of several points raised can be found at:security-privacyin5g-6g.github.io. | Minghao Wang Tianqing Zhu Tao Zhang Jun Zhang Shui Yu Wanlei Zhou | 2020 | Digital Communications and Networks2020，6，3： | 2 |
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