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| 1 | Characteristics of non-Darcy flow in low-permeability reservoirs显示文摘很好测试作为精确地获得低渗透的水库的形成参数并且有效地分析 deliverability 的一个有效工具被认出。很好,测试模型必须在低渗透的水库遵循流动的特别特征以便获得合理的井测试解释。目前,在低渗透的水库的 non-Darcy 流动正在吸引许多注意。在这研究,排水量测试在从低渗透的水库拿的典型核心上被进行。二个无尺寸的变量被介绍给分析收集了试验性的数据。无尺寸的分析的结果显示出 non-Darcy 流动是否发生取决于液体和多孔的媒介和压力的性质微分。上述三个参数的联合作为无尺寸的标准系数(两重棉包线) 被说出。当 DCC 的价值比一个批评雷纳兹数字(CRN ) 低时,当两重棉包线比 CRN 高时,流动不能被 Darcys 法律(所谓的 non-Darcy 流动) 很好描述,流动遵守了 Darcys 法律。最后,这份报纸建立在低渗透的水库考虑 Darcy 流动和 non-Darcy 流动的一个短暂数学模型,并且建议方法论解决模型。答案技术,基于 Boltzmann 转变,很好适合解决低渗透的水库的流动模型。基于典型曲线分析,压力和它的衍生物曲线被象 non-Darcy 流动索引和流动特征的如此的参数决定,这被发现。结果能被用于低渗透的水库的测试分析很好。 | Yao Yuedong Ge Jiali | 2011 | Petroleum Science2011，8，1： | 15 |
| 2 | Decreased osteogenesis of adult mesenchymal stem cel s by reactive oxygen species under cyclic stretch: a possible mechanism of age related osteoporosis显示文摘Age related defect of the osteogenic differentiation of mesenchymal stem cells(MSCs) plays a key role in osteoporosis. Mechanical loading is one of the most important physical stimuli for osteoblast differentiation.Here, we compared the osteogenic potential of MSCs from young and adult rats under three rounds of 2 h of cyclic stretch of 2.5% elongation at 1 Hz on 3 consecutive days. Cyclic stretch induced a significant osteogenic differentiation of MSCs from young rats, while a compromised osteogenesis in MSCs from the adult rats.Accordingly, there were much more reactive oxygen species(ROS) production in adult MSCs under cyclic stretch compared to young MSCs. Moreover, ROS scavenger N-acetylcysteine rescued the osteogenic differentiation of adult MSCs under cyclic stretch. Gene expression analysis revealed that superoxide dismutase 1(SOD1) was significantly downregulated in those MSCs from adult rats. In summary, our data suggest that reduced SOD1 may result in excessive ROS production in adult MSCs under cyclic stretch, and thus manipulation of the MSCs from the adult donors with antioxidant would improve their osteogenic ability. | Jiali Tan Xin Xu Zhongchun Tong Jiong lin Qiujun Yu Yao Lin Wei Kuang | 2015 | Bone Research2015，3，1： | 15 |
| 3 | Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation显示文摘Osteoporosis is a common disease that affects patient quality of life, especially among the elderly population.Although inflammation contributes significantly to osteoporosis, the underlying mechanism is unclear. In this study, we found that tumor necrosis factor(TNF)-α, an inflammatory environment mimic, inhibits osteogenesis of bone mesenchymal stem cells(BMSCs), induces mi R-146 a and decreases Smad4. Moreover,overexpression of mi R-146 a inhibited the osteogenic ability of BMSCs, whereas blocking mi R-146 a partially rescued the osteogenesis deficiency under TNF-α treatment. Molecularly, mi R-146 a decreased Smad4 expression at the protein level by binding to an element located in the Smad4 30-untranslated region, and restoration of Smad4 reversed the inhibitory effects of mi R-146 a on osteogenesis. Together, our results showed that the inflammatory environment mimic TNF-α inhibits osteogenesis via upregulation of mi R-146 a and subsequent downregulation of Smad4, thus suggesting that therapeutic manipulation of mi R-146 a maybe a potential strategy to improve osteogenesis in the context of osteoporosis. | Wei Kuang Liwei Zheng Xin Xu Yao Lin Jiong Lin Jiahua Wu Jiali Tan | 2017 | Bone Research2017，5，4： | 13 |
| 4 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 5 | Single-shot compressed ultrafast photography: a review显示文摘Compressed ultrafast photography(CUP)is a burgeoning single-shot computational imaging technique that provides an imaging speed as high as 10 trillion frames per second and a sequence depth of up to a few hundred frames.This technique synergizes compressed sensing and the streak camera technique to capture nonrepeatable ultrafast transient events with a single shot.With recent unprecedented technical developments and extensions of this methodology,it has been widely used in ultrafast optical imaging and metrology,ultrafast electron diffraction and microscopy,and information security protection.We review the basic principles of CUP,its recent advances in data acquisition and image reconstruction,its fusions with other modalities,and its unique applications in multiple research fields. | Dalong Qi Shian Zhang Chengshuai Yang Yilin He Fengyan Cao Jiali Yao Pengpeng Ding Liang Gao Tianqing Jia Jinyang Liang Zhenrong Sun Lihong V.Wange | 2020 | Advanced Photonics2020，2，1： | 5 |
| 6 | Multi-modal anti-counterfeiting and encryption enabled through silicon-based materials featuring pH-responsive fluorescence and room-temperature phosphorescence显示文摘Nano Research volume 13,pages1614–1619(2020)Cite this article 236 Accesses Metrics details Abstract Optical silicon(Si)-based materials are highly attractive due to their widespread applications ranging from electronics to biomedicine.It is worth noting that while extensive efforts have been devoted to developing fluorescent Si-based structures,there currently exist no examples of Si-based materials featuring phosphorescence emission,severely limiting Si-based wide-ranging optical applications.To address this critical issue,we herein introduce a kind of Si-based material,in which metal-organic frameworks(MOFs)are in-situ growing on the surface of Si nanoparticles(SiNPs)assisted by microwave irradiation.Of particular significance,the resultant materials,i.e.,MOFs-encapsulated SiNPs(MOFs@SiNPs)could exhibit pH-responsive fluorescence,whose maximum emission wavelength is red-shifted from 442 to 592 nm when the pH increases from 2 to 13.More importantly,distinct room-temperature phosphorescence(maximum emission wavelength:505 nm)could be observed in this system,with long lifetime of 215 ms.Taking advantages of above-mentioned unique optical properties,the MOFs@SiNPs are further employed as high-quality anti-counterfeiting inks for advanced encryption.In comparison to conventional fluorescence anti-counterfeiting techniques(static fluorescence outputs are generally used,thus being easily duplicated and leading to counterfeiting risk),pH-responsive fluorescence and room-temperature phosphorescence of the resultant MOFs@SiNPs-based ink could offer advanced multi-modal security,which is therefore capable of realizing higher-level information security against counterfeiting. | Jinhua Wang Bin Song Jiali Tang Guyue Hu Jingyang Wang Mingyue Cui Yao He | 2020 | Nano Research2020，13，6： | 3 |
| 7 | Single-shot spectral-volumetric compressed ultrafast photography显示文摘In ultrafast optical imaging,it is critical to obtain the spatial structure,temporal evolution,and spectral composition of the object with snapshots in order to better observe and understand unrepeatable or irreversible dynamic scenes.However,so far,there are no ultrafast optical imaging techniques that can simultaneously capture the spatial–temporal–spectral five-dimensional(5D)information of dynamic scenes.To break the limitation of the existing techniques in imaging dimensions,we develop a spectral-volumetric compressed ultrafast photography(SV-CUP)technique.In our SV-CUP,the spatial resolutions in the x,y and z directions are,respectively,0.39,0.35,and 3 mm with an 8.8 mm×6.3 mm field of view,the temporal frame interval is 2 ps,and the spectral frame interval is 1.72 nm.To demonstrate the excellent performance of our SV-CUP in spatial–temporal–spectral 5D imaging,we successfully measure the spectrally resolved photoluminescent dynamics of a 3D mannequin coated with CdSe quantum dots.Our SV-CUP brings unprecedented detection capabilities to dynamic scenes,which has important application prospects in fundamental research and applied science. | Pengpeng Ding Yunhua Yao Dalong Qi Chengshuai Yang Fengyan Cao Yilin He Jiali Yao Chengzhi Jin Zhengqi Huang Li Deng Lianzhong Deng Tianqing Jia Jinyang Liang Zhenrong Sun Shian Zhang | 2021 | Advanced Photonics2021，3，4： | 3 |
| 8 | High-fidelity image reconstruction for compressed ultrafast photography via an augmented-Lagrangian and deep-learning hybrid algorithm显示文摘Compressed ultrafast photography(CUP) is the fastest single-shot passive ultrafast optical imaging technique,which has shown to be a powerful tool in recording self-luminous or non-repeatable ultrafast phenomena.However, the low fidelity of image reconstruction based on the conventional augmented-Lagrangian(AL)and two-step iterative shrinkage/thresholding(Tw IST) algorithms greatly prevents practical applications of CUP, especially for those ultrafast phenomena that need high spatial resolution. Here, we develop a novel AL and deep-learning(DL) hybrid(i.e., AL+DL) algorithm to realize high-fidelity image reconstruction for CUP. The AL+DL algorithm not only optimizes the sparse domain and relevant iteration parameters via learning the dataset but also simplifies the mathematical architecture, so it greatly improves the image reconstruction accuracy. Our theoretical simulation and experimental results validate the superior performance of the AL+DL algorithm in image fidelity over conventional AL and Tw IST algorithms, where the peak signalto-noise ratio and structural similarity index can be increased at least by 4 d B(9 d B) and 0.1(0.05) for a complex(simple) dynamic scene, respectively. This study can promote the applications of CUP in related fields, and it will also enable a new strategy for recovering high-dimensional signals from low-dimensional detection. | CHENGSHUAI YANG YUNHUA YAO CHENGZHI JIN DALONG QI FENGYAN CAO YILIN HE JIALI YAO PENGPENG DING LIANG GAO TIANQING JIA JINYANG LIANG ZHENRONG SUN SHIAN ZHANG | 2021 | Photonics Research2021，9，2： | 2 |
| 9 | Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice显示文摘Introduction:We previously demonstrated that magnesium ions(Mg^(2+))was a novel therapeutic alternative for osteoarthritis(OA)through promoting the hypoxia inducible factor-1α(HIF-1α)-mediated cartilage matrix synthesis.However,oxidative stress can inhibit the expression of HIF-1α,amplify the inflammation that potentially impairs the therapeutic efficacy of Mg^(2+) in OA.Vitamin(VC),a potent antioxidant,may enhance the efficacy of Mg^(2+) in OA treatment.This study aims to investigate the efficacy of combination of Mg^(2+)and VC on alleviating joint destruction and pain in OA.Material and methods:Anterior cruciate ligament transection with partial medial meniscectomy induced mice OA model were randomly received intra-articular injection of either saline,MgCl2(0.5 mol/L),VC(3 mg/ml)or MgCl2(0.5 mol/L)plus VC(3 mg/ml)at week 2 post-operation,twice weekly,for 2 weeks.Joint pain and pathological changes were assessed by gait analysis,histology,western blotting and micro-CT.Results:Mg^(2+) and VC showed additive effects to significantly alleviate the joint destruction and pain.The efficacy of this combined therapy could sustain for 3 months after the last injection.We demonstrated that VC enhanced the promotive effect of Mg^(2+) on HIF-1αexpression in cartilage.Additionally,combination of Mg^(2+) and VC markedly promoted the M2 polarization of macrophages in synovium.Furthermore,combination of Mg^(2+) and VC inhibited osteophyte formation and expressions of pain-related neuropeptides.Conclusions:Intra-articular administration of Mg^(2+)and VC additively alleviates joint destruction and pain in OA.Our current formulation may be a cost-effective alternative treatment for OA. | Hao Yao Jiankun Xu Jiali Wang Yifeng Zhang Nianye Zheng Jiang Yue Jie Mi Lizhen Zheng Bingyang Dai Wenhan Huang Shuhang Yung Peijie Hu Yechun Ruan Qingyun Xue Kiwai Ho Ling Qin | 2021 | Bioactive Materials2021，6，5： | 1 |
| 10 | PIM1 overexpression in T-cell lymphomas protects tumor cells from apoptosis and confers doxorubicin resistance by upregulating c-myc expression显示文摘 | Xixi Xiang Di Yuan Yao Liu Jiali Li Qin Wen Peiyan Kong Lei Gao Cheng Zhang Li Gao Xiangui Peng Xi Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 1 |
| 11 | Summer Extreme Precipitation in the Key Region of the Sichuan-Tibet Railway显示文摘The Sichuan-Tibet Railway,mainly located in the southeastern Qinghai-Tibet Plateau,is affected by summertime extreme precipitation(SEP).Using daily rain-gauge observations and ERA5 reanalysis data for the summers of 1979-2020,the spatiotemporal distribution characteristics of SEP in the key region of the Sichuan-Tibet Railway(28°-33°N,90°-105°E,hereafter KR)are revealed,and the mechanism for SEP amount(SEPA)variation in the KR is investigated.The results show that SEPA in the KR contributes nearly 30%to the total summer precipitation.Regional differences are evident in SEP,justifying thresholds higher in the plateau-dominated central-western KR(CWKR)and lower in the basindominated eastern KR(EKR).In addition,SEP in the CWKR is less intense but more frequent than SEP in the EKR.During 1979-2020,the SEPA in the KR increased slightly while the SEPA in the CWKR increased significantly and peaked in the last decade.When anticyclonic circulation(AC)anomalies dominate the 500 hPa pattern over the Bay of Bengal and Mongolia,the southerly flow and cyclonic shear over the southeastern plateau will be strengthened,favoring more SEPA in the CWKR.When an AC anomaly dominates the 500 hPa pattern over the Bohai Sea,the low-level easterly wind over the basin will be strengthened,favoring more SEPA in the EKR.The strengthening of the ascent,water vapor convergence,and convective instability is conducive to more SEPA in the KR.Our results deepen the understanding of the characteristics and the physical mechanisms responsible for extreme precipitation in the KR. | Jiali MA Xiuping YAO | 2023 | Advances in Atmospheric Sciences2023，40，5： | 1 |
| 12 | Exploring Femtosecond Laser Ablation by Snapshot Ultrafast Imaging and Molecular Dynamics Simulation显示文摘Femtosecond laser ablation(FLA)has been playing a prominent role in precision fabrication of material because of its circumvention of thermal effect and extremely high spatial resolution.Molecular dynamics modeling,as a powerful tool to study the mechanism of femtosecond laser ablation,still lacks the connection between its simulation results and experimental observations at present.Here we combine a single-shot chirped spectral mapping ultrafast photography(CSMUP)technique in experiment and a three-dimensional two-temperature model-based molecular dynamics(3D TTM-MD)method in theory to jointly investigate the FLA process of bulky gold.Our experimental and simulated results show quite high consistency in time-resolved morphologic dynamics.According to the highly accurate simulations,the FLA process of gold at the high laser fluence is dominated by the phase explosion,which shows drastic vaporized cluster eruption and pressure dynamics,while the FLA process at the low laser fluence mainly results from the photomechanical spallation,which shows moderate temperature and pressure dynamics.This study reveals the ultrafast dynamics of gold with different ablation schemes,which has a guiding significance for the applications of FLA on various kinds of materials. | Jiali Yao Dalong Qi Hongtao Liang Yilin He Yunhua Yao Tianqing Jia Yang Yang Zhenrong Sun Shian Zhang | 2022 | Ultrafast Science2022，，5： | 1 |
| 13 | Formation process of the bonding joint in Ti/Al diffusion bonding显示文摘 | Yao Wei Wu Aiping Zou Guisheng Ren Jialie | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 14 | Identification of chemical compositions from“featureless”optical absorption spectra:Machine learning predictions and experimental validations显示文摘Rapid and accurate chemical composition identification is critically important in chemistry.While it can be achieved with optical absorption spectrometry by comparing the experimental spectra with the reference data when the chemical compositions are simple,such application is limited in more complicated scenarios especially in nano-scale research.This is due to the difficulties in identifying optical absorption peaks(i.e.,from“featureless”spectra)arose from the complexity.In this work,using the ultraviolet-visible(UV-Vis)absorption spectra of metal nanoclusters(NCs)as a demonstration,we develop a machine-learningbased method to unravel the compositions of metal NCs behind the“featureless”spectra.By implementing a one-dimensional convolutional neural network,good matches between prediction results and experimental results and low mean absolute error values are achieved on these optical absorption spectra that human cannot interpret.This work opens a door for the identification of nanomaterials at molecular precision from their optical properties,paving the way to rapid and high-throughput characterizations. | Tiankai Chen Jiali Li Pengfei Cai Qiaofeng Yao Zekun Ren Yixin Zhu Saif Khan Jianping Xie Xiaonan Wang | 2023 | Nano Research2023，16，3： | 0 |
| 15 | Observation of regular pulse train in a narrow-band optoelectronic oscillator显示文摘We have experimentally observed a new operating state of a regular pulse train in a narrow-band optoelectronic oscillator(OEO) system, where the direct-current(DC) bias of the Mach-Zehnder modulator is set at the maximum value of the transmission transfer function instead of the usual quadrature point. The observed quasi-steady-state pulse train is distinctly periodic, with a period of 10.5 μs and a center frequency of 10 GHz, and resembles a mode-locked OEO in its waveform. The formation of regular pulses here may arise from the dynamic balance of nonlinearity and narrow-band filter effects, with the transient characteristics of the pulses arising mainly from instabilities between the gain and cavity loss. Our results are of great importance for deepening the understanding of the nonlinear dynamical processes in OEO systems. | ZHAO Chunbo TUO Zhuoyue YAO Jiali HE Yuling ZHAI Shenghua MENG Yansong | 2024 | Optoelectronics Letters2024，20，2： | 0 |
| 16 | IN VITRO ACTIVITY OF EXTRACTS OF FIVE MEDICINAL PLANT SPECIES ON PLANT PATHOGENIC FUNGI显示文摘The antifungal effectiveness of extracts of five medicinal plant species was determined.The inhibitory activity of extracts of Eucalyptus tereticornis,Xanthium sibiricum,Artemisia argyi,Tupistra chinensis and Pyrola calliantha were evaluated against the mycelial growth of the plant pathogenic fungi Aspergillus niger,Botrytis cinerea,Penicillium digitatum,P.expansum,P.italicum and Rhizopus stolonifer.All plant extracts were prepared at 60°C using solvents(either water,50%ethanol(v/v),95%ethanol(v/v),ethyl acetate or petroleum ether).Fungicidal effects of all plants tested were confirmed.Different extracts from the same plant species gave different degrees of inhibition.All aqueous extracts had weak or no activity on all fungi tested.Ethyl acetate and 95%ethanol extracts from T.chinensis rhizomes gave greater inhibition and a broader spectrum inhibition than the other extracts.T.chinensis may have potential as a new natural fungicide and may be used for the preservation of agricultural and forestry products such as fruits and vegetables. | Shufeng YAO Jiali XU Haibo ZHANG Hong GAO Shibin SHANG Dan WANG | 2021 | Frontiers of Agricultural Science and Engineering2021，8，4： | 0 |
| 17 | High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification显示文摘After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing stage.With good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during transplantation.Microstructure,tensile strength,degradation,and cytotoxicity of ZG21 wire are evaluated.The rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT,histology,and mechanical test.The SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying mechanism.Material tests demonstrate the high formability of ZG21 wire as surgical suture.Micro-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing interface.The mechanical test shows higher ultimate load in the ZG21 group.The SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)deposition.IHC results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of healing.In vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate osteogenesis.Ex vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon tissue.In conclusion,the ZG21 wire is feasible for tendon graft bunching.Its degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction. | Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang Lizhen Zheng Jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li Patrick Shu-hang Yung Guangyin Yuan Ling Qin | 2024 | Journal of Magnesium and Alloys2024，12，1： | 0 |
| 18 | High performance flexible energy storage device based on copper foam supported NiMoO4 nanosheets-CNTs-CuO nanowires composites with core–shell holey nanostructure显示文摘Because of the intensified electrochemical activities,mixed metal oxides as a representative for pseudocapacitive materials play a key role for high performance supercapacitor electrodes.Nevertheless,low ion and electron transfer rate and poor cycling performance in the electrode practically restrict further promotion of their electrochemical performance.In order to offset the defect,a novel copper(Cu)foamsupported nickel molybdate nanosheet decorated carbon nanotube wrapped copper oxide nanowire array(NiMoO4 NSs-CNTs-CuO NWAs/Cu foam)flexible electrode is constructed.The as-prepared electrode demonstrates a unique core-shell holey nanostructure with a large active surface area,which can provide a large number of active sites for redox reactions.Besides,the CNTs networks supply improved conductivity,which can hasten electron transport.Through this simple and efficient design method,the spatial distribution of each component in the flexible electrode is more orderly,short and fast electron transport path with low intrinsic resistance.As a result,the NiMoO4 NSs-CNTs-CuO NWAs/Cu foam as an adhesiveless supercapacitor electrode material exhibits excellent ene rgy storage perfo rmance with high specific areal capacitance of 23.40 F cm^(-2)at a current density of 2 mA cm^(-2),which outperforms most of the flexible electrodes re ported recently.The assembled asymmetric supercapacitor demonstrates an energy density up to 96.40 mW h cm^(-3)and a power density up to 0.4 W cm^(-3)under a working voltage window of 1.7 V.In addition,outstanding flexibility of up to 100°bend and good cycling stability with the capacitance retention of 82.53%after 10,000 cycles can be obtained. | Pingping Yao Chenyang Li Jiali Yu Shuo Zhang Meng Zhang Huichao Liu Muwei Ji Guangtao Cong Tao Zhang Caizhen Zhu Jian Xu | 2021 | Journal of Materials Science & Technology2021，，26： | 0 |
| 19 | H3‑T6SS of Pseudomonas aeruginosa PA14 contributes to environmental adaptation via secretion of a biofilm‑promoting effector显示文摘Microbial species often occur in complex communities and exhibit intricate synergistic and antagonistic interactions.To avoid predation and compete for favorable niches,bacteria have evolved specialized protein secretion systems.The type VI secretion system(T6SS)is a versatile secretion system widely distributed among Gram-negative bacteria that translocates effectors into target cells or the extracellular milieu via various physiological processes.Pseudomonas aeruginosa is an opportunistic pathogen responsible for many diseases,and it has three independent T6SSs(H1-,H2-,and H3-T6SS).In this study,we found that the H3-T6SS of highly virulent P.aeruginosa PA14 is negatively regulated by OxyR and OmpR,which are global regulatory proteins of bacterial oxidative and acid stress.In addition,we identified a H3-T6SS effector PA14_33970,which is located upstream of VgrG3.PA14_33970 interacted directly with VgrG3 and translocated into host cells.Moreover,we found that H3-T6SS and PA14_33970 play crucial roles in oxidative,acid,and osmotic stress resistance,as well as in motility and biofilm formation.PA14_33970 was identified as a new T6SS effec-tor promoting biofilm formation and thus named TepB.Furthermore,we found that TepB contributes to the virulence of P.aeruginosa PA14 toward Caenorhabditis elegans.Overall,our study indicates that H3-T6SS and its biofilm-promot-ing effector TepB are regulated by OxyR and OmpR,both of which are important for adaptation of P.aeruginosa PA14 to multiple stressors,providing insights into the regulatory mechanisms and roles of T6SSs in P.aeruginosa. | Yantao Yang Damin Pan Yanan Tang Jiali Li Kaixiang Zhu Zonglan Yu Lingfang Zhu Yao Wang Peng Chen Changfu Li | 2022 | Stress Biology2022，2，1： | 0 |
| 20 | Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/β-catenin signaling显示文摘Magnesium metal and its alloys are being developed as effective orthopedic implants;however,the mechanisms underlying the actions of magnesium on bones remain unclear.Cystic fibrosis,the most common genetic disease in Caucasians caused by the mutation of CFTR,has shown bone disorder as a key clinical manifestation,which currently lacks effective therapeutic options.Here we report that implantation of magnesium-containing implant stimulates bone formation and improves bone fracture healing in CFTR-mutant mice.Wnt/β-catenin signaling in the bone is enhanced by the magnesium implant,and inhibition of Wnt/β-catenin by iCRT14 blocks the magnesium implant to improve fracture healing in CFTR-mutant mice.We further demonstrate that magnesium ion enters osteocytes,increases intracellular cAMP level and activates ATF4,a key transcription factor known to regulate Wnt/β-catenin signaling.In vivo knockdown of ATF4 abolishes the magnesium implant-activated β-catenin in bones and reverses the improved-fracture healing in CFTR-mutant mice.In addition,oral supplementation of magnesium activates ATF4 and β-catenin as well as enhances bone volume and density in CFTR-mutant mice.Together,these results show that magnesium implantation or supplementation may serve as a potential anabolic therapy for cystic fibrosis-related bone disease.Activation of ATF4-dependent Wnt/β-catenin signaling in osteocytes is identified as a previously undefined mechanism underlying the beneficial effect of magnesium on bone formation. | Jiankun Xu Peijie Hu Xiaotian Zhang Junjiang Chen Jiali Wang Jieting Zhang Ziyi Chen Mei Kuen Yu Yiu Wa Chung Yan Wang Xiaohu Zhang Yifeng Zhang Nianye Zheng Hao Yao Jiang Yue Hsiao Chang Chan Ling Qin Ye Chun Ruan | 2022 | Bioactive Materials2022，7，2： | 0 |
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