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| 1 | Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset显示文摘Objective Intravenous tissue plasminogen activator(tPA)is the standard therapy for patients with acute ischaemic stroke(AIS)within 4.5 hours of onset.Recent trials have expanded the endovascular treatment window to 24 hours.We investigated the efficacy and safety of using multimodal MRI to guide intravenous tPA treatment for patients with AIS of unknown time of onset(UTO).Methods Data on patients with AIS with UTO and within 4.5 hours of onset were reviewed.Data elements collected and analysed included:demographics,National Institutes of Health Stroke Scale(NIHSS)score at baseline and 2 hours,24 hours,7 days after thrombolysis and before discharge,the modified Rankin Scale(mRS)score at 3 months after discharge,imaging findings and any adverse event.results Forty-two patients with UTO and 62 in control group treated within 4.5 hours of onset were treated with intravenous tPA.The NIHSS scores after thrombolysis and/or before discharge in UTO group were significantly improved compared with the baseline(p<0.05).Between the two groups,no significant differences in NIHSS score were observed(p>0.05).Utilising the non-inferiority test,to compare mRS scores(0-2)at 3 months between the two groups,the difference was 5.2%(92%CI,OR 0.196).Patients in the UTO group had mRS scores of 0-2,which were non-inferior to the control group.Their incidence of adverse events was similar.Conclusions Utilising multimodal MRI to guide intravenous only thrombolysis for patients with AIS with UTO was safe and effective.In those patients with AIS between 6 and 24 hours of time of onset but without large arterial occlusion,intravenous thrombolysis could be considered an option. | Jie Zhao Hongmei Zhao Runtao Li Jiangtao Li Chang Liu Juan Lv Yanan Li Wei Liu Dongpu Ma Huaihai Hao Xinguang Xiao Junzhong Liu Yongfeng Yin Rongli Liu Qiaoyan Yu Yingjie Wei Pengyan Li Yue Wang Runqing Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 8 |
| 2 | Geochronology, geochemistry and Hf isotopes of andesites in the Sandaowanzi gold deposit(Great Xing’an Range, NE China): implications for petrogenesis, tectonic setting,and mineralization显示文摘The Sandaowanzi gold deposit is an extremely Au-rich deposit in the Northern Great Hinggan Range in recent years.Zircon U-Pb geochronology,Hf isotope analysis,and the geochemistry of andesites of the Longjiang Formation from the Sandaowanzi gold deposit were used to investigate the origin,magmatic evolution as well as mineralization and tectonic setting of the Early Cretaceous epithermal gold deposits in the northern Great Hinggan Range area.Zircon U-Pb dating reveals an emplacement age of 123.4±0.3 Ma,indicating that the andesites of the Sandaowanzi gold deposit was formed during the Early Cretaceous.The andesites are enriched in light rare earth elements relative to heavy rare earth elements and have weak negative Eu anomalies(δEu=0.76-0.90).The rocks are also enriched in large-ion lithophile elements,such as Rb,Ba,Th,U,and K,and depleted in the high-field-strength elements,such as Nb,Ta,and P.These characteristics are typical of volcanic rocks related to subduction.Igneous zircons from the andesite samples have relatively homogeneous Hf isotope ratios,176Hf/177Hf values of 0.282343-0.282502,εHf(t)values of-12.58 to-6.95,and two-stage model ages(TDM2)of 1743-1431 Ma.The characteristics of the andesites of the Longjiang Formation are consistent with derivation from partial melting of enriched mantle wedge metasomatized by subducted-slab-derived fluids.These rocks formed in an extensional environment associated with the closure of the Mongol-Okhotsk Ocean and subduction of the Paleo-Pacific Plate.Mineralization occurred towards the end of volcanism,and the magmatic activity and mineralization are products of the same geodynamic setting. | Runtao Yu Bile Li Fengyue Sun Zhihua Li Huawei Li Yufan Shi | 2021 | Acta Geochimica2021，40，2： | 2 |
| 3 | Assessment of dairy cow feed intake based on BP neural network with polynomial decay learning rate显示文摘To overcome the shortcomings of traditional dairy cow feed intake assessment model andBP neural network, this paper proposes a method of optimizing BP neural network usingpolynomial decay learning rate, taking the cow’s body weight, lying duration, lying times,walking steps, foraging duration and concentrate-roughage ratio as input variables andtaking the actual feed intake is the output variable to establish a dairy cow feed intakeassessment model, and the model is trained and verified by experimental data collectedon site. For the sake of comparative study, feed intake is simultaneously assessed by SVRmodel, KNN logistic regression model, traditional BP neural network model, and multilayerBP neural network model. The results show that the established BP model using the polynomial decay learning rate has the highest assessment accuracy, the MSPE, RMSE, MAE,MAPE and R2 are 0.043 kg2/d and 0.208 kg/d, 0.173 kg/d, 1.37% and 0.94 respectively. Compared with SVR model and KNN mode, the RMSE value reduced by 43.9% and 26.5%, it isalso found that the model designed in this paper has many advantages in comparison withthe BP model and multilayer BP model in terms of precision and generalization. Therefore,this method is ready to be applied for accurately evaluating the dairy cow feed intake, andit can provide theoretical guidance and technical support for the precise-feeding and canalso be of high significance in the improvement of dairy precise-breeding. | Weizheng Shen Gen Li Xiaoli Wei Qiang Fu Yonggen Zhang Tengyu Qu Congcong Chen Runtao Wang | 2022 | Information Processing in Agriculture2022，9，2： | 2 |
| 4 | In vitro screening of reversible and time-dependent inhibition on CYP3A by TM208 and TM209 in rat liver microsomes显示文摘TM208 and TM209,dithiocarbamate derivatives with potential anti-cancer effects,were evaluated in reversible and time-dependent cytochrome P450(CYP)3A inhibition assays in rat liver microsomes using testosterone as probe substrate.Both compounds were found to be weak reversible inhibitors and moderate mechanism-based inhibitors of rat CYP3A.For reversible inhibition on rat CYP3A,the Ki values of competitive inhibition model were 12.10±1.75 and 13.94±1.31 μM,respectively.For time-dependent inhibition,the inactivation constants(K_(l))were 31.93±12.64 and 32.91±15.58 μM,respectively,and the maximum inactivation rates(kinact)were 0.0349770.0069 and 0.0725970.0172 min^(-1) respectively.These findings would provide useful in vitro information for future in vivo DDI studies on TM208 or TM209。 | Miaoran Ning Liang Li Jian Li Zaiquan Li Runtao Li Tianyan Zhou Wei Lu | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 1 |
| 5 | An Adaptive Estimating Detaipreserving Filter for Image Processing显示文摘 | Li Xiangji Ding Runtao | 1998 | Transactions on Tianjin University1998，4，2： | 1 |
| 6 | An adaptive estimating detailpreserving filter for image processing 显示文摘 | Li Xiangji Ding Runtao | 1998 | Transactions on Tianjin University1998，4，2： | 1 |
| 7 | Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3 H )-ones in water显示文摘 | Xu Yan Shuo Zhou Yuanqiang Wang Zemei Ge Tieming Cheng Runtao Li | 2012 | Tetrahedron2012，，38： | 1 |
| 8 | Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3 H )-ones in water显示文摘 | Xu Yan Shuo Zhou Yuanqiang Wang Zemei Ge Tieming Cheng Runtao Li | 2012 | Tetrahedron2012，，38： | 1 |
| 9 | Continuous-flow synthesis of nitriles from aldehydes via Schmidt reaction显示文摘A continuous-flow synthesis of nitriles by Schmidt reaction has been developed.Using this procedure,a variety of aldehydes could be smoothly transformed into the desired nitriles in good to excellent yields.The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up. | Wei Zhan Meng Tong Ling Ji Han Zhang Zemei Ge Xin Wang Runtao Li | 2019 | Chinese Chemical Letters2019，30，5： | 0 |
| 10 | Biodiversity Risk and Opportunity Assessment in BAT Cooperative Tobacco-growing Areas显示文摘Using the method in Biodiversity Risk and Opportunity Assessment Handbook of British American Tobacco Biodiversity Partnership,we assess biodiversity risks and opportunities in BAT and China's cooperative tobacco-growing areas. The assessment results indicate that there are 8 risks and 1 opportunity. Action and monitoring plans have been made for medium and high risks as well as opportunity,to reduce impact on biodiversity. | Long XU Jingming WANG Kun FENG Yanfa CAI Bin LI Honghui YIN Dafei LI Lianchuan ZHOU Ying MA Gang WANG Pengcheng LIU Runtao LI Changhua ZHOU Ke YANG Jian CHEN | 2016 | Asian Agricultural Research2016，8，2： | 0 |
| 11 | Block Copolymer Solid Electrolytes Based on Comb-Like Poly(ethylene glycol)Plasticized Poly(ionic liquid)s for Lithium-Ion Batteries显示文摘Electrolytes based on poly(ionic liquid)s(PILs)have attracted great attention in the fields of next-generation solid lithium-ion batteries.However,the low ionic conductivity prevents their practical applications.Herein,we report novel solid electrolytes based on block copolymers composed of PILs and comb-like poly(ethylene glycol)(PEG),which were synthesized via ring-opening metathesis polymerization of 3-(2-(bicyclo[2.2.1]hept-5-en-2-yl)ethyl)-1-butyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide and poly(ethylene glycol monomethyl ether)bicyclo[2.2.1]hept-5-ene-2-carboxylate.Comb-like PEG acts as plasticizers in block copolymers dominated by PILs to promote the mobility of PILs segments.Effects of the copolymer composition and length of the comb-like PEG chain on ionic conductivity were investigated.The optimized electrolyte delivers the highest ionic conductivity of 1.5×10^(–5)S·cm^(–1)at 30℃,and robust electrochemical stability up to 4.6 V.A solid-state Li/LiFePO4 cell using the optimized electrolyte demonstrates good cycle performance at 0.2 C with high capacity retention of 92%after 70 cycles at 50℃. | Runtao Zhao Jixing Yang Bin Wang Zhe Ma Li Pan Yuesheng Li | 2023 | Chinese Journal of Chemistry2023，41，19： | 0 |
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