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| 1 | Achieving strength-ductility synergy in cold spray additively manufactured Al/B4C composites through a hybrid post-deposition treatment显示文摘Cold spray additive manufacturing(CSAM) provides a potential solid state manufacturing route to fabricate variety of aluminum matrix composites(AMCs) with reduced possibility of undesired chemical reactions and residual thermal stresses. This study presents a hybrid(i.e. hot compression + hot rolling)post-deposition treatment to reinvigorate the mechanical properties of cold spray additively manufactured Al/B4 C composites. The as-deposited samples were initially subjected to 30% thickness reduction via hot compression treatment at 500°C followed by a hot rolling treatment with 40% thickness reduction in 2 passes. Electron backscatter diffraction(EBSD) and high resolution transmission electron microscopy(HRTEM) results revealed that after hybrid post-deposition treatment(involving 70%accumulative thickness reduction), the aluminum grains in the matrix were extensively refined due to simultaneous operation of continuous dynamic recrystallization(CDRX) and geometric dynamic recrystallization(GDRX). Furthermore, interfacial defects were remarkably reduced while the nature of Al/Al and Al/B4C interfacial bonding was changed from sheer mechanical interlocking to metallurgical bonding which facilitated efficient transference of applied load to uniformly dispersed bimodal B4C particles. As a result, ultimate tensile strength(UTS) and elongation(EL) of the as-deposited sample were simultaneously improved from 37 to 185 MPa and 0.3% to 6.2%, respectively. | Naeem ul Haq Tariq Lawrence Gyansah Xiang Qiu Chunnijia Hasan Bin Awais Chengwu Zheng Hao Du Jiqiang Wang Tianying Xiong | 2019 | Journal of Materials Science & Technology2019，35，6： | 7 |
| 2 | Curcumin inhibits the replication of enterovirus 71 in vitro显示文摘Human enterovirus 71(EV71)is the main causative pathogen of hand,foot,and mouth disease(HFMD)in children.The epidemic of HFMD has been a public health problem in Asia-Pacific region for decades,and no vaccine and effective antiviral medicine are available.Curcumin has been used as a traditional medicine for centuries to treat a diversity of disorders including viral infections.In this study,we demonstrated that curcumin showed potent antiviral effect again EV71.In Vero cells infected with EV71,the addition of curcumin significantly suppressed the synthesis of viral RNA,the expression of viral protein,and the overall production of viral progeny.Similar with the previous reports,curcumin reduced the production of ROS induced by viral infection.However,the antioxidant property of curcumin did not contribute to its antiviral activity,since N-acetyl-L-cysteine,the potent antioxidant failed to suppress viral replication.This study also showed that extracellular signal-regulated kinase(ERK)was activated by either viral infection or curcumin treatment,but the activated ERK did not interfere with the antiviral effect of curcumin,indicating ERK is not involved in the antiviral mechanism of curcumin.Unlike the previous reports that curcumin inhibited protein degradation through ubiquitin–proteasome system(UPS),we found that curcumin had no impact on UPS in control cells.However,curcumin did reduce the activity of proteasomes which was increased by viral infection.In addition,the accumulation of the short-lived proteins,p53 and p21,was increased by the treatment of curcumin in EV71-infected cells.We further probed the antiviral mechanism of curcumin by examining the expression of GBF1 and PI4KB,both of which are required for the formation of viral replication complex.We found that curcumin significantly reduced the level of both proteins.Moreover,the decreased expression of either GBF1 or PI4KB by the application of siRNAs was sufficient to suppress viral replication.We also demonstrated that curcumin showed anti-apoptotic activity at the early stage of viral infection.The results of this study provide solid evidence that curcumin has potent anti-EV71 activity.Whether or not the down-regulated GBF1 and PI4KB by curcumin contribute to its antiviral effect needs further studies. | Ying Qin Lexun Lin Yang Chen Shuo Wu Xiaoning Si Heng Wu Xia Zhai Yan Wang Lei Tong Bo Pan Xiaoyan Zhong Tianying Wang Wenran Zhao Zhaohua Zhong | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 5 |
| 3 | Heat Dissipation Performance of Porous Copper with Elongated Cylindrical Pores显示文摘The purpose of this paper is to investigate heat dissipation performance of porous copper with long cylindrical pores fabricated by a unidirectional solidification method.Three samples with porosity of 29.87%,34.47%and 50.98%were chosen and cut into size of 60 mm(length)26 mm(width)2 mm(thickness)along the vertical direction of pore axis.Their heat dissipation performance was evaluated by a nonsteady method in air and compared to those of not only bulk copper but also bored coppers with porosity of 30.61%and32.20%.It is found that the porous copper dissipated heat faster by a forced air convection than that by natural convection from 80 C to room temperature and both porosity and pore size play an important role in the performance for the porous copper.Furthermore,the heat dissipation rate is higher when the forced air was circulated along the specimens than that perpendicular to the specimens for the porous copper.It is revealed that porous copper with bigger porosity and a proper pore size possesses a higher heat dissipation rate.It is concluded that the porous copper with elongated cylindrical pores has larger heat dissipation performance than both the bulk copper and the bored copper,which is attributed to its higher specific surface area.Application of the porous copper for heat dissipation is promising. | Hao Du Dongzhu Lu Jianzhong Qi Yanfang Shen Lisong Yin Yuan Wang Zhongguang Zheng Tianying Xiong | 2014 | Journal of Materials Science & Technology2014，30，9： | 3 |
| 4 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 5 | Microstructure and bioactivity of a cold sprayed rough/porous Ta coating on Ti6Al4V substrate显示文摘To improve the bioactivity and biocompatibility of titanium implants,a rough/porous tantalum(Ta)coating was firstly prepared on Ti6Al4V substrate by cold spraying.The results indicated that the surface of Ta coating is extremely rough with lots of visible holes,because of poor deposition quality.Microstructure and microhardness results showed that different layers appeared in the inner and outer parts of coatings,corresponding to porosity,due to lack of subsequent compaction.The simulated body fluid(SBF)soaking test showed that spherical apatite sediments were mineralized on rough/porous surface in SBF after 2–4 weeks,which demonstrated that the cold sprayed Ta coating had good bioactivity.This was mainly attributed to the rough/porous surface of Ta coating obtained by cold spraying,which is conducive to the heterogeneous nucleation of apatite on it. | TANG JunRong ZHAO ZhiPo CUI XinYu WANG JiQiang XIONG TianYing | 2020 | Science China(Technological Sciences)2020，63，5： | 3 |
| 6 | A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys显示文摘 | Ciming Kang Lin Xia Yuanzhi Chen Tianying Zhang Yiwen Wang Bing Zhou Min You Quan Yuan Chi-Meng Tzeng Zhiqiang An Wenxin Luo Ningshao Xia | 2018 | Protein & Cell2018，9，1： | 3 |
| 7 | Study of Mean Time to Lose Lock and Lock Detector Threshold in GPS Carrier Tracking Loops显示文摘 | JIN Tiani WANG Yubao LV Weifeng | 2013 | Chinese Journal of Electronics2013，22，1： | 2 |
| 8 | Stress Granule Formation is One of the Early Antiviral Mechanisms for Host Cells Against Coxsackievirus B Infection显示文摘Stress granules(SGs) are intracellular granules formed when cellular translation is blocked and have been reported to be involved in a variety of viral infections. Our previous studies revealed that SGs are involved in the coxsackievirus B(CVB)infection process, but the role of SGs in CVB infection has not been fully explored. In this study, we found that CVB type 3(CVB3) could induce SG formation in the early phase of infection. Results showed that levels of CVB3 RNA and protein were significantly inhibited during the early stage of CVB3 infection by the elevated formation of SGs, while viral RNA and protein synthesis were significantly promoted when SG formation was blocked. Our findings suggest that SG formation is one of the early antiviral mechanisms for host cells against CVB infection. | Xia Zhai Shuo Wu Lexun Lin Tianying Wang Xiaoyan Zhong Yang Chen Weizhen Xu Lei Tong Yan Wang Wenran Zhao Zhaohua Zhong | 2018 | Virologica Sinica2018，33，4： | 2 |
| 9 | Evolution Behaviors of Oxides in Severely Plastic Deformed Region of AISI 52100 Steel during Dry Sliding Wear显示文摘Under dry sliding wear, the evolution of oxides in severely plastic deformed(SPD) regions of metals has a great impact on the wear behaviors. To study the evolution behaviors of oxides in the SPD region, an SPD region was prefabricated on the surface of AISI 52100 steel by supersonic ?ne particle bombarding(SFPB) treatment. Dry sliding wear tests were carried out on both of the SFPB-treated and original samples.Wear volume loss of the SPBF-treated samples were compared with those of the original samples at different loads. Microstructure, element composition and oxides distribution in the SPD region were characterized by scanning electron microscopy(SEM), transmission electron microscopy(TEM) and an electron probe microanalysis(EPMA). The results show that the evolution behaviors of the oxides in the SPD region change signi?cantly with the load. Under low loads, oxides are usually formed on the contact surface. It inhibits adhesive wear on the steel. However, under high loads, oxides are apt to distribute along the cracks in the subsurface layer. The internal oxidation along the cracks can accelerate the cracks propagation, resulting in severe delamination wear on the steel. | Yuanxia Lao Hao Du Tianying Xiong Yuan Wang | 2017 | Journal of Materials Science & Technology2017，33，4： | 2 |
| 10 | Concept design of a new non-ship-shaped FPSO显示文摘 | WANG Tianying ZHANG Jian LIU Jinkun | 2012 | Applied Mechanics and Materials2012，，： | 1 |
| 11 | 显示文摘 | GUO Tianying XIA Yongqing WANG Jin | 2004 | Biomaterials2004，25，： | 1 |
| 12 | 显示文摘 | GUO Tianying XIA Yongqing WANG Jin etal | 2005 | Biomaterials2005，26，： | 1 |
| 13 | Microstructure and Mechanical Properties of Ti–Ta Composites Prepared Through Cold Spray Additive Manufacturing显示文摘In this study, an innovative approach was used to fabricate Ti–Ta composite biomaterials through cold spray additive manufacturing followed by a diff usion treatment. The microstructure and mechanical properties of the composites were investigated in detail using field emission scanning electron microscopy, electron backscatter diff raction, 3D X-ray computed tomography, tensile test, nanohardness test and resonance vibration test. The obtained results indicated that the prepared composites have inhomogeneity in their microstructure and composition. A unique microstructure, composed of Ti-rich, Ta-rich and diff usion regions, was evolved in the composites due to incomplete diff usion between Ti and Ta splats. Further, Kirkendall pores were formed in the composites due to uneven diff usion of the two phases(of Ti and Ta) during high-temperature heat treatment. The prepared composites simultaneously showed low elastic modulus and high tensile strength which is required for a good biomaterial. Low elastic modulus was associated with the residual pores and the alloying eff ect of Ta in Ti, while high tensile strength was related to the solid solution strengthening eff ects. The obtained results indicated that the prepared Ti–Ta composites have a great potential to become a new candidate for biomedical applications. | Junrong Tang Naeem ul Haq Tariq Zhipo Zhao Mingxiao Guo Hanhui Liu Yupeng Ren Xinyu Cui Yanfang Shen Jiqiang Wang Tianying Xiong | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，9： | 1 |
| 14 | Oxidation Behavior of Thermal Barrier Coatings with a TiAl 3 Bond Coat on γ-TiAl Alloy显示文摘 | Jiqiang Wang Lingyan Kong Tiefan Li Tianying Xiong | 2015 | Journal of Thermal Spray Technology2015，，： | 1 |
| 15 | Chitosan beads as molecularly imprinted polymer matrix for selective separation of proteins显示文摘 | Guo TianYing Xia Yong Qing Wang Jin | 2005 | Biomaterials2005，26，： | 1 |
| 16 | A Novel Turn-on Fluorescent Probe for Highly Selective Detection of Phosphate Ion in Living Cell显示文摘A novel fluorescent probe was synthesized and studied.Fluorescent probe 1 undergoes a unique Pi induced hydrolytic reaction in DMSO-HEPES at physiological pH that produces a colorimetric change associated with a 76nm red-shift in the UV-vis absorption maximum and up to a 210-fold enhancement in the fluorescence intensity.It has successfully been used to stain and record microscopy images of HeLa cells.Moreover,the mechanistic proposal that these spectroscopic changes are associated with the reaction of Pi and probe 1 to form 2-(2-hydroxyphenyl)benzothiazole gains support from the results of mass spectrometry studied. | Jin Zhang Si Wang Changhui Liu Guowen He Tianying Peng | 2018 | Chinese Journal of Chemistry2018，36，12： | 1 |
| 17 | BET protein inhibitor apabetalone represses Porphyromonas gingivalis LPS-induced macrophage M1 polarization via regulating miR-130a/STAT3 axis显示文摘Periodontitis is a frequent chronic inflammatory disorder destroying periodontium.Recent studies have revealed the role of bromodomain and extraterminal domain inhibitor(BETi)and microRNA(miR)-130a in regulating macrophage polarization and pro-inflammatory response.However,little is known about whether apabetalone(a novel BETi)and miR-130a are correlated with chronic inflammatory state in periodontitis by regulating macrophage polarization.Here murine RAW264.7 macrophages were applied as an in vitro inflammatory model.After treatment with Porphyromonas gingivalis-derived lipopolysaccharide(Pg LPS)and apabetalone,the expression of macrophage M1 polarization markers and inflammatory cytokines was assessed using real-time PCR,western blot,and enzyme-linked immuno sorbent assay(ELISA).MiR-130a level was assessed using real-time PCR,and the target gene was identified using dual luciferase reporter assay.We demonstrated that apabetalone repressed Pg LPS-induced macrophage M1 polarization in a dose-dependent manner,as evidenced by decreased expression of inducible nitric oxide synthase(iNOS),CD86,and pro-inflammatory cytokines,and increased expression of Arg-1 and CD206.Mechanistically,Pg LPS increased miR-130a expression in macrophages,whereas apabetalone treatment repressed the effect.Functionally,forced expression of miR-130a promoted macrophage M1 polarization,and signal transducer and activator of transcription(STAT)-3 was the direct target gene of miR-130a in the process.Taken together,apabetalone decreases Pg LPS-induced macrophage M1 polarization via regulating miR-130a-3p/STAT3 axis,and may be a promising target for the clinical management of periodontitis. | MEIHUA CHEN HUIHUI WANG XIAOFENG CHEN YAN CHEN TIANYING BIAN | 2022 | BIOCELL2022，46，10： | 1 |
| 18 | The hip stress level analysis for human routine activities显示文摘 | WANG Xishi WANG Tianying JIANG Fuchuan | 2005 | Biomedical Engineering2005，17，3： | 1 |
| 19 | Chitosan beads as molecularly imprinted polymer matrix for selective separation of proteins显示文摘 | GUO Tianying XlAYongqing WANG Jin | 2005 | Biomaterials2005，26，28： | 1 |
| 20 | IoT Security Situational Awareness Based on Q-Learning and Bayesian Game显示文摘IoT security is very crucial to IoT applications,and security situational awareness can assess the overall security status of the IoT.Traditional situational awareness methods only consider the unilateral impact of attack or defense,but lackconsideration of joint actions by both parties.Applying gametheory to security situational awareness can measure the impact of the opposition and interdependence of the offensive and defensive parties.This paper proposes an IoT security situational awareness method based on Q-Learning and Bayesian game.Through Q-Learning update,the long-term benefits of action strategies in specific states were obtained,and static Bayesian game methods were used to solve the Bayesian Nash Equilibrium of participants of different types.The proposed method comprehensively considers offensive and defensive actions,obtains optimal defense decisions in multi-state and multi-type situations,and evaluates security situation.Experimental results prove the effectiveness of this method. | Yang Li Tianying Liu Jianming Zhu Xiuli Wang | 2021 | 国际计算机前沿大会会议论文集2021，，2： | 0 |
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