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| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | Subtemporal transpetrosal apex approach: study on its use in large and giant petroclival meningiomas显示文摘背景 subtemporal transtentoral 途径被报导将近二十年了;然而,它很好没在处理大、巨大的 petroclival meningiomas 由于一些限制被使用。修改 subtemporal transpetrosal 顶的临床的结果和优点在大、巨大的 petroclival meningiomas ,以及选择来临,改进和在如此的病人的 microsurgical 途径的治疗策略完全在这 study.Methods 被评估经历的大、巨大的 petroclival meningiomas 的 25 个案例在2004年4月和2010年1月之间的修改 subtemporal transpetrosal 顶途径在这研究被注册。途径,解剖的基础和相关研究,附件设备的效果,肿瘤的暴露和 neurofunction 操作前的变化的选择和改进并且操作以后都回顾地被考察。在这条途径的操作结果和复杂并发症也与在在所有 25 个案例经历了的一样的 period.Results 在 14 种情况中做的 transpetrous presigmoid 途径的那些相比在头部的神经和大脑茎功能监视的 electrophysiologic 下面的修改 subtemporal transpetrosal 顶途径。软骨轮的神经部分在 14 种情况中被包,完全包了,但是能在在 8 种情况中的小脑 tentorium 的起始的片断被探索,完全包了并且不能被看见直到肿瘤部分在 3 种情况中被移开。小脑 tentorium 从顶的前面的部分沿着时间的骨头被切到优异岩石湾穴的乳突部分成 6 种情况,从到在 19 种情况中的优异岩石湾穴的乳突部分的顶的以后的部分。粗野肿瘤切除术在 17 被完成(68%) 病人,在 7 的小计切除术(28%) 在 1 的病人,和部分切除术(4%) 病人。最普通的手术后的复杂并发症是先存在的新神经病学的赤字或恶化赤字(64%) 。后续从 3 ~ 69 个月。与在一样的时期在 14 种情况中做的 transpetrous presigmoid 途径相比,修改 subtemporal transpetrosal 顶途径在操作显示出象简洁那样的明显的优点, microinvasiveness ,不太费时间,更少的复杂并发症,尽管粗野肿瘤切除术力量的率具有修改的没有重要 difference.Conclusions ,更高肿瘤切除术评价 subtemporal transpetrosal 顶途径与 transpetrous presigmoid 途径相比有明显的优点。一些复杂并发症需要被途径的实践以及经验的累积解决。 | YANG Jun MA Shun-chang FANG Tie QI Jian-fa HU Ye-shuai YU Chun-jiang | 2011 | Chinese Medical Journal2011，，1： | 11 |
| 3 | Intelligent coding metasurface holograms by physics-assisted unsupervised generative adversarial network显示文摘Intelligent coding metasurface is a kind of information-carrying metasurface that can manipulate electromagnetic waves and associate digital information simultaneously in a smart way.One of its widely explored applications is to develop advanced schemes of dynamic holographic imaging.By now,the controlling coding sequences of the metasurface are usually designed by performing iterative approaches,including the Gerchberg–Saxton(GS)algorithm and stochastic optimization algorithm,which set a large barrier on the deployment of the intelligent coding metasurface in many practical scenarios with strong demands on high efficiency and capability.Here,we propose an efficient non-iterative algorithm for designing intelligent coding metasurface holograms in the context of unsupervised conditional generative adversarial networks(cGANs),which is referred to as physics-driven variational auto-encoder(VAE)cGAN(VAE-cGAN).Sharply different from the conventional cGAN with a harsh requirement on a large amount of manual-marked training data,the proposed VAE-cGAN behaves in a physics-driving way and thus can fundamentally remove the difficulties in the conventional cGAN.Specifically,the physical operation mechanism between the electric-field distribution and metasurface is introduced to model the VAE decoding module of the developed VAE-cGAN.Selected simulation and experimental results have been provided to demonstrate the state-of-the-art reliability and high efficiency of our VAE-cGAN.It could be faithfully expected that smart holograms could be developed by deploying our VAE-cGAN on neural network chips,finding more valuable applications in communication,microscopy,and so on. | Che Liu Wen Ming Yu Qian Ma Lianlin Li Tie Jun Cui | 2021 | Photonics Research2021，9，4： | 7 |
| 4 | Enhanced hydrogen evolution reaction over molybdenum carbide nanoparticles confined inside single-walled carbon nanotubes显示文摘Carbon nanotubes(CNTs) have shown as unique nanoreactors to tune the catalytic activity of confined nano-catalysts. Here we report that the catalytic performance of molybdenum carbide nanoparticles(MoC_x NPs) for the hydrogen evolution reaction(HER) process can be enhanced by encapsulation within single-walled carbon nanotubes(SWNTs) with a diameter of 1–2 nm. The catalyst with MoC_x NPs located on the interior surface of SWNTs(MoCx@SWNTs) exhibits a lower onset over-potential and a smaller Tafel slope than the one with MoC_x NPs attached on the exterior surface(MoCx/SWNTs). This is likely attributed to the much smaller particle size and the more reduced states of the confined MoC_x NPs, as well as the larger specific surface area of MoCx@SWNTs compared with Mo Cx/SWNTs. In addition, the electronic structure of the confined MoC_x NPs might be modified by the confinement effects of SWNTs, and hence the adsorption free energy of H atoms on the confined MoC_x NPs, which could also contribute to their higher performance. These results suggest that the SWNTs can be further explored for constructing novel catalysts with beneficial catalytic performance. | Tingting Cui Jinhu Dong Xiulian Pan Tie Yu Qiang Fu Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，1： | 7 |
| 5 | A novel phenylpropanoid glycosides and a new derivation of phenolic glycoside from Paris Polyphylla var. yunnanensis显示文摘A novel phenylpropanoid glycosides 1, named parispolyside F, and a novel derivation of phenolic glycoside 2, named parispolyside G, as well as two known flavonoid glycosides were isolated from the rhizome of Paris polyphylla var. yunnanensis. Their structures were elucidated by spectroscopic methods. | Yu Wang Wen Yuan Gao Tie Jun Zhang Yuan Qiang Guo | 2007 | Chinese Chemical Letters2007，18，5： | 7 |
| 6 | The complete mitochondrial genomes sequences of Asio flammeus and Asio otus and comparative analysis显示文摘The complete mitochondrial genomes of Asio flammeus and Asio otus were se- quenced and found to span 18858 bp and 18493 bp, respectively. It is surprising to find the for- mer to be the largest among all avian mitochondrial genomes sequenced so far. The two ge- nomes have very similar gene order with that of Gallus gallus, neither contains the pseudo con- trol region, but both have a single extra base, namely Cytidine, at position 174 in ND3 gene. The control regions of Asio flammeus and Asio otus’ mitochondrial genomes span 3288 bp and 2926 bp respectively, which are the longest among vertebrates except for Myxine glutinosa and con- tribute to the large size of two genomes. The 3′end of the control region of Asio flammeus and Asio otus contains many tandemly repeated sequences, which are highly similar to a putative control element, i.e. Mt5, and may form stable stem-loop secondary structures. Such repeated sequences probably play an important role in regulating transcription and replication of mito- chondrial genome. Our results may provide important clues for uncovering the origin and evolu- tion mechanisms of mitochondrion genome. | SUN Yi1, MA Fei1, XIAO Bing1, ZHENG Junjie2, YUAN Xiaodong2, TANG Minqian2, WANG Li3, YU Yefei3 & Li Qingwei1 1. College of Life Sciences, Liaoning Normal University, Dalian 116029, China 2. TaKaRa Biotechnology (Dalian) Co., Ltd., Dalian 116600, China 3. The Administrative Office of the Natural Protective Zone of Snake Island-Lao Tie Hill, Dalian 116041, China Correspondence should be addressed to Li Qingwei | 2004 | Science China(Life Sciences)2004，47，6： | 6 |
| 7 | Evolution of secondary phase particles during deformation of Al-5Ti-1B master alloy and their effect on α-Al grain refinement显示文摘Addition of Al-5Ti-1B alloy to molten aluminum alloys can refine α-Al grains effectively and thereby improve their strength and toughness. TiAl_3 and TiB_2 in Al-5Ti-1B alloy are the main secondary-phase particles for refinement, while the understanding on the effect of their sizes on α-Al grain refinement continues to be fragmented. Therefore, Al-5Ti-1B alloys with various sizes and morphologies of the secondary-phase particles were prepared by equal channel angular pressing(ECAP). Evolution of the secondary-phase particles during ECAP process and their impact on α-Al grain refinement were studied by X-ray diffraction and scanning electron microscope(SEM). Results show that during the ECAP process, micro-cracks firstly appeared inside TiAl_3 particles and then gradually expanded, which resulted in continuous refinement of TiAl_3 particles. In addition, micro-distribution uniformity of TiB_2 particles was improved due to the impingement of TiAl_3 particles to TiB_2 clusters during deformation. Excessively large sizes of TiAl_3 particles would reduce the number of effective heterogeneous nucleus and thus resulted in poor grain refinement effectiveness. Moreover, excessively small TiAl_3 particles would reduce inhibitory factors for grain growth Q and weaken grain refinement effectiveness. Therefore, an optimal size range of 18-22 μm for TiAl_3 particles was suggested. | Hong Yu Ning Wang Renguo Guan Di Tie Zheng Li Yanan An Yang Zhang | 2018 | Journal of Materials Science & Technology2018，34，12： | 6 |
| 8 | Active digital spoof plasmonics显示文摘Digital coding and digital modulation are the foundation of modern information science.The combination of digital technology with metamaterials provides a powerful scheme for spatial and temporal controls of electromagnetic waves.Such a technique,however,has thus far been limited to the control of free-space light.Its application to plasmonics to shape subwavelength fields still remains elusive.Here,we report the design and experimental realization of a tunable conformal plasmonic metasurface;which is capable of digitally coding and modulating designer surface plasmons at the deep-subwavelength scale.Based on dynamical switching between two discrete dispersion states in a controlled manner;we achieve digital modulations ofboth amplitude and phase of surface waves with nearly 100%modulation depth on a single device.Our study not only introduces a new approach for active dispersion engineering,but also constitutes an important step towards the realization of subwavelength integrated plasmonic circuits. | Hao Chi Zhang Tie Jun Cui Yu Luo Jingjing Zhang Jie Xu Pei Hang He Le Peng Zhang | 2020 | National Science Review2020，7，2： | 5 |
| 9 | Targeting folate receptorβpositive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex显示文摘Tumor-associated macrophages(TAMs)facilitate cancer progression by promoting tumor invasion,angiogenesis,metastasis,inflammatory responses,and immunosuppression.Folate receptorβ(FRβ)is overexpressed in TAMs.However,the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood.In this study,we verified that FRβoverexpression in lung cancer TAMs was associated with poor prognosis.We utilized a folate-modified lipoplex comprising a folatemodified liposome(F-PLP)delivering a BIM-S plasmid to target both lung cancer cells and FRβ-positive macrophages in the tumor microenvironment.Transfection of LL/2 cells and MH-S cells with F-PLP/pBIM induced cell apoptosis.Injection of F-PLP/pBIM into LL/2 and A549 lung cancer models significantly depleted FRβ-positive macrophages and reduced tumor growth.Treatment of tumor-bearing mice with F-PLP/pBIM significantly inhibited tumor growth in vivo by inducing tumor cell and macrophage apoptosis,reducing tumor proliferation,and inhibiting tumor angiogenesis.In addition,a preliminary safety evaluation demonstrated a good safety profile of F-PLP/pBIM as a gene therapy administered intravenously.This work describes a novel application of lipoplexes in lung cancer targeted therapy that influences the tumor microenvironment by targeting TAMs. | Yan Tie Heng Zheng Zhiyao He Jingyun Yang Bin Shao Li Liu Min Luo Xia Yuan Yu Liu Xiangxian Zhang Hongyi Li Min Wu Xiawei Wei | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 10 | Neoadjuvant endocrine therapy: A potential strategy for ER-positive breast cancer显示文摘A potential strategy for patients with estrogen receptor(ER)-positive breast cancer is necessary to replace neoadjuvant chemotherapy which has limited benefit.Neoadjuvant endocrine therapy(NAE)has been indicated to be a favorable alternate approach to downstage large or locally advanced breast cancer in ER-positive,human epidermal growth factor receptor 2(HER2)-negative(ER+/HER2-)patients,especially postmenopausal women.Previous studies have demonstrated the efficacy of various endocrine agents in NAE.Aromatase inhibitors(AIs)have proven superiority over tamoxifen as a suitable choice to optimize treatment efficacy.Fulvestrant was recently reported as an effective agent,similar to AIs.Furthermore,the addition of targeted agents exerts synergistic antiproliferative effects with endocrine agents and rapidly improves response rates in both endocrine sensitive and resistant tumors.The neoadjuvant platform provides a unique opportunity to define the appropriate strategy and address the mechanisms of endocrine resistance.In addition,the predictive value of biomarkers and genomic assays in NAE is under investigation to evaluate individual effects and validate biomarker-based strategies.In this review,we discuss the most relevant evidence on the potential of NAE for ER+breast cancer.The current understanding also offers new insights into the identification of the optimal settings and valuable predictive tools of NAE to guide clinical treatment decisions and achieve beneficial therapeutic effects. | Li-Tong Yao Mo-Zhi Wang Meng-Shen Wang Xue-Ting Yu Jing-Yi Guo Tie Sun Xin-Yan Li Ying-Ying Xu | 2019 | World Journal of Clinical Cases2019，7，15： | 4 |
| 11 | A phase 3,double-blind,randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapynaı¨ve patients with mCRPC in China,Malaysia,Thailand and Russia显示文摘Objective:This double-blind,placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate+prednisone(abiraterone)to prednisone alone in chemotherapy-naı¨ve,asymptomatic or mildly symptomatic metastatic castrationresistant prostate cancer(mCRPC)patients from China,Malaysia,Thailand and Russia.Methods:Adult chemotherapy-naı¨ve patients with confirmed prostate adenocarcinoma,Eastern Cooperative Oncology Group(ECOG)performance status(PS)grade 0e1,ongoing androgen deprivation(serum testosterone<50 ng/dL)with prostate specific antigen(PSA)or radiographic progression were randomized to receive abiraterone acetate(1000 mg,QD)t prednisone(5 mg,BID)or placebo t prednisone(5 mg,BID),until disease progression,unacceptable toxicity or consent withdrawal.Primary endpoint was improvements in time to PSA progression(TTPP).Results:Totally,313 patients were randomized(abiraterone:n Z 157;prednisone:n Z 156);and baseline characteristics were balanced.At clinical cut-off(median follow-up time:3.9 months),80% patients received treatment(abiraterone:n Z 138,prednisone:n Z 112).Median time to PSA progression was not reached with abiraterone versus 3.8 months for prednisone,attaining 58%reduction in PSA progression risk(HR=0.418;p<0.0001).Abirateronetreated patients had higher confirmed PSA response rate(50%vs.21%;relative odds=2.4;p<0.0001)and were 5 times more likely to achieve radiographic response than prednisonetreated patients(22.9%vs.4.8%,p=0.0369).Median survival was not reached.Most common(≥10% abiraterone vs.prednisone-treated)adverse events:bone pain(7%vs.14%),pain in extremity(6%vs.12%),arthralgia(10%vs.8%),back pain(7%vs.11%),and hypertension(15%vs.14%).Conclusion:Interim analysis confirmed favorable benefit-to-risk ratio of abiraterone in chemotherapy-naı¨ve men with mCRPC,consistent with global study,thus supporting use of abiraterone in this patient population. | Dingwei Ye Yiran Huang Fangjian Zhou Keji Xie Vsevolod Matveev Changling Li Boris Alexeev Ye Tian Mingxing Qiu Hanzhong Li Tie Zhou Peter De Porre Margaret Yu Vahid Naini Hongchuan Liang Zhuli Wu Yinghao Sun | 2017 | Asian Journal of Urology2017，4，2： | 3 |
| 12 | A metasurface-based light-to-microwave transmitter for hybrid wireless communications显示文摘Signal conversion plays an important role in many applications such as communication,sensing,and imaging.Realizing signal conversion between optical and microwave frequencies is a crucial step to construct hybrid communication systems that combine both optical and microwave wireless technologies to achieve better features,which are highly desirable in the future wireless communications.However,such a signal conversion process typically requires a complicated relay to perform multiple operations,which will consume additional hardware/time/energy resources.Here,we report a light-to-microwave transmitter based on the time-varying and programmable metasurface integrated with a high-speed photoelectric detection circuit into a hybrid.Such a transmitter can convert a light intensity signal to two microwave binary frequency shift keying signals by using the dispersion characteristics of the metasurface to implement the frequency division multiplexing.To illustrate the metasurface-based transmitter,a hybrid wireless communication system that allows dual-channel data transmissions in a light-to-microwave link is demonstrated,and the experimental results show that two different videos can be transmitted and received simultaneously and independently.Our metasurface-enabled signal conversion solution may enrich the functionalities of metasurfaces,and could also stimulate new information-oriented applications. | Xin Ge Zhang Ya Lun Sun Bingcheng Zhu Wei Xiang Jiang Qian Yu Han Wei Tian Cheng-Wei Qiu Zaichen Zhang Tie Jun Cui | 2022 | Light(Science & Applications)2022，11，6： | 3 |
| 13 | The effect of Al3+ coordination structure on the propane dehydrogenation activity of Pt/Ga/Al2O3 catalysts显示文摘The effect of the Al2O3 structure on the performance of Pt/Ga/Al2O3 catalysts is investigated for the direct dehydrogenation of propane. The study unveils that the structure of Al3+determines the bulk structure of catalysts, particularly a high content of coordinatively unsaturated Al3+sites(penta-coordinated Al3+,denoted as Al3+penta) could lead to a remarkably improved dehydrogenation activity of the catalyst. The bulk characterization reveals that the sufficient amount of Al3+pentain Al2O3 benefit the dispersion of Pt and Ga2O3 on the Al2O3 support. At the same time, TPR results reveal that the presence of Pt facilitates the reduction of Ga2O3, likely due to the hydrogen spillover between the well dispersed Pt and Ga2O3,which consequently enhances the synergistic function between Pt and Ga2O3 in the dehydrogenation of propane. Recyclability tests demonstrate that the dehydrogenation activity stabilizes after three cycles over the Pt/Ga/Al2O3 catalyst. | Qinqin Yu Tie Yu Hongyu Chen Guangzong Fang Xiulian Pan Xinhe Bao | 2020 | Journal of Energy Chemistry2020，29，2： | 3 |
| 14 | Characteristics and source apportionment of VOCs measured in Shanghai, China显示文摘 | Changjie Cai Fuhai Geng Xuexi Tie Qiong Yu Junlin An | 2010 | Atmospheric Environment2010，，38： | 2 |
| 15 | Emergence of fatalPRRSV variants; unpar alleled outbreaks of atypical PRRS in China andmolecular dissection of the unique hallmark显示文摘 | Tian ke gong Yu xiu ling Zhao tie zhu | 2007 | PLos ONE2007，2，6： | 1 |
| 16 | Characteristics and source apportionment of VOCs measured in Shanghai, China显示文摘 | Changjie Cai Fuhai Geng Xuexi Tie Qiong Yu Junlin An | 2010 | Atmospheric Environment2010，，38： | 1 |
| 17 | Study on graphene-oxide-based polyacrylamide composite hydrogels显示文摘 | Jianfeng Shen Bo Yan Tie Li Yu Long Na Li Mingxin Ye | 2012 | Composites Part A2012，，9： | 1 |
| 18 | Metabolism of flavone C-glucosides and p-coumaric acid from antioxidant of bamboo leaves (AOB) in rats显示文摘 | Xiaowei Tie Bili Bao | 2007 | British Journal of Nutrition2007，97，： | 1 |
| 19 | Characteristics and source apportionment of VOCs measured in Shanghai, China显示文摘 | Changjie Cai Fuhai Geng Xuexi Tie Qiong Yu Junlin An | 2010 | Atmospheric Environment2010，，38： | 1 |
| 20 | Comparison of contrast‐enhanced sonography with MRI in the diagnosis of complex cystic renal masses显示文摘 | Yu Chen Ning Wu Tie Xue Yuzhi Hao Jingrui Dai | 2015 | J. Clin. Ultrasound2015，，4： | 1 |
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