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| 1 | Epigenetic repression of miR-132 expression by the hepatitis B virus x protein in hepatitis B virus-related hepatocellular carcinoma显示文摘 | Xufu Wei Cui Tan Chengyong Tang Guosheng Ren Tingxiu Xiang Zhu Qiu Rui Liu Zhongjun Wu | 2013 | Cellular Signalling2013，，5： | 8 |
| 2 | The hepatitis B virus-associated estrogen receptor alpha (ERα) was regulated by microRNA-130a in HepG2.2.15 human hepatocellular carcinoma cells显示文摘雌激素受体(ERs ) 在 hepatocarcinogenesis 起重要作用,它被坚持的肝炎 B 总是促进病毒(HBV ) 感染。最近的研究连接了 microRNAs (miRNAs ) 到病毒的致病或 oncogenesis。嗯能导致房间周期前进或 apoptosis 的抑制,当时嗯有的相反的效果。这里,我们建议 HBV 在病毒的 oncogenesis 影响了 ERs 表示,它可能被 miRNAs 触发。蛋白质表示嗯在 HepG2 房间在 HepG2.2.15 房间是比那强壮得多的,它不与它在这些房间的 mRNA 表示一致。MicroRNA-130a (miR-130a ) 被预言是一个管理者嗯由指向它的 3 untranslated 区域(3-UTR ) 。提高的绿荧光蛋白质(EGFP ) 记者实验证实了 miR-130a 的直接相互作用并且嗯。而且,嗯蛋白质水平相反地与 miR-130a 水平被相关。一起拿,我们的研究支持了感染可能稀释的那 HBV miR-130a 表示并且嗯是 miR-130a 的一个直接目标。在在 HepG2 和 HepG2.2.15 房间之间的 miR-130a 层次的差别导致了差别在嗯表示,在病毒的致病暗示主人病毒串音由 miRNAs 调停了。 | Liping Tang Yong Pu Danny Ka-Ho Wong Tao Liu Hua Tang Tingxiu Xiang Man-Fung Yuen Guosheng Ren | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 3 |
| 3 | Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin显示文摘Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulate neurobiological responses is unknown. Herein, the effects of chronic stress on the epigenetic modification of HCRT and its association with depression were explored with regard to a potential role in cancer progression. In the study, Sprague Dawley (SD) rats were used to establish an animal model of cancer with depression by administrating n-nitrosodiethylamine (DEN) and chronic unpredictable mild stress (CUMS). RNA-sequencing was used to detect differentially expressed genes in the hippocampus of rats and quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the results of RNA-sequencing. The status of HCRT promoter methylation was assessed by methylation specific polymerase chain reaction. Behavioral tests showed that rats exposed to CUMS had significant depressive-like behaviors. The number of liver tumors and tumor load in depressed rats exposed to CUMS was higher than in SD rats without CUMS. RNA-sequencing revealed that HCRT was one of the most siginificantly downregulated gene in the hippocampus of SD rats with CUMS compared to non-stressed group, which was validated by qRT-PCR. HCRT mRNA expression was downregulated and the promoter for HCRT was hyper-methylated in those with depression. These results identified a critical role for chronic psychological stressors in tumorigenesis and cancer progression, via epigenetic HCRT downregulation. Such epigenetic downregulation may be the molecular basis for the association of cancer with depression. | Chunyun Pu Shaorong Tian Sanxiu He Weihong Chen Yuanyuan He Hongyan Ren Jing Zhu Jun Tang Xiaolan Huang Ying Xiang Yixiao Fu Tingxiu Xiang | 2022 | Genes & Diseases2022，9，4： | 2 |
| 4 | Dihydroartemisinin induces endoplasmic reticulum stress-mediated apoptosis in HepG2 human hepatoma cells显示文摘 | Xiaoling Gao Ziguo Luo Tingxiu Xiang | | 0，，06： | 1 |
| 5 | Antioxidative and immunoprotective effects of Pyracantha fortuneana (Maxim.) Li polysaccharides in mice显示文摘 | Chengfu Yuan Changdong Wang Youquan Bu Tingxiu Xiang Xiuning Huang Zhiwei Wang Faping Yi Guosheng Ren Geli Liu Fangzhou Song | 2010 | Immunology Letters2010，，1： | 1 |
| 6 | Epigenetic repression of miR-132 expression by the hepatitis B virus x protein in hepatitis B virus-related hepatocellular carcinoma显示文摘 | Xufu Wei Cui Tan Chengyong Tang Guosheng Ren Tingxiu Xiang Zhu Qiu Rui Liu Zhongjun Wu | 2013 | Cellular Signalli ng2013，114，5： | 1 |
| 7 | Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β‐catenin signalling and apoptosis regulation in breast cancer cells显示文摘 | Tingxiu Xiang Lili Li Xuedong Yin Lan Zhong Weiyan Peng Zhu Qiu Guosheng Ren Qian Tao | 2013 | J. Cell. Mol. Med2013，，10： | 1 |
| 8 | Antioxidative and immunoprotective effects of Pyracantha fortuneana (Maxim.) Li polysaccharides in mice显示文摘 | Chengfu Yuan Changdong Wang Youquan Bu Tingxiu Xiang Xiuning Huang Zhiwei Wang Faping Yi Guosheng Ren Geli Liu Fangzhou Song | 2010 | Immunology Letters2010，，1： | 1 |
| 9 | Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer显示文摘Our previous studies found that Zinc-finger protein 382(ZNF382)played as a tumor suppressor gene in esophageal and gastric cancers,and a positive correlation between the high expression of ZNF382 and better outcome in breast cancer patients.However,the biological roles and mechanisms of ZNF382 in breast cancer remains unclear.We detected ZNF382 expression by reverse-transcription PCR(RT-PCR)and real-time quantitative PCR(qRT-PCR)in breast cancer cells and tissues,and explored the impacts and mechanisms of ectopic ZNF382 expression in breast cancer cells in vitro and in vivo,respectively.Our results revealed that ZNF382 was significantly down-regulated in breast cancer tissues compared with adjacent non-cancer tissues.Restoration of ZNF382 expression in silenced breast cancer cells not only inhibited tumor cell colony formation,viability,migration and invasion,and epithelial-mesenchymal-transition(EMT),but also induced apoptosis and G0/G1 arrest.In conclusion,ZNF382 could induce G0/G1 cell cycle arrest through inhibiting CDC25A signaling,and,inhibit cell migration,invasion and EMT by antagonizing ZEB1 signaling in breast cancer cells. | Shuman Li Xiaoqian He Yan Wang Weihong Chen Ran Sun Shaorong Tian Sanxiu He Chunyun Pu Chen Li Dishu Zhou Yu Jiang Qian Tao Lili Li Lin Ye Yue Wu Weiyan Peng Tingxiu Xiang | 2023 | Genes & Diseases2023，10，2： | 1 |
| 10 | LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma显示文摘This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma(HCC),further,to explore the effect of LPCAT1 on overall survival(OS)in patients with HCC,and its possible mechanism.Bioinformatics analysis using high throughput RNA-sequencing data from TCGA was utilized to explore the differential expression of LPCAT1 between normal and tumor tissues,and the associations between LPCAT1 expression and clinicopathological parameters.Survival analyses and subgroup survival analyses were utilized to elucidate the effect of LPCAT1 on OS in patients with HCC.Univariate analysis and multivariate analysis were used to investigate the prognostic factors.Potential LPCAT1 related tumor genes were identified by the methodology of differentially expressed genes(DEGs)screening.GO term enrichment analysis,KEGG pathway analysis and the PPI network were used to explore the potential mechanism.LPCAT1 was significantly overexpressed in HCC tumor tissues compared with normal tissues.The LPCAT1 expression was related to tumor grade,ECOG score,AFP and TNM stage,with P values of 0.000,0.000,0.007 and 0.000,respectively.Multivariate analysis demonstrated that LPCAT1 expression was independently associated with OS,with an HR of 1.04(CI:1.01–1.06,P=0.003).The KEGG pathway enrichment analyses showed that overlapped DEGs mainly participate in the cell cycle.Finally,we identified a hub gene,CDK1,which has been reported to act on the cell cycle,consistent with the result of KEGG enrichment analysis.Collectively,these data confirmed LPCAT1 was upregulated in HCC,and was an independent predictor of the prognosis. | Hongbin Zhang Ke Xu Qin Xiang Lijuan Zhao Benxu Tan Ping Ju Xiufu Lan Yi Liu Jian Zhang Zheng Fu Chao Li Jinzhi Wang Jixiang Song Yun Xiao Zhaobo Cheng Yan Wang Shu Zhang Tingxiu Xiang | 2022 | Genes & Diseases2022，9，1： | 0 |
| 11 | Correspondence(reply):The application conditions of false discovery rate control显示文摘We have carefully read the correspondence“False Discov-ery Rate Control in Cancer Biomarker Selection”authored by Li.The author clarified the need of paying attention to the control of false discovery rate(FDR)when screening for cancer biomarkers.They expressed concerns about whether the 30 genes concluded in Figure 7 in our published paper“LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma”call for FDR control. | Hongbin Zhang Xin Le Tingxiu Xiang | 2023 | Genes & Diseases2023，10，4： | 0 |
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