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| 1 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 2 | Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C显示文摘AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse(ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage(β = 0.1865, P < 0.0001) and hyaluronic acid levels(β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated significantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index(BMI)(β =-0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels(β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage(β = 0.2921, P = 0.0044) and hyaluronic acid levels(β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage. | Toru Nishikawa Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Mizuno Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Naohiro Ichino Keisuke Osakabe Kentaro Yoshioka | 2014 | World Journal of Gastroenterology2014，20，5： | 7 |
| 3 | A new index for non-invasive assessment of liver fibrosis显示文摘AIM:To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver f ibrosis. METHODS:A new f ibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS,platelet count and prothrombin time. The values of the Fibro-Stiffness index differed signif icantly between neighboring f ibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F≥2 (0.90), F≥ 3 (0.90) and F= 4(0.92) in the estimation group and those for F≥ 3 (0.93) and F =4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F≥2, F≥3 and F=4 in both the estimation and validation groups. The diagnostic performance for F= 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2,3 and 4. | Naohiro Ichino Keisuke Osakabe Toru Nishikawa Hiroko Sugiyama Miho Kato Shiho Kitahara Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Arima Hiroaki Shimazaki Koji Suzuki Kentaro Yoshioka | 2010 | World Journal of Gastroenterology2010，16，38： | 7 |
| 4 | Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study显示文摘 | Yukio Osaki Yoshihide Ueda Hiroyuki Marusawa Jun Nakajima Toru Kimura Ryuichi Kita Hiroki Nishikawa Sumio Saito Shinichiro Henmi Azusa Sakamoto Yuji Eso Tsutomu Chiba | 2012 | Journal of Gastroenterology2012，，4： | 3 |
| 5 | Radiofrequency ablation for hepatocellular carcinoma显示文摘 | Hiroki Nishikawa Toru Kimura Ryuichi Kita Yukio Osaki | 2013 | International Journal of Hyperthermia2013，，6： | 2 |
| 6 | Synchronous Double Cancer of the Stomach and Rectum With Situs Inversus Totalis and Polysplenia Syndrome显示文摘 | Takeshi Iwamura Naoya Shibata Yasuaki Haraguchi Yosuke Hisashi Takushi Nishikawa Hiroki Yamada Toru Hayashi Kiyokazu Toyoda | 2001 | Journal of Clinical Gastroenterology2001，，2： | 1 |
| 7 | A high-speed, high-sensitivity digital CMOS image sensor with a global shutter and 12-bit column-parallel cyclic A/D converters 显示文摘 | Masanori Furuta Yukinari Nishikawa Toru Inoue | 2007 | IEEE Journal of Solid-State Circuits2007，42，4： | 1 |
| 8 | Radiative Heat Transfer and Hydrostatic Stability in Nocturnal Fog显示文摘 | Toru Nishikawa Shigenao Maruyama Seigo Sakai | | 0，，： | 1 |
| 9 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 10 | Donepezil‐induced sleep spindle in a patient with dementia with Lewy bodies: a case report显示文摘 | Asami OZAKI Masaki NISHIDA Keiko KOYAMA Kinya ISHIKAWA Toru NISHIKAWA | 2012 | Psychogeriatrics2012，，4： | 1 |
| 11 | Effect of treatment with branched‐chain amino acids during sorafenib therapy for unresectable hepatocellular carcinoma显示文摘 | Haruhiko Takeda Hiroki Nishikawa Eriko Iguchi Yoshiaki Ohara Azusa Sakamoto Sumio Saito Norihiro Nishijima Akihiro Nasu Hideyuki Komekado Ryuichi Kita Toru Kimura Yukio Osaki | 2014 | Hepatol Res2014，，3： | 1 |
| 12 | Radiative Heat Transfer and Hydrostatic Stability in Nocturnal Fog显示文摘 | Toru Nishikawa Shigenao Maruyama Seigo Sakai | 2004 | Boundary - Layer Meteorology2004，，2： | 1 |
| 13 | Temporal variation in the wavelength of hummocky cross-stratification:Implications for storm intensity through Mesozoic and Cenozoic显示文摘 | Makoto Ito Asako Ishigaki Toru Nishikawa Takahiro Saito | 2001 | Geology2001，29，： | 1 |
| 14 | Androgen metabolite-dependent growth of hormone receptor-positive breast cancer as a possible aromatase inhibitor-resistance mechanism显示文摘 | Toru Hanamura Toshifumi Niwa Sayo Nishikawa Hiromi Konno Tatsuyuki Gohno Chika Tazawa Yasuhito Kobayashi Masafumi Kurosumi Hiroyuki Takei Yuri Yamaguchi Ken-ichi Ito Shin-ichi Hayashi | 2013 | Breast Cancer Research and Treatment2013，，3： | 1 |
| 15 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 16 | A high-speed,high-sensitivity digital CMOS image sensor with a global shutter and 12-bit column-parallel cyclic A/D converters显示文摘 | Furuta Masanori Nishikawa Yukinari Inoue Toru | 2007 | IEEE Journal of Solid-State Circuits2007，42，4： | 1 |
| 17 | Oral clonidine premedication reduces induction dose and prolongs awakening time from propofol-nitrous oxide anedthesia显示文摘 | TORU GOYAGI M D MAKOTO TANAKA M D TOSHI-AKI NISHIKAWA M D | 1999 | Can J Anesth1999，46，9： | 1 |
| 18 | Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C显示文摘AIM: To evaluate the changes of shear-wave velocity(Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C.METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon(IFN) plus ribavirin(RBV). Vs value(m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment(EOT), 1 year after EOT, and 2 years after EOT.RESULTS: In patients with a sustained virological response(SVR)(n = 41), Vs significantly decreased at EOT [1.19(1.07-1.37), P = 0.0004], 1 year after EOT [1.10(1.00-1.22), P = 0.0001], and 2 years after EOT [1.05(0.95-1.16), P < 0.0001] compared with baseline [1.27(1.11-1.49)]. In patients with a relapse(n = 26), Vs did not significantly decrease at EOT [1.23(1.12-1.55)], 1 year after EOT [1.20(1.12-1.80)], and 2 years after EOT [1.41(1.08-2.01)] compared with baseline [1.39(1.15-1.57)]. In patients with a nonvirological response(n = 20), Vs did not significantly decrease at EOT [1.64(1.43-2.06)], 1 year after EOT [1.66(1.30-1.95)], and 2 years after EOT [1.61(1.36-2.37)] compared with baseline [1.80(1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28(1.04-1.40)] than in non-SVR patients [1.56(1.20-1.83)](P = 0.0142).CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse. | Keisuke Osakabe Naohiro Ichino Toru Nishikawa Hiroko Sugiyama Miho Kato Ai Shibata Wakana Asada Naoto Kawabe Senju Hashimoto Michihito Murao Takuji Nakano Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Takamitsu Kurashita Tomoki Takamura Kentaro Yoshioka | 2015 | World Journal of Gastroenterology2015，21，35： | 0 |
| 19 | 选择性β1肾上腺素受体阻滞剂艾司洛尔及兰地洛尔对大鼠脊髓缺血和再灌注损伤的神经保护作用显示文摘背景在胸科手术及胸腹部大动脉手术中,截瘫时有发生,它是一种严重的不可预料的并发症。由于超短效选择性β1-肾上腺素受体阻滞剂能在脑缺血后提供神经保护作用,因此我们推断:它们也能减轻大鼠短暂性脑缺血和再灌注所引起的脊髓损伤。方法将雄性Sprague.Dawley鼠随机分成四组:生理盐水组(以0.5ml/L速率静脉输注0.9%盐水,n=8)、艾司洛尔组(200μg.kg^-1·min^-1,n=8)、兰地洛尔组(50μg·kg^-1·min^-1)或假手术组(n=6)。从脊髓缺血前30分钟开始输注生理盐水或药物,并持续到再灌注后24小时。通过主动脉内球囊阻塞联合持续近端动脉低血压10分钟的方法来建立脊髓缺血模型,然后对脊髓进行24小时再灌注。缺血性损伤程度是通过再灌注24小时后的后肢运动损伤指数分数和位于脊髓前角的有活力的运动神经细胞数量来进行评估的。结果艾司洛尔组及兰地洛尔组的运动损伤指数分数较生理盐水组显著性降低(P〈0.05)。组织病理学评估发现艾司洛尔组及兰地洛尔组的脊髓损伤程度较生理盐水组轻(P〈0.05)。结论上述结果显示超短效选择性β1-肾上腺素受体阻滞剂能在大鼠脊髓缺血一再灌注损伤模型中减轻神经损伤。 | Shino Umehara, MD Toru Goyagi, MD Toshiaki Nishikawa, MD PhD, Yoshitsugu Tobe, BS 韩柳(译) 李成辉(校) | 2011 | 麻醉与镇痛2011，7，6： | 0 |
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