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| 1 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 2 | Assessment of liver fibrosis by a noninvasive method of transient elastography and biochemical markers显示文摘瞄准:为了是估计在纤维变性区域(FA ) 之间的关联,并且把 FibroScan 的诊断精确性比作用操作的接收装置的标记弄弯的另外的存在的肝纤维变性(LF ) ,由数字图象分析(DIA ) 计算了分析。方法:我们招募了包括正常的肝,肝炎 B,和丙肝为三不同病原学经历了肝切除术的 30 个病人。肝僵硬被使用 FibroScan 测量。FA 然后被 DIA 计算评估 LF 以便避免任何采样偏爱。结果:FA 否定地与凝血素相关时间(磅) ,血小板计数,卵磷脂胆固醇 acyltransferase (LCAT ) ,和白朊前(白长袍的) 。在另一方面, FibroScan 的调查结果与类似的标记相关。FA 断然与 FibroScan,浆液 hyaluronate 水平,和类型 IV 骨胶原相关水平,和 aspartate 转氨酶到血小板比率索引(APRI ) 。在操作的接收装置下面的区域弯因为 FibroScan 为另外的标记比那高,尽管统计意义是最小的。结论:我们的调查结果建议 FibroScan 能开始被用来作为肝活体检视(磅) 和血清诊断的一种选择估计 LF,因为它是有可比较的诊断精确性考虑的一个安全方法存在 LF 标记。 | Masaki Kawamoto Toru Mizuguchi Tadashi Katsuramaki Minoru Nagayama Hideki Oshima Hiroyuki Kawasaki Takayuki Nobuoka Yasutoshi Kimura Koichi Hirata | 2006 | World Journal of Gastroenterology2006，12，27： | 12 |
| 3 | Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma显示文摘AIM:To compare the prognoses of hepatocellular carcinoma(HCC)patients that underwent anatomic liver resection(AR)or non-anatomic liver resection(NAR)using propensity score-matched populations.METHODS:Between January 2002 and December2010,268 consecutive HCC patients,including 110 and158 patients that underwent AR and NAR,respectively,were retrospectively enrolled in this study.Forty-four patients from each group were selected and matched using logistic multivariate analysis followed by propensity score analysis.RESULTS:In the whole analysis set,the histological background of the liver,liver function,and tumor marker levels differed significantly among the groups.Although the overall survival(OS)and recurrence-free survival rates of the two groups did not differ significantly in the whole analysis set,the OS of the AR group was significantly longer than that of the NAR group after propensity matching(76.2±6.3 mo vs 58.9±6.3mo;P=0.0039).Although AR(HR=0.456,P=0.039)was found to be a prognostic factor in the univariate analysis,only vascular invasion(HR=0.228,P=0.002)and the hepatocyte growth factor level(HR=52.366,P=0.035)were subsequently found to be independent prognostic factors.CONCLUSION:AR conveys a survival advantage over NAR in specific subpopulations of HCC patients with tumors of less than 5 cm in diameter,single tumor,and good liver function. | Masayuki Ishii Toru Mizuguchi Masaki Kawamoto Makoto Meguro Shigenori Ota Toshihiko Nishidate Kenji Okita Yasutohsi Kimura Thomas T Hui Koichi Hirata | 2014 | World Journal of Gastroenterology2014，20，12： | 12 |
| 4 | Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer显示文摘AIM:To characterize the implications of vascular endothelial growth factor(VEGF)-A in stromal cells and colorectal cancer and the expression of VEGF-A splice variants.METHODS:VEGF-A expression in tumor and stromal cells from 165 consecutive patients with colorectal cancer was examined by immunohistochemistry.The association between VEGF-A expression status and clinicopathological factors was investigated.Twenty freshfrozen samples were obtained for laser capture microdissection to analyze the splice variants of VEGF-A.RESULTS:VEGF-A was expressed in 53.9% and 42.4% of tumor and stromal cells,respectively.VEGF-A expression in tumor cells(t-VEGF-A) was associated with advanced clinical stage(stage 0,1/9;stage 1,2/16;stage 2,32/55;stage 3,38/66;stage 4,16/19,P < 0.0001).VEGF-A expression in stromal cells(s-VEGF-A) increased in the earlier clinical stage(stage 0,7/9;stage 1,6/16;stage 2,33/55;stage 3,22/66;stage 4,5/19;P = 0.004).Multivariate analyses for risk factors of recurrence showed that only s-VEGF-A expression was an independent risk factor for recurrence(relative risk 0.309,95% confidence interval 0.141-0.676,P = 0.0033).The five-year disease-free survival(DFS) rates of t-VEGF-A-positive and-negative cases were 51.4% and 62.9%,respectively.There was no significant difference in t-VEGF-A expression status.The five-year DFS rates of s-VEGF-A-positive and-negative cases were 73.8% and 39.9%,respectively.s-VEGFA-positive cases had significantly better survival than s-VEGF-A-negative cases(P = 0.0005).Splice variant analysis revealed that t-VEGF-A was mainly composed of VEGF165 and that s-VEGF-A included both VEGF165 and VEGF165b.In cases with no venous invasion(v0),the level of VEGF165b mRNA was significantly higher(v0 204.5 ± 122.7,v1 32.5 ± 36.7,v2 2.1 ± 1.7,P = 0.03).The microvessel density tended to be lower in cases with higher VEGF165b mRNA levels.CONCLUSION:s-VEGF-A appears be a good prognostic factor for colorectal cancer and includes VEGF165 and VEGF165b. | Makoto Tayama Tomohisa Furuhata Yoshiko Inafuku Kenji Okita Toshihiko Nishidate Toru Mizuguchi Yasutoshi Kimura Koichi Hirata | 2011 | World Journal of Gastroenterology2011，17，44： | 10 |
| 5 | Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis显示文摘AIM To investigate the significance of heat shock protein 110(HSP110) in gastric cancer(GC) patients with peritoneal metastasis undergoing hyperthermochemotherapy.METHODS Primary GC patients(n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery. We analyzed nuclear HSP110 expression in surgically resected tumors using immunohistochemistry. Additionally, the effect of HSP110 suppression on hyptherthermochemosensitivity was assessed in vitro in the MKN45 GC cell line using the HSP inhibitor KNK437. RESULTS HSP110 immnohistochemical staining in 14 GC patients showed that five(35.7%) samples belonged to the low expression group, and nine(64.3%) samples belonged to the high expression group. Progression-free survival was significantly shorter in the HSP110 high-expression group than in the low-expression group(P = 0.0313). However, no significant relationships were identified between HSP110 expression and the clinicopathological characteristics of patients. Furthermore, high HSP110 expression was not an independent prognostic factor in GC patients with peritoneal metastasis(P = 0.0625). HSP110 expression in MKN45 cells was suppressed by KNK437 at the hyperthermic temperature of 43 ℃ in vitro. Comparison of MKN45 cell proliferation in the presence and absence of KNK437 at 43 ℃, revealed that proliferation was significantly decreased when HSP110 was inhibited by KNK437. Additionally, HSP110 suppression via HSP inhibitor treatment increased cellular sensitivity to hyperthermo-chemotherapy in vitro.CONCLUSION The expression of nuclear HSP110 in GC patients might be a new marker of chemosensitivity and a therapeutic target for patients who are tolerant to existing hyperthermo-chemotherapies. | Akiharu Kimura Kyoichi Ogata Bolag Altan Takehiko Yokobori Erito Mochiki Mitsuhiro Yanai Norimichi Kogure Toru Yanoma Masaki Suzuki Tuya Bai Hiroyuki Kuwano | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 6 | Successful resection of metachronous para-aortic, Virchow lymph node and liver metastatic recurrence of rectal cancer显示文摘A 66-year-old female presented with the main complaint of defecation trouble and abdominal distention. With diagnosis of rectal cancer, c SS, c N0, c H0, c P0, c M0 c Stage Ⅱ, Hartmann's operation with D3 lymph node dissection was performed and a para-aortic lymph node and a disseminated node near the primary tumor were resected. Histological examination showed moderately differentiated adenocarcinoma, p SS, p N3, p H0, p P1, p M1(para-aortic lymph node, dissemination) f Stage Ⅳ. After the operation, the patient received chemotherapy with FOLFIRI regimen. After 12 cycles of FOLFIRI regimen, computed tomography(CT) detected an 11 mm of liver metastasis in the posteroinferior segment of right hepatic lobe. With diagnosis of liver metastatic recurrence, we performed partial hepatectomy. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer with cut end microscopically positive. After the second operation, the patient received chemotherapy with TS1 alone for 2 years. Ten months after the break, CT detected a 20 mm of paraaortic lymph node metastasis and a 10 mm of lymph node metastasis at the hepato-duodenal ligament. With diagnosis of lymph node metastatic recurrences, we performed lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as metastatic rectal cancer in paraaortic and hepato-duodenal ligament areas. After the third operation, we started chemotherapy with modified FOLFOX6 regimen. After 2 cycles of modified FOLFOX6 regimen, due to the onset of neutropenia and liver dysfunction, we switched to capecitabine aloneand continued it for 6 mo and then stopped. Eleven months after the break, CT detected two swelling 12 mm of lymph nodes at the left supraclavicular region. With diagnosis of Virchow lymph node metastatic recurrence, we started chemotherapy with capecitabine plus bevacizumab regimen. Due to the onset of neutropenia and hand foot syndrome(Grade 3), we managed to continue capecitabine administration with extension of interval period and dose reduction. After 2 years and 2 mo from starting capecitabine plus bevacizumab regimen, Virchow lymph nodes had slowly grown up to 17 mm. Because no recurrence had been detected besides Virchow lymph nodes for this follow up period, considering the side effects and quality of life, surgical resection was selected. We performed left supraclavicular lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer. After the fourth operation, the patient selected follow up without chemotherapy. Now we follow up her without recurrence and keep her quality of life high. | Nobuyoshi Takeshita Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Isamu Hoshino Takumi Ota Tetsuro Maruyama Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，44： | 4 |
| 7 | Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study显示文摘 | Yukio Osaki Yoshihide Ueda Hiroyuki Marusawa Jun Nakajima Toru Kimura Ryuichi Kita Hiroki Nishikawa Sumio Saito Shinichiro Henmi Azusa Sakamoto Yuji Eso Tsutomu Chiba | 2012 | Journal of Gastroenterology2012，，4： | 3 |
| 8 | Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage显示文摘 | Yasuhide Kuwabara Koh Ono Takahiro Horie Hitoo Nishi Kazuya Nagao Minako Kinoshita Shin Watanabe Osamu Baba Yoji Kojima Satoshi Shizuta Masao Imai Toshihiro Tamura Toru Kita Takeshi Kimura | 2011 | Circulation: Cardiovascular Genetics2011，，： | 2 |
| 9 | Crystal structure and hydrogen storage properties of(La,Ce)Ni_(5-x)M_x(M = Al, Fe, or Co) alloys显示文摘The effects of partial substitution of La by Ce and Ni by Al, Fe, or Co in LaNi_5-based alloys on hydrogen storage performance were systematically studied. All samples were prepared using vacuum arc melting in an argon atmosphere. The results showed that for LaNi_(5-x)M_x(M = Al, Fe, or Co) alloys, the lattice constants and unit cell volumes increased with an increasing amount of Al and Fe. On the other hand, these parameters decreased upon partial substitution of La by Ce. In addition, the lattice constant remained almost constant in the La_(0.6)Ce_(0.4)Ni_(5–x)Cox alloys regardless of the value of x(x = 0.3, 0.6, or 0.9), as Ce might enhance the homogeneity of the CaCu_5-type phase in Co-containing alloys. The hydrogen storage properties of the alloys were investigated using pressure, composition, and temperature isotherms. The experimental results showed that the plateau pressure decreased with an increasing content of Al, Fe, or Co, but it increased with Ce addition. Furthermore, the plateau pressures of all Co-containing alloys were almost identical upon substitution with Ce. Finally, the enthalpy(ΔH) and entropy(ΔS) values for all alloys were calculated using van't Hoff plots. The relationship between the lattice parameters and enthalpy changes for hydrogenation will be discussed. | Wan-liang Mi Zhao-sen Liu Toru Kimura Atsunori Kamegawa Hai-liang Wang | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，1： | 2 |
| 10 | Comparison of Perioperative and Long-term Outcomes of Total and Proximal Gastrectomy for Early Gastric Cancer: A Multi-institutional Retrospective Study显示文摘 | Toru Masuzawa Shuji Takiguchi Motohiro Hirao Hiroshi Imamura Yutaka Kimura Junya Fujita Isao Miyashiro Shigeyuki Tamura Masahiro Hiratsuka Kenji Kobayashi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2014 | World Journal of Surgery2014，，5： | 2 |
| 11 | Radiofrequency ablation for hepatocellular carcinoma显示文摘 | Hiroki Nishikawa Toru Kimura Ryuichi Kita Yukio Osaki | 2013 | International Journal of Hyperthermia2013，，6： | 2 |
| 12 | Electrohydraulic lithotripsy and rendezvous nasal endoscopic cholangiography for common bile duct stone: A case report显示文摘BACKGROUND In patients with large stones in the common bile duct(CBD),advanced treatment modalities are generally needed.Here,we present an interesting case of a huge CBD stone treated with electrohydraulic lithotripsy(EHL)by the percutaneous approach and rendezvous endoscopic retrograde cholangiography(ERC)using a nasal endoscope.CASE SUMMARY A 91-year-old woman underwent ERC for a symptomatic large CBD stone with a diameter of 50 mm.She was referred to our institution after the failure of lithotomy by ERC,and after undergoing percutaneous transhepatic biliary drainage.We attempted to fragment the stone by transhepatic cholangioscopy using EHL.However,the stones were too large and partly soft clay-like for lithotripsy.Next,we attempted lithotomy with ERC and cholangioscopy by the rendezvous technique using a nasal endoscope and achieved complete lithotomy.No complication was observed at the end of this procedure.CONCLUSION Cholangioscopy by rendezvous technique using a nasal endoscope is a feasible and safe endoscopic method for removing huge CBD stones. | Koichi Kimura Kensuke Kudo Tomoharu Yoshizumi Takeshi Kurihara Shohei Yoshiya Yohei Mano Kazuki Takeishi Shinji Itoh Noboru Harada Toru Ikegami Tetsuo Ikeda | 2019 | World Journal of Clinical Cases2019，7，10： | 2 |
| 13 | Esophageal intramural pseudodiverticulosis of the residual esophagus after esophagectomy for esophageal cancer显示文摘A 91-year-old man was referred to our hospital with intermittent dysphagia. He had undergone esophagectomy for esophageal cancer(T3N2M0 Stage Ⅲ) 11 years earlier. Endoscopic examination revealed an anastomotic stricture; signs of inflammation,including redness,erosion,edema,bleeding,friability,and exudate with white plaques; and multiple depressions in the residual esophagus. Radiographical examination revealed numerous fine,gastrografinfilled projections and an anastomotic stricture. Biopsy specimens from the area of the anastomotic stricture revealed inflammatory changes without signs of malignancy. Candida glabrata was detected with a culture test of the biopsy specimens. The stricture was diagnosed as a benign stricture that was caused by esophageal intramural pseudodiverticulosis. Accordingly,endoscopic balloon dilatation was performed and antifungal therapy was started in the hospital. Seven weeks later,endoscopic examination revealed improvement in the mucosal inflammation; only the pseudodiverticulosis remained. Consequently,the patient was discharged. At the latest follow-up,the patient was symptomfree and the pseudodiverticulosis remained in the residual esophagus without any signs of stricture or inflammation. | Nobuyoshi Takeshita Naoki Kanda Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Masaya Uesato Tetsutaro Sazuka Tetsuro Maruyama Naohiro Aida Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 14 | Long-Term Survival After Report Resection of Pulmonary Metastases from Hepatocellular Carcinoma: Report of Two Cases显示文摘 | Toru Nakamura Taizo Kimura Yasuhiko Umehara Kenji Suzuki Kazuya Okamoto Takuya Okumura Sei Morizumi Toshiki Kawabata Akira Komiyama | 2005 | Surgery Today2005，，10： | 1 |
| 15 | Biliary injury after laparoscopic cholecystectomy: end-to-end anastomosis covered with umbilical vein显示文摘 | Yasutoshi Kimura Koichi Hirata Mitsuhiro Mukaiya Toru Mizuguchi Takayuki Nobuoka Tomohisa Furuhata Tadashi Katsuramaki | 2005 | Journal of Hepato - Biliary - Pancreatic Surgery2005，，3： | 1 |
| 16 | Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice显示文摘 | Tsuneaki Kawashima Yasutaka Inuzuka Junji Okuda Takao Kato Shinichiro Niizuma Yodo Tamaki Yoshitaka Iwanaga Akira Kawamoto Michiko Narazaki Tetsuya Matsuda Souichi Adachi Genzou Takemura Toru Kita Takeshi Kimura Tetsuo Shioi | 2011 | Journal of Molecular and Cellular Cardiology2011，，6： | 1 |
| 17 | Clinical significance of gastrointestinal bleeding after living donor liver transplantation显示文摘 | Koichi Kimura Toru Ikegami Yuki Bekki Mizuki Ninomiya Yo‐ichi Yamashita Tomoharu Yoshizumi Shohei Yoshiya Yuji Soejima Noboru Harada Ken Shirabe Yoshihiko Maehara | 2014 | Transpl Int2014，，7： | 1 |
| 18 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 19 | Measurements of baseline and follow-up concentrations of cardiac troponin-T and brain natriuretic peptide in patients with heart failure from various etiologies显示文摘 | Ryoji Taniguchi Yukihito Sato Yukiko Nishio Takeshi Kimura Toru Kita | 2006 | Heart and Vessels2006，，6： | 1 |
| 20 | Radiofrequency ablation during continuous saline infusion can extend ablation margins显示文摘AIM:To determine whether fluid injection during radiofrequency ablation(RFA) can increase the coagulation area.METHODS:Bovine liver(1-2 kg) was placed on an aluminum tray with a return electrode affixed to the base,and the liver was punctured by an expandable electrode.During RFA,5% glucose;50% glucose;or saline fluid was infused continuously at a rate of 1.0 mL/min through the infusion line connected to the infusion port.The area and volume of the thermocoagulated region of bovine liver were determined after RFA.The Joule heat generated was determined from the temporal change in output during the RFA experiment.RESULTS:No liquid infusion was 17.3 ± 1.6 mL,similar to the volume of a 3-cm diameter sphere(14.1 mL).Mean thermocoagulated volume was significantly larger with continuous infusion of saline(29.3 ± 3.3 mL) than with 5% glucose(21.4 ± 2.2 mL),50%glucose(16.5 ± 0.9 mL) or no liquid infusion(17.3 ± 1.6 mL).The ablated volume for RFA with saline was approximately 1.7-times greater than for RFA with no liquid infusion,representing a significant difference between these two conditions.Total Joule heat generated during RFA was highest with saline,and lowest with 50% glucose.CONCLUSION:RFA with continuous saline infusion achieves a large ablation zone,and may help inhibit local recurrence by obtaining sufficient ablation margins.RFA during continuous saline infusion can extend ablation margins,and may be prevent local recurrence. | Toru Ishikawa Tomoyuki Kubota Ryoko Horigome Naruhiro Kimura Hiroki Honda Akito Iwanaga Keiichi Seki Terasu Honma Toshiaki Yoshida | 2013 | World Journal of Gastroenterology2013，19，8： | 1 |
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