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| 1 | Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis显示文摘AIM: To evaluate the effect of pyrrolidine dithio- carbamate (PDTC; an NF-κB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis. METHODS: Mice were divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+PDTC-treated groupⅠ(low-dose group), and DSS+PDTC-treated groupⅡ (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue were measured. RESULTS: The DSS+PDTC-treated groupⅡ exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels were significantly lower in DSS+PDTC- treated groupⅡ. CONCLUSION: These findings suggest that PDTC is useful for the treatment of ulcerative colitis. | Ichiro Hirata Shingo Yasumoto Ken Toshina Takuya Inoue Takashi Nishikawa Naoko Murano Mitsuyuki Murano Fang-Yu Wang Ken-ichi Katsu | 2007 | World Journal of Gastroenterology2007，13，11： | 20 |
| 2 | Usefulness of fecal lactoferrin and hemoglobin in diagnosis of colorectal diseases显示文摘AIM:To evaluate prospectively usefulness of fecal lactoferrin(Lf)and fecal hemoglobin(Hb)in the diagnosis of colorectal diseases.METHODS:Fecal Lf and Hb were measured using ELISA in 872 patients before they underwent colorectal endoscopy.RESULTS:Lf was positive in 18(50%)of 36 patients with colorectal cancer,25(15.9%)of 157 with colorectal polyps,29(46.8%)of 62 with ulcerative colitis,and 25(62.5%)of 40(62.5%)with Crohn's disease.The Hb-positive rates were 50%,12.1%,41.9% and 32.5%,respectively.Of the 318 patients free of abnormalities by colorectal endoscopy,Lf was positive in 29(9.1%)and Hb was positive in 15(4.7%).Among patients with Crohn's disease,the Lf-positive rate was significantly higher than the Hb-positive rate.If either high Lf or Hb levels were considered positive,the positive rates rose to 61.1%,51.6%,and 67.5% in the colorectal cancer group,ulcerative colitis group,and Crohn's disease group,respectively.If both high Lf and Hb levels were rated positive,the positive predictive values(PPV)were 21% for colorectal cancer,33% for ulcerative colitis,and 17% for Crohn's disease,and PPV of high Hb level alone was 18%,25% and 13%,respectively.CONCLUSION:Fecal Lf and Hb were found useful in the detection of colorectal diseases,and the combination of the two measurements appears to increase the sensitivity and efficacy of diagnosis. | Ichiro Hirata Masahiro Hoshimoto Osamu Saito Masanobu Kayazawa Takashi Nishikawa Mitsuyuki Murano Ken Toshina Fang-Yu Wang Ryoichi Matsuse | 2007 | World Journal of Gastroenterology2007，13，10： | 3 |
| 3 | Hepatic injury and gluconeogenesis after subcutaneous injection of monochloroacetic acid in rats显示文摘 | Toshina Y Dote T Usda K | 2004 | Environmental Health and Preventive Medicine2004，9，： | 1 |
| 4 | Refractory ulcerative colitis accompanied with cytomegalovirus colitis and multiple liver abscesses: A case report显示文摘Various hepato-biliary complications are an increased incidence in patients with inflammatory bowel disease,and portal bacteremia is well documented in patients with ulcerative colitis (UC). However, few reports mention UC in association with liver abscesses. Recently, there are several reports describing cytomegalovirus (CMV) infection in association with disease exacerbation and steroid refractoriness in patients with UC. Here we present a case of refractory UC accompanied with multiple liver abscesses and CMV colitis. The patient, a 72-year-old male, with a five-year history of repeated admissions to our hospital for UC, presented with an exacerbation of his UC.Sigmoidoscopy performed on admission suggested that his UC was exacerbated, then he was given prednisolone and mesalazine orally, and betamethasone enemas.However, he had exacerbated symptoms. Repeat sigmoidoscopy revealed multiple longitudinal ulcers and pseudopolyps in the rectosigmoid colon. Although immunohistochemical staining of biopsy specimens and the serum testing for antigenemia were negative on admission and after the repeat sigmoidoscopy, they became histologically positive for CMV. Nonetheless, the patient developed spiking fevers, soon after ganciclovir was administered. Laboratory studies revealed an increased white cell count with left shift, and Enterococcus fecalis grew in blood cultures. An abdominal computed tomography (CT) scan was obtained and the diagnosis of liver abscesses associated with UC was made, based on CT results. The hepatic abscesses were successfully treated with intravenous meropenem for 6 wk, without further percutaneous drainage. To our knowledge, this is the first reported case of multiple liver abscesses that develop during UC exacerbation complicated by CMV colitis. | Takuya Inoue Ichiro Hirata Yutaro Egashira Kumi Ishida Ken Kawakami Eijiro Morita Naoko Murano Shingo Yasumoto Mitsuyuki Murano Ken Toshina Takashi Nishikawa Norihiro Hamamoto Ken Nakagawa Ken-Ichi Katsu | 2005 | World Journal of Gastroenterology2005，11，33： | 1 |
| 5 | Experssion of the EP4 prostaglandin E2 receptor subtype with rat dextran sodium sulphate colitis:colitis suppression by a selective agonist, ONO-AE1-329 显示文摘 | Nitta M Hirata I Toshina K | 2002 | Scand J Immunol2002，56，1： | 1 |
| 6 | Acute dose and time-dependent toxicity of monochloroacetic acid after subcutaneous injection in rats 显示文摘 | Toshina Y Dote T Usuda K | 2004 | Bulletin of the Medical College2004，50，12： | 1 |
| 7 | Increased proliferation of middle to distal colonic cells during colorectalcarcinogenesis in experimental murine ulcerative colitis显示文摘 | Takuya Inoue Mitsuyuki Murano Takanori Kuramoto Kumi Ishida Ken Kawakami Yosuke Abe Eijiro Morita Naoko Murano Ken Toshina Takashi Nishikawa Kentaro Maemura Chikao Shimamoto Ichiro Hirata Ken-Ichi Katsu Kazuhide Higuchi | 2007 | Oncology Reports2007，，6： | 1 |
| 8 | Comparative study of conventional colonoscopy and pan-colonic narrow-band imaging system in the detection of neoplastic colonic polyps: a randomized, controlled trial显示文摘 | Takuya Inoue Mitsuyuki Murano Naoko Murano Takanori Kuramoto Ken Kawakami Yosuke Abe Eijiro Morita Ken Toshina Hideo Hoshiro Yutaro Egashira Eiji Umegaki Kazuhide Higuchi | 2008 | Journal of Gastroenterology2008，，1： | 1 |
| 9 | Novel ring-opening polymerization of lactide by lipase显示文摘 | Matsumura S Mabuchi K Toshina K | 1998 | Macromol Symp1998，130，1： | 1 |
| 10 | Histopathological and genetic differences between polypoid and non-polypoid submucosal colorectal carcinoma显示文摘瞄准:调查水虫息似的生长(PG ) 和非水虫息似的生长(NPG ) 之间的组织病理学说、基因的差别粘膜下层的侵略肤色表面的癌(CRC ) 。方法:粘膜下层 CRC 的 96 个案例的一个总数根据他们的生长类型被划分成二个组;PG 的 60 个案例和 NPG 的 36 个案例。尺寸,发育异常的组织学的度,粘膜下层侵略的深度和淋巴节点转移在二个组之间被比较。而且, p53 的表示被免疫检测组织化学的染色,并且 K 地岬基因变化被聚合酶链反应检验基于的单个海滨的符合构造多型性(SSCP ) 。结果:在 NPG 组的损害的平均尺寸是比在 PG 组的那些显著地小的(7.5 公里对 13.8 公里, P <
0.001 ) 。当粘膜下层的巨大的侵略和淋巴节点转移的发生比在 PG 组在 NPG 类型更高显著地是两个时,发育异常的组织学的度趋于在 NPG 组更严重(64.3% 对 43.3% , P = 0.004;43% 对 7% , P = 0.008,分别地) 。另外, K 地岬基因变化在 NPG 组在 PG 组,而是没有在 67% 损害被检测,当在组织化学的表示在二之间被发现的 p53 免疫的差别都不组织时。结论:与 PG 粘膜下层的 CRC 相比, NPG 类型表明更经常的粘膜下层的巨大的侵略,更多的淋巴节点转移和更高的度发育异常。遗传上, NPG 类型显示出更不经常的 K 地岬变化。 | Ichiro Hirata Fang-Yu Wang Mitsuyuki Murano Takuya Inoue Ken Toshina Takashi Nishikawa Kentaro Maemura | 2007 | World Journal of Gastroenterology2007，13，14： | 0 |
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