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| 1 | Prospective study of differential diagnosis of hepatic tumors by pattern-based classification of contrast-enhanced sonography显示文摘AIM: To prospectively evaluate the usefulness of a pattern-based classification of contrast-enhanced sonographic findings for differential diagnosis of hepatic tumors. METHODS: We evaluated the enhancement pattern of the contrast-enhanced sonography images in 586 patients with 586 hepatic lesions, consisting of 383 hepatocellular carcinomas, 89 metastases, and 114 hemangiomas. After injecting a galactose-palmitic acid contrast agent, lesions were scanned by contrast- enhanced harmonic gray-scale sonography in three phases: arterial, portal, and late. The enhancement patterns of the initial 303 lesions were classified retrospectively, and multiple logistic regression analysis was used to identify enhancement patterns that allowed differentiation between hepatic tumors. We then used the pattern-based classification of enhancement we had retrospectively devised to prospectively diagnose 283 liver tumors. RESULTS: Seven enhancement patterns were found to be significant predictors of different hepatic tumors. The presence of homogeneous or heterogeneous enhancement both in the arterial and portal phase was the typical enhancement pattern for hepatocellular carcinoma, while the presence of peritumoral vessels in the arterial phase and ring enhancement or a perfusion defect in the portal phase was the typical enhancement pattern for metastases, and the presence of peripheral nodular enhancement both in the arterial and portal phase was the typical enhancement pattern forhemangioma. The sensitivity, specificity, and accuracy of prospective diagnosis based on the combinations of enhancement patterns, respectively, were 93.2%, 96.2%, and 94.0% for hepatocellular carcinoma, 87.9%, 99.6%, and 98.2% for metastasis, and 95.6%, 94.1%, and 94.3% for hemangioma. CONCLUSION: The pattern-based classification of the contrast-enhanced sonographic findings is useful for differentiating among hepatic tumors. | Kazushi Numata Tetsuo Isozaki Manabu Morimoto Kazuya Sugimori Reiko Kunisaki Toshio Morizane Katsuaki Tanaka | 2006 | World Journal of Gastroenterology2006，12，39： | 18 |
| 2 | Quality of ulcer healing in gastrointestinal tract:Its pathophysiology and clinical relevance显示文摘In this paper,we review the concept of quality of ulcer healing(QOUH) in the gastrointestinal tract and its role in the ulcer recurrence.In the past,peptic ulcer disease(PUD) has been a chronic disease with a cycle of repeated healing/remission and recurrence.The main etiological factor of PUD is Helicobacter pylori(H.pylori),which is also the cause of ulcer recurrence.However,H.pylori-negative ulcers are present in 12%-20% of patients;they also recur and are on occasion intractable.QOUH focuses on the fact that mucosal and submucosal structures within ulcer scars are incompletely regenerated.Within the scars of healed ulcers,regenerated tissue is immature and with distorted architecture,suggesting poor QOUH.The abnormalities in mucosal regeneration can be the basis for ulcer recurrence.Our studies have shown that persistence of macrophages in the regenerated area plays a key role in ulcer recurrence.Our studies in a rat model of ulcer recurrence have indicated that proinflammatory cytokines trigger activation of macrophages,which in turn produce increased amounts of cytokines and chemokines,which attract neutrophils to the regenerated area.Neutrophils release proteolytic enzymes that destroy the tissue,resulting in ulcer recurrence.Another important factor in poor QOUH can be deficiency of endogenous prostaglandins and a deficiency and/or an imbalance of endogenous growth factors.Topically active mucosal protective and antiulcer drugs promote high QOUH and reduce inflammatory cell infiltration in the ulcer scar.In addition to PUD,the concept of QOUH is likely applicable to inflammatory bowel diseases including Crohn's disease and ulcerative colitis. | Tetsuo Arakawa Toshio Watanabe Tetsuya Tanigawa Kazunari Tominaga Yasuhiro Fujiwara Kenichi Morimoto | 2012 | World Journal of Gastroenterology2012，18，35： | 16 |
| 3 | 间歇和连续静脉输注法莫替丁对消化性溃疡患者胃酸的影响显示文摘 | Yozo Watanabe Hidenori Tsumura Hiroshi Sasaki Toshio Morimoto 孙钢 | 2000 | 中华消化杂志2000，20，5： | 6 |
| 4 | Continuous {low determination of aqueous sulfur by atmospheric- pressure helium microwave-induced plasma atomic e- mission spectrometry with gas-phase sample introduc- tion显示文摘 | Nakahara T Toshio M Morimoto S | 1995 | Spectroehimica Aeta Part B1995，50，47： | 1 |
| 5 | An improved method for recovering rabies virus from cloned cDNA显示文摘 | Ken-ichi Inoue Youko Shoji Ichiro Kurane Toshio Iijima Takeo Sakai Kinjiro Morimoto | 2002 | Journal of Virological Methods2002，，2： | 1 |
| 6 | Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone显示文摘 | Akihide Nampei Jun Hashimoto Kenji Hayashida Hideki Tsuboi Kenrin Shi Isamu Tsuji Hideaki Miyashita Takao Yamada Naomichi Matsukawa Masayuki Matsumoto Shigeto Morimoto Toshio Ogihara Takahiro Ochi Hideki Yoshikawa | 2004 | Journal of Bone and Mineral Metabolism2004，，3： | 1 |
| 7 | Expression of Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor in Vascular Endothelial Cells显示文摘 | Bingbing Jiang Shigeto Morimoto Jin Yang Tadaaki Niinoabu Keisuke Fukuo Toshio Ogihara | 1998 | Journal of Cardiovascular Pharmacology1998，，： | 1 |
| 8 | Flexural properties of glass fiber reinforced rigid polyurethane foam 显示文摘 | Morimoto K Toshio S Yosomiya R | 1984 | Industrial and Engineering Chemistry Product Research and Development1984，23，1： | 1 |
| 9 | Relationship Between Left Ventricular Geometry and Natriuretic Peptide Levels in Essential Hypertension显示文摘 | Toshio Nishikimi Fumiki Yoshihara Atsushi Morimoto Kazuhiko Ishikawa Toshihiko Ishimitsu Yoshihiko Saito Kenji Kangawa Hisayuki Matsuo Teruo Omae Hiroaki Matsuoka | 1996 | Hypertension1996，，1： | 1 |
| 10 | Ventricular adrenomedullin levels correlate with the extent of cardiac hypertrophy in rats显示文摘 | Toshio Nishikimi Fumiki Yoshihara | 1999 | Hypertension1999，33，5： | 1 |
| 11 | Treatment of hepatocellular carcinoma with radiofrequency ablation: Radiologic-histologic correlation during follow-up periods显示文摘 | Manabu Morimoto Kazuya Sugimori Kazuhito Shirato Atsushi Kokawa Naohiko Tomita Takafumi Saito Noriko Tanaka Akinori Nozawa Masamichi Hara Hisahiko Sekihara Hiroshi Shimada Toshio Imada Katsuaki Tanaka | 2002 | Hepatology2002，，6： | 1 |
| 12 | A highly attenuated rabies virus HEP-Flury strain reverts to virulent by single amino acid substitution to arginine at position 333 in glycoprotein显示文摘 | Mutsuyo Takayama-Ito Ken-ichi Inoue Yoko Shoji Satoshi Inoue Toshio Iijima Takeo Sakai Ichiro Kurane Kinjiro Morimoto | 2006 | Virus Research2006，，2： | 1 |
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