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124篇 您的检索式：作者名="Tremblay H"

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	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3kinase/Akt and GluT-4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats显示文摘	Tremblay F Lavigne C Jacques H	2003	Diabetes2003，52，1：	1
3	The mesoscale dy namics of freezing rain storms over eastern Canada显示文摘	Szeto K K Tremblay A Guan H	1999	J At mos Sci1999，56，10：	1
4	Evidence that brain-derived neurotrophic factor neuroprotection is linked to its abilitto reverse the NMDA-induced inactivation of protein Kinase C in cortical neurons显示文摘	Tremblay K H ewitt H Lesiuk G	1999	J Neurochem1999，72，：	1
5	Evidence that brain-derived neurotrophic factor neuro protection is linked to its ability to reverse the NMDA induced inactivation of protein kinas C in cortical neurons 显示文摘	Tremblay R Hewit t K Lesiuk H	1999	J Neurochem1999，72，1：	1
6	Evidence that BDNF neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons显示文摘	Tremblay R Hewitt K Lesiuk H		0，，01：	1
7	Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B-and atypical protein kinase C activities显示文摘	Tremblay F Lavigne C Jacques H	2001	Diabetes2001，50，：	1
8	The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘	International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M	2010	Science2010，330，6010：	1
9	Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both AKT/protein kinase B and atypical protein kinase C activities显示文摘	Tremblay F Lavigne C Jacques H	2001	Diabetes2001，50，8：	1
10	Mechanical and hydraullic behavior of a soft inorganic clay treated with lime显示文摘	LOCAT J TREMBLAY H LEROUUEIL S	1996	Canadian Geotechnical Journal1996，33，4：	1
11	Flower mi- celles of poly (N-isopropylacrylamide) with azobenzene moieties regularly inserted into the main chain 显示文摘	Boissiere O Han D H Tremblay L	2011	Soft Matter2011，7，19：	1
12	Role of dietary proteins and amino acids in the pathogenesis of insulin resistance显示文摘	Tremblay F Lavigne C Jacques H	2007	Annu Rev Nutr2007，27，：	1
13	Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alternation in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities显示文摘	Tremblay F Lavigne C Jacques H	2001	Diabetes2001，50，：	1
14	Influence of the nature of organic compounds on fine Soil stabilization with cement显示文摘	Tremblay H Duchesne J Locat J	2002	Canadian Geotectmical Testing Journal2002，39，3：	1
15	Expression of the Streptoco- ccus mutans essential two-component regulatory system VicRKis pH and growth-phase dependent and controlled by the Lia- FSR three-component regulatory system 显示文摘	Tremblay TD Lo H Li YH et d	2009	Microbiology2009，155，9：	1
16	The mesoscale dynamics of freezing rain storms over eastern Canada显示文摘	Szelo K K A Tremblay H Guan	1999	J At mos Sci1999，56，10：	1
17	Oil-mineral aggregate formation on oiled beaches: natural attenuation and sediment relocation显示文摘	LEE K STOFFYN EGLI P TREMBLAY G H	2003	Spill Science and Technology Bulletin2003，8，3：	1
18	Atlantic salmon (Salmo salar) fed l-carnitine exhibit altered intermediary metabolism and reduced tissue lipid,but no change in growth rate显示文摘	JI H BRADLEY T M TREMBLAY G C	1996	J Nutr1996，126，：	1
19	The development of a high-yield recombinant protein bioreactor throughRNAiin- duced knockdown of ATP/ADP transporter inSolanum tu- berosum显示文摘	Tremblay R Diao H Htiner N	2011	J Biotechnol2011，156，1：	1
20	Cervical spine motion during tracheal intubation with manual in-line stabilization:direct laryngoscopy versus GlideScope videolaryngoscopy显示文摘	ROBITAILLE A WILLIAMS S R TREMBLAY M H		0，，03：	1

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